Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators
Aird, Daniel, Teng, Teng, Huang, Chia-Ling, Pazolli, Ermira, Banka, Deepti, Cheung-Ong, Kahlin, Eifert, Cheryl, Furman, Craig, Wu, Zhenhua Jeremy, Seiler, Michael, Buonamici, Silvia, Fekkes, Peter, Karr, Craig, Palacino, James, Park, Eunice, Smith, Peter G., Yu, Lihua, Mizui, Yoshiharu, Warmuth, Markus, Chicas, Agustin, Corson, Laura, Zhu, Ping
Published in Nature communications (11.01.2019)
Published in Nature communications (11.01.2019)
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Splicing factor SF3b as a target of the antitumor natural product pladienolide
Mizui, Yoshiharu, Kotake, Yoshihiko, Sagane, Koji, Owa, Takashi, Mimori-Kiyosue, Yuko, Shimizu, Hajime, Uesugi, Mai, Ishihama, Yasushi, Iwata, Masao
Published in Nature chemical biology (01.09.2007)
Published in Nature chemical biology (01.09.2007)
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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
Teng, Teng, Tsai, Jennifer HC, Puyang, Xiaoling, Seiler, Michael, Peng, Shouyong, Prajapati, Sudeep, Aird, Daniel, Buonamici, Silvia, Caleb, Benjamin, Chan, Betty, Corson, Laura, Feala, Jacob, Fekkes, Peter, Gerard, Baudouin, Karr, Craig, Korpal, Manav, Liu, Xiang, T. Lowe, Jason, Mizui, Yoshiharu, Palacino, James, Park, Eunice, Smith, Peter G., Subramanian, Vanitha, Wu, Zhenhua Jeremy, Zou, Jian, Yu, Lihua, Chicas, Agustin, Warmuth, Markus, Larsen, Nicholas, Zhu, Ping
Published in Nature communications (25.05.2017)
Published in Nature communications (25.05.2017)
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Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D
Kanada, Regina M., Itoh, Daisuke, Nagai, Mitsuo, Niijima, Jun, Asai, Naoki, Mizui, Yoshiharu, Abe, Shinya, Kotake, Yoshihiko
Published in Angewandte Chemie (International ed.) (01.01.2007)
Published in Angewandte Chemie (International ed.) (01.01.2007)
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E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase (MEK)-1 and MEK Kinase-1: In Vitro Characterization of Its Anti-Inflammatory and Antihyperproliferative Activities
Goto, Masaki, Chow, Jesse, Muramoto, Kenzo, Chiba, Ken-ichi, Yamamoto, Satoshi, Fujita, Masanori, Obaishi, Hiroshi, Tai, Kenji, Mizui, Yoshiharu, Tanaka, Isao, Young, Donna, Yang, Hua, Wang, Yuan J, Shirota, Hiroshi, Gusovsky, Fabian
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107: III. In Vitro and In Vivo Antitumor Activities
MIZUI, YOSHIHARU, SAKAI, TAKASHI, IWATA, MASAO, UENAKA, TOSHIMITSU, OKAMOTO, KIYOSHI, SHIMIZU, HAJIME, YAMORI, TAKAO, YOSHIMATSU, KENTARO, ASADA, MAKOTO
Published in Journal of antibiotics (01.03.2004)
Published in Journal of antibiotics (01.03.2004)
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Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107: I. Taxonomy, Fermentation, Isolation and Screening
SAKAI, TAKASHI, SAMESHIMA, TOMOHIRO, MATSUFUJI, MOTOKO, KAWAMURA, NAOTO, DOBASHI, KAZUYUKI, MIZUI, YOSHIHARU
Published in Journal of antibiotics (01.03.2004)
Published in Journal of antibiotics (01.03.2004)
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Microregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitor
OKAMOTO, KIYOSHI, ITO, DAISUKE, MIYAZAKI, KAZUKI, WATANABE, SAORI, TOHYAMA, OSAMU, YOKOI, AKIRA, OZAWA, YOICHI, ASANO, MAKOTO, KAWAMURA, TAKANORI, YAMANE, YOSHINOBU, NAGAO, SATOSHI, FUNASAKA, SETSUO, KAMATA, JUNICHI, KOTAKE, YOSHIHIKO, AOKI, MIKA, TSUKAHARA, NAOKO, MIZUI, YOSHIHARU, TANAKA, ISAO, SAWADA, KOHEI
Published in International journal of molecular medicine (01.04.2012)
Published in International journal of molecular medicine (01.04.2012)
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Journal Article
Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D
Kanada, Regina M, Itoh, Daisuke, Nagai, Mitsuo, Niijima, Jun, Asai, Naoki, Mizui, Yoshiharu, Abe, Shinya, Kotake, Yoshihiko
Published in Angewandte Chemie (International ed.) (26.11.2007)
Published in Angewandte Chemie (International ed.) (26.11.2007)
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H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers
Seiler, Michael, Yoshimi, Akihide, Darman, Rachel, Chan, Betty, Keaney, Gregg, Thomas, Michael, Agrawal, Anant A, Caleb, Benjamin, Csibi, Alfredo, Sean, Eckley, Fekkes, Peter, Karr, Craig, Klimek, Virginia, Lai, George, Lee, Linda, Kumar, Pavan, Lee, Stanley Chun-Wei, Liu, Xiang, Mackenzie, Crystal, Meeske, Carol, Mizui, Yoshiharu, Padron, Eric, Park, Eunice, Pazolli, Ermira, Peng, Shouyong, Prajapati, Sudeep, Taylor, Justin, Teng, Teng, Wang, John, Warmuth, Markus, Yao, Huilan, Yu, Lihua, Zhu, Ping, Abdel-Wahab, Omar, Smith, Peter G, Buonamici, Silvia
Published in Nature medicine (01.04.2018)
Published in Nature medicine (01.04.2018)
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Altered Expression of HES-1, BETA2/NeuroD, and PDX-1 Is Involved in Impaired Insulin Synthesis Induced by Glucocorticoids in HIT-T15 Cells
Shinozuka, Yoriko, Okada, Masayuki, Oki, Tohru, Sagane, Koji, Mizui, Yoshiharu, Tanaka, Isao, Katayama, Kouichi, Murakami-Murofushi, Kimiko
Published in Biochemical and biophysical research communications (14.09.2001)
Published in Biochemical and biophysical research communications (14.09.2001)
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Journal Article
Biological validation that SF3b is a target of the antitumor macrolide pladienolide
Yokoi, Akira, Kotake, Yoshihiko, Takahashi, Kentaro, Kadowaki, Tadashi, Matsumoto, Yoshiko, Minoshima, Yukinori, Sugi, Naoko H., Sagane, Koji, Hamaguchi, Makoto, Iwata, Masao, Mizui, Yoshiharu
Published in The FEBS journal (01.12.2011)
Published in The FEBS journal (01.12.2011)
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Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors
ESKENS, Ferry A. L. M, RAMOS, Francisco J, TABERNERO, Josep, BURGER, Herman, O'BRIEN, James P, PIERA, Adelaida, DE JONGE, Maja J. A, MIZUI, Yoshiharu, WIEMER, Erik A. C, CARRERAS, Maria Josepa, BASELGA, José
Published in Clinical cancer research (15.11.2013)
Published in Clinical cancer research (15.11.2013)
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Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point
Darman, Rachel B., Seiler, Michael, Agrawal, Anant A., Lim, Kian H., Peng, Shouyong, Aird, Daniel, Bailey, Suzanna L., Bhavsar, Erica B., Chan, Betty, Colla, Simona, Corson, Laura, Feala, Jacob, Fekkes, Peter, Ichikawa, Kana, Keaney, Gregg F., Lee, Linda, Kumar, Pavan, Kunii, Kaiko, MacKenzie, Crystal, Matijevic, Mark, Mizui, Yoshiharu, Myint, Khin, Park, Eun Sun, Puyang, Xiaoling, Selvaraj, Anand, Thomas, Michael P., Tsai, Jennifer, Wang, John Y., Warmuth, Markus, Yang, Hui, Zhu, Ping, Garcia-Manero, Guillermo, Furman, Richard R., Yu, Lihua, Smith, Peter G., Buonamici, Silvia
Published in Cell reports (Cambridge) (03.11.2015)
Published in Cell reports (Cambridge) (03.11.2015)
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Characterization of 5'-flanking region of human aggrecanase-1 (ADAMTS4) gene
Mizui, Y, Yamazaki, K, Kuboi, Y, Sagane, K, Tanaka, I
Published in Molecular biology reports (01.09.2000)
Published in Molecular biology reports (01.09.2000)
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Abstract 281: Sensitivity to splicing modulation of BCL2 family genes reveals cancer therapeutic strategies for splicing modulators
Aird, Daniel, Teng, Teng, Huang, Chia-Ling, Pazolli, Ermira, Banka, Deepti, Cheung-Ong, Kahlin, Eifert, Cheryl, Furman, Craig, Wu, Jeremy, Seiler, Michael, Buonamici, Silvia, Fekkes, Peter, Karr, Craig, Palacino, James, Park, Eunice, Smith, Peter, Yu, Lihua, Mizui, Yoshiharu, Warmuth, Markus, Chicas, Agustin, Corson, Laura, Zhu, Ping
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 3013: Identification of PHF5A as a common cellular target of splicing-modulating chemical probes
Teng, Teng, Puyang, Xiaoling, Peng, Shouyong, Feala, Jacob, Chan, Betty, Tsai, Jennifer, Caleb, Benjamin, Karr, Craig, Park, Eunice, Corson, Laura, Mizui, Yoshiharu, Smith, Peter, Larsen, Nicholas, Yu, Lihua, Warmuth, Markus, Zhu, Ping, Chicas, Agustin
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 126: A chemogenomic approach reveals the action of splicing modulators at the branch point adenosine binding pocket defined by the PHF5A/SF3b complex
Teng, Teng, Tsai, Jennifer, Puyang, Xiaoling, Seiler, Michael, Peng, Shouyong, Aird, Daniel, Buonamici, Silvia, Caleb, Benjamin, Chan, Betty, Corson, Laura, Feala, Jacob, Fekkes, Peter, Karr, Craig, Korpal, Manav, Mizui, Yoshiharu, Park, Eunice, Palacino, James, Smith, Peter, Subramanian, Vanitha, Wu, Jeremy, Yu, Lihua, Chicas, Agustin, Warmuth, Markus, Larsen, Nicholas, Zhu, Ping
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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