Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability
Iwai, Kenichi, Yaguchi, Masahiro, Nishimura, Kazuho, Yamamoto, Yukiko, Tamura, Toshiya, Nakata, Daisuke, Dairiki, Ryo, Kawakita, Yoichi, Mizojiri, Ryo, Ito, Yoshiteru, Asano, Moriteru, Maezaki, Hironobu, Nakayama, Yusuke, Kaishima, Misato, Hayashi, Kozo, Teratani, Mika, Miyakawa, Shuichi, Iwatani, Misa, Miyamoto, Maki, Klein, Michael G, Lane, Wes, Snell, Gyorgy, Tjhen, Richard, He, Xingyue, Pulukuri, Sai, Nomura, Toshiyuki
Published in EMBO molecular medicine (01.06.2018)
Published in EMBO molecular medicine (01.06.2018)
Get full text
Journal Article
Expedient Construction of Multiple Stereogenic Centers in an Acyclic System via the Addition of Aldehydes, Ketones, and Chiral Imines to an Enyne−Titanium Alkoxide Complex
Hamada, Takashi, Mizojiri, Ryo, Urabe, Hirokazu, Sato, Fumie
Published in Journal of the American Chemical Society (26.07.2000)
Published in Journal of the American Chemical Society (26.07.2000)
Get full text
Journal Article
Design and synthesis of a monocyclic derivative as a selective ACC1 inhibitor by chemical modification of biphenyl ACC1/2 dual inhibitors
Mizojiri, Ryo, Tomita, Daisuke, Sasaki, Masako, Satoh, Yoshihiko, Yamamoto, Yukiko, Sumi, Hiroyuki, Maezaki, Hironobu
Published in Bioorganic & medicinal chemistry (01.04.2021)
Published in Bioorganic & medicinal chemistry (01.04.2021)
Get full text
Journal Article
The identification and pharmacological evaluation of potent, selective and orally available ACC1 inhibitor
Mizojiri, Ryo, Asano, Moriteru, Sasaki, Masako, Satoh, Yoshihiko, Yamamoto, Yukiko, Sumi, Hiroyuki, Maezaki, Hironobu
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
Get full text
Journal Article
Design and synthesis of a novel 1H-pyrrolo[3,2-b]pyridine-3-carboxamide derivative as an orally available ACC1 inhibitor
Mizojiri, Ryo, Nii, Noriyuki, Asano, Moriteru, Sasaki, Masako, Satoh, Yoshihiko, Yamamoto, Yukiko, Sumi, Hiroyuki, Maezaki, Hironobu
Published in Bioorganic & medicinal chemistry (15.06.2019)
Published in Bioorganic & medicinal chemistry (15.06.2019)
Get full text
Journal Article
Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors
Mizojiri, Ryo, Asano, Moriteru, Tomita, Daisuke, Banno, Hiroshi, Nii, Noriyuki, Sasaki, Masako, Sumi, Hiroyuki, Satoh, Yoshihiko, Yamamoto, Yukiko, Moriya, Takeo, Satomi, Yoshinori, Maezaki, Hironobu
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
Get full text
Journal Article
Efficient and Stereoselective Syntheses of Isomerically Pure 4‑Aminotetrahydro‑2H‑thiopyran 1‑Oxide Derivatives
Mizojiri, Ryo, Takami, Kazuaki, Ito, Tatsuya, Maeda, Hiroyuki, Yamano, Mitsuhisa, Kawamoto, Tetsuji
Published in Organic process research & development (21.07.2017)
Published in Organic process research & development (21.07.2017)
Get full text
Journal Article
Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus
Hirose, Hideki, Yamasaki, Takeshi, Ogino, Masaki, Mizojiri, Ryo, Tamura-Okano, Yumiko, Yashiro, Hiroaki, Muraki, Yo, Nakano, Yoshihide, Sugama, Jun, Hata, Akito, Iwasaki, Shinji, Watanabe, Masanori, Maekawa, Tsuyoshi, Kasai, Shizuo
Published in Bioorganic & medicinal chemistry (01.08.2017)
Published in Bioorganic & medicinal chemistry (01.08.2017)
Get full text
Journal Article
Efficient and Stereoselective Syntheses of Isomerically Pure 4-Aminotetrahydro-2 H -thiopyran 1-Oxide Derivatives
Mizojiri, Ryo, Takami, Kazuaki, Ito, Tatsuya, Maeda, Hiroyuki, Yamano, Mitsuhisa, Kawamoto, Tetsuji
Published in Organic process research & development (21.07.2017)
Published in Organic process research & development (21.07.2017)
Get full text
Journal Article
Abstract B060: Small molecule inhibitor of pre-mRNA splicing evokes antitumor activity via MDM4-p53 pathway
Nishimura, Kazuho, Yaguchi, Masahiro, Yamamoto, Yukiko, Ebara, Shunsuke, Yoichi, Kawakita, Mizojiri, Ryo, Nakayama, Yusuke, Hayashi, Kozo, Miyakawa, Shuichi, Iwai, Kenichi, Nomura, Toshiyuki
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
Get full text
Journal Article
Abstract 2793: Design, synthesis and evaluations of novel class of orally bioavailable eIF4A3-selective inhibitors
Mizojiri, Ryo, Nakata, Daisuke, Satoh, Yoshihiko, Morishita, Daisuke, Shibata, Sachio, Iwatani-Yoshihara, Misa, Kosugi, Yohei, Kosaka, Mai, Takeda, Junpei, Sasaki, Shigekazu, Takami, Kazuaki, Fukuda, Koichiro, Kamaura, Masahiro, Sasaki, Shinobu, Arai, Ryosuke, Cary, Douglas R., Imaeda, Yasuhiro
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode
Fujimoto, Jun, Kurasawa, Osamu, Takagi, Terufumi, Liu, Xin, Banno, Hiroshi, Kojima, Takuto, Asano, Yasutomi, Nakamura, Akito, Nambu, Tadahiro, Hata, Akito, Ishii, Tsuyoshi, Sameshima, Tomoya, Debori, Yasuyuki, Miyamoto, Maki, Klein, Michael G, Tjhen, Richard, Sang, Bi-Ching, Levin, Irena, Lane, Scott Weston, Snell, Gyorgy P, Li, Ke, Kefala, Georgia, Hoffman, Isaac D, Ding, Steve C, Cary, Douglas R, Mizojiri, Ryo
Published in ACS medicinal chemistry letters (10.10.2019)
Published in ACS medicinal chemistry letters (10.10.2019)
Get full text
Journal Article
Discovery of Novel 5‑(Piperazine-1-carbonyl)pyridin-2(1H)‑one Derivatives as Orally eIF4A3-Selective Inhibitors
Mizojiri, Ryo, Nakata, Daisuke, Satoh, Yoshihiko, Morishita, Daisuke, Shibata, Sachio, Iwatani-Yoshihara, Misa, Kosugi, Yohei, Kosaka, Mai, Takeda, Junpei, Sasaki, Shigekazu, Takami, Kazuaki, Fukuda, Koichiro, Kamaura, Masahiro, Sasaki, Shinobu, Arai, Ryosuke, Cary, Douglas R, Imaeda, Yasuhiro
Published in ACS medicinal chemistry letters (12.10.2017)
Published in ACS medicinal chemistry letters (12.10.2017)
Get full text
Journal Article
Large-scale synthesis of 1,1,3,3,6-pentamethyl-1,3-disilaindan-5-ol via a CoBr2/Zn-catalyzed [2+2+2] cycloaddition reaction
Mizojiri, Ryo, Conroy, Richard, Daiss, Jürgen, Kotani, Etsuo, Tacke, Reinhold, Miller, David, Walsh, Louise, Kawamoto, Tetsuji
Published in Tetrahedron (25.09.2010)
Published in Tetrahedron (25.09.2010)
Get full text
Journal Article
헤테로시클릭 화합물
HIRAYAMA TAKAHARU, SAKAUCHI NOBUKI, ASANO MORITERU, ONO KOJI, HIRATA YASUHIRO, ITO MASAHIRO, TANAKA TOSHIO, FUJIMOTO JUN, KOKUBO HIRONORI, MIZOJIRI RYO, CARY DOUGLAS ROBERT, ARIKAWA YASUYOSHI, IMAEDA YASUHIRO, TOKUHARA HIDEKAZU, MAEZAKI HIRONOBU, TOITA AKINORI, MORISHITA NAO, CHO NOBUO, BANNO HIROSHI
Year of Publication 09.12.2020
Get full text
Year of Publication 09.12.2020
Patent