Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals
Kamiya, Yusuke, Handa, Kentaro, Miura, Tomonori, Ohori, Junya, Kato, Airi, Shimizu, Makiko, Kitajima, Masato, Yamazaki, Hiroshi
Published in Biological & pharmaceutical bulletin (01.01.2022)
Published in Biological & pharmaceutical bulletin (01.01.2022)
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Forward and reverse dosimetry for aniline and 2,6-dimethylaniline in humans extrapolated from humanized-liver mouse data using simplified physiologically based pharmacokinetic models
Miura, Tomonori, Uehara, Shotaro, Shimizu, Makiko, Suemizu, Hiroshi, Yamazaki, Hiroshi
Published in Journal of toxicological sciences (2022)
Published in Journal of toxicological sciences (2022)
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An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats
Kamiya, Yusuke, Handa, Kentaro, Miura, Tomonori, Ohori, Junya, Shimizu, Makiko, Kitajima, Masato, Shono, Fumiaki, Funatsu, Kimito, Yamazaki, Hiroshi
Published in Chemical research in toxicology (18.10.2021)
Published in Chemical research in toxicology (18.10.2021)
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Plasma and Hepatic Concentrations of Chemicals after Virtual Oral Administrations Extrapolated Using Rat Plasma Data and Simple Physiologically Based Pharmacokinetic Models
Kamiya, Yusuke, Otsuka, Shohei, Miura, Tomonori, Takaku, Hiroka, Yamada, Rio, Nakazato, Mayuko, Nakamura, Hitomi, Mizuno, Sawa, Shono, Fumiaki, Funatsu, Kimito, Yamazaki, Hiroshi
Published in Chemical research in toxicology (22.01.2019)
Published in Chemical research in toxicology (22.01.2019)
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In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals
Kamiya, Yusuke, Handa, Kentaro, Miura, Tomonori, Yanagi, Mayu, Shigeta, Kazuki, Hina, Shiori, Shimizu, Makiko, Kitajima, Masato, Shono, Fumiaki, Funatsu, Kimito, Yamazaki, Hiroshi
Published in Chemical research in toxicology (15.02.2021)
Published in Chemical research in toxicology (15.02.2021)
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Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats
Kamiya, Yusuke, Otsuka, Shohei, Miura, Tomonori, Yoshizawa, Manae, Nakano, Ayane, Iwasaki, Miyu, Kobayashi, Yui, Shimizu, Makiko, Kitajima, Masato, Shono, Fumiaki, Funatsu, Kimito, Yamazaki, Hiroshi
Published in Chemical research in toxicology (20.07.2020)
Published in Chemical research in toxicology (20.07.2020)
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Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4′- and 5‑Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice
Miura, Tomonori, Uehara, Shotaro, Shimizu, Makiko, Murayama, Norie, Utoh, Masahiro, Suemizu, Hiroshi, Yamazaki, Hiroshi
Published in Chemical research in toxicology (17.02.2020)
Published in Chemical research in toxicology (17.02.2020)
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Pharmacokinetics of primary oxidative metabolites of thalidomide in rats and in chimeric mice humanized with different human hepatocytes
Miura, Tomonori, Uehara, Shotaro, Shimizu, Makiko, Suemizu, Hiroshi, Yamazaki, Hiroshi
Published in Journal of toxicological sciences (2021)
Published in Journal of toxicological sciences (2021)
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Correction to “An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats”
Kamiya, Yusuke, Handa, Kentaro, Miura, Tomonori, Ohori, Junya, Shimizu, Makiko, Kitajima, Masato, Shono, Fumiaki, Funatsu, Kimito, Yamazaki, Hiroshi
Published in Chemical research in toxicology (15.08.2022)
Published in Chemical research in toxicology (15.08.2022)
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Journal Article
Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model
Miura, Tomonori, Uehara, Shotaro, Shigeta, Kazuki, Yoshizawa, Manae, Kamiya, Yusuke, Murayama, Norie, Shimizu, Makiko, Suemizu, Hiroshi, Yamazaki, Hiroshi
Published in Chemical research in toxicology (15.02.2021)
Published in Chemical research in toxicology (15.02.2021)
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Journal Article
Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential
Miura, Tomonori, Shimizu, Makiko, Uehara, Shotaro, Yoshizawa, Manae, Nakano, Ayane, Yanagi, Mayu, Kamiya, Yusuke, Murayama, Norie, Suemizu, Hiroshi, Yamazaki, Hiroshi
Published in Chemical research in toxicology (21.12.2020)
Published in Chemical research in toxicology (21.12.2020)
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Plasma, liver, and kidney exposures in rats after oral doses of industrial chemicals predicted using physiologically based pharmacokinetic models: A case study of perfluorooctane sulfonic acid
Kamiya, Yusuke, Yanagi, Mayu, Hina, Shiori, Shigeta, Kazuki, Miura, Tomonori, Yamazaki, Hiroshi
Published in Journal of toxicological sciences (2020)
Published in Journal of toxicological sciences (2020)
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Journal Article
Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice
Miura, Tomonori, Uehara, Shotaro, Shimizu, Makiko, Murayama, Norie, Suemizu, Hiroshi, Yamazaki, Hiroshi
Published in Journal of toxicological sciences (2021)
Published in Journal of toxicological sciences (2021)
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Journal Article
Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling
Toda, Akiko, Shimizu, Makiko, Uehara, Shotaro, Sasaki, Tatsuro, Miura, Tomonori, Mogi, Masayuki, Utoh, Masahiro, Suemizu, Hiroshi, Yamazaki, Hiroshi
Published in Xenobiotica (03.04.2021)
Published in Xenobiotica (03.04.2021)
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Journal Article
Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model
Miura, Tomonori, Kamiya, Yusuke, Hina, Shiori, Kobayashi, Yui, Murayama, Norie, Shimizu, Makiko, Yamazaki, Hiroshi
Published in Journal of toxicological sciences (01.01.2020)
Published in Journal of toxicological sciences (01.01.2020)
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Journal Article
Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice
Shimizu, Makiko, Suemizu, Hiroshi, Mizuno, Sawa, Kusama, Takashi, Miura, Tomonori, Uehara, Shotaro, Yamazaki, Hiroshi
Published in Journal of toxicological sciences (01.01.2018)
Published in Journal of toxicological sciences (01.01.2018)
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Journal Article
Human plasma and liver concentrations of styrene estimated by combining a simple physiologically based pharmacokinetic model with rodent data
Miura, Tomonori, Uehara, Shotaro, Nakazato, Mayuko, Kusama, Takashi, Toda, Akiko, Kamiya, Yusuke, Murayama, Norie, Shimizu, Makiko, Suemizu, Hiroshi, Yamazaki, Hiroshi
Published in Journal of toxicological sciences (2019)
Published in Journal of toxicological sciences (2019)
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Journal Article
AlN bulk single crystal growth on 6H-SiC substrates by sublimation method
Nagai, Ichiro, Kato, Tomohisa, Miura, Tomonori, Kamata, Hiroyuki, Naoe, Kunihiro, Sanada, Kazuo, Okumura, Hajime
Published in Journal of crystal growth (15.09.2010)
Published in Journal of crystal growth (15.09.2010)
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