Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure
Follmann, Markus, Ackerstaff, Jens, Redlich, Gorden, Wunder, Frank, Lang, Dieter, Kern, Armin, Fey, Peter, Griebenow, Nils, Kroh, Walter, Becker-Pelster, Eva-Maria, Kretschmer, Axel, Geiss, Volker, Li, Volkhart, Straub, Alexander, Mittendorf, Joachim, Jautelat, Rolf, Schirok, Hartmut, Schlemmer, Karl-Heinz, Lustig, Klemens, Gerisch, Michael, Knorr, Andreas, Tinel, Hanna, Mondritzki, Thomas, Trübel, Hubert, Sandner, Peter, Stasch, Johannes-Peter
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
Get full text
Journal Article
The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators
Follmann, Markus, Griebenow, Nils, Hahn, Michael G., Hartung, Ingo, Mais, Franz-Josef, Mittendorf, Joachim, Schäfer, Martina, Schirok, Hartmut, Stasch, Johannes-Peter, Stoll, Friederike, Straub, Alexander
Published in Angewandte Chemie (International ed.) (02.09.2013)
Published in Angewandte Chemie (International ed.) (02.09.2013)
Get full text
Journal Article
Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases
Bärfacker, Lars, Kuhl, Alexander, Hillisch, Alexander, Grosser, Rolf, Figueroa-Pérez, Santiago, Heckroth, Heike, Nitsche, Adam, Ergüden, Jens-Kerim, Gielen-Haertwig, Heike, Schlemmer, Karl-Heinz, Mittendorf, Joachim, Paulsen, Holger, Platzek, Johannes, Kolkhof, Peter
Published in ChemMedChem (01.08.2012)
Published in ChemMedChem (01.08.2012)
Get full text
Journal Article
Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension
Mittendorf, Joachim, Weigand, Stefan, Alonso-Alija, Cristina, Bischoff, Erwin, Feurer, Achim, Gerisch, Michael, Kern, Armin, Knorr, Andreas, Lang, Dieter, Muenter, Klaus, Radtke, Martin, Schirok, Hartmut, Schlemmer, Karl-Heinz, Stahl, Elke, Straub, Alexander, Wunder, Frank, Stasch, Johannes-Peter
Published in ChemMedChem (11.05.2009)
Published in ChemMedChem (11.05.2009)
Get full text
Journal Article
Characterization of the Diarylether Sulfonylester (â)-(R)-3-(2-Hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271) as a Potent Cannabinoid Receptor Agonist with Neuroprotective Properties
Mauler, Frank, Mittendorf, Joachim, Horváth, Ervin, De Vry, Jean
Published in The Journal of pharmacology and experimental therapeutics (01.07.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2002)
Get full text
Journal Article
In Vitro Activity and In Vivo Efficacy of Icofungipen (PLD-118), a Novel Oral Antifungal Agent, against the Pathogenic Yeast Candida albicans
HASENOEHRL, Andreja, GALIE, Tatjana, ERGOVIE, Gabrijela, MARSIE, Natasa, SKERLEV, Mihael, MITTENDORF, Joachim, GESCHKE, Ulrich, SCHMIDT, Axel, SCHOENFELD, Wolfgang
Published in Antimicrobial Agents and Chemotherapy (01.09.2006)
Published in Antimicrobial Agents and Chemotherapy (01.09.2006)
Get full text
Journal Article
Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042)
Hahn, Michael G, Lampe, Thomas, El Sheikh, Sherif, Griebenow, Nils, Woltering, Elisabeth, Schlemmer, Karl-Heinz, Dietz, Lisa, Gerisch, Michael, Wunder, Frank, Becker-Pelster, Eva-Maria, Mondritzki, Thomas, Tinel, Hanna, Knorr, Andreas, Kern, Armin, Lang, Dieter, Hueser, Joerg, Schomber, Tibor, Benardeau, Agnes, Eitner, Frank, Truebel, Hubert, Mittendorf, Joachim, Kumar, Vijay, van den Akker, Focco, Schaefer, Martina, Geiss, Volker, Sandner, Peter, Stasch, Johannes-Peter
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
Get full text
Journal Article
BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic ?(2B) Antagonist
Meibom, Daniel, Meyer, Jutta, von Buehler, Clemens-Jeremias, Collins, Karl D., Maassen, Stefanie, Gericke, Kersten Matthias, Hueser, Joerg, Mittendorf, Joachim, Hernandez, Nuria Ortega, Schamberger, Jens, Stampfuss, Jan, Straub, Alexander, Torge, Afra, Witowski, Norbert, Wunder, Frank
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
Get full text
Journal Article
BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α 2B Antagonist
Meibom, Daniel, Meyer, Jutta, von Buehler, Clemens-Jeremias, Collins, Karl D, Maassen, Stefanie, Gericke, Kersten Matthias, Hüser, Jörg, Mittendorf, Joachim, Ortega Hernandez, Nuria, Schamberger, Jens, Stampfuss, Jan, Straub, Alexander, Torge, Afra, Witowski, Norbert, Wunder, Frank
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
Get full text
Journal Article
BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor
Meibom, Daniel, Wasnaire, Pierre, Beyer, Kristin, Broehl, Andreas, Cancho-Grande, Yolanda, Elowe, Nadine, Henninger, Kerstin, Johannes, Sarah, Jungmann, Natalia, Krainz, Tanja, Lindner, Niels, Maassen, Stefanie, MacDonald, Bryan, Menshykau, Denis, Mittendorf, Joachim, Sanchez, Guzman, Schaefer, Martina, Stefan, Eric, Torge, Afra, Xing, Yi, Zubov, Dmitry
Published in Journal of medicinal chemistry (22.02.2024)
Published in Journal of medicinal chemistry (22.02.2024)
Get full text
Journal Article
Structure–Permeability Relationship of Semipeptidic MacrocyclesUnderstanding and Optimizing Passive Permeability and Efflux Ratio
Le Roux, Antoine, Blaise, Émilie, Boudreault, Pierre-Luc, Comeau, Christian, Doucet, Annie, Giarrusso, Marilena, Collin, Marie-Pierre, Neubauer, Thomas, Kölling, Florian, Göller, Andreas H, Seep, Lea, Tshitenge, Dieudonné T, Wittwer, Matthias, Kullmann, Maximilian, Hillisch, Alexander, Mittendorf, Joachim, Marsault, Eric
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
Get full text
Journal Article
BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α2B Antagonist
Meibom, Daniel, Meyer, Jutta, von Buehler, Clemens-Jeremias, Collins, Karl D., Maassen, Stefanie, Gericke, Kersten Matthias, Hüser, Jörg, Mittendorf, Joachim, Ortega Hernandez, Nuria, Schamberger, Jens, Stampfuss, Jan, Straub, Alexander, Torge, Afra, Witowski, Norbert, Wunder, Frank
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
Get full text
Journal Article
Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A1 Receptor Agonist for the Chronic Treatment of Heart Diseases
Meibom, Daniel, Albrecht‐Küpper, Barbara, Diedrichs, Nicole, Hübsch, Walter, Kast, Raimund, Krämer, Thomas, Krenz, Ursula, Lerchen, Hans‐Georg, Mittendorf, Joachim, Nell, Peter G., Süssmeier, Frank, Vakalopoulos, Alexandros, Zimmermann, Katja
Published in ChemMedChem (22.05.2017)
Published in ChemMedChem (22.05.2017)
Get full text
Journal Article
New Generation of sGC Stimulators: Discovery of Imidazo[1,2‑a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension
Vakalopoulos, Alexandros, Wunder, Frank, Hartung, Ingo V., Redlich, Gorden, Jautelat, Rolf, Buchgraber, Philipp, Hassfeld, Jorma, Gromov, Alexey V., Lindner, Niels, Bierer, Donald, Gries, Jörg, Kroh, Walter, Paulsen, Holger, Mittendorf, Joachim, Lang, Dieter, Becker-Pelster, Eva, Brockschnieder, Damian, Geiss, Volker, Li, Volkhart, Straub, Alexander, Knorr, Andreas, Mondritzki, Thomas, Trübel, Hubert, Raschke, Marian, Schaefer, Martina, Thomas, Dirk, Sandner, Peter, Stasch, Johannes-Peter, Follmann, Markus
Published in Journal of medicinal chemistry (08.06.2023)
Published in Journal of medicinal chemistry (08.06.2023)
Get full text
Journal Article
Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A(1) Receptor Agonist for the Chronic Treatment of Heart Diseases
Meibom, Daniel, Albrecht-Kuepper, Barbara, Diedrichs, Nicole, Huebsch, Walter, Kast, Raimund, Kraemer, Thomas, Krenz, Ursula, Lerchen, Hans-Georg, Mittendorf, Joachim, Nell, Peter G., Suessmeier, Frank, Vakalopoulos, Alexandros, Zimmermann, Katja
Published in ChemMedChem (22.05.2017)
Published in ChemMedChem (22.05.2017)
Get full text
Journal Article
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases
von Nussbaum, Franz, Li, Volkhart M. -J., Allerheiligen, Swen, Anlauf, Sonja, Baerfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F., Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schaefer, Martina, Schaefer, Stefan, Schamberger, Jens, Telan, Leila A., Tersteegen, Adrian
Published in ChemMedChem (01.07.2015)
Published in ChemMedChem (01.07.2015)
Get full text
Journal Article
Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model
von Nussbaum, Franz, Li, Volkhart M., Meibom, Daniel, Anlauf, Sonja, Bechem, Martin, Delbeck, Martina, Gerisch, Michael, Harrenga, Axel, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Mittendorf, Joachim, Schäfer, Martina, Schäfer, Stefan, Schamberger, Jens
Published in ChemMedChem (19.01.2016)
Published in ChemMedChem (19.01.2016)
Get full text
Journal Article
Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b]pyridines as soluble guanylate cyclase stimulators
Griebenow, Nils, Schirok, Hartmut, Mittendorf, Joachim, Straub, Alexander, Follmann, Markus, Stasch, Johannes-Peter, Knorr, Andreas, Schlemmer, Karl-Heinz, Redlich, Gorden
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Get full text
Journal Article
Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A 1 Receptor Agonist for the Chronic Treatment of Heart Diseases
Meibom, Daniel, Albrecht-Küpper, Barbara, Diedrichs, Nicole, Hübsch, Walter, Kast, Raimund, Krämer, Thomas, Krenz, Ursula, Lerchen, Hans-Georg, Mittendorf, Joachim, Nell, Peter G, Süssmeier, Frank, Vakalopoulos, Alexandros, Zimmermann, Katja
Published in ChemMedChem (22.05.2017)
Published in ChemMedChem (22.05.2017)
Get full text
Journal Article
Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial AdenosineA1 Receptor Agonist for the Chronic Treatment of Heart Diseases
Meibom, Daniel, Albrecht-Kupper, Barbara, Diedrichs, Nicole, Hubsch, Walter, Kast, Raimund, Kramer, Thomas, Krenz, Ursula, Lerchen, Hans-Georg, Mittendorf, Joachim, Nell, Peter G, Sussmeier, Frank, Vakalopoulos, Alexandros, Zimmermann, Katja
Published in ChemMedChem (01.05.2017)
Published in ChemMedChem (01.05.2017)
Get full text
Journal Article