RNA Reduction and Hepatotoxic Potential Caused by Non-Gapmer Antisense Oligonucleotides
Hori, Shin-Ichiro, Mitsuoka, Yasunori, Kugimiya, Akira
Published in Nucleic acid therapeutics (01.02.2019)
Published in Nucleic acid therapeutics (01.02.2019)
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Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency
Mitsuoka, Yasunori, Yamamoto, Tsuyoshi, Kugimiya, Akira, Waki, Reiko, Wada, Fumito, Tahara, Saori, Sawamura, Motoki, Noda, Mio, Fujimura, Yuko, Kato, Yuki, Hari, Yoshiyuki, Obika, Satoshi
Published in Journal of organic chemistry (06.01.2017)
Published in Journal of organic chemistry (06.01.2017)
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Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure
Mitsuoka, Yasunori, Aoyama, Hiroshi, Kugimiya, Akira, Fujimura, Yuko, Yamamoto, Tsuyoshi, Waki, Reiko, Wada, Fumito, Tahara, Saori, Sawamura, Motoki, Noda, Mio, Hari, Yoshiyuki, Obika, Satoshi
Published in Organic & biomolecular chemistry (01.01.2016)
Published in Organic & biomolecular chemistry (01.01.2016)
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A bridged nucleic acid, 2',4'-BNA COC: synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2',4'-BNA COC monomers and RNA-selective nucleic-acid recognition
Mitsuoka, Yasunori, Kodama, Tetsuya, Ohnishi, Ryo, Hari, Yoshiyuki, Imanishi, Takeshi, Obika, Satoshi
Published in Nucleic acids research (01.03.2009)
Published in Nucleic acids research (01.03.2009)
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Synthesis of Novel 2′-Deoxy Type Trans-3′,4′-Bridged Nucleic Acid
Osaki, Tomohisa, Obika, Satoshi, Harada, Yasuki, Mitsuoka, Yasunori, Sugaya, Kensaku, Sekiguchi, Mitsuaki, Roongjang, Somjing, Imanishi, Takeshi
Published in Nucleosides, nucleotides & nucleic acids (26.11.2007)
Published in Nucleosides, nucleotides & nucleic acids (26.11.2007)
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Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction
Nakahara, Kenji, Mitsuoka, Yasunori, Kasuya, Satoshi, Yamamoto, Takahiko, Yamamoto, Shiho, Ito, Hisanori, Kido, Yasuto, Kusakabe, Ken-ichi
Published in European journal of medicinal chemistry (15.04.2021)
Published in European journal of medicinal chemistry (15.04.2021)
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MEDICINE THAT TARGETS ACC2
SHIMAZAKI ATSUYUKI, MITSUOKA YASUNORI, UNO (USUI) MAI, MORINAGA TAKUMI
Year of Publication 15.05.2023
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Year of Publication 15.05.2023
Patent
NUCLEIC ACID DRUG TARGETING ITGAV
FUJIWARA Takahiro, MITSUOKA Yasunori, NAGAI Ryohei, SEKIGUCHI Mitsuaki, YOKOTA Shinnichi
Year of Publication 22.09.2022
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Year of Publication 22.09.2022
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Rational Design of Novel 1,3-Oxazine Based β‑Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P‑gp Efflux Leading to Robust Aβ Reduction in the Brain
Fuchino, Kouki, Mitsuoka, Yasunori, Masui, Moriyasu, Kurose, Noriyuki, Yoshida, Shuhei, Komano, Kazuo, Yamamoto, Takahiko, Ogawa, Masayoshi, Unemura, Chie, Hosono, Motoko, Ito, Hisanori, Sakaguchi, Gaku, Ando, Shigeru, Ohnishi, Shuichi, Kido, Yasuto, Fukushima, Tamio, Miyajima, Hirofumi, Hiroyama, Shuichi, Koyabu, Kiyotaka, Dhuyvetter, Deborah, Borghys, Herman, Gijsen, Harrie J. M, Yamano, Yoshinori, Iso, Yasuyoshi, Kusakabe, Ken-ichi
Published in Journal of medicinal chemistry (28.06.2018)
Published in Journal of medicinal chemistry (28.06.2018)
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Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structureElectronic supplementary information (ESI) available. CCDC 1415387. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ob01051b
Mitsuoka, Yasunori, Aoyama, Hiroshi, Kugimiya, Akira, Fujimura, Yuko, Yamamoto, Tsuyoshi, Waki, Reiko, Wada, Fumito, Tahara, Saori, Sawamura, Motoki, Noda, Mio, Hari, Yoshiyuki, Obika, Satoshi
Year of Publication 06.07.2016
Year of Publication 06.07.2016
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A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity
Kusakabe, Ken-ichi, Ide, Nobuyuki, Daigo, Yataro, Itoh, Takeshi, Yamamoto, Takahiko, Kojima, Eiichi, Mitsuoka, Yasunori, Tadano, Genta, Tagashira, Sachie, Higashino, Kenichi, Okano, Yousuke, Sato, Yuji, Inoue, Makiko, Iguchi, Motofumi, Kanazawa, Takayuki, Ishioka, Yukichi, Dohi, Keiji, Kido, Yasuto, Sakamoto, Shingo, Ando, Shigeru, Maeda, Masahiro, Higaki, Masayo, Yoshizawa, Hidenori, Murai, Hitoshi, Nakamura, Yusuke
Published in Bioorganic & medicinal chemistry (01.05.2015)
Published in Bioorganic & medicinal chemistry (01.05.2015)
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NUCLEIC ACID DERIVATIVE HAVING IMMUNOSTIMULATORY ACTIVITY
TANINO, Tetsuya, SEKIGUCHI, Mitsuaki, NAKAMURA, Jun, MITSUOKA, Yasunori, KUGIMIYA, Akira, KURODA, Norikazu
Year of Publication 04.10.2018
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Year of Publication 04.10.2018
Patent
COMPLEX OF NUCLEIC ACID MEDICINE AND MULTIBRANCHED LIPID
TANINO Tetsuya, KUGIMIYA Akira, NAKAMURA Jun, KASUYA Takeshi, KATO Yasuharu, KURODA Norikazu, MITSUOKA Yasunori, SEKIGUCHI Mitsuaki
Year of Publication 04.10.2018
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Year of Publication 04.10.2018
Patent
면역 부활 활성을 갖는 핵산 유도체
KUGIMIYA AKIRA, NAKAMURA JUN, MITSUOKA YASUNORI, SEKIGUCHI MITSUAKI, KURODA NORIKAZU, TANINO TETSUYA
Year of Publication 24.05.2018
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Year of Publication 24.05.2018
Patent
microRNA-143 DERIVATIVE
SASAKI, Yasuo, SEKIGUCHI, Mitsuaki, MITSUOKA, Yasunori, KUGIMIYA, Akira, AKAO, Yukihiro, KITADE, Yukio
Year of Publication 19.10.2017
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Year of Publication 19.10.2017
Patent
Development of a novel nucleoside analogue with S-type sugar conformation: 2′-deoxy- trans-3′,4′-bridged nucleic acids
Osaki, Tomohisa, Obika, Satoshi, Harada, Yasuki, Mitsuoka, Yasunori, Sugaya, Kensaku, Sekiguchi, Mitsuaki, Roongjang, Somjing, Imanishi, Takeshi
Published in Tetrahedron (03.09.2007)
Published in Tetrahedron (03.09.2007)
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