The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia
Witzenrath, Martin, Pache, Florence, Lorenz, Daniel, Koppe, Uwe, Gutbier, Birgitt, Tabeling, Christoph, Reppe, Katrin, Meixenberger, Karolin, Dorhoi, Anca, Ma, Jiangtao, Holmes, Ashleigh, Trendelenburg, George, Heimesaat, Markus M, Bereswill, Stefan, van der Linden, Mark, Tschopp, Jürg, Mitchell, Timothy J, Suttorp, Norbert, Opitz, Bastian
Published in The Journal of immunology (1950) (01.07.2011)
Published in The Journal of immunology (1950) (01.07.2011)
Get full text
Journal Article
Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia
Preston, Julie A, Bewley, Martin A, Marriott, Helen M, McGarry Houghton, A, Mohasin, Mohammed, Jubrail, Jamil, Morris, Lucy, Stephenson, Yvonne L, Cross, Simon, Greaves, David R, Craig, Ruth W, van Rooijen, Nico, Bingle, Colin D, Read, Robert C, Mitchell, Timothy J, Whyte, Moira K B, Shapiro, Steven D, Dockrell, David H
Published in American journal of respiratory and critical care medicine (01.07.2019)
Published in American journal of respiratory and critical care medicine (01.07.2019)
Get full text
Journal Article
A Novel Data-Driven Approach to Preoperative Mapping of Functional Cortex Using Resting-State Functional Magnetic Resonance Imaging
Mitchell, Timothy J., Hacker, Carl D., Breshears, Jonathan D., Szrama, Nick P., Sharma, Mohit, Bundy, David T., Pahwa, Mrinal, Corbetta, Maurizio, Snyder, Abraham Z., Shimony, Joshua S., Leuthardt, Eric C.
Published in Neurosurgery (01.12.2013)
Published in Neurosurgery (01.12.2013)
Get full text
Journal Article
Active release of pneumolysin prepores and pores by mammalian cells undergoing a Streptococcus pneumoniae attack
Wolfmeier, Heidi, Radecke, Julika, Schoenauer, Roman, Koeffel, René, Babiychuk, Viktoria S., Drücker, Patrick, Hathaway, Lucy J., Mitchell, Timothy J., Zuber, Benoît, Draeger, Annette, Babiychuk, Eduard B.
Published in Biochimica et biophysica acta (01.11.2016)
Published in Biochimica et biophysica acta (01.11.2016)
Get full text
Journal Article
Dendritic spine loss deep in the neocortex and dendrite distortion with diffusion disturbances occur early in experimental pneumococcal meningitis
Baronti, Dario, Tomov, Nikola, Hupp, Sabrina, Mitchell, Timothy J, Iliev, Asparouh I
Published in Frontiers in neuroscience (10.01.2023)
Published in Frontiers in neuroscience (10.01.2023)
Get full text
Journal Article
Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia
Gutbier, Birgitt, Jiang, Xiaohui, Dietert, Kristina, Ehrler, Carolin, Lienau, Jasmin, Van Slyke, Paul, Kim, Harold, Hoang, Van C, Maynes, Jason T, Dumont, Daniel J, Gruber, Achim D, Weissmann, Norbert, Mitchell, Timothy J, Suttorp, Norbert, Witzenrath, Martin
Published in Critical care (London, England) (13.11.2017)
Published in Critical care (London, England) (13.11.2017)
Get full text
Journal Article
Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle
Badgujar, Dilip C, Anil, Anjali, Green, Angharad E, Surve, Manalee Vishnu, Madhavan, Shilpa, Beckett, Alison, Prior, Ian A, Godsora, Barsa K, Patil, Sanket B, More, Prachi Kadam, Sarkar, Shruti Guha, Mitchell, Andrea, Banerjee, Rinti, Phale, Prashant S, Mitchell, Timothy J, Neill, Daniel R, Bhaumik, Prasenjit, Banerjee, Anirban
Published in PLoS pathogens (20.11.2020)
Published in PLoS pathogens (20.11.2020)
Get full text
Journal Article
Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia
Hupp, Sabrina, Grandgirard, Denis, Mitchell, Timothy J, Leib, Stephen L, Hathaway, Lucy J, Iliev, Asparouh I
Published in Journal of neuroinflammation (18.05.2019)
Published in Journal of neuroinflammation (18.05.2019)
Get full text
Journal Article
Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure
Letsiou, Eleftheria, Teixeira Alves, Luiz Gustavo, Felten, Matthias, Mitchell, Timothy J, Müller-Redetzky, Holger C, Dudek, Steven M, Witzenrath, Martin
Published in Cells (Basel, Switzerland) (18.12.2021)
Published in Cells (Basel, Switzerland) (18.12.2021)
Get full text
Journal Article
Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue
Fatykhova, Diana, Rabes, Anne, Machnik, Christoph, Guruprasad, Kunchur, Pache, Florence, Berg, Johanna, Toennies, Mario, Bauer, Torsten T, Schneider, Paul, Schimek, Maria, Eggeling, Stephan, Mitchell, Timothy J, Mitchell, Andrea M, Hilker, Rolf, Hain, Torsten, Suttorp, Norbert, Hippenstiel, Stefan, Hocke, Andreas C, Opitz, Bastian
Published in PloS one (28.08.2015)
Published in PloS one (28.08.2015)
Get full text
Journal Article
Host-Derived Microvesicles Carrying Bacterial Pore-Forming Toxins Deliver Signals to Macrophages: A Novel Mechanism of Shaping Immune Responses
Köffel, René, Wolfmeier, Heidi, Larpin, Yu, Besançon, Hervé, Schoenauer, Roman, Babiychuk, Viktoria S, Drücker, Patrick, Pabst, Thomas, Mitchell, Timothy J, Babiychuk, Eduard B, Draeger, Annette
Published in Frontiers in immunology (27.07.2018)
Published in Frontiers in immunology (27.07.2018)
Get full text
Journal Article
Interleukin-1β Regulates CXCL8 Release and Influences Disease Outcome in Response to Streptococcus pneumoniae, Defining Intercellular Cooperation between Pulmonary Epithelial Cells and Macrophages
MARRIOTT, Helen M, GASCOYNE, Kate A, DOCKRELL, David H, GOWDA, Ravi, GEARY, Ian, NICKLIN, Martin J. H, LANNELLI, Francesco, POZZI, Gianni, MITCHELL, Timothy J, WHYTE, Moira K. B, SABROE, Ian
Published in Infection and Immunity (01.03.2012)
Published in Infection and Immunity (01.03.2012)
Get full text
Journal Article
A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci
Bewley, Martin A, Marriott, Helen M, Tulone, Calogero, Francis, Sheila E, Mitchell, Timothy J, Read, Robert C, Chain, Benny, Kroemer, Guido, Whyte, Moira K B, Dockrell, David H
Published in PLoS pathogens (01.01.2011)
Published in PLoS pathogens (01.01.2011)
Get full text
Journal Article
NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence
Kostadinova, Elena, Chaput, Catherine, Gutbier, Birgitt, Lippmann, Juliane, Sander, Leif E., Mitchell, Timothy J., Suttorp, Norbert, Witzenrath, Martin, Opitz, Bastian
Published in Scientific reports (01.08.2016)
Published in Scientific reports (01.08.2016)
Get full text
Journal Article
Developing Novel Host-Based Therapies Targeting Microbicidal Responses in Macrophages and Neutrophils to Combat Bacterial Antimicrobial Resistance
Watson, Katie, Russell, Clark D, Baillie, J Kenneth, Dhaliwal, Kev, Fitzgerald, J Ross, Mitchell, Timothy J, Simpson, A John, Renshaw, Stephen A, Dockrell, David H
Published in Frontiers in immunology (05.06.2020)
Published in Frontiers in immunology (05.06.2020)
Get full text
Journal Article