Design and Synthesis of Diazatricyclodecane Agonists of the G‑Protein-Coupled Receptor 119
Darout, Etzer, Robinson, Ralph P, McClure, Kim F, Corbett, Matthew, Li, Bryan, Shavnya, Andrei, Andrews, Melissa P, Jones, Christopher S, Li, Qifang, Minich, Martha L, Mascitti, Vincent, Guimarães, Cristiano R. W, Munchhof, Michael J, Bahnck, Kevin B, Cai, Cuiman, Price, David A, Liras, Spiros, Bonin, Paul D, Cornelius, Peter, Wang, Ruduan, Bagdasarian, Victoria, Sobota, Colleen P, Hornby, Sam, Masterson, Victoria M, Joseph, Reena M, Kalgutkar, Amit S, Chen, Yue
Published in Journal of medicinal chemistry (10.01.2013)
Published in Journal of medicinal chemistry (10.01.2013)
Get full text
Journal Article
Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle
Pfefferkorn, Jeffrey A., Lou, Jihong, Minich, Martha L., Filipski, Kevin J., He, Mingying, Zhou, Ru, Ahmed, Syed, Benbow, John, Perez, Angel-Guzman, Tu, Meihua, Litchfield, John, Sharma, Raman, Metzler, Karen, Bourbonais, Francis, Huang, Cong, Beebe, David A., Oates, Peter J.
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
Get full text
Journal Article
5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog
Sakya, Subas M., Lundy DeMello, Kristin M., Minich, Martha L., Rast, Bryson, Shavnya, Andrei, Rafka, Robert J., Koss, David A., Cheng, Hengmiao, Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Lund, Lisa A., Denis, Suzanne St, Hickman, Anne, Haven, Michelle L., Lynch, Michael P.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Get full text
Journal Article
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2
Corbett, Jeffrey W., Freeman-Cook, Kevin D., Elliott, Richard, Vajdos, Felix, Rajamohan, Francis, Kohls, Darcy, Marr, Eric, Zhang, Hailong, Tong, Liang, Tu, Meihua, Murdande, Sharad, Doran, Shawn D., Houser, Janet A., Song, Wei, Jones, Christopher J., Coffey, Steven B., Buzon, Leanne, Minich, Martha L., Dirico, Kenneth J., Tapley, Susan, Kirk McPherson, R., Sugarman, Eliot, James Harwood, H., Esler, William
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Get full text
Journal Article
Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide
Robinson, Ralph P., Bartlett, Jeremy A., Bertinato, Peter, Bessire, Andrew J., Cosgrove, Judith, Foley, Patrick M., Manion, Tara B., Minich, Martha L., Ramos, Brenda, Reese, Matthew R., Schmahai, Theodore J., Swick, Andrew G., Tess, David A., Vaz, Alfin, Wolford, Angela
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
Get full text
Journal Article
5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile
Sakya, Subas M., Hou, Xinjun, Minich, Martha L., Rast, Bryson, Shavnya, Andrei, DeMello, Kristin M.L., Cheng, Hengmiao, Li, Jin, Jaynes, Burton H., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Haven, Michelle L.
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
Get full text
Journal Article
Synthesis of compounds designed to inhibit bacterial cell wall transglycosylation
Hecker, Scott J, Minich, Martha L, Lackey, Karen
Published in Journal of organic chemistry (01.08.1990)
Published in Journal of organic chemistry (01.08.1990)
Get full text
Journal Article
Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors
Cheng, Hengmiao, Lundy DeMello, Kristin M., Li, Jin, Sakya, Subas M., Ando, Kazuo, Kawamura, K., Kato, Tomoki, Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Stevens, Rod, Lund, Lisa A., Mann, Donald W., Kilroy, Carolyn, Haven, Michelle L., Nimz, Erik L., Dutra, Jason K., Li, Chao, Minich, Martha L., Kolosko, Nicole L., Petras, Carol, Silvia, Annette M., Seibel, Scott B.
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Get full text
Journal Article
5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers
Sakya, Subas M., Cheng, Hengmiao, Lundy DeMello, Kristin M., Shavnya, Andrei, Minich, Martha L., Rast, Bryson, Dutra, Jason, Li, Chao, Rafka, Robert J., Koss, David A., Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Hickman, Anne, Haven, Michelle L., Lynch, Michael P.
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Get full text
Journal Article
Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine
Li, Jin, DeMello, Kristin M.Lundy, Cheng, Henry, Sakya, Subas M., Bronk, Brian S., Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Kilroy, Carolyn, Mann, Donald W., Nimz, Eric L., Lynch, Michael P., Haven, Michelle L., Kolosko, Nicole L., Minich, Martha L., Li, Chao, Dutra, Jason K., Rast, Bryson, Crosson, Rhonda M., Morton, Barry J., Kirk, Glen W., Callaghan, Kathleen M., Koss, David A., Shavnya, Andrei, Lund, Lisa A., Seibel, Scott B., Petras, Carol F., Silvia, Annette
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
Get full text
Journal Article
Azalide 3,6-Ketals: antibacterial activity and structure–Activity relationships of aryl and hetero aryl substituted analogues
Sakya, Subas M, Bertinato, Peter, Pratt, Bryan, Suarez-Contreras, Melani, Lundy, Kristin M, Minich, Martha L, Cheng, Hengmiao, Ziegler, Carl B, Kamicker, Barbara J, Hayashi, Shigeru F, Santoro, Sheryl L, George, David M, Bertsche, Camilla D
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Get full text
Journal Article
Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus
Pfefferkorn, Jeffrey A, Guzman-Perez, Angel, Litchfield, John, Aiello, Robert, Treadway, Judith L, Pettersen, John, Minich, Martha L, Filipski, Kevin J, Jones, Christopher S, Tu, Meihua, Aspnes, Gary, Risley, Hud, Bian, Jianwei, Stevens, Benjamin D, Bourassa, Patricia, D’Aquila, Theresa, Baker, Levenia, Barucci, Nicole, Robertson, Alan S, Bourbonais, Francis, Derksen, David R, MacDougall, Margit, Cabrera, Over, Chen, Jing, Lapworth, Amanda Lee, Landro, James A, Zavadoski, William J, Atkinson, Karen, Haddish-Berhane, Nahor, Tan, Beijing, Yao, Lili, Kosa, Rachel E, Varma, Manthena V, Feng, Bo, Duignan, David B, El-Kattan, Ayman, Murdande, Sharad, Liu, Shenping, Ammirati, Mark, Knafels, John, DaSilva-Jardine, Paul, Sweet, Laurel, Liras, Spiros, Rolph, Timothy P
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
Get full text
Journal Article
Novel and efficient synthesis of 4-sulfonyl-2-pyridones
Minich, Martha L., Watson, Isa D., Filipski, Kevin J., Pfefferkorn, Jeffrey A.
Published in Tetrahedron letters (06.05.2009)
Published in Tetrahedron letters (06.05.2009)
Get full text
Journal Article
Discovery of ( S )-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1 H -imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus
Pfefferkorn, Jeffrey A., Guzman-Perez, Angel, Litchfield, John, Aiello, Robert, Treadway, Judith L., Pettersen, John, Minich, Martha L., Filipski, Kevin J., Jones, Christopher S., Tu, Meihua, Aspnes, Gary, Risley, Hud, Bian, Jianwei, Stevens, Benjamin D., Bourassa, Patricia, D’Aquila, Theresa, Baker, Levenia, Barucci, Nicole, Robertson, Alan S., Bourbonais, Francis, Derksen, David R., MacDougall, Margit, Cabrera, Over, Chen, Jing, Lapworth, Amanda Lee, Landro, James A., Zavadoski, William J., Atkinson, Karen, Haddish-Berhane, Nahor, Tan, Beijing, Yao, Lili, Kosa, Rachel E., Varma, Manthena V., Feng, Bo, Duignan, David B., El-Kattan, Ayman, Murdande, Sharad, Liu, Shenping, Ammirati, Mark, Knafels, John, DaSilva-Jardine, Paul, Sweet, Laurel, Liras, Spiros, Rolph, Timothy P.
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
Get full text
Journal Article
ChemInform Abstract: Novel and Efficient Synthesis of 4-Sulfonyl-2-pyridones
Minich, Martha L., Watson, Isa D., Filipski, Kevin J., Pfefferkorn, Jeffrey A.
Published in ChemInform (18.08.2009)
Published in ChemInform (18.08.2009)
Get full text
Journal Article