Asymmetric synthesis of novel quaternary α-Hydroxy-δ-lactam dipeptide surrogates
Minami, Nathaniel K., Reiner, John E., Semple, J. Edward
Published in Bioorganic & medicinal chemistry letters (06.09.1999)
Published in Bioorganic & medicinal chemistry letters (06.09.1999)
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Design, Synthesis, and Evolution of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors: P1-Argininal Derivatives Incorporating P3-P4 Lactam Sulfonamide Moieties
Semple, J. Edward, Rowley, David C, Brunck, Terence K, Ha-Uong, Theresa, Minami, Nathaniel K, Owens, Timothy D, Tamura, Susan Y, Goldman, Erick A, Siev, Daniel V, Ardecky, Robert J, Carpenter, Stephen H, Ge, Yu, Richard, Brigitte M, Nolan, Thomas G, Håkanson, Kjell, Tulinsky, Al, Nutt, Ruth F, Ripka, William C
Published in Journal of medicinal chemistry (08.11.1996)
Published in Journal of medicinal chemistry (08.11.1996)
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Rational design and synthesis of a novel, selective class of thrombin inhibitors : Pl-ARGININAL derivatives incorporating P3-P4 quaternary lactam dipeptide surrogates
SEMPLE, J. E, MINAMI, N. K, TAMURA, S. Y, BRUNCK, T. K, NUTT, R. F, RIPKA, W. C
Published in Bioorganic & medicinal chemistry letters (1997)
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Published in Bioorganic & medicinal chemistry letters (1997)
Journal Article
Non-covalent thrombin inhibitors featuring p 3 -heterocycles with P 1 -monocyclic arginine surrogates
Reiner, John E, Siev, Daniel V, Araldi, Gian-Luca, Cui, Jingrong Jean, Ho, Jonathan Z, Reddy, Komandla Malla, Mamedova, Lala, Vu, Phong H, Lee, Kuen-Shan S, Minami, Nathaniel K, Gibson, Tony S, Anderson, Susanne M, Bradbury, Annette E, Nolan, Thomas G, Semple, J.Edward
Published in Bioorganic & medicinal chemistry letters (22.04.2002)
Published in Bioorganic & medicinal chemistry letters (22.04.2002)
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Journal Article
Potent and selective thrombin inhibitors featuring hydrophobic, basic P 3P 4-aminoalkyllactam moieties
Semple, J.Edward, Rowley, David C., Owens, Timothy D., Minami, Nathaniel K., Uong, Theresa H., Brunck, Terence K.
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
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Journal Article
Rational design and synthesis of a novel, selective class of thrombin inhibitors: P 1-argininal derivatives incorporating P 3P 4 quaternary lactam dipeptide surrogates
Semple, J.Edward, Minami, Nathaniel K., Tamura, Susan Y., Brunck, Terence K., Nutt, Ruth F., Ripka, William C.
Published in Bioorganic & medicinal chemistry letters (23.09.1997)
Published in Bioorganic & medicinal chemistry letters (23.09.1997)
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