Target and tissue selectivity of PROTAC degraders
Guenette, Robert G, Yang, Seung Wook, Min, Jaeki, Pei, Baikang, Potts, Patrick Ryan
Published in Chemical Society reviews (18.07.2022)
Published in Chemical Society reviews (18.07.2022)
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Journal Article
CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss
Teitz, Tal, Fang, Jie, Goktug, Asli N, Bonga, Justine D, Diao, Shiyong, Hazlitt, Robert A, Iconaru, Luigi, Morfouace, Marie, Currier, Duane, Zhou, Yinmei, Umans, Robyn A, Taylor, Michael R, Cheng, Cheng, Min, Jaeki, Freeman, Burgess, Peng, Junmin, Roussel, Martine F, Kriwacki, Richard, Guy, R Kiplin, Chen, Taosheng, Zuo, Jian
Published in The Journal of experimental medicine (02.04.2018)
Published in The Journal of experimental medicine (02.04.2018)
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Journal Article
Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs
Min, Jaeki, Mayasundari, Anand, Keramatnia, Fatemeh, Jonchere, Barbara, Yang, Seung Wook, Jarusiewicz, Jamie, Actis, Marisa, Das, Sourav, Young, Brandon, Slavish, Jake, Yang, Lei, Li, Yong, Fu, Xiang, Garrett, Shalandus H., Yun, Mi‐Kyung, Li, Zhenmei, Nithianantham, Stanley, Chai, Sergio, Chen, Taosheng, Shelat, Anang, Lee, Richard E., Nishiguchi, Gisele, White, Stephen W., Roussel, Martine F., Potts, Patrick Ryan, Fischer, Marcus, Rankovic, Zoran
Published in Angewandte Chemie International Edition (13.12.2021)
Published in Angewandte Chemie International Edition (13.12.2021)
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Journal Article
Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
Yang, Seung Wook, Huang, Xin, Lin, Wenwei, Min, Jaeki, Miller, Darcie J., Mayasundari, Anand, Rodrigues, Patrick, Griffith, Elizabeth C., Gee, Clifford T., Li, Lei, Li, Wei, Lee, Richard E., Rankovic, Zoran, Chen, Taosheng, Potts, Patrick Ryan
Published in Nature communications (01.10.2020)
Published in Nature communications (01.10.2020)
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Journal Article
Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia
Churchman, Michelle L., Low, Jonathan, Qu, Chunxu, Paietta, Elisabeth M., Kasper, Lawryn H., Chang, Yunchao, Payne-Turner, Debbie, Althoff, Mark J., Song, Guangchun, Chen, Shann-Ching, Ma, Jing, Rusch, Michael, McGoldrick, Dan, Edmonson, Michael, Gupta, Pankaj, Wang, Yong-Dong, Caufield, William, Freeman, Burgess, Li, Lie, Panetta, John C., Baker, Sharyn, Yang, Yung-Li, Roberts, Kathryn G., McCastlain, Kelly, Iacobucci, Ilaria, Peters, Jennifer L., Centonze, Victoria E., Notta, Faiyaz, Dobson, Stephanie M., Zandi, Sasan, Dick, John E., Janke, Laura, Peng, Junmin, Kodali, Kiran, Pagala, Vishwajeeth, Min, Jaeki, Mayasundari, Anand, Williams, Richard T., Willman, Cheryl L., Rowe, Jacob, Luger, Selina, Dickins, Ross A., Guy, R. Kiplin, Chen, Taosheng, Mullighan, Charles G.
Published in Cancer cell (14.09.2015)
Published in Cancer cell (14.09.2015)
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Journal Article
Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia
Chang, Yunchao, Min, Jaeki, Jarusiewicz, Jamie A., Actis, Marisa, Yu-Chen Bradford, Shanshan, Mayasundari, Anand, Yang, Lei, Chepyala, Divyabharathi, Alcock, Lisa J., Roberts, Kathryn G., Nithianantham, Stanley, Maxwell, Dylan, Rowland, Lauren, Larsen, Randolph, Seth, Aman, Goto, Hiroaki, Imamura, Toshihiko, Akahane, Koshi, Hansen, Baranda S., Pruett-Miller, Shondra M., Paietta, Elisabeth M., Litzow, Mark R., Qu, Chunxu, Yang, Jun J., Fischer, Marcus, Rankovic, Zoran, Mullighan, Charles G.
Published in Blood (09.12.2021)
Published in Blood (09.12.2021)
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Journal Article
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F
Cencic, Regina, Hall, David R., Robert, Francis, Du, Yuhong, Min, Jaeki, Li, Lian, Qui, Min, Lewis, Iestyn, Kurtkaya, Serdar, Dingledine, Ray, Fu, Haian, Kozakov, Dima, Vajda, Sandor, Pelletier, Jerry, Housman, David E.
Published in Proceedings of the National Academy of Sciences - PNAS (18.01.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (18.01.2011)
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Journal Article
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells
Paugh, Steven W, Bonten, Erik J, Savic, Daniel, Ramsey, Laura B, Thierfelder, William E, Gurung, Prajwal, Malireddi, R K Subbarao, Actis, Marcelo, Mayasundari, Anand, Min, Jaeki, Coss, David R, Laudermilk, Lucas T, Panetta, John C, McCorkle, J Robert, Fan, Yiping, Crews, Kristine R, Stocco, Gabriele, Wilkinson, Mark R, Ferreira, Antonio M, Cheng, Cheng, Yang, Wenjian, Karol, Seth E, Fernandez, Christian A, Diouf, Barthelemy, Smith, Colton, Hicks, J Kevin, Zanut, Alessandra, Giordanengo, Audrey, Crona, Daniel, Bianchi, Joy J, Holmfeldt, Linda, Mullighan, Charles G, den Boer, Monique L, Pieters, Rob, Jeha, Sima, Dunwell, Thomas L, Latif, Farida, Bhojwani, Deepa, Carroll, William L, Pui, Ching-Hon, Myers, Richard M, Guy, R Kiplin, Kanneganti, Thirumala-Devi, Relling, Mary V, Evans, William E
Published in Nature genetics (01.06.2015)
Published in Nature genetics (01.06.2015)
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Journal Article
Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation
Hammill, Jared T, Bhasin, Deepak, Scott, Daniel C, Min, Jaeki, Chen, Yizhe, Lu, Yan, Yang, Lei, Kim, Ho Shin, Connelly, Michele C, Hammill, Courtney, Holbrook, Gloria, Jeffries, Cynthia, Singh, Bhuvanesh, Schulman, Brenda A, Guy, R. Kiplin
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Journal Article
Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase
Scott, Daniel C, Hammill, Jared T, Min, Jaeki, Rhee, David Y, Connelly, Michele, Sviderskiy, Vladislav O, Bhasin, Deepak, Chen, Yizhe, Ong, Su-Sien, Chai, Sergio C, Goktug, Asli N, Huang, Guochang, Monda, Julie K, Low, Jonathan, Kim, Ho Shin, Paulo, Joao A, Cannon, Joe R, Shelat, Anang A, Chen, Taosheng, Kelsall, Ian R, Alpi, Arno F, Pagala, Vishwajeeth, Wang, Xusheng, Peng, Junmin, Singh, Bhuvanesh, Harper, J Wade, Schulman, Brenda A, Guy, R Kip
Published in Nature chemical biology (01.08.2017)
Published in Nature chemical biology (01.08.2017)
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Journal Article
Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication
CENCIC, Regina, DESFORGES, Marc, PELLETIER, Jerry, HALL, David R, KOZAKOV, Dima, YUHONG DU, MIN, Jaeki, DINGLEDINE, Raymond, HAIAN FU, VAJDA, Sandor, TALBOT, Pierre J
Published in Journal of Virology (01.07.2011)
Published in Journal of Virology (01.07.2011)
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Journal Article
Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–Protein Inhibition
Vara, Brandon A, Mayasundari, Anand, Tellis, John C, Danneman, Michael W, Arredondo, Vanessa, Davis, Tyler A, Min, Jaeki, Finch, Kristin, Guy, R. Kiplin, Johnston, Jeffrey N
Published in Journal of organic chemistry (01.08.2014)
Published in Journal of organic chemistry (01.08.2014)
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Journal Article
Monitoring Ligand-Induced Protein Ordering in Drug Discovery
Grace, Christy R., Ban, David, Min, Jaeki, Mayasundari, Anand, Min, Lie, Finch, Kristin E., Griffiths, Lyra, Bharatham, Nagakumar, Bashford, Donald, Kiplin Guy, R., Dyer, Michael A., Kriwacki, Richard W.
Published in Journal of molecular biology (27.03.2016)
Published in Journal of molecular biology (27.03.2016)
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Journal Article
Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins
Ippagunta, Sirish K, Pollock, Julie A, Sharma, Naina, Lin, Wenwei, Chen, Taosheng, Tawaratsumida, Kazuki, High, Anthony A, Min, Jaeki, Chen, Yizhe, Guy, R Kiplin, Redecke, Vanessa, Katzenellenbogen, John A, Häcker, Hans
Published in Science signaling (14.08.2018)
Published in Science signaling (14.08.2018)
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Journal Article
Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening
Ortiz, Diana, Guiguemde, W Armand, Hammill, Jared T, Carrillo, Angela K, Chen, Yizhe, Connelly, Michele, Stalheim, Kayla, Elya, Carolyn, Johnson, Alex, Min, Jaeki, Shelat, Anang, Smithson, David C, Yang, Lei, Zhu, Fangyi, Guy, R Kiplin, Landfear, Scott M
Published in PLoS neglected tropical diseases (01.12.2017)
Published in PLoS neglected tropical diseases (01.12.2017)
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Journal Article
Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds
Ortiz, Diana, Guiguemde, W Armand, Johnson, Alex, Elya, Carolyn, Anderson, Johanna, Clark, Julie, Connelly, Michele, Yang, Lei, Min, Jaeki, Sato, Yuko, Guy, R Kiplin, Landfear, Scott M
Published in PloS one (20.04.2015)
Published in PloS one (20.04.2015)
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Journal Article
On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53
Bista, Michal, Smithson, David, Pecak, Aleksandra, Salinas, Gabriella, Pustelny, Katarzyna, Min, Jaeki, Pirog, Artur, Finch, Kristin, Zdzalik, Michal, Waddell, Brett, Wladyka, Benedykt, Kedracka-Krok, Sylwia, Dyer, Michael A, Dubin, Grzegorz, Guy, R Kiplin
Published in PloS one (04.06.2012)
Published in PloS one (04.06.2012)
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Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen
Tanaka, Takeshi Q, Guiguemde, W Armand, Barnett, David S, Maron, Maxim I, Min, Jaeki, Connelly, Michele C, Suryadevara, Praveen Kumar, Guy, R Kiplin, Williamson, Kim C
Published in Antimicrobial agents and chemotherapy (01.03.2015)
Published in Antimicrobial agents and chemotherapy (01.03.2015)
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Journal Article
Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction
Pettersson, Mariell, Quant, Maria, Min, Jaeki, Iconaru, Luigi, Kriwacki, Richard W, Waddell, M Brett, Guy, R Kiplin, Luthman, Kristina, Grøtli, Morten
Published in PloS one (01.10.2015)
Published in PloS one (01.10.2015)
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