Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor
Thoma, Gebhard, Miltz, Wolfgang, Srinivas, Honnappa, Penno, Carlos A., Kiffe, Michael, Gajewska, Monika, Klein, Kai, Evans, Amanda, Beerli, Christian, Röhn, Till A.
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
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Journal Article
Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis
Velcicky, Juraj, Miltz, Wolfgang, Oberhauser, Berndt, Orain, David, Vaupel, Andrea, Weigand, Klaus, Dawson King, Janet, Littlewood-Evans, Amanda, Nash, Mark, Feifel, Roland, Loetscher, Pius
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Journal Article
Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase
Thoma, Gebhard, Markert, Christian, Lueoend, Rainer, Miltz, Wolfgang, Spanka, Carsten, Bollbuck, Birgit, Wolf, Romain M., Srinivas, Honnappa, Penno, Carlos A., Kiffe, Michael, Gajewska, Monika, Bednarczyk, Dallas, Wieczorek, Grazyna, Evans, Amanda, Beerli, Christian, Röhn, Till A.
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Journal Article
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A(4) Hydrolase
Markert, Christian, Thoma, Gebhard, Srinivas, Honnappa, Bollbuck, Birgit, Lueoend, Rainer M., Miltz, Wolfgang, Waelchli, Rudolf, Wolf, Romain, Hinrichs, Juergen, Bergsdorf, Christian, Azzaoui, Kamal, Penno, Carlos A., Klein, Kai, Wack, Nathalie, Jaeger, Petra, Hasler, Franziska, Beerli, Christian, Loetscher, Pius, Dawson, Janet, Wieczorek, Grazyna, Numao, Shin, Littlewood-Evans, Amanda, Roehn, Till A.
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Journal Article
Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis
Miltz, Wolfgang, Velcicky, Juraj, Dawson, Janet, Littlewood-Evans, Amanda, Ludwig, Marie-Gabrielle, Seuwen, Klaus, Feifel, Roland, Oberhauser, Berndt, Meyer, Arndt, Gabriel, Daniela, Nash, Mark, Loetscher, Pius
Published in Bioorganic & medicinal chemistry (15.08.2017)
Published in Bioorganic & medicinal chemistry (15.08.2017)
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Journal Article
Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors
Numao, Shin, Hasler, Franziska, Laguerre, Claire, Srinivas, Honnappa, Wack, Nathalie, Jäger, Petra, Schmid, Andres, Osmont, Arnaud, Röthlisberger, Patrik, Houguenade, Jeremy, Bergsdorf, Christian, Dawson, Janet, Carte, Nathalie, Hofmann, Andreas, Markert, Christian, Hardaker, Liz, Billich, Andreas, Wolf, Romain M, Penno, Carlos A, Bollbuck, Birgit, Miltz, Wolfgang, Röhn, Till A
Published in Scientific reports (19.10.2017)
Published in Scientific reports (19.10.2017)
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Journal Article
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase
Markert, Christian, Thoma, Gebhard, Srinivas, Honnappa, Bollbuck, Birgit, Lüönd, Rainer M, Miltz, Wolfgang, Wälchli, Rudolf, Wolf, Romain, Hinrichs, Jürgen, Bergsdorf, Christian, Azzaoui, Kamal, Penno, Carlos A, Klein, Kai, Wack, Nathalie, Jäger, Petra, Hasler, Franziska, Beerli, Christian, Loetscher, Pius, Dawson, Janet, Wieczorek, Grazyna, Numao, Shin, Littlewood-Evans, Amanda, Röhn, Till A
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Journal Article
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase
Markert, Christian, Thoma, Gebhard, Srinivas, Honnappa, Bollbuck, Birgit, Lüönd, Rainer M, Miltz, Wolfgang, Wälchli, Rudolf, Wolf, Romain, Hinrichs, Jürgen, Bergsdorf, Christian, Azzaoui, Kamal, Penno, Carlos A, Klein, Kai, Wack, Nathalie, Jäger, Petra, Hasler, Franziska, Beerli, Christian, Loetscher, Pius, Dawson, Janet, Wieczorek, Grazyna, Numao, Shin, Littlewood-Evans, Amanda, Röhn, Till A
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Journal Article
LTA4H 억제제로서의 헤테로아릴 아미노프로판올 유도체
MILTZ WOLFGANG, ROEHN TILL, THOMA GEBHARD, KORDIKOWSKI ANDREAS, MARKERT CHRISTIAN, LUOND RAINER MARTIN, SPANKA CARSTEN, LIU YUGANG, XIE TIAN
Year of Publication 22.12.2023
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Year of Publication 22.12.2023
Patent
헤테로아릴 치환된 스피로피페리디닐 유도체 및 이의 제약 용도
MILTZ WOLFGANG, ROEHN TILL, THOMA GEBHARD, SANDHAM DAVID ANDREW, CULSHAW ANDREW JAMES, ORAIN DAVID, HURLEY TIMOTHY BRIAN, BUSHABOINA MALLESH, CHEUNG ATWOOD KIM, RAJAGOPALAN SRINIVASAN, CHEN XIN, PATEL TAJESH, WAELCHLI RUDOLF, TICHKULE RITESH BHANUDASJI, LABBE GIGUERE NANCY
Year of Publication 17.04.2023
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Year of Publication 17.04.2023
Patent
Targeting monocyte chemoattractant protein-1 signalling in disease
Dawson, Janet, Miltz, Wolfgang, Mir, Anis K, Wiessner, Christoph
Published in Expert opinion on therapeutic targets (01.02.2003)
Published in Expert opinion on therapeutic targets (01.02.2003)
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Journal Article
PYRAZOLO PYRIMIDINE DERIVATIVES
MILTZ WOLFGANG, OBERHAUSER BERNDT, VAUPEL ANDREA, WEIGAND KLAUS, LIU YUGANG, LELETI RAJENDER REDDY, DU ZHENGMING, VELCICKY JURAJ
Year of Publication 26.02.2014
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Year of Publication 26.02.2014
Patent
Novel Heteroaryl Aminopropanol Derivatives
Liu, Yugang, Miltz, Wolfgang, Spanka, Carsten, Thoma, Gebhard, Markert, Christian, Lüönd, Rainer Martin, XIE, Tian, Kordikowski, Andreas, Roehn, Till
Year of Publication 20.06.2024
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Year of Publication 20.06.2024
Patent
Heteroaryl aminopropanol derivatives
Liu, Yugang, Miltz, Wolfgang, Spanka, Carsten, Thoma, Gebhard, Xie, Tian, Markert, Christian, Lüönd, Rainer Martin, Kordikowski, Andreas, Roehn, Till
Year of Publication 19.03.2024
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Year of Publication 19.03.2024
Patent
HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H
SPANKA, Carsten, KORDIKOWSKI, Andreas, LÜÖND, Rainer Martin, MILTZ, Wolfgang, ROEHN, Till, THOMA, Gebhard, LIU, Yugang, XIE, Tian, MARKERT, Christian
Year of Publication 21.02.2024
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Year of Publication 21.02.2024
Patent
HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H
SPANKA, Carsten, KORDIKOWSKI, Andreas, LÜÖND, Rainer Martin, MILTZ, Wolfgang, ROEHN, Till, THOMA, Gebhard, LIU, Yugang, XIE, Tian, MARKERT, Christian
Year of Publication 31.08.2023
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Year of Publication 31.08.2023
Patent