Lipoprotein-Associated Phospholipase A2, Platelet-Activating Factor Acetylhydrolase, Is Expressed by Macrophages in Human and Rabbit Atherosclerotic Lesions
Häkkinen, Tomi, Luoma, Jukka S, Hiltunen, Mikko O, Macphee, Colin H, Milliner, Kevin J, Patel, Lisa, Rice, Simon Q, Tew, David G, Karkola, Kari, Ylä-Herttuala, NA
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.1999)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.1999)
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Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor
MacPhee, C H, Moores, K E, Boyd, H F, Dhanak, D, Ife, R J, Leach, C A, Leake, D S, Milliner, K J, Patterson, R A, Suckling, K E, Tew, D G, Hickey, D M
Published in Biochemical journal (01.03.1999)
Published in Biochemical journal (01.03.1999)
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The identification of clinical candidate SB-480848 : A potent inhibitor of lipoprotein-associated phospholipase A2
BLACKIE, Josie A, BLOOMER, Jackie C, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, BROWN, Murray J. B, CHENG, Hung-Yuan, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
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The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-associated phospholipase A2 for evaluation in man
BLACKIE, Josie A, BLOOMER, Jackie C, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, BROWN, Murray J. B, CHENG, Hung-Yuan, ELLIOTT, Richard L, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones
BOYD, Helen F, FELL, Stephen C. M, STANSFIELD, Ian G, STANWAY, Steven J, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2
BOYD, Helen F, FELL, Stephen C. M, PORTER, Rod A, RAWLINGS, D. Anthony, SMITH, Stephen A, STANSFIELD, Ian G, TEW, David G, THEOBALD, Colin J, WHITTAKER, Caroline M, FLYNN, Sean T, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
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1-(Arylpiperazinylamidoalkyl)-pyrimidones : Orally active inhibitors of lipoprotein-associated phospholipase A2
BLOOMER, Jackie C, BOYD, Helen F, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
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The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2
BOYD, Helen F, HAMMOND, Beverley, STANSFIELD, Ian G, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, SMITH, Stephen A
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
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Journal Article
Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor
MACPHEE, Colin H., MOORES, Kitty E., BOYD, Helen F., DHANAK, Dash, IFE, Robert J., LEACH, Colin A., LEAKE, David S., MILLINER, Kevin J., PATTERSON, Rebecca A., SUCKLING, Keith E., TEW, David G., HICKEY, Deirdre M. B.
Published in Biochemical journal (01.03.1999)
Published in Biochemical journal (01.03.1999)
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Studies on the mechanism of action of omeprazole
Keeling, D J, Fallowfield, C, Milliner, K J, Tingley, S K, Ife, R J, Underwood, A H
Published in Biochemical pharmacology (15.08.1985)
Published in Biochemical pharmacology (15.08.1985)
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Journal Article
Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones
Boyd, Helen F, Fell, Stephen C M, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Macphee, Colin H, Milliner, Kevin J, Pinto, Ivan L, Rawlings, D Anthony, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Theobald, Colin J, Whittaker, Caroline M
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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Journal Article
The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A 2
Blackie, Josie A., Bloomer, Jackie C., Brown, Murray J.B., Cheng, Hung-Yuan, Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J.
Published in Bioorganic & medicinal chemistry letters (2003)
Published in Bioorganic & medicinal chemistry letters (2003)
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Journal Article
Potent, orally active inhibitors of lipoprotein-associated phospholipase A 2: 1-(biphenylmethylamidoalkyl)-pyrimidones
Boyd, Helen F., Fell, Stephen C.M., Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Macphee, Colin H., Milliner, Kevin J., Pinto, Ivan L., Rawlings, D.Anthony, Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Theobald, Colin J., Whittaker, Caroline M.
Published in Bioorganic & medicinal chemistry letters (2002)
Published in Bioorganic & medicinal chemistry letters (2002)
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Journal Article
The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man
Blackie, Josie A, Bloomer, Jackie C, Brown, Murray J B, Cheng, Hung-Yuan, Elliott, Richard L, Hammond, Beverley, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Lewis, V Ann, Macphee, Colin H, Milliner, Kevin J, Moores, Kitty E, Pinto, Ivan L, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Taylor, Maxine A, Theobald, Colin J, Whittaker, Caroline M
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
Get full text
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
Journal Article
Lipoprotein-Associated Phospholipase A 2 , Platelet-Activating Factor Acetylhydrolase, Is Expressed by Macrophages in Human and Rabbit Atherosclerotic Lesions
Häkkinen, Tomi, Luoma, Jukka S., Hiltunen, Mikko O., Macphee, Colin H., Milliner, Kevin J., Patel, Lisa, Rice, Simon Q., Tew, David G., Karkola, Kari, Ylä-Herttuala, Seppo
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.1999)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.1999)
Get full text
Journal Article
The discovery of SB-435495
Blackie, Josie A., Bloomer, Jackie C., Brown, Murray J.B., Cheng, Hung-Yuan, Elliott, Richard L., Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J., Whittaker, Caroline M.
Published in Bioorganic & medicinal chemistry letters (01.09.2002)
Published in Bioorganic & medicinal chemistry letters (01.09.2002)
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Journal Article
The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A 2
Boyd, Helen F., Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Theobald, Colin J., Whittaker, Caroline M.
Published in Bioorganic & medicinal chemistry letters (2001)
Published in Bioorganic & medicinal chemistry letters (2001)
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Journal Article
The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-Associated phospholipase A 2 for evaluation in man
Blackie, Josie A., Bloomer, Jackie C., Brown, Murray J.B., Cheng, Hung-Yuan, Elliott, Richard L., Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J., Whittaker, Caroline M.
Published in Bioorganic & medicinal chemistry letters (2002)
Published in Bioorganic & medicinal chemistry letters (2002)
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Journal Article
2-(alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2
BOYD, H. F, FLYNN, S. T, SMITH, S. A, STANSFIELD, I. G, TEW, D. G, THEOBALD, C. J, HICKEY, D. M. B, IFE, R. J, JONES, M, LEACH, C. A, MACPHEE, C. H, MILLINER, K. J, RAWLINGS, D. A, SLINGSBY, B. P
Published in Bioorganic & medicinal chemistry letters (21.02.2000)
Published in Bioorganic & medicinal chemistry letters (21.02.2000)
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Journal Article