Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function
Jean, Christine, Chen, Xiao Lei, Nam, Ju-Ock, Tancioni, Isabelle, Uryu, Sean, Lawson, Christine, Ward, Kristy K, Walsh, Colin T, Miller, Nichol L G, Ghassemian, Majid, Turowski, Patric, Dejana, Elisabetta, Weis, Sara, Cheresh, David A, Schlaepfer, David D
Published in The Journal of cell biology (20.01.2014)
Published in The Journal of cell biology (20.01.2014)
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Journal Article
Rgnef promotes ovarian tumor progression and confers protection from oxidative stress
Kleinschmidt, Elizabeth G., Miller, Nichol L. G., Ozmadenci, Duygu, Tancioni, Isabelle, Osterman, Carlos Díaz, Barrie, Allison M., Taylor, Kristin N., Ye, Aaron, Jiang, Shulin, Connolly, Denise C., Stupack, Dwayne G., Schlaepfer, David D.
Published in Oncogene (01.09.2019)
Published in Oncogene (01.09.2019)
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Journal Article
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression
Lim, Ssang-Taek, Miller, Nichol L G, Chen, Xiao Lei, Tancioni, Isabelle, Walsh, Colin T, Lawson, Christine, Uryu, Sean, Weis, Sara M, Cheresh, David A, Schlaepfer, David D
Published in The Journal of cell biology (25.06.2012)
Published in The Journal of cell biology (25.06.2012)
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Journal Article
Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation
Lim, Ssang-Taek, Chen, Xiao Lei, Tomar, Alok, Miller, Nichol L.G., Yoo, Jiyeon, Schlaepfer, David D.
Published in The Journal of biological chemistry (09.07.2010)
Published in The Journal of biological chemistry (09.07.2010)
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Journal Article
FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth
Tancioni, Isabelle, Miller, Nichol L G, Uryu, Sean, Lawson, Christine, Jean, Christine, Chen, Xiao Lei, Kleinschmidt, Elizabeth G, Schlaepfer, David D
Published in Breast cancer research : BCR (28.03.2015)
Published in Breast cancer research : BCR (28.03.2015)
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Journal Article
Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression
Ward, Kristy K., Tancioni, Isabelle, Lawson, Christine, Miller, Nichol L. G., Jean, Christine, Chen, Xiao Lei, Uryu, Sean, Kim, Josephine, Tarin, David, Stupack, Dwayne G., Plaxe, Steven C., Schlaepfer, David D.
Published in Clinical & experimental metastasis (01.06.2013)
Published in Clinical & experimental metastasis (01.06.2013)
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Journal Article
Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer
Shah, Nina R, Tancioni, Isabelle, Ward, Kristy K, Lawson, Christine, Chen, Xiao Lei, Jean, Christine, Sulzmaier, Florian J, Uryu, Sean, Miller, Nichol L.G, Connolly, Denise C, Schlaepfer, David D
Published in Gynecologic oncology (01.07.2014)
Published in Gynecologic oncology (01.07.2014)
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Journal Article
Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6
Larder, Rachel, Clark, Daniel D, Miller, Nichol L G, Mellon, Pamela L
Published in The Journal of neuroscience (12.01.2011)
Published in The Journal of neuroscience (12.01.2011)
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Journal Article
FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth
Tancioni, Isabelle, Uryu, Sean, Sulzmaier, Florian J, Shah, Nina R, Lawson, Christine, Miller, Nichol L G, Jean, Christine, Chen, Xiao Lei, Ward, Kristy K, Schlaepfer, David D
Published in Molecular cancer therapeutics (01.08.2014)
Published in Molecular cancer therapeutics (01.08.2014)
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Journal Article
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate
Crosignani, Stefano, Bingham, Patrick, Bottemanne, Pauline, Cannelle, Hélène, Cauwenberghs, Sandra, Cordonnier, Marie, Dalvie, Deepak, Deroose, Frederik, Feng, Jun Li, Gomes, Bruno, Greasley, Samantha, Kaiser, Stephen E, Kraus, Manfred, Négrerie, Michel, Maegley, Karen, Miller, Nichol, Murray, Brion W, Schneider, Manfred, Soloweij, James, Stewart, Albert E, Tumang, Joseph, Torti, Vince R, Van Den Eynde, Benoit, Wythes, Martin
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Journal Article
Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer
Freeman-Cook, Kevin D, Hoffman, Robert L, Behenna, Douglas C, Boras, Britton, Carelli, Jordan, Diehl, Wade, Ferre, Rose Ann, He, You-Ai, Hui, Andrea, Huang, Buwen, Huser, Nanni, Jones, Rhys, Kephart, Susan E, Lapek, John, McTigue, Michele, Miller, Nichol, Murray, Brion W, Nagata, Asako, Nguyen, Lisa, Niessen, Sherry, Ninkovic, Sacha, O’Doherty, Inish, Ornelas, Martha A, Solowiej, James, Sutton, Scott C, Tran, Khanh, Tseng, Elaine, Visswanathan, Ravi, Xu, Meirong, Zehnder, Luke, Zhang, Qin, Zhang, Cathy, Dann, Stephen
Published in Journal of medicinal chemistry (08.07.2021)
Published in Journal of medicinal chemistry (08.07.2021)
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Journal Article
Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells
Masià-Balagué, Miriam, Izquierdo, Ismael, Garrido, Georgina, Cordomí, Arnau, Pérez-Benito, Laura, Miller, Nichol L.G., Schlaepfer, David D., Gigoux, Véronique, Aragay, Anna M.
Published in The Journal of biological chemistry (12.06.2015)
Published in The Journal of biological chemistry (12.06.2015)
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Journal Article
p190RhoGEF (Rgnef) Promotes Colon Carcinoma Tumor Progression via Interaction with Focal Adhesion Kinase
YU, Hong-Gang, NAM, Ju-Ock, SCHLAEPFER, David D, MILLER, Nichol L. G, TANJONI, Isabelle, WALSH, Colin, LEI SHI, KIM, Linda, XIAO LEI CHEN, TOMAR, Alok, LIM, Ssang-Taek
Published in Cancer research (Chicago, Ill.) (15.01.2011)
Published in Cancer research (Chicago, Ill.) (15.01.2011)
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Journal Article
Enhancers of GnRH Transcription Embedded in an Upstream Gene Use Homeodomain Proteins to Specify Hypothalamic Expression
Iyer, Anita K, Miller, Nichol L. G, Yip, Kathleen, Tran, Brian H, Mellon, Pamela L
Published in Molecular endocrinology (Baltimore, Md.) (01.10.2010)
Published in Molecular endocrinology (Baltimore, Md.) (01.10.2010)
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Journal Article
Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy
Gomes, Bruno, Driessens, Gregory, Bartlett, Derek, Cai, Danying, Cauwenberghs, Sandra, Crosignani, Stefano, Dalvie, Deepak, Denies, Sofie, Dillon, Christopher P, Fantin, Valeria R, Guo, Jie, Letellier, Marie-Claire, Li, Wenlin, Maegley, Karen, Marillier, Reece, Miller, Nichol, Pirson, Romain, Rabolli, Virginie, Ray, Chad, Streiner, Nicole, Torti, Vince R, Tsaparikos, Konstantinos, Van den Eynde, Benoit J, Wythes, Martin, Yao, Li-Chin, Zheng, Xianxian, Tumang, Joseph, Kraus, Manfred
Published in Molecular cancer therapeutics (01.12.2018)
Published in Molecular cancer therapeutics (01.12.2018)
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Journal Article
The Groucho-related Gene Family Regulates the Gonadotropin-releasing Hormone Gene through Interaction with the Homeodomain Proteins MSX1 and OCT1
Rave-Harel, Naama, Miller, Nichol L.G., Givens, Marjory L., Mellon, Pamela L.
Published in The Journal of biological chemistry (02.09.2005)
Published in The Journal of biological chemistry (02.09.2005)
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Journal Article