Phylogenetic Footprinting Reveals Evolutionarily Conserved Regions of the Gonadotropin-Releasing Hormone Gene that Enhance Cell-Specific Expression
Givens, Marjory L, Kurotani, Reiko, Rave-Harel, Naama, Miller, Nichol L. G, Mellon, Pamela L
Published in Molecular endocrinology (Baltimore, Md.) (01.12.2004)
Published in Molecular endocrinology (Baltimore, Md.) (01.12.2004)
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Journal Article
Antitumor activity of KIN-2787, a next-generation pan-RAF inhibitor, in combination with MEK inhibition in preclinical models of human NRAS mutant melanoma
Miller, Nichol, Wang, Tim Sen, Lee, Catherine, Severson, Paul, Ke, Eugene, Kobayashi, Ken, Williams, Richard Thomas
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Journal Article
The next-generation pan-RAF inhibitor, KIN-2787, is active in class II and class III BRAF mutant models
Franovic, Aleksandra, Miller, Nichol, Severson, Paul, Kanouni, Toufike, Timple, Noelito, Jiang, Ping, Murphy, Eric, Martin, Eric
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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Journal Article
Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
Arora, Mansi, Moser, Justin, Hoffman, Timothy E., Watts, Lotte P., Min, Mingwei, Musteanu, Monica, Rong, Yao, Ill, C. Ryland, Nangia, Varuna, Schneider, Jordan, Sanclemente, Manuel, Lapek, John, Nguyen, Lisa, Niessen, Sherry, Dann, Stephen, VanArsdale, Todd, Barbacid, Mariano, Miller, Nichol, Spencer, Sabrina L.
Published in Cell (08.06.2023)
Published in Cell (08.06.2023)
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Journal Article
Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
Freeman-Cook, Kevin, Hoffman, Robert L., Miller, Nichol, Almaden, Jonathan, Chionis, John, Zhang, Qin, Eisele, Koleen, Liu, Chaoting, Zhang, Cathy, Huser, Nanni, Nguyen, Lisa, Costa-Jones, Cinthia, Niessen, Sherry, Carelli, Jordan, Lapek, John, Weinrich, Scott L., Wei, Ping, McMillan, Elizabeth, Wilson, Elizabeth, Wang, Tim S., McTigue, Michele, Ferre, Rose Ann, He, You-Ai, Ninkovic, Sacha, Behenna, Douglas, Tran, Khanh T., Sutton, Scott, Nagata, Asako, Ornelas, Martha A., Kephart, Susan E., Zehnder, Luke R., Murray, Brion, Xu, Meirong, Solowiej, James E., Visswanathan, Ravi, Boras, Britton, Looper, David, Lee, Nathan, Bienkowska, Jadwiga R., Zhu, Zhou, Kan, Zhengyan, Ding, Ying, Mu, Xinmeng Jasmine, Oderup, Cecilia, Salek-Ardakani, Shahram, White, Michael A., VanArsdale, Todd, Dann, Stephen G.
Published in Cancer cell (11.10.2021)
Published in Cancer cell (11.10.2021)
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Abstract 1954: Identifying synthetic lethality with novel CDK2 small molecule inhibitors via integration of high-content microscopy and -omics level platforms
Wang, Tim Sen, Almaden, Jon, Shen, Chen, Lapek, John, Niessen, Sherry, Miller, Nichol, Dann, Stephen, VanArsdale, Todd
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Activity of KIN-3248, a next-generation pan-FGFR inhibitor, against acquired FGFR-gatekeeper and molecular-brake drug resistance mutations
Franovic, Aleksandra, Mohan, Adithi, Uryu, Sean, Wu, Qibiao, Jiang, Ping, Miller, Nichol, Tyhonas, John, Timple, Noelito, Severson, Paul, Kania, Robert, Murphy, Eric, Bardeesy, Nabeel, Martin, Eric
Published in Journal of clinical oncology (01.02.2022)
Published in Journal of clinical oncology (01.02.2022)
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Journal Article
Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations
Tyhonas, John S., Arnold, Lee D., Cox, Jason M., Franovic, Aleksandra, Gardiner, Elisabeth, Grandinetti, Kathryn, Kania, Robert, Kanouni, Toufike, Lardy, Matthew, Li, Chun, Martin, Eric S., Miller, Nichol, Mohan, Adithi, Murphy, Eric A., Perez, Michelle, Soroceanu, Liliana, Timple, Noel, Uryu, Sean, Womble, Scott, Kaldor, Stephen W.
Published in Journal of medicinal chemistry (08.02.2024)
Published in Journal of medicinal chemistry (08.02.2024)
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Journal Article
Design and Synthesis of Functionally Active 5‑Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1
Gallego, Rebecca A., Bernier, Louise, Chen, Hui, Cho-Schultz, Sujin, Chung, Loanne, Collins, Michael, Del Bel, Matthew, Elleraas, Jeff, Costa Jones, Cinthia, Cronin, Ciaran N., Edwards, Martin, Fang, Xu, Fisher, Timothy, He, Mingying, Hoffman, Jacqui, Huo, Ruiduan, Jalaie, Mehran, Johnson, Eric, Johnson, Ted W., Kania, Robert S., Kraus, Manfred, Lafontaine, Jennifer, Le, Phuong, Liu, Tongnan, Maestre, Michael, Matthews, Jean, McTigue, Michele, Miller, Nichol, Mu, Qiming, Qin, Xulong, Ren, Shijian, Richardson, Paul, Rohner, Allison, Sach, Neal, Shao, Li, Smith, Graham, Su, Ruirui, Sun, Bin, Timofeevski, Sergei, Tran, Phuong, Wang, Shuiwang, Wang, Wei, Zhou, Ru, Zhu, Jinjiang, Nair, Sajiv K.
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Journal Article
EXTH-42. PRECLINICAL INVESTIGATION OF A NOVEL BRAIN PENETRANT MEK INHIBITOR TO TARGET BRAIN METASTASIS
Yamazawa, Erika, Nayyar, Naema, Ijad, Nazanin, Torrini, Consuelo, De Sauvage, Magali, Migliarese, Christian, Summers, Elizabeth, Marion, Braxton, Lee, Catherine, Suriben, Rowena, Perez, Michelle, Powell, Ben, Miller, Nichol, Grandinetti, Brooke, Wakimoto, Hiroaki, Brastianos, Priscilla
Published in Neuro-oncology (Charlottesville, Va.) (10.11.2023)
Published in Neuro-oncology (Charlottesville, Va.) (10.11.2023)
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Journal Article
The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition
Chen, Young K., Kanouni, Toufike, Arnold, Lee D., Cox, Jason M., Gardiner, Elisabeth, Grandinetti, Kathryn, Jiang, Ping, Kaldor, Stephen W., Lee, Catherine, Li, Chun, Martin, Eric S., Miller, Nichol, Murphy, Eric A., Timple, Noel, Tyhonas, John S., Vassar, Angie, Wang, Tim S., Williams, Richard, Yuan, Ding, Kania, Robert S.
Published in Journal of medicinal chemistry (08.02.2024)
Published in Journal of medicinal chemistry (08.02.2024)
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Journal Article
Discovery of Highly Selective Inhibitors of Microtubule-Associated Serine/Threonine Kinase-like (MASTL)
Gallego, Rebecca A., Scales, Stephanie, Toledo, Chad, Auth, Marin, Bernier, Louise, Berry, Madeline, Brun, Sonja, Chung, Loanne, Davis, Carl, Diehl, Wade, Dress, Klaus, Eisele, Koleen, Elleraas, Jeff, Ewanicki, Jason, Fobian, Yvette, Greasley, Samantha, Greenwald, Eric C., Johnson, Ted W., Khamphavong, Penney, Lafontaine, Jennifer, Li, Jian, Linton, Angelica, Maestre, Michael, Miller, Nichol, Murtaza, Anwar, Patman, Ryan L., Quinlan, Casey L., Ramms, Dana J., Richardson, Paul, Sach, Neal, Salomon-Ferrer, Romelia, Silva, Francisco, Timofeevski, Sergei, Tran, Phuong, Tran-Dubé, Michelle, Wang, Fen, Wang, Wei, Wythes, Martin, Yang, Shouliang, Zou, Aihua, VanArsdale, Todd, McAlpine, Indrawan
Published in Journal of medicinal chemistry (05.11.2024)
Published in Journal of medicinal chemistry (05.11.2024)
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Journal Article
Abstract 2960: A novel mouse model of pancreatic cancer reveals new insights into cell cycle deregulation
Adams, Christina, Wang, Lynn, Wang, Tim S., Miller, Nichol, McMillan, Elizabeth, Ramstetter, Monica, Chionis, John, Eisele, Koleen, Almaden, Jonathan, Affolter, Timothy, Pillai, Smitha, VanArsdale, Todd, Dillon, Chris, Dann, Stephen G.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract B47: Rgnef (p190RhoGEF/Arhgef28) loss impairs ovarian tumor metastatic growth
Kleinschmidt, Elizabeth G., Tancioni, Isabelle, Taylor, Kristin, Osterman-Diaz, Carlos, Miller, Nichol L. G., Jiang, Shulin, Schlaepfer, David D.
Published in Clinical cancer research (01.08.2018)
Published in Clinical cancer research (01.08.2018)
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Journal Article
Abstract 4927: Exarafenib (KIN-2787) is a potent, selective pan-RAF inhibitor with activity in preclinical models of BRAF class II/III mutant and NRAS mutant melanoma
Wang, Tim S., Lee, Catherine, Severson, Paul, Pelham, Robert J., Williams, Richard, Miller, Nichol L. G.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
RAF 억제제를 이용하는 암의 치료
MARTIN ERIC, MILLER NICHOL L. G, KOBAYASHI KEN, FRANOVIC ALEKSANDRA, MURPHY ERIC, WILLIAMS RICHARD THOMAS
Year of Publication 02.01.2024
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Year of Publication 02.01.2024
Patent
FGFR 키나제 억제제를 이용하는 암의 치료
KOBAYASHI KEN, MARTIN ERIC S, MURPHY ERIC A, VASSAR ANGIE, FRANOVIC ALEKSANDRA, TYHONAS JOHN, COX JASON M, TIMPLE NOELITO, WILLIAMS RICHARD THOMAS, KANIA ROBERT, MILLER NICHOL
Year of Publication 26.07.2024
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Year of Publication 26.07.2024
Patent
Abstract 4122: Occurrence of BRAF class II and III alterations is common across solid tumors and is associated with inferior clinical outcomes in NSCLC and melanoma
Severson, Paul L., Donderici, Elifnur Yay, Zhang, Nicole, Franovic, Aleksandra, Miller, Nichol, Martin, Eric, Murphy, Eric, Williams, Richard
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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