Design and Preclinical Development of TransCon PTH, an Investigational Sustained‐Release PTH Replacement Therapy for Hypoparathyroidism
Holten‐Andersen, Lars, Pihl, Susanne, Rasmussen, Caroline E, Zettler, Joachim, Maitro, Guillaume, Baron, Julia, Heinig, Stefan, Hoffmann, Eric, Wegge, Thomas, Krusch, Mathias, Faltinger, Frank, Killian, Steffen, Sprogoe, Kennett, Karpf, David B, Breinholt, Vibeke Miller, Cleemann, Felix
Published in Journal of bone and mineral research (01.11.2019)
Published in Journal of bone and mineral research (01.11.2019)
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Journal Article
Intratumoral delivery of TransCon™ TLR7/8 Agonist promotes sustained anti-tumor activity and local immune cell activation while minimizing systemic cytokine induction
Zúñiga, Luis Alejandro, Leßmann, Torben, Uppal, Karan, Bisek, Nicola, Hong, Enping, Rasmussen, Caroline E., Karlsson, Jens-Jakob, Zettler, Joachim, Holten-Andersen, Lars, Bang, Kathy, Thakar, Dhruv, Lee, Yu-Chi, Martinez, Salomon, Sabharwal, Simran Singh, Stark, Sebastian, Faltinger, Frank, Kracker, Oliver, Weisbrod, Samuel, Müller, Robin, Voigt, Tobias, Bigott, Kornelia, Tabrizifard, Mohammad, Breinholt, Vibeke Miller, Mirza, Amer M., Rosen, David B., Sprogøe, Kennett, Punnonen, Juha
Published in Cancer cell international (19.09.2022)
Published in Cancer cell international (19.09.2022)
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Journal Article
TransCon IL-2 β/γ: a novel long-acting prodrug with sustained release of an IL-2Rβ/γ-selective IL-2 variant with improved pharmacokinetics and potent activation of cytotoxic immune cells for the treatment of cancer
Rosen, David B, Kvarnhammar, Anne Månsson, Laufer, Burkhardt, Knappe, Thomas, Karlsson, Jens Jakob, Hong, Enping, Lee, Yu-Chi, Thakar, Dhruv, Zúñiga, Luis Alejandro, Bang, Kathy, Sabharwal, Simran Singh, Uppal, Karan, Olling, Janne Damm, Kjaergaard, Kristian, Kurpiers, Thomas, Schnabel, Meike, Reich, Diana, Glock, Philipp, Zettler, Joachim, Krusch, Mathias, Bernhard, Ana, Heinig, Stefan, Konjik, Valentino, Wegge, Thomas, Hehn, Yvonne, Killian, Steffen, Viet, Laura, Runz, Josefine, Faltinger, Frank, Tabrizi, Mohammad, Abel, Kristin Laura, Breinholt, Vibeke Miller, Singel, Stina M, Sprogøe, Kennett, Punnonen, Juha
Published in Journal for immunotherapy of cancer (01.07.2022)
Published in Journal for immunotherapy of cancer (01.07.2022)
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Journal Article
782 TransCon TLR7/8 agonist induces sustained local and systemic immune activation in patients with solid tumors
Davar, Diwakar, Kriegbaum, Mette, Aghmesheh, Morteza, Algazi, Alain, Bajor, David, Ganju, Vinod, Laux, Douglas, Spira, Alexander I, Krapp, Christian, Lança, Telma, Morris, Joan, Singel, Stina, Poulsen, Thomas Tuxen, Breinholt, Vibeke Miller, Gabrail, Nashat
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
TransCon CNP, a Sustained-Release C-Type Natriuretic Peptide Prodrug, a Potentially Safe and Efficacious New Therapeutic Modality for the Treatment of Comorbidities Associated with Fibroblast Growth Factor Receptor 3-Related Skeletal Dysplasias
Breinholt, Vibeke Miller, Rasmussen, Caroline E, Mygind, Per Holse, Kjelgaard-Hansen, Mads, Faltinger, Frank, Bernhard, Ana, Zettler, Joachim, Hersel, Ulrich
Published in The Journal of pharmacology and experimental therapeutics (01.09.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2019)
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Journal Article
Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamics results of a long‐acting C‐type natriuretic peptide prodrug, TransCon CNP
Breinholt, Vibeke Miller, Mygind, Per Holse, Christoffersen, Eva Dam, Zhang, Ying, Ota, Sho, Will Charlton, R., Viuff, Dorthe
Published in British journal of clinical pharmacology (01.11.2022)
Published in British journal of clinical pharmacology (01.11.2022)
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Journal Article
Weekly Lonapegsomatropin in Treatment-Naïve Children With Growth Hormone Deficiency: The Phase 3 heiGHt Trial
Thornton, Paul S, Maniatis, Aristides K, Aghajanova, Elena, Chertok, Elena, Vlachopapadopoulou, Elpis, Lin, Zhengning, Song, Wenjie, Christoffersen, Eva Dam, Breinholt, Vibeke Miller, Kovalenko, Tatiana, Giorgadze, Elene, Korpal-Szczyrska, Maria, Hofman, Paul L, Karpf, David B, Shu, Aimee D, Beckert, Michael
Published in The journal of clinical endocrinology and metabolism (01.11.2021)
Published in The journal of clinical endocrinology and metabolism (01.11.2021)
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Journal Article
An Antibody-Drug Conjugate That Targets Tissue Factor Exhibits Potent Therapeutic Activity against a Broad Range of Solid Tumors
BREIJ, Esther C. W, DE GOEIJ, Bart E. C. G, PARREN, Paul W. H. I, VERPLOEGEN, Sandra, SCHUURHUIS, Danita H, AMIRKHOSRAVI, Ali, FRANCIS, John, MILLER, Vibeke Breinholt, HOUTKAMP, Mischa, BLEEKER, Wim K, SATIJN, David
Published in Cancer research (Chicago, Ill.) (15.02.2014)
Published in Cancer research (Chicago, Ill.) (15.02.2014)
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Journal Article
TransCon IL-2 β/γ, a novel long-acting prodrug with sustained release of an IL-2Rβ/γ-selective IL-2 analog, demonstrates improved pharmacokinetics and profound expansion of cytotoxic immune cells in non-human primates
Rosen, David, Månsson Kvarnhammar, Anne, Olling, Janne Damm, Laufer, Burkhardt, Knappe, Thomas, Karlsson, Jens Jakob, Kurpiers, Thomas, Zettler, Joachim, Runz, Josefine, Faltinger, Frank, Viet, Laura, Krusch, Mathias, Schnabel, Meike, Reich, Diana, Glock, Philipp, Singel, Stina Mui, Sprogøe, Kennett, Abel, Kristin Laura, Breinholt, Vibeke Miller, Punnonen, Juha
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Journal Article
Response to Letter to the Editor From L. Sävendahl et al: "Weekly Lonapegsomatropin in Treatment-Naïve Children With Growth Hormone Deficiency: The Phase 3 heiGHt Trial"
Thornton, Paul S, Maniatis, Aristides K, Aghajanova, Elena, Chertok, Elena, Vlachopapadopoulou, Elpis, Lin, Zhengning, Song, Wenjie, Christoffersen, Eva Dam, Breinholt, Vibeke Miller, Kovalenko, Tatiana, Giorgadze, Elene, Korpal-Szczyrska, Maria, Hofman, Paul L, Karpf, David B, Shu, Aimee D, Beckert, Michael
Published in The journal of clinical endocrinology and metabolism (17.02.2022)
Published in The journal of clinical endocrinology and metabolism (17.02.2022)
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Journal Article
Response to Letter to the Editor From Malozowski: "Weekly Lonapegsomatropin in Treatment-Naïve Children With Growth Hormone Deficiency: The Phase 3 heiGHt Trial"
Thornton, Paul S, Maniatis, Aristides K, Aghajanova, Elena, Chertok, Elena, Lin, Zhengning, Song, Wenjie, Christoffersen, Eva Dam, Breinholt, Vibeke Miller, Giorgadze, Elene, Korpal-Szczyrska, Maria, Hofman, Paul L, Karpf, David B, Shu, Aimee D, Beckert, Michael
Published in The journal of clinical endocrinology and metabolism (19.04.2022)
Published in The journal of clinical endocrinology and metabolism (19.04.2022)
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Journal Article