Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization
Miller, Randy R, Madeira, Maria, Wood, Harold B, Geissler, Wayne M, Raab, Conrad E, Martin, Iain J
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
Get full text
Journal Article
Molnupiravir: Mechanism of action, clinical, and translational science
Maas, Brian M., Strizki, Julie, Miller, Randy R., Kumar, Sushma, Brown, Michelle, Johnson, Matthew G., Cheng, Mickie, De Anda, Carisa, Rizk, Matthew L., Stone, Julie A.
Published in Clinical and translational science (01.02.2024)
Published in Clinical and translational science (01.02.2024)
Get full text
Journal Article
Evaluating the efficacy of Seattle-PAP for the respiratory support of premature neonates: study protocol for a randomized controlled trial
Backes, Carl H, Notestine, Jennifer L, Lamp, Jane M, Balough, Jeanne C, Notestine, Allison M, Alfred, Crystal M, Kern, Juli M, Stenger, Michael R, Rivera, Brian K, Moallem, Mohannad, Miller, Randy R, Naik, Apurwa, Cooper, Jennifer N, Howard, Christopher R, Welty, Stephen E, Hillman, Noah H, Zupancic, John A F, Stanberry, Larissa I, Hansen, Thomas N, Smith, Charles V
Published in Current controlled trials in cardiovascular medicine (18.01.2019)
Published in Current controlled trials in cardiovascular medicine (18.01.2019)
Get full text
Journal Article
Comprehensive genotoxicity and carcinogenicity assessment of molnupiravir
Escobar, Patricia A, Sobol, Zhanna, Miller, Randy R, Ferry-Martin, Sandrine, Stermer, Angela, Jacob, Binod, Muniappa, Nagaraja, Sanchez, Rosa, Blanchard, Kerry T, Galijatovic-Idrizbegovic, Alema, Amin, Rupesh P, Troth, Sean P
Published in Toxicological sciences (20.09.2024)
Published in Toxicological sciences (20.09.2024)
Get full text
Journal Article
Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus
Madani, Abdeldjalil, Negatu, Dereje A., El Marrouni, Abdellatif, Miller, Randy R., Boyce, Christopher W., Murgolo, Nicholas, Bungard, Christopher J., Zimmerman, Matthew D., Dartois, Véronique, Gengenbacher, Martin, Olsen, David B., Dick, Thomas
Published in Antimicrobial agents and chemotherapy (20.09.2022)
Published in Antimicrobial agents and chemotherapy (20.09.2022)
Get full text
Journal Article
Short-course empiric antibiotic therapy for possible early-onset sepsis in the NICU
Sánchez, Pablo J., Prusakov, Pavel, de Alba Romero, Concepción, Zamora-Flores, Elena, Reyes Escamilla, María Camila, White, Natalie O., Miller, Randy R., Moraille, Richard, Theile, Anthony R., Magers, Jacqueline K.
Published in Journal of perinatology (01.06.2023)
Published in Journal of perinatology (01.06.2023)
Get full text
Journal Article
Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury
Monroe, James J, Tanis, Keith Q, Podtelezhnikov, Alexei A, Nguyen, Truyen, Machotka, Sam V, Lynch, Donna, Evers, Raymond, Palamanda, Jairam, Miller, Randy R, Pippert, Todd, Cabalu, Tamara D, Johnson, Timothy E, Aslamkhan, Amy G, Kang, Wen, Tamburino, Alex M, Mitra, Kaushik, Agrawal, Nancy G B, Sistare, Frank D
Published in Toxicological sciences (01.09.2020)
Published in Toxicological sciences (01.09.2020)
Get full text
Journal Article
Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii : From Screening Impurity to In Vivo Efficacy
Skudlarek, Jason W, Cooke, Andrew J, Mitchell, Helen J, Babaoglu, Kerim, Shaw, Anthony W, Tong, Ling, Nomland, Ashley B, Labroli, Marc, Sha, Deyou, Mulhearn, James J, Wu, Chengwei, Li, Sarah W, Beshore, Douglas C, Hughes, Jonathan M E, Jouffroy, Matthieu, Wang, Hao, Balibar, Carl J, Painter, Ronald E, Shen, Pamela, Lange, Henry S, Ishchenko, Andrii, Chen, Yun-Ting, Klein, Daniel J, Tracy, Rodger W, Miller, Randy R, Cabalu, Tamara D, Wu, Zhe, Leithead, Andrew, Scapin, Giovanna, Hruza, Alan W, Dzhekieva, Liudmila, Bukhtiyarova, Marina, Homsher, Michelle F, Xu, Min, Bahnck-Teets, Carolyn, McKenney, David, Buevich, Alexei V, Liu, Jian, Zhang, Li-Kang, Meng, Tao, Kelly, Terri, DiNunzio, Edward, Soisson, Stephen, Cheng, Robert K Y, Hennig, Michael, Raheem, Izzat, Walker, Scott S
Published in Journal of medicinal chemistry (12.09.2024)
Published in Journal of medicinal chemistry (12.09.2024)
Get full text
Journal Article
Discovery of N‑[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia
Debenham, John S, Madsen-Duggan, Christina, Clements, Matthew J, Walsh, Thomas F, Kuethe, Jeffrey T, Reibarkh, Mikhail, Salowe, Scott P, Sonatore, Lisa M, Hajdu, Richard, Milligan, James A, Visco, Denise M, Zhou, Dan, Lingham, Russell B, Stickens, Dominique, DeMartino, Julie A, Tong, Xinchun, Wolff, Michael, Pang, Jianmei, Miller, Randy R, Sherer, Edward C, Hale, Jeffrey J
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
Get full text
Journal Article
Short-course antibiotic therapy for pneumonia in the neonatal intensive care unit
Lewald, Zachery S., Prusakov, Pavel, Magers, Jacqueline K., Kielt, Matthew J., de Alba Romero, Concepción, White, Natalie O., Miller, Randy R., Moraille, Richard, Theile, Anthony R., Sánchez, Pablo J.
Published in Journal of perinatology (01.09.2023)
Published in Journal of perinatology (01.09.2023)
Get full text
Journal Article
Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder
Edmondson, Scott D, Zhu, Cheng, Kar, Nam Fung, Di Salvo, Jerry, Nagabukuro, Hiroshi, Sacre-Salem, Beatrice, Dingley, Karen, Berger, Richard, Goble, Stephen D, Morriello, Gregori, Harper, Bart, Moyes, Christopher R, Shen, Dong-Ming, Wang, Liping, Ball, Richard, Fitzmaurice, Aileen, Frenkl, Tara, Gichuru, Loise N, Ha, Sookhee, Hurley, Amanda L, Jochnowitz, Nina, Levorse, Dorothy, Mistry, Shruty, Miller, Randy R, Ormes, James, Salituro, Gino M, Sanfiz, Anthony, Stevenson, Andra S, Villa, Katherine, Zamlynny, Beata, Green, Stuart, Struthers, Mary, Weber, Ann E
Published in Journal of medicinal chemistry (28.01.2016)
Published in Journal of medicinal chemistry (28.01.2016)
Get full text
Journal Article
A trial comparing continuous positive airway pressure (CPAP) devices in preterm infants
Backes, Carl H., Cooper, Jennifer N., Notestine, Jennifer L., Alfred, Crystal M., Ball, Molly K., Rivera, Brian K., Lamp, Jane M., Marzec, Laura, Stenger, Michael R., Moallem, Mohannad, Miller, Randy R., Naik, Apurwa, Beer, Lindsey J., Howard, Christopher R., Welty, Stephen E., Peter Richardson, C., Hillman, Noah H., Zupancic, John A. F., Stanberry, Larissa I., Hansen, Thomas N., Smith, Charles V.
Published in Journal of perinatology (01.08.2020)
Published in Journal of perinatology (01.08.2020)
Get full text
Journal Article
Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii
Wang, Hao, Ishchenko, Andrii, Skudlarek, Jason, Shen, Pamela, Dzhekieva, Liudmila, Painter, Ronald E., Chen, Yun-Ting, Bukhtiyarova, Marina, Leithead, Andrew, Tracy, Rodger, Babaoglu, Kerim, Bahnck-Teets, Carolyn, Buevich, Alexei, Cabalu, Tamara D., Labroli, Marc, Lange, Henry, Lei, Ying, Li, Wei, Liu, Jian, Mann, Paul A., Meng, Tao, Mitchell, Helen J., Mulhearn, James, Scapin, Giovanna, Sha, Deyou, Shaw, Anthony W., Si, Qian, Tong, Ling, Wu, Chengwei, Wu, Zhe, Xiao, Jing Chen, Xu, Min, Zhang, Li-Kang, McKenney, David, Miller, Randy R., Black, Todd A., Cooke, Andrew, Balibar, Carl J., Klein, Daniel J., Raheem, Izzat, Walker, Scott S.
Published in Nature microbiology (01.05.2024)
Published in Nature microbiology (01.05.2024)
Get full text
Journal Article
Discovery of benzamides as potent human β3 adrenergic receptor agonists
Zhu, Cheng, Kar, Nam F., Li, Bing, Costa, Melissa, Dingley, Karen H., Di Salvo, Jerry, Ha, Sookhee N., Hurley, Amanda L., Li, Xiaofang, Miller, Randy R., Salituro, Gino M., Struthers, Mary, Weber, Ann E., Hale, Jeffrey J., Edmondson, Scott D.
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Get full text
Journal Article
Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder
Harper, Bart H., Wang, Liping, Zhu, Cheng, Kar, Nam F., Li, Bing, Moyes, Christopher R., Goble, Stephen D., Costa, Melissa, Dingley, Karen, Di Salvo, Jerry, Ha, Sookhee N., Hurley, Amanda, Li, Xiaofang, Miller, Randy R., Nagabukuro, Hiroshi, Salituro, Gino M., Smith, Sean, Struthers, Mary, Hale, Jeffrey J., Edmondson, Scott D., Berger, Richard
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Get full text
Journal Article
Investigation of piperazine benzamides as human β 3 adrenergic receptor agonists for the treatment of overactive bladder
Harper, Bart H, Wang, Liping, Zhu, Cheng, Kar, Nam F, Li, Bing, Moyes, Christopher R, Goble, Stephen D, Costa, Melissa, Dingley, Karen, Di Salvo, Jerry, Ha, Sookhee N, Hurley, Amanda, Li, Xiaofang, Miller, Randy R, Nagabukuro, Hiroshi, Salituro, Gino M, Smith, Sean, Struthers, Mary, Hale, Jeffrey J, Edmondson, Scott D, Berger, Richard
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Get full text
Journal Article
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity
He, Shuwen, Ye, Zhixiong, Dobbelaar, Peter H., Bakshi, Raman K., Hong, Qingmei, Dellureficio, James P., Sebhat, Iyassu K., Guo, Liangqin, Liu, Jian, Jian, Tianying, Lai, Yingjie, Franklin, Christopher L., Reibarkh, Mikhail, Holmes, Mark A., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Get full text
Journal Article
Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist
Hong, Qingmei, Bakshi, Raman K., Palucki, Brenda L., Park, Min K., Ye, Zhixiong, He, Shuwen, Pollard, Patrick G., Sebhat, Iyassu K., Liu, Jian, Guo, Liangqin, Cashen, Doreen E., Martin, William J., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., MacIntyre, D. Euan, Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Get full text
Journal Article
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist
He, Shuwen, Ye, Zhixiong, Dobbelaar, Peter H., Sebhat, Iyassu K., Guo, Liangqin, Liu, Jian, Jian, Tianying, Lai, Yingjie, Franklin, Christopher L., Bakshi, Raman K., Dellureficio, James P., Hong, Qingmei, Tsou, Nancy N., Ball, Richard G., Cashen, Doreen E., Martin, William J., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., MacIntyre, D. Euan, Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Get full text
Journal Article