Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064
Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Jones, Stacey A., Kaldor, Istvan, Liu, Yaping, Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., III, Frank Navas, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Journal Article
FXR agonist activity of conformationally constrained analogs of GW 4064
Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Navas, Frank, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Bruce Wisely, G.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Journal Article
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Parks, Derek J., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
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Journal Article
Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene
Akwabi-Ameyaw, Adwoa, Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., Miller, Aaron B., Navas, Frank, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
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X-ray Crystal Structures of the Estrogen-related Receptor-γ Ligand Binding Domain in Three Functional States Reveal the Molecular Basis of Small Molecule Regulation
Wang, Liping, Zuercher, William J., Consler, Thomas G., Lambert, Millard H., Miller, Aaron B., Orband-Miller, Lisa A., McKee, David D., Willson, Timothy M., Nolte, Robert T.
Published in The Journal of biological chemistry (08.12.2006)
Published in The Journal of biological chemistry (08.12.2006)
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Journal Article
Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP)
Haffner, Curt D., Diaz, Caroline J., Miller, Aaron B., Reid, Robert A., Madauss, Kevin P., Hassell, Annie, Hanlon, Mary H., Porter, David J.T., Becherer, J. David, Carter, Luke H.
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Journal Article
Identification and Structure−Activity Relationship of Phenolic Acyl Hydrazones as Selective Agonists for the Estrogen-Related Orphan Nuclear Receptors ERRβ and ERRγ
Zuercher, William J, Gaillard, Stéphanie, Orband-Miller, Lisa A, Chao, Esther Y. H, Shearer, Barry G, Jones, David G, Miller, Aaron B, Collins, Jon L, McDonnell, Donald P, Willson, Timothy M
Published in Journal of medicinal chemistry (05.05.2005)
Published in Journal of medicinal chemistry (05.05.2005)
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Journal Article
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRγ
Chao, Esther Y.H., Collins, Jon L., Gaillard, Stéphanie, Miller, Aaron B., Wang, Liping, Orband-Miller, Lisa A., Nolte, Robert T., McDonnell, Donald P., Willson, Timothy M., Zuercher, William J.
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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Journal Article
The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist
Madauss, Kevin P., Burkhart, William A., Consler, Thomas G., Cowan, David J., Gottschalk, William K., Miller, Aaron B., Short, Steven A., Tran, Thuy B., Williams, Shawn P.
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2009)
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2009)
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Journal Article
Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands
Fang, Jing, Akwabi-Ameyaw, Adwoa, Britton, Jonathan E., Katamreddy, Subba R., Navas, Frank, Miller, Aaron B., Williams, Shawn P., Gray, David W., Orband-Miller, Lisa A., Shearin, Jean, Heyer, Dennis
Published in Bioorganic & medicinal chemistry (15.09.2008)
Published in Bioorganic & medicinal chemistry (15.09.2008)
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Journal Article
On the Intractability of Estrogen-Related Receptor α as a Target for Activation by Small Molecules
Hyatt, Stephen M, Lockamy, Elizabeth L, Stein, Rebecca A, McDonnell, Donald P, Miller, Aaron B, Orband-Miller, Lisa A, Willson, Timothy M, Zuercher, William J
Published in Journal of medicinal chemistry (27.12.2007)
Published in Journal of medicinal chemistry (27.12.2007)
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Journal Article
Design of Potent, Selective, and Orally Bioavailable Inhibitors of Cysteine Protease Cathepsin K
Tavares, Francis X, Boncek, Virginia, Deaton, David N, Hassell, Anne M, Long, Stacey T, Miller, Aaron B, Payne, Alan A, Miller, Larry R, Shewchuk, Lisa M, Wells-Knecht, Kevin, Willard, Derril H, Wright, Lois L, Zhou, Hui-Qiang
Published in Journal of medicinal chemistry (29.01.2004)
Published in Journal of medicinal chemistry (29.01.2004)
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Journal Article
Structure-Based Design of Potent Retinoid X Receptor α Agonists
Haffner, Curt D., Lenhard, James M., Miller, Aaron B., McDougald, Darryl L., Dwornik, Kate, Ittoop, Olivia R., Gampe, Robert T., Xu, H. Eric, Blanchard, Steve, Montana, Valerie G., Consler, Tom G., Bledsoe, Randy K., Ayscue, Andrea, Croom, Dallas
Published in Journal of medicinal chemistry (08.04.2004)
Published in Journal of medicinal chemistry (08.04.2004)
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Journal Article
Novel and potent cyclic cyanamide-based cathepsin K inhibitors
Deaton, David N., Hassell, Anne M., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Shewchuk, Lisa M., Tavares, Francis X., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (01.04.2005)
Published in Bioorganic & medicinal chemistry letters (01.04.2005)
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Journal Article
Potent and Selective Ketoamide-Based Inhibitors of Cysteine Protease, Cathepsin K
Tavares, Francis X, Deaton, David N, Miller, Aaron B, Miller, Larry R, Wright, Lois L, Zhou, Hui-Qiang
Published in Journal of medicinal chemistry (07.10.2004)
Published in Journal of medicinal chemistry (07.10.2004)
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Journal Article
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite
Deaton, David N, Gao, Enoch N, Graham, Kevin P, Gross, Jeffrey W, Miller, Aaron B, Strelow, John M
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
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Journal Article
Acyclic cyanamide-based inhibitors of cathepsin K
Barrett, David G., Deaton, David N., Hassell, Anne M., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Payne, J. Alan, Shewchuk, Lisa M., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (15.06.2005)
Published in Bioorganic & medicinal chemistry letters (15.06.2005)
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Journal Article
Acyclic, orally bioavailable ketone-based cathepsin K inhibitors
Barrett, David G., Catalano, John G., Deaton, David N., Long, Stacey T., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Samano, Vicente, Tavares, Francis X., Wells-Knecht, Kevin J., Wright, Lois L., Zhou, Hui-Qiang Q.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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