Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity
Mihalic, Jeffrey T., Chen, Xiaoqi, Fan, Pingchen, Chen, Xi, Fu, Ying, Liang, Lingming, Reed, Michael, Tang, Liang, Chen, Jin-Long, Jaen, Juan, Li, Leping, Dai, Kang
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
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Journal Article
Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models
Motani, Alykhan S., Luo, Jian, Liang, Lingming, Mihalic, Jeffrey T., Chen, Xiaoqi, Tang, Liang, Li, Leping, Jaen, Juan, Chen, Jin‐Long, Dai, Kang
Published in Pharmacology research & perspectives (01.10.2013)
Published in Pharmacology research & perspectives (01.10.2013)
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Journal Article
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition
Mihalic, Jeffrey T., Fan, Pingchen, Chen, Xiaoqi, Chen, Xi, Fu, Ying, Motani, Alykhan, Liang, Lingming, Lindstrom, Michelle, Tang, Liang, Chen, Jin-Long, Jaen, Juan, Dai, Kang, Li, Leping
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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Journal Article
Discovery of a new class of ghrelin receptor antagonists
Mihalic, Jeffrey T., Kim, Yong-Jae, Lizarzaburu, Mike, Chen, Xiaoqi, Deignan, Jeff, Wanska, Malgorzata, Yu, Ming, Fu, Jiasheng, Chen, Xi, Zhang, Alex, Connors, Richard, Liang, Lingming, Lindstrom, Michelle, Ma, Ji, Tang, Liang, Dai, Kang, Li, Leping
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
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Journal Article
Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists
Li, An-Rong, Johnson, Michael G., Liu, Jiwen, Chen, Xiaoqi, Du, Xiaohui, Mihalic, Jeffrey T., Deignan, Jeffrey, Gustin, Darin J., Duquette, Jason, Fu, Zice, Zhu, Liusheng, Marcus, Andrew P., Bergeron, Phillipe, McGee, Lawrence R., Danao, Jay, Lemon, Bryan, Carabeo, Teresa, Sullivan, Timothy, Ma, Ji, Tang, Liang, Tonn, George, Collins, Tassie L., Medina, Julio C.
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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Journal Article
Design and optimization of imidazole derivatives as potent CXCR3 antagonists
Du, Xiaohui, Chen, Xiaoqi, Mihalic, Jeffrey T., Deignan, Jeffrey, Duquette, Jason, Li, An-Rong, Lemon, Bryan, Ma, Ji, Miao, Shichang, Ebsworth, Karen, Sullivan, Timothy J., Tonn, George, Collins, Tassie L., Medina, Julio C.
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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Journal Article
Evaluation of AMG 076, a potent and selective MCHR 1 antagonist, in rodent and primate obesity models
Motani, Alykhan S., Luo, Jian, Liang, Lingming, Mihalic, Jeffrey T., Chen, Xiaoqi, Tang, Liang, Li, Leping, Jaen, Juan, Chen, Jin‐Long, Dai, Kang
Published in Pharmacology research & perspectives (01.10.2013)
Published in Pharmacology research & perspectives (01.10.2013)
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Journal Article
Incorporation of an Amide into 5-Phosphonoalkyl-6-d-ribitylaminopyrimidinedione Lumazine Synthase Inhibitors Results in an Unexpected Reversal of Selectivity for Riboflavin Synthase vs Lumazine Synthase
Cushman, Mark, Yang, Donglai, Mihalic, Jeffrey T, Chen, Jinhua, Gerhardt, Stefan, Huber, Robert, Fischer, Markus, Kis, Klaus, Bacher, Adelbert
Published in Journal of organic chemistry (04.10.2002)
Published in Journal of organic chemistry (04.10.2002)
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Journal Article
APJ 수용체의 트라이아졸 작용제
NISHIMURA NOBUKO, MIHALIC JEFFREY T, MEDINA JULIO C, DRANSFIELD PAUL JOHN, FU ZICE, DU XIAOHUI, HOUZE JONATHAN, WANG XIAODONG, LAI SU JEN, CHENG ALAN C, CHEN YINHONG, YEH WEN CHEN, KAYSER FRANK, MA ZHIHUA, HEDLEY SIMON J, SWAMINATH GAYATHRI, KHAKOO AARIF YUSUF, DEBENEDETTO MIKKEL V, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, KOPECKY DAVID JOHN, YANG KEVIN, PATTAROPONG VATEE, CONNORS RICHARD V, CHEN NING, FARRELL ROBERT P, MCGEE LAWRENCE R, OLSON STEVEN H, JUDD TED C, HORNE DANIEL B, KALLER MATTHEW R
Year of Publication 31.01.2018
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Year of Publication 31.01.2018
Patent
Abstract 3423: NX-2127: A first-in-class clinical stage degrader of BTK and IKZF1/3 for the treatment of patients with B cell malignancies
Mihalic, Jeffrey T., Brathaban, Nivetha, Bravo, Brandon, Ingallinera, Timothy, Kato, Daisuke, Lu, Hao, Ma, Jun, McIntosh, Joel, Tenn-McClellan, Austin, Mukerji, Ratul, Noviski, Mark A., Peng, Ge, Perez, Luz, Rountree, Ryan, Tan, May, Wu, Jeffrey, Ye, Jordan, Yung, Stephanie
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Bromotriazole intermediates
Fu, Zice, Pattaropong, Vatee, Dransfield, Paul John, Heath, Julie Anne, Mihalic, Jeffrey T
Year of Publication 09.07.2019
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Year of Publication 09.07.2019
Patent
BROMOTRIAZOLE INTERMEDIATES
Fu, Zice, Pattaropong, Vatee, Dransfield, Paul John, Heath, Julie Anne, Mihalic, Jeffrey T
Year of Publication 04.04.2019
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Year of Publication 04.04.2019
Patent
TRIAZOLE AGONISTS OF THE APJ RECEPTOR
WANG, XIAODONG, CHEN, NING, SWAMINATH, GAYATHRI, YEH, WENN, DEIGNAN, JEFFREY, CHEN, YINHONG, DRANSFIELD, PAUL JOHN, KALLER, MATTHEW R, OLSON, STEVEN H, LAI, SU-JEN, YANG, KEVIN, FARRELL, ROBERT P, MEDINA, JULIO C, HEDLEY, SIMON J, HORNE, DANIEL B, MCGEE, LAWRENCE R, JUDD, TED C, CHENG, ALAN C, DEBENEDETTO, MIKKEL V, DU, XIAOHUI, MIHALIC, JEFFREY T, HEATH, JULIE ANNE, NISHIMURA, NOBUKO, KOPECKY, DAVID JOHN, MA, ZHIHUA, CONNORS, RICHARD V, KHAKOO, AARIF YUSUF, FU, ZICE, HOUZE, JONATHAN, CHEN, XIAOQI, PATTAROPONG, VATEE, KAYSER, FRANK
Year of Publication 10.10.2023
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Year of Publication 10.10.2023
Patent
Triazole agonists of the apj receptor
Cheng, Alan C, Houze, Jonathan, Olson, Steven H, Chen, Xiaoqi, Heath, Julie Anne, Khakoo, Aarif Yusuf, Yang, Kevin, Fu, Zice, Deignan, Jeffrey, Ma, Zhihua, Wang, Xiaodong, Medina, Julio C, Dransfield, Paul John, Swaminath, Gayathri, Horne, Daniel B, Kopecky, David John, Kayser, Frank, Farrell, Robert P, Chen, Ning, Hedley, Simon J, Connors, Richard V, Mcgee, Lawrence R, Yeh, Wen-Chen, Debenedetto, Mikkel V, Mihalic, Jeffrey T, Kaller, Matthew, Nishimura, Nobuko, Judd, Ted C, Pattaropong, Vatee, Chen, Yinhong, Du, Xiaohui, Lai, Su-Jen
Year of Publication 28.10.2022
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Year of Publication 28.10.2022
Patent
TRIAZOLE AGONISTS OF THE APJ RECEPTOR
HEDLEY, Simon J, DRANSFIELD, Paul John, YEH, Wen-Chen, DEBENEDETTO, Mikkel V, MIHALIC, Jeffrey T, KAYSER, Frank, YANG, Kevin C, CONNORS, Richard V, HEATH, Julie Anne, DEIGNAN, Jeffrey, CHEN, Yinhong, KHAKOO, Aarif Yusuf, CHENG, Alan C, WANG, Xiaodong, FU, Zice, SWAMINATH, Gayathri, HOUZE, Jonathan, MA, Zhihua, KALLER, Matthew R, LAI, Su-Jen, MCGEE, Lawrence R, OLSON, Steven H, PATTAROPONG, Vatee, CHEN, Xiaoqi, JUDD, Ted C, KOPECKY, David John, MEDINA, Julio C, FARRELL, Robert P, DU, Xiaohui, HORNE, Daniel B, CHEN, Ning, NISHIMURA, Nobuko
Year of Publication 30.11.2022
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Year of Publication 30.11.2022
Patent
TRIAZOLE AGONISTS OF THE APJ RECEPTOR
KEVIN YANG, XIAOHUI DU, DAVID JOHN KOPECKY, SIMON J. HEDLEY, ROBERT P. FARRELL, NING CHEN, RICHARD V. CONNORS, SU-JEN LAI, AARIF YUSUF KHAKOO, TED C. JUDD, FRANK KAYSER, JEFFREY T. MIHALIC, LAWRENCE R. MCGEE, JULIE ANNE HEATH, XIAOQI CHEN, WENN YEH, ZHIHUA MA, XIAODONG WANG, YINHONG CHEN, MATTHEW R. KALLER, GAYATHRI SWAMINATH, JEFFREY DEIGNAN, NOBUKO NISHIMURA, JONATHAN HOUZE, STEVEN H. OLSON, VATEE PATTAROPONG, ALAN C. CHENG, MIKKEL V. DEBENEDETTO, JULIO C. MEDINA, DANIEL B. HORNE, PAUL JOHN DRANSFIELD, ZICE FU
Year of Publication 27.10.2022
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Year of Publication 27.10.2022
Patent
Triazole furan compounds as agonists of the APJ receptor
Cheng, Alan C, Heumann, Lars V, Houze, Jonathan, Olson, Steven H, Chen, Xiaoqi, Heath, Julie Anne, Khakoo, Aarif Yusuf, Fu, Zice, Deignan, Jeffrey, Wanska, Malgorzata, Ma, Zhihua, Wang, Xiaodong, Medina, Julio C, Dransfield, Paul John, Swaminath, Gayathri, Kayser, Frank, Chen, Ning, Brown, Matthew, Connors, Richard V, Harvey, James S, Yeh, Wen-Chen, Mihalic, Jeffrey T, Pattaropong, Vatee, Chen, Yinhong, Du, Xiaohui, Lai, Su-Jen, Kopecky, David j
Year of Publication 11.08.2020
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Year of Publication 11.08.2020
Patent
TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR
DRANSFIELD, Paul John, YEH, Wen-Chen, MIHALIC, Jeffrey T, HARVEY, James S, HEUMANN, Lars V, KAYSER, Frank, CONNORS, Richard V, HEATH, Julie Anne, DEIGNAN, Jeffrey, CHEN, Yinhong, KHAKOO, Aarif Yusuf, CHENG, Alan C, WANG, Xiaodong, FU, Zice, SWAMINATH, Gayathri, HOUZE, Jonathan, MA, Zhihua, BROWN, Matthew, LAI, Su-Jen, KOPECKY, David J, OLSON, Steven H, PATTAROPONG, Vatee, CHEN, Xiaoqi, WANSKA, Malgorzata, MEDINA, Julio C, DU, Xiaohui, CHEN, Ning
Year of Publication 23.12.2020
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Year of Publication 23.12.2020
Patent