Search Results - "MICOLOCHICK STEUER, Holly M" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus

Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus

by Lam, Angela M, Espiritu, Christine, Bansal, Shalini, Micolochick Steuer, Holly M, Niu, Congrong, Zennou, Veronique, Keilman, Meg, Zhu, Yuao, Lan, Shuiyun, Otto, Michael J, Furman, Phillip A
Published in Antimicrobial Agents and Chemotherapy (01.06.2012)

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Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

by Murakami, Eisuke, Tolstykh, Tatiana, Bao, Haiying, Niu, Congrong, Steuer, Holly M. Micolochick, Bao, Donghui, Chang, Wonsuk, Espiritu, Christine, Bansal, Shalini, Lam, Angela M., Otto, Michael J., Sofia, Michael J., Furman, Phillip A.
Published in The Journal of biological chemistry (05.11.2010)

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Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation

by Mani, Nagraj, Cole, Andrew G, Phelps, Janet R, Ardzinski, Andrzej, Cobarrubias, Kyle D, Cuconati, Andrea, Dorsey, Bruce D, Evangelista, Ellen, Fan, Kristi, Guo, Fang, Guo, Haitao, Guo, Ju-Tao, Harasym, Troy O, Kadhim, Salam, Kultgen, Steven G, Lee, Amy C H, Li, Alice H L, Long, Quanxin, Majeski, Sara A, Mao, Richeng, McClintock, Kevin D, Reid, Stephen P, Rijnbrand, Rene, Snead, Nicholas M, Micolochick Steuer, Holly M, Stever, Kim, Tang, Sunny, Wang, Xiaohe, Zhao, Qiong, Sofia, Michael J
Published in Antimicrobial agents and chemotherapy (01.06.2018)

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PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

by LAM, Angela M, MURAKAMI, Eisuke, MORREY, John D, SMEE, Donald F, FRICK, David N, HECK, Julie A, PEIYUAN WANG, NAGARATHNAM, Dhanapalan, ROSS, Bruce S, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, ESPIRITU, Christine, MICOLOCHICK STEUER, Holly M, NIU, Congrong, KEILMAN, Meg, HAIYING BAO, ZENNOU, Veronique, BOURNE, Nigel, JULANDER, Justin G
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)

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Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA

Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA

by LAM, Angela M, ESPIRITU, Christine, BANSAL, Shalini, MICOLOCHICK STEUER, Holly M, ZENNOU, Veronique, OTTO, Michael J, FURMAN, Phillip A
Published in Journal of Virology (01.12.2011)

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Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

by MURAKAMI, Eisuke, HAIYING BAO, FURMAN, Phillip A, RAMESH, Mangala, MCBRAYER, Tamara R, WHITAKER, Tony, MICOLOCHICK STEUER, Holly M, SCHINAZI, Raymond F, STUYVER, Lieven J, OBIKHOD, Aleksandr, OTTO, Michael J
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)

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Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

by LAM, Angela M, ESPIRITU, Christine, VESELENAK, Ronald L, GANAPATI REDDY, P, CHANG, Wonsuk, JINFA DU, NAGARATHNAM, Dhanapalan, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, MURAKAMI, Eisuke, ZENNOU, Veronique, BANSAL, Shalini, MICOLOCHICK STEUER, Holly M, CONGRONG NIU, KEILMAN, Meg, HAIYING BAO, BOURNE, Nigel
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)

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Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

by Liu, Fei, Lee, Amy C. H, Guo, Fang, Kondratowicz, Andrew S, Micolochick Steuer, Holly M, Miller, Angela, Bailey, Lauren D, Wang, Xiaohe, Chen, Shuai, Kultgen, Steven G, Cuconati, Andrea, Cole, Andrew G, Gotchev, Dimitar, Dorsey, Bruce D, Rijnbrand, Rene, Lam, Angela M, Sofia, Michael J, Gao, Min
Published in Journal of virology (25.08.2021)

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Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein

Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein

by Mani, Nagraj, Cole, Andrew G., Phelps, Janet R., Ardzinski, Andrzej, Burns, Robbin, Chiu, Tim, Cuconati, Andrea, Dorsey, Bruce D., Evangelista, Ellen, Fan, Kristi, Guo, Fang, Harasym, Troy O., Kadhim, Salam, Kowalski, Roseann, Kultgen, Steven G., Lee, Amy C.H., Li, Alice H., Majeski, Sara A., Miller, Angela, Pasetka, Chris, Reid, Stephen P., Rijnbrand, Rene, Micolochick Steuer, Holly M., Stever, Kim, Tang, Sunny, Teng, Xiaowei, Wang, Xiaohe, Sofia, Michael J.
Published in Antiviral research (01.01.2022)

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Discovery of a Novel Class of Potent HCV NS4B Inhibitors: SAR Studies on Piperazinone Derivatives

Discovery of a Novel Class of Potent HCV NS4B Inhibitors: SAR Studies on Piperazinone Derivatives

by Kakarla, Ramesh, Liu, Jian, Naduthambi, Devan, Chang, Wonsuk, Mosley, Ralph T., Bao, Donghui, Steuer, Holly M. Micolochick, Keilman, Meg, Bansal, Shalini, Lam, Angela M., Seibel, William, Neilson, Sandra, Furman, Phillip A., Sofia, Michael J.
Published in Journal of medicinal chemistry (13.03.2014)

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Use of 2′-Spirocyclic Ethers in HCV Nucleoside Design

Use of 2′-Spirocyclic Ethers in HCV Nucleoside Design

by Du, Jinfa, Chun, Byoung-Kwon, Mosley, Ralph T., Bansal, Shalini, Bao, Haiying, Espiritu, Christine, Lam, Angela M., Murakami, Eisuke, Niu, Congrong, Micolochick Steuer, Holly M., Furman, Phillip A., Sofia, Michael J.
Published in Journal of medicinal chemistry (13.03.2014)

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Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/ nucleotide inhibitors

Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/ nucleotide inhibitors

by CONGRONG NIU, HAIYING BAO, TOLSTYKH, Tatiana, MICOLOCHICK STEUER, Holly M, MURAKAMI, Eisuke, KORBA, Brent, FURMAN, Phillip A
Published in Antiviral therapy (01.01.2010)

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The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

by Murakami, Eisuke, Niu, Congrong, Bao, Haiying, Micolochick Steuer, Holly M, Whitaker, Tony, Nachman, Tammy, Sofia, Michael A, Wang, Peiyuan, Otto, Michael J, Furman, Phillip A
Published in Antimicrobial Agents and Chemotherapy (01.02.2008)

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β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study

β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study

by Du, Jinfa, Bao, Donghui, Chun, Byoung-Kwon, Jiang, Ying, Ganapati Reddy, P., Zhang, Hai-Ren, Ross, Bruce S., Bansal, Shalini, Bao, Haiying, Espiritu, Christine, Lam, Angela M., Murakami, Eisuke, Niu, Congrong, Micolochick Steuer, Holly M., Furman, Phillip A., Otto, Michael J., Sofia, Michael J.
Published in Bioorganic & medicinal chemistry letters (15.09.2012)

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Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

by Sofia, Michael J, Bao, Donghui, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S, Wang, Peiyuan, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine, Keilman, Meg, Lam, Angela M, Steuer, Holly M. Micolochick, Niu, Congrong, Otto, Michael J, Furman, Phillip A
Published in Journal of medicinal chemistry (14.10.2010)

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Mechanism of Action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl)thymine as an anti-HIV agent

Mechanism of Action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl)thymine as an anti-HIV agent

by Murakami, Eisuke, Bao, Haiying, Basavapathruni, Aravind, Bailey, Christopher M, Du, Jinfa, Steuer, Holly M Micolochick, Niu, Congrong, Whitaker, Tony, Anderson, Karen S, Otto, Michael J, Furman, Phillip A
Published in Antiviral chemistry & chemotherapy (01.04.2007)

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Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators

Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators

by Mesaros, Eugen F., Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Fan, Kristi Yi, Dugan, Benjamin J., Ardzinski, Andrzej, Stever, Kim, Micolochick Steuer, Holly M., Graves, Ingrid, Tang, Sunny, Harasym, Troy O., Lam, Angela M., Thi, Emily P., Dorsey, Bruce D., Sofia, Michael J.
Published in ACS medicinal chemistry letters (12.09.2024)

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Discovery of C‑Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV‑2

Discovery of C‑Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV‑2

by Mesaros, Eugen F., Dugan, Benjamin J., Gao, Min, Sheraz, Muhammad, McGovern-Gooch, Kayleigh, Xu, Fran, Fan, Kristi Yi, Nguyen, Duyan, Kultgen, Steven G., Lindstrom, Aaron, Stever, Kim, Tercero, Breanna, Binder, Randall J., Liu, Fei, Micolochick Steuer, Holly M., Mani, Nagraj, Harasym, Troy O., Thi, Emily P., Cuconati, Andrea, Dorsey, Bruce D., Cole, Andrew G., Lam, Angela M., Sofia, Michael J.
Published in ACS infectious diseases (10.05.2024)

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Synthesis of Stable Isotope Labeled Analogs of the Anti-Hepatitis C Virus Nucleotide Prodrugs PSI-7977 and PSI-352938

Synthesis of Stable Isotope Labeled Analogs of the Anti-Hepatitis C Virus Nucleotide Prodrugs PSI-7977 and PSI-352938

by Chun, Byoung-Kwon, Du, Jinfa, Zhang, Hai-Ren, Chang, Wonsuk, Ross, Bruce S., Jiang, Ying, Bao, Donghui, Espiritu, Christine L., Keilman, Meg, Steuer, Holly M. Micolochick, Furman, Phillip A., Sofia, Michael J.
Published in Nucleosides, nucleotides & nucleic acids (01.11.2011)

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In vitro Selection of HCV Replicons with Reduced Sensitivity to PSI-352938, A Cyclicphosphate Prodrug of β- d-2′-α-F-2′-β- C-Methylguanosine

In vitro Selection of HCV Replicons with Reduced Sensitivity to PSI-352938, A Cyclicphosphate Prodrug of β- d-2′-α-F-2′-β- C-Methylguanosine

by Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Steuer, Holly M. Micolochick, Zennou, Veronique, Otto, Michael J., Furman, Phillip A.
Published in Antiviral research (01.05.2011)

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