GPCR activation mechanisms across classes and macro/microscales
Hauser, Alexander S., Kooistra, Albert J., Munk, Christian, Heydenreich, Franziska M., Veprintsev, Dmitry B., Bouvier, Michel, Babu, M. Madan, Gloriam, David E.
Published in Nature structural & molecular biology (01.11.2021)
Published in Nature structural & molecular biology (01.11.2021)
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Common coupling map advances GPCR-G protein selectivity
Hauser, Alexander S, Avet, Charlotte, Normand, Claire, Mancini, Arturo, Inoue, Asuka, Bouvier, Michel, Gloriam, David E
Published in eLife (18.03.2022)
Published in eLife (18.03.2022)
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Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET
Namkung, Yoon, Le Gouill, Christian, Lukashova, Viktoria, Kobayashi, Hiroyuki, Hogue, Mireille, Khoury, Etienne, Song, Mideum, Bouvier, Michel, Laporte, Stéphane A.
Published in Nature communications (11.07.2016)
Published in Nature communications (11.07.2016)
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How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling
Latorraca, Naomi R., Masureel, Matthieu, Hollingsworth, Scott A., Heydenreich, Franziska M., Suomivuori, Carl-Mikael, Brinton, Connor, Townshend, Raphael J.L., Bouvier, Michel, Kobilka, Brian K., Dror, Ron O.
Published in Cell (23.12.2020)
Published in Cell (23.12.2020)
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The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites
Hedderich, Janik B., Persechino, Margherita, Becker, Katharina, Heydenreich, Franziska M., Gutermuth, Torben, Bouvier, Michel, Bünemann, Moritz, Kolb, Peter
Published in Nature communications (10.05.2022)
Published in Nature communications (10.05.2022)
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Community guidelines for GPCR ligand bias: IUPHAR review 32
Kolb, Peter, Kenakin, Terry, Alexander, Stephen P. H., Bermudez, Marcel, Bohn, Laura M., Breinholt, Christian S., Bouvier, Michel, Hill, Stephen J., Kostenis, Evi, Martemyanov, Kirill A., Neubig, Rick R., Onaran, H. Ongun, Rajagopal, Sudarshan, Roth, Bryan L., Selent, Jana, Shukla, Arun K., Sommer, Martha E., Gloriam, David E.
Published in British journal of pharmacology (01.07.2022)
Published in British journal of pharmacology (01.07.2022)
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Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
Venkatakrishnan, A. J., Deupi, Xavier, Lebon, Guillaume, Heydenreich, Franziska M., Flock, Tilman, Miljus, Tamara, Balaji, Santhanam, Bouvier, Michel, Veprintsev, Dmitry B., Tate, Christopher G., Schertler, Gebhard F. X., Babu, M. Madan
Published in Nature (London) (25.08.2016)
Published in Nature (London) (25.08.2016)
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Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
Avet, Charlotte, Mancini, Arturo, Breton, Billy, Le Gouill, Christian, Hauser, Alexander S, Normand, Claire, Kobayashi, Hiroyuki, Gross, Florence, Hogue, Mireille, Lukasheva, Viktoriya, St-Onge, Stéphane, Carrier, Marilyn, Héroux, Madeleine, Morissette, Sandra, Fauman, Eric B, Fortin, Jean-Philippe, Schann, Stephan, Leroy, Xavier, Gloriam, David E, Bouvier, Michel
Published in eLife (18.03.2022)
Published in eLife (18.03.2022)
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Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling
Trauelsen, Mette, Hiron, Thomas K, Lin, Da, Petersen, Jacob E, Breton, Billy, Husted, Anna Sofie, Hjorth, Siv A, Inoue, Asuka, Frimurer, Thomas M, Bouvier, Michel, O'Callaghan, Chris A, Schwartz, Thue W
Published in Cell reports (Cambridge) (15.06.2021)
Published in Cell reports (Cambridge) (15.06.2021)
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Site-specific Phosphorylation of CXCR4 Is Dynamically Regulated by Multiple Kinases and Results in Differential Modulation of CXCR4 Signaling
Busillo, John M., Armando, Sylvain, Sengupta, Rajarshi, Meucci, Olimpia, Bouvier, Michel, Benovic, Jeffrey L.
Published in The Journal of biological chemistry (05.03.2010)
Published in The Journal of biological chemistry (05.03.2010)
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A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling
Beautrait, Alexandre, Paradis, Justine S., Zimmerman, Brandon, Giubilaro, Jenna, Nikolajev, Ljiljana, Armando, Sylvain, Kobayashi, Hiroyuki, Yamani, Lama, Namkung, Yoon, Heydenreich, Franziska M., Khoury, Etienne, Audet, Martin, Roux, Philippe P., Veprintsev, Dmitry B., Laporte, Stéphane A., Bouvier, Michel
Published in Nature communications (18.04.2017)
Published in Nature communications (18.04.2017)
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Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors
Namkung, Yoon, LeGouill, Christian, Kumar, Sahil, Cao, Yubo, Teixeira, Larissa B, Lukasheva, Viktoriya, Giubilaro, Jenna, Simões, Sarah C, Longpré, Jean-Michel, Devost, Dominic, Hébert, Terence E, Piñeyro, Graciela, Leduc, Richard, Costa-Neto, Claudio M, Bouvier, Michel, Laporte, Stéphane A
Published in Science signaling (04.12.2018)
Published in Science signaling (04.12.2018)
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Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein
Quoyer, Julie, Janz, Jay M, Luo, Jiansong, Ren, Yong, Armando, Sylvain, Lukashova, Viktoria, Benovic, Jeffrey L, Carlson, Kenneth E, Hunt, 3rd, Stephen W, Bouvier, Michel
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2013)
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Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity
Schönegge, Anne-Marie, Gallion, Jonathan, Picard, Louis-Philippe, Wilkins, Angela D., Le Gouill, Christian, Audet, Martin, Stallaert, Wayne, Lohse, Martin J., Kimmel, Marek, Lichtarge, Olivier, Bouvier, Michel
Published in Nature communications (18.12.2017)
Published in Nature communications (18.12.2017)
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