Computationally designed GPCR quaternary structures bias signaling pathway activation
Paradis, Justine S., Feng, Xiang, Murat, Brigitte, Jefferson, Robert E., Sokrat, Badr, Szpakowska, Martyna, Hogue, Mireille, Bergkamp, Nick D., Heydenreich, Franziska M., Smit, Martine J., Chevigné, Andy, Bouvier, Michel, Barth, Patrick
Published in Nature communications (11.11.2022)
Published in Nature communications (11.11.2022)
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Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy
Teixeira, Larissa B., Parreiras-e-Silva, Lucas T., Bruder-Nascimento, Thiago, Duarte, Diego A., Simões, Sarah C., Costa, Rafael M., Rodríguez, Deisy Y., Ferreira, Pedro A. B., Silva, Carlos A. A., Abrao, Emiliana P., Oliveira, Eduardo B., Bouvier, Michel, Tostes, Rita C., Costa-Neto, Claudio M.
Published in Scientific reports (19.09.2017)
Published in Scientific reports (19.09.2017)
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Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
Brouwers, Bas, de Oliveira, Edson Mendes, Marti-Solano, Maria, Monteiro, Fabiola B.F., Laurin, Suli-Anne, Keogh, Julia M., Henning, Elana, Bounds, Rebecca, Daly, Carole A., Houston, Shane, Ayinampudi, Vikram, Wasiluk, Natalia, Clarke, David, Plouffe, Bianca, Bouvier, Michel, Babu, M. Madan, Farooqi, I. Sadaf, Mokrosiński, Jacek
Published in Cell reports (Cambridge) (23.03.2021)
Published in Cell reports (Cambridge) (23.03.2021)
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Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion
Hamoud, Noumeira, Tran, Viviane, Aimi, Takahiro, Kakegawa, Wataru, Lahaie, Sylvie, Thibault, Marie-Pier, Pelletier, Ariane, Wong, G. William, Kim, In-San, Kania, Artur, Yuzaki, Michisuke, Bouvier, Michel, Côté, Jean-François
Published in Nature communications (26.10.2018)
Published in Nature communications (26.10.2018)
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Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function
Angers, Stephane, Salahpour, Ali, Bouvier, Michel
Published in Annual review of pharmacology and toxicology (01.01.2002)
Published in Annual review of pharmacology and toxicology (01.01.2002)
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GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics
Wright, Shane C., Motso, Aikaterini, Koutsilieri, Stefania, Beusch, Christian M., Sabatier, Pierre, Berghella, Alessandro, Blondel-Tepaz, Élodie, Mangenot, Kimberley, Pittarokoilis, Ioannis, Sismanoglou, Despoina-Christina, Le Gouill, Christian, Olsen, Jesper V., Zubarev, Roman A., Lambert, Nevin A., Hauser, Alexander S., Bouvier, Michel, Lauschke, Volker M.
Published in Nature communications (09.10.2023)
Published in Nature communications (09.10.2023)
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G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits
Kossatz, Elk, Diez-Alarcia, Rebeca, Gaitonde, Supriya A., Ramon-Duaso, Carla, Stepniewski, Tomasz Maciej, Aranda-Garcia, David, Muneta-Arrate, Itziar, Tepaz, Elodie, Saen-Oon, Suwipa, Soliva, Robert, Shahraki, Aida, Moreira, David, Brea, Jose, Loza, Maria Isabel, de la Torre, Rafael, Kolb, Peter, Bouvier, Michel, Meana, J. Javier, Robledo, Patricia, Selent, Jana
Published in Nature communications (29.05.2024)
Published in Nature communications (29.05.2024)
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The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool
Sénéchal, Charlotte, Fujita, Ryo, Jamet, Solène, Maiga, Arhamatoulaye, Dort, Junio, Orfi, Zakaria, Dumont, Nicolas A., Bouvier, Michel, Crist, Colin
Published in Cell reports (Cambridge) (15.11.2022)
Published in Cell reports (Cambridge) (15.11.2022)
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Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes
Bouvier, Michel, Galés, Céline, Van Durm, Joost J J, Schaak, Stéphane, Pontier, Stéphanie, Percherancier, Yann, Audet, Martin, Paris, Hervé
Published in Nature structural & molecular biology (01.09.2006)
Published in Nature structural & molecular biology (01.09.2006)
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How carvedilol does not activate β2-adrenoceptors
Lefkowitz, Robert J., Rockman, Howard A., Shim, Paul J., Liu, Samuel, Ahn, Seungkirl, Pani, Biswaranjan, Rajagopal, Sudarshan, Shenoy, Sudha K., Bouvier, Michel, Benovic, Jeffrey L., Liggett, Stephen B., Ruffolo, Robert R., Bristow, Michael R., Packer, Milton
Published in Nature communications (30.11.2023)
Published in Nature communications (30.11.2023)
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Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling
Gallion, Jonathan, Koire, Amanda, Katsonis, Panagiotis, Schoenegge, Anne‐Marie, Bouvier, Michel, Lichtarge, Olivier
Published in Human mutation (01.05.2017)
Published in Human mutation (01.05.2017)
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Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response
Benredjem, Besma, Gallion, Jonathan, Pelletier, Dennis, Dallaire, Paul, Charbonneau, Johanie, Cawkill, Darren, Nagi, Karim, Gosink, Mark, Lukasheva, Viktoryia, Jenkinson, Stephen, Ren, Yong, Somps, Christopher, Murat, Brigitte, Van Der Westhuizen, Emma, Le Gouill, Christian, Lichtarge, Olivier, Schmidt, Anne, Bouvier, Michel, Pineyro, Graciela
Published in Nature communications (09.09.2019)
Published in Nature communications (09.09.2019)
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In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure
Gargalovic, Peter, Wong, Pancras, Onorato, Joelle, Finlay, Heather, Wang, Tao, Yan, Mujing, Crain, Earl, St-Onge, Stéphane, Héroux, Madeleine, Bouvier, Michel, Xu, Carrie, Chen, Xue-Qing, Generaux, Claudia, Lawrence, Michael, Wexler, Ruth, Gordon, David
Published in Circulation. Heart failure (01.03.2021)
Published in Circulation. Heart failure (01.03.2021)
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Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer
Mercier, Jean-François, Salahpour, Ali, Angers, Stéphane, Breit, Andreas, Bouvier, Michel
Published in The Journal of biological chemistry (01.11.2002)
Published in The Journal of biological chemistry (01.11.2002)
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NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay
Nourreddine, Sami, Lavoie, Geneviève, Paradis, Justine, Ben El Kadhi, Khaled, Méant, Antoine, Aubert, Léo, Grondin, Benoit, Gendron, Patrick, Chabot, Benoit, Bouvier, Michel, Carreno, Sébastien, Roux, Philippe P.
Published in Cell reports (Cambridge) (19.05.2020)
Published in Cell reports (Cambridge) (19.05.2020)
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Monitoring ligand-dependent assembly of receptor ternary complexes in live cells by BRETFect
Cotnoir-White, David, El Ezzy, Mohamed, Boulay, Pierre-Luc, Rozendaal, Marieke, Bouvier, Michel, Gagnon, Etienne, Mader, Sylvie
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (13.03.2018)
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New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans
Merali, Samira, Wang, Zhaoqing, Frost, Charles, Callejo, Mario, Hedrick, Michael, Hui, Lester, Meadows Shropshire, Stephanie, Xu, Ke, Bouvier, Michel, DeSouza, Mary M., Yang, Jing
Published in Platelets (Edinburgh) (03.10.2022)
Published in Platelets (Edinburgh) (03.10.2022)
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Systematic protein–protein interaction mapping for clinically relevant human GPCRs
Sokolina, Kate, Kittanakom, Saranya, Snider, Jamie, Kotlyar, Max, Maurice, Pascal, Gandía, Jorge, Benleulmi‐Chaachoua, Abla, Tadagaki, Kenjiro, Oishi, Atsuro, Wong, Victoria, Malty, Ramy H, Deineko, Viktor, Aoki, Hiroyuki, Amin, Shahreen, Yao, Zhong, Morató, Xavier, Otasek, David, Kobayashi, Hiroyuki, Menendez, Javier, Auerbach, Daniel, Angers, Stephane, Pržulj, Natasa, Bouvier, Michel, Babu, Mohan, Ciruela, Francisco, Jockers, Ralf, Jurisica, Igor, Stagljar, Igor
Published in Molecular systems biology (01.03.2017)
Published in Molecular systems biology (01.03.2017)
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International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers
Pin, Jean-Philippe, Neubig, Richard, Bouvier, Michel, Devi, Lakshmi, Filizola, Marta, Javitch, Jonathan A, Lohse, Martin J, Milligan, Graeme, Palczewski, Krzysztof, Parmentier, Marc, Spedding, Michael
Published in Pharmacological reviews (01.03.2007)
Published in Pharmacological reviews (01.03.2007)
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