MP-08.14: Eradication of osteoblastic and osteolytic skeletal metastases of hormone refractory prostate cancer (mHRPC) after treatment with pegylated trispecific disulfide linked Fv (sdFv) targeting epitopes of EGFR, PTHrP and RANKL conjugated covalently with SATA to vinorelbine tartrate
Get full text
Journal Article
GENETICALLY ENGINEERED VRL-LOADED ENDOTHELIAL CELLS EXPRESSING FGFR1/TRAIL/APO-2L CAUSED APOPTOTIC-INDUCED DRUG DELIVERY (AIDD) LEADING TO BYSTANDER KILLING EFFECT IN CHEMORESISTANT OVARIAN CARCINOMA CHARACTERISED BY OVER- EXPRESSION OF MDR-1 AND BCL-2
Giannios, J., Alexandropoulos, N., Michailakis, E.
Published in International journal of gynecological cancer (01.09.2004)
Published in International journal of gynecological cancer (01.09.2004)
Get full text
Journal Article
713 POSTER Molecularly targeted immunochemotherapeutic formulation (SEVINA) composed of pegylated trispecific disulfide linked Fv (sdFv) targeting epitopes of EGFR, PTHrP and RANKL conjugated covalently with SATA to vinorelbine eradicated osteolytic metastases of multiple myeloma inhibiting proliferation of tumor associated and bone microvascular endothelial cells inducing ADCC, AMP and type I, II, III PCD
Giannios, J, Michailakis, E, Alexandropulos, N
Published in European journal of cancer supplements (2007)
Published in European journal of cancer supplements (2007)
Get full text
Journal Article
PDT WITH SNET2-ASSOCIATED LDL AND VINORELBINE EXERT SYNERGISTIC MT DEPOLYMERIZING ACTION, ANTIANGIOGENICITY, ANTIMETASTATIC POTENTIAL AND INDUCTION OF D2 APOPTOSIS IN CHEMO- AND RADIORESISTANT HYPERCALCEMIC TYPE OF SMALL CELL CA OF THE OVARY (HTSCCO) WITH DIFFUSE INTRA-ABDOMINAL METASTASES OVEREXPRESSING BCL-2, MMP-9 AND MDR-1
Giannios, J., Kanelopulos, G., Michailakis, E., Lambrinos, F., Alexandropoulos, N.
Published in International journal of gynecological cancer (01.09.2004)
Published in International journal of gynecological cancer (01.09.2004)
Get full text
Journal Article
Colloidal cDNA encoding recombinant multimodular proteins rMDVA comprising disintegrin/cysteine rich disulfide bond 2RGD, and C-terminal domain (ammodystatin), metalloprotease-domain (ammodylysin), and dimeric disintegrin/MLD-VGD domain (VADD) isolated from vipera ammodytes, exerted synergistic action with vinorelbine against metastatic NSCLC, circumventing chemotherapy-mediated systemic toxicity
Dritsas, J., Giannios, J., Michailakis, E., Alexandropoulos, N.
Published in Journal of clinical oncology (20.05.2009)
Published in Journal of clinical oncology (20.05.2009)
Get full text
Journal Article
Pegylated liposomal anti-eIF3c shRNA-vinorelbine tartrate formulation (SEVINA-V) inhibits oncogenic protein translational initiation, and oncogene addiction inducing PCD type I, II, and III in NSCLC chemoresistant to taxanes
Giannios, J., Michailakis, E., Alexandropulos, N., Kanellopoulos, A.
Published in Journal of clinical oncology (20.05.2008)
Published in Journal of clinical oncology (20.05.2008)
Get full text
Journal Article
Immunochemoconjugate of anti-DNMT1/HDAC2 bispecific F(ab)2-bsAb linked with cleavable disulfide to vinorelbine induces apoptosis in chemoresistant infiltrating ductal carcinoma (IDC) characterised by HDAC2 overexpression and 5'CpG island hypermethylation of the FHIT, RAR-β2, BRCA-1, APC, p16(CDKN2A), RASSF1A, CDH1(E-cadherin), 14–3-3-σ (stratifin), HIC1 and MDG1 tumor suppressor genes
Get full text
Journal Article
Immunochemoconjugate of anti-DNMT1/HDAC2 bispecific F(ab)2-bsAb linked with cleavable disulfide to vinorelbine induces apoptosis in chemoresistant infiltrating ductal carcinoma (IDC) characterised by HDAC2 overexpression and 5'CpG island hypermethylation of the FHIT, RAR-β2, BRCA-1, APC, p16(CDKN2A), RASSF1A, CDH1(E-cadherin), 14–3-3-σ (stratifin), HIC1 and MDG1 tumor suppressor genes
Get full text
Journal Article
P-950 Combined antisense chemoradioimmunotherapy consistingof anti-HER2 scFv linked onto high energy radioisotopes, vinorelbine and 21-nucleotide double stranded siRNA targeted to DNMT1 induce PCD in metastatic NSCLC characterised by hypermethylated oncosuppressor p16 promoter CpG islands and overexpression of oncogenes cdc25c, Raf-1, HER-2 and bcl-2
Giannios, J., Lambrinos, P., Michailakis, E.
Published in Lung cancer (Amsterdam, Netherlands) (01.07.2005)
Published in Lung cancer (Amsterdam, Netherlands) (01.07.2005)
Get full text
Journal Article
P-951 Combined ADM of antisense chemoradioimmunotherapy(ACRIT) consisting of antiHER2 scFv linked onto high energy radioisotopes and triplex forming oligonucleotides (TFO) targeted to DNMT1 and conjugated to vinorelbine tartrate induce apoptosis in metastatic NSCLC characterised by hypermethylated oncosuppressor genes VHL, p53, p16, RASSF1A, Rar-b2, TIMP3, PTEN, H-cadherin, BRCA2, p14ARF and overexpression of HIF-1, VEGF, MMP-2, MMP-9, Glut-1, IGF1R, bcl-2, cdc25c, Raf-1, TGFa, UPAR, c-met and E
Giannios, J., Michailakis, E., Ginopoulos, P.
Published in Lung cancer (Amsterdam, Netherlands) (01.07.2005)
Published in Lung cancer (Amsterdam, Netherlands) (01.07.2005)
Get full text
Journal Article
Liposome-Formulated siRNA Against Msi1 and Docetaxel Treatment in an Animal Model of Advanced Gastric Adenocarcinoma Eradicates Cancer Stem Cells and Metastasis
Giannios, J., Michailakis, E., Delia, S., Alexandropoulos, N.
Published in Gastrointestinal cancer research (01.01.2010)
Get full text
Published in Gastrointestinal cancer research (01.01.2010)
Journal Article
Synergistic induction of D2 apoptosis, mt depolymerizing action, angioinhibition and antimetastatic action against radio- and chemoresistant metastatic hormone refractory prostate ca (HRPC) overexpressing bcl-2,MMP-9 and MDR-1 after photodynamic treatment with porfimer sodium associated LDL and vinorelbine tartrate (VRL)
GIANNIOS, J, MICHAILAKIS, E, LAMBRINOS, P, MARAGUDAKIS, E
Published in International journal of radiation oncology, biology, physics (01.09.2004)
Published in International journal of radiation oncology, biology, physics (01.09.2004)
Get full text
Journal Article
Synergistic induction of D2 apoptosis, mt depolymerizing action, angioinhibition and antimetastatic action against radio- and chemoresistant metastatic hormone refractory prostate ca (HRPC) overexpressing bcl-2,MMP-9 and MDR-1 after photodynamic treatment with porfimer sodium associated LDL and vinorelbine tartrate (VRL)
Giannios, J., Michailakis, E., Lambrinos, P., Maragudakis, E.
Published in International journal of radiation oncology, biology, physics (01.09.2004)
Published in International journal of radiation oncology, biology, physics (01.09.2004)
Get full text
Journal Article
Antisense chemoradioimmunotherapy consisting of anti-IGF-I/HGF bs-scFv linked onto high-energy radioisotopes and TFO targeted to DNMT1 and conjugated to vinorelbine induce ADCC, apoptosis and anoikis in metastatic NSCLC characterised by radio and chemoresistance
John, G. N., Michailakis, E., Maragudakis, E., Alexandropoulos, N., Giannios, J.
Published in Journal of clinical oncology (01.06.2005)
Published in Journal of clinical oncology (01.06.2005)
Get full text
Journal Article
Combined administration of hydrophilic antimitotic desoxyepothilone B and vinorelbine induce PUMA, suppression of microtubule dynamics, development of hypodiploidy and multinucleation, cell cycle perturbation at G2/M and apoptosis in advanced breast carcinoma (ABC) characterised by MDR-1 (Pgp),bcl-2 and mutant b-tubulin
John, G. N., Giannios, J., Michailakis, E., Konstandinidou, S., Xepapadakis, G., Alexandropoulos, N., Kononas, T.
Published in Journal of clinical oncology (15.07.2004)
Published in Journal of clinical oncology (15.07.2004)
Get full text
Journal Article
Combined administration of hydrophilic antimitotic desoxyepothilone B and vinorelbine induce PUMA, suppression of microtubule dynamics, development of hypodiploidy and multinucleation, cell cycle perturbation at G2/M and apoptosis in advanced breast carcinoma (ABC) characterised by MDR-1 (Pgp),bcl-2 and mutant b-tubulin
John, G. N., Giannios, J., Michailakis, E., Konstandinidou, S., Xepapadakis, G., Alexandropoulos, N., Kononas, T.
Published in Journal of clinical oncology (15.07.2004)
Published in Journal of clinical oncology (15.07.2004)
Get full text
Journal Article
Cytogenetic findings in three primary hepatocellular carcinomas
Bardi, G, Rizou, H, Michailakis, E, Dietrich, C, Pandis, N, Heim, S
Published in Cancer genetics and cytogenetics (15.07.1998)
Published in Cancer genetics and cytogenetics (15.07.1998)
Get full text
Journal Article
97 Eradication by induced apoptosis of chemoresistant infiltrating ductal carcinoma (IDC) characterised by HDAC2 overexpression and 5′CpG island hypermethylation of the FHIT, RARb2, BRCA1, APC, p16(CDKN2A), RASSF1A, CDH1(Ecadherin), stratifin, MDG1 and HIC1 oncosuppressor genes after combined treatment consisting of immunochemoconjugate of anti-DNMT1/HDAC2 bispecific F(ab)2-bsAb linked with cleavable disulfide onto vinorelbine (I-VRL)
Giannios, J., Michailakis, E., Lambrinos, P.
Published in European journal of cancer supplements (01.09.2004)
Published in European journal of cancer supplements (01.09.2004)
Get full text
Journal Article