Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium
Patel, Asha Kumari, Kaczmarek, James C., Bose, Suman, Kauffman, Kevin J., Mir, Faryal, Heartlein, Michael W., DeRosa, Frank, Langer, Robert, Anderson, Daniel G.
Published in Advanced materials (Weinheim) (01.02.2019)
Published in Advanced materials (Weinheim) (01.02.2019)
Get full text
Journal Article
Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs
Kaczmarek, James C., Patel, Asha K., Kauffman, Kevin J., Fenton, Owen S., Webber, Matthew J., Heartlein, Michael W., DeRosa, Frank, Anderson, Daniel G.
Published in Angewandte Chemie (International ed.) (24.10.2016)
Published in Angewandte Chemie (International ed.) (24.10.2016)
Get full text
Journal Article
Optimization of a Degradable Polymer–Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells
Kaczmarek, James C, Kauffman, Kevin J, Fenton, Owen S, Sadtler, Kaitlyn, Patel, Asha K, Heartlein, Michael W, DeRosa, Frank, Anderson, Daniel G
Published in Nano letters (10.10.2018)
Published in Nano letters (10.10.2018)
Get full text
Journal Article
Improved Efficacy in a Fabry Disease Model Using a Systemic mRNA Liver Depot System as Compared to Enzyme Replacement Therapy
DeRosa, Frank, Smith, Lianne, Shen, Yinghua, Huang, Yan, Pan, Jing, Xie, Hongsheng, Yahalom, Barak, Heartlein, Michael W.
Published in Molecular therapy (10.04.2019)
Published in Molecular therapy (10.04.2019)
Get full text
Journal Article
Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes
Fenton, Owen S., Kauffman, Kevin J., Kaczmarek, James C., McClellan, Rebecca L., Jhunjhunwala, Siddharth, Tibbitt, Mark W., Zeng, Manhao D., Appel, Eric A., Dorkin, Joseph R., Mir, Faryal F., Yang, Jung H., Oberli, Matthias A., Heartlein, Michael W., DeRosa, Frank, Langer, Robert, Anderson, Daniel G.
Published in Advanced materials (Weinheim) (01.09.2017)
Published in Advanced materials (Weinheim) (01.09.2017)
Get full text
Journal Article
Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs
Fenton, Owen S., Kauffman, Kevin J., McClellan, Rebecca L., Kaczmarek, James C., Zeng, Manhao D., Andresen, Jason L., Rhym, Luke H., Heartlein, Michael W., DeRosa, Frank, Anderson, Daniel G.
Published in Angewandte Chemie International Edition (08.10.2018)
Published in Angewandte Chemie International Edition (08.10.2018)
Get full text
Journal Article
CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorder
Calias, Pericles, Papisov, Mikhail, Pan, Jing, Savioli, Nancy, Belov, Vasily, Huang, Yan, Lotterhand, Jason, Alessandrini, Mary, Liu, Nan, Fischman, Alan J, Powell, Jan L, Heartlein, Michael W
Published in PloS one (18.01.2012)
Published in PloS one (18.01.2012)
Get full text
Journal Article
mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo
Rybakova, Yulia, Kowalski, Piotr S., Huang, Yuxuan, Gonzalez, John T., Heartlein, Michael W., DeRosa, Frank, Delcassian, Derfogail, Anderson, Daniel G.
Published in Molecular therapy (07.08.2019)
Published in Molecular therapy (07.08.2019)
Get full text
Journal Article
Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
Kauffman, Kevin J, Dorkin, J. Robert, Yang, Jung H, Heartlein, Michael W, DeRosa, Frank, Mir, Faryal F, Fenton, Owen S, Anderson, Daniel G
Published in Nano letters (11.11.2015)
Published in Nano letters (11.11.2015)
Get full text
Journal Article
Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles
Kaczmarek, James C., Patel, Asha Kumari, Rhym, Luke H., Palmiero, Umberto Capasso, Bhat, Balkrishen, Heartlein, Michael W., DeRosa, Frank, Anderson, Daniel G.
Published in Biomaterials (01.08.2021)
Published in Biomaterials (01.08.2021)
Get full text
Journal Article
Human Sulfatase 2 inhibits in vivo tumor growth of MDA-MB-231 human breast cancer xenografts
Peterson, Sarah M, Iskenderian, Andrea, Cook, Lynette, Romashko, Alla, Tobin, Kristen, Jones, Michael, Norton, Angela, Gómez-Yafal, Alicia, Heartlein, Michael W, Concino, Michael F, Liaw, Lucy, Martini, Paolo G V
Published in BMC cancer (13.08.2010)
Published in BMC cancer (13.08.2010)
Get full text
Journal Article
Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
Fenton, Owen S., Kauffman, Kevin J., McClellan, Rebecca L., Appel, Eric A., Dorkin, J. Robert, Tibbitt, Mark W., Heartlein, Michael W., DeRosa, Frank, Langer, Robert, Anderson, Daniel G.
Published in Advanced materials (Weinheim) (20.04.2016)
Published in Advanced materials (Weinheim) (20.04.2016)
Get full text
Journal Article
Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo
Kauffman, Kevin J, Mir, Faryal F, Jhunjhunwala, Siddharth, Kaczmarek, James C, Hurtado, Juan E, Yang, Jung H, Webber, Matthew J, Kowalski, Piotr S, Heartlein, Michael W, DeRosa, Frank, Anderson, Daniel G
Published in Biomaterials (01.12.2016)
Published in Biomaterials (01.12.2016)
Get full text
Journal Article
Gene Delivery: Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium (Adv. Mater. 8/2019)
Patel, Asha Kumari, Kaczmarek, James C., Bose, Suman, Kauffman, Kevin J., Mir, Faryal, Heartlein, Michael W., DeRosa, Frank, Langer, Robert, Anderson, Daniel G.
Published in Advanced materials (Weinheim) (01.02.2019)
Published in Advanced materials (Weinheim) (01.02.2019)
Get full text
Journal Article
Recombinant human complement component C2 produced in a human cell line restores the classical complement pathway activity in-vitro: an alternative treatment for C2 deficiency diseases
Martini, Paolo G V, Cook, Lynette C, Alderucci, Scott, Norton, Angela W, Lundberg, Dianna M, Fish, Susan M, Langsetmo, Knut, Jönsson, Göran, Lood, Christian, Gullstrand, Birgitta, Zaleski, Kate J, Savioli, Nancy, Lottherand, Jason, Bedard, Charles, Gill, John, Concino, Michael F, Heartlein, Michael W, Truedsson, Lennart, Powell, Jan L, Tzianabos, Arthur O
Published in BMC immunology (20.08.2010)
Published in BMC immunology (20.08.2010)
Get full text
Journal Article
Erythropoietin Produced in a Human Cell Line (Dynepo) Has Significant Differences in Glycosylation Compared with Erythropoietins Produced in CHO Cell Lines
Shahrokh, Zahra, Royle, Louise, Saldova, Radka, Bones, Jonathan, Abrahams, Jodie L, Artemenko, Natalia V, Flatman, Steve, Davies, Mike, Baycroft, Alison, Sehgal, Surinder, Heartlein, Michael W, Harvey, David J, Rudd, Pauline M
Published in Molecular pharmaceutics (07.02.2011)
Published in Molecular pharmaceutics (07.02.2011)
Get full text
Journal Article
Safety evaluation of chronic intrathecal administration of idursulfase-IT in cynomolgus monkeys
Felice, Brian R, Wright, Teresa L, Boyd, Robert B, Butt, Mark T, Pfeifer, Richard W, Pan, Jing, Ruiz, Juan A, Heartlein, Michael W, Calias, Pericles
Published in Toxicologic pathology (01.08.2011)
Published in Toxicologic pathology (01.08.2011)
Get more information
Journal Article
Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs
Fenton, Owen S., Kauffman, Kevin J., McClellan, Rebecca L., Kaczmarek, James C., Zeng, Manhao D., Andresen, Jason L., Rhym, Luke H., Heartlein, Michael W., DeRosa, Frank, Anderson, Daniel G.
Published in Angewandte Chemie (08.10.2018)
Published in Angewandte Chemie (08.10.2018)
Get full text
Journal Article