Exploring the UDP pocket of LpxC through amino acid analogs
Hale, Michael R., Hill, Pamela, Lahiri, Sushmita, Miller, Matthew D., Ross, Philip, Alm, Richard, Gao, Ning, Kutschke, Amy, Johnstone, Michele, Prince, Bryan, Thresher, Jason, Yang, Wei
Published in Bioorganic & medicinal chemistry letters (15.04.2013)
Published in Bioorganic & medicinal chemistry letters (15.04.2013)
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Journal Article
Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir
FURFINE, Eric S, BAKER, Christopher T, HALE, Michael R, REYNOLDS, David J, SALISBURY, Jo A, SEARLE, Andy D, STUDENBERG, Scott D, TODD, Dan, TUNG, Roger D, SPALTENSTEIN, Andrew
Published in Antimicrobial Agents and Chemotherapy (01.03.2004)
Published in Antimicrobial Agents and Chemotherapy (01.03.2004)
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Journal Article
Translating slow-binding inhibition kinetics into cellular and in vivo effects
Walkup, Grant K, You, Zhiping, Ross, Philip L, Allen, Eleanor K H, Daryaee, Fereidoon, Hale, Michael R, O'Donnell, John, Ehmann, David E, Schuck, Virna J A, Buurman, Ed T, Choy, Allison L, Hajec, Laurel, Murphy-Benenato, Kerry, Marone, Valerie, Patey, Sara A, Grosser, Lena A, Johnstone, Michele, Walker, Stephen G, Tonge, Peter J, Fisher, Stewart L
Published in Nature chemical biology (01.06.2015)
Published in Nature chemical biology (01.06.2015)
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Journal Article
Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control
Aronov, Alex M, Tang, Qing, Martinez-Botella, Gabriel, Bemis, Guy W, Cao, Jingrong, Chen, Guanjing, Ewing, Nigel P, Ford, Pamella J, Germann, Ursula A, Green, Jeremy, Hale, Michael R, Jacobs, Marc, Janetka, James W, Maltais, Francois, Markland, William, Namchuk, Mark N, Nanthakumar, Suganthini, Poondru, Srinivasu, Straub, Judy, ter Haar, Ernst, Xie, Xiaoling
Published in Journal of medicinal chemistry (22.10.2009)
Published in Journal of medicinal chemistry (22.10.2009)
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Journal Article
Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors
Aronov, Alex M, Baker, Christopher, Bemis, Guy W, Cao, Jingrong, Chen, Guanjing, Ford, Pamella J, Germann, Ursula A, Green, Jeremy, Hale, Michael R, Jacobs, Marc, Janetka, James W, Maltais, Francois, Martinez-Botella, Gabriel, Namchuk, Mark N, Straub, Judy, Tang, Qing, Xie, Xiaoling
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
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Journal Article
Negishi cross-coupling enabled synthesis of novel NAD+-dependent DNA ligase inhibitors and SAR development
Murphy-Benenato, Kerry E., Gingipalli, Lakshmaiah, Boriack-Sjodin, P. Ann, Martinez-Botella, Gabriel, Carcanague, Dan, Eyermann, Charles J., Gowravaram, Madhu, Harang, Jenna, Hale, Michael R., Ioannidis, Georgine, Jahic, Harris, Johnstone, Michele, Kutschke, Amy, Laganas, Valerie A., Loch, James T., Miller, Matthew D., Oguto, Herbert, Patel, Sahil Joe
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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Journal Article
Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors
Murphy-Benenato, Kerry E, Olivier, Nelson, Choy, Allison, Ross, Philip L, Miller, Matthew D, Thresher, Jason, Gao, Ning, Hale, Michael R
Published in ACS medicinal chemistry letters (13.11.2014)
Published in ACS medicinal chemistry letters (13.11.2014)
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Journal Article
Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain
Gao, Ning, McLeod, Sarah M., Hajec, Laurel, Olivier, Nelson B., Lahiri, Sushmita D., Bryan Prince, D., Thresher, Jason, Ross, Philip L., Whiteaker, James D., Doig, Peter, Li, Amanda Haixi, Hill, Pamela J., Cornebise, Mark, Reck, Folkert, Hale, Michael R.
Published in Protein expression and purification (01.12.2014)
Published in Protein expression and purification (01.12.2014)
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Journal Article
Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385
Miller, John F., Andrews, C. Webster, Brieger, Michael, Furfine, Eric S., Hale, Michael R., Hanlon, Mary H., Hazen, Richard J., Kaldor, Istvan, McLean, Ed W., Reynolds, David, Sammond, Douglas M., Spaltenstein, Andrew, Tung, Roger, Turner, Elizabeth M., Xu, Robert X., Sherrill, Ronald G.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Journal Article
Abstract A089: NST-628 is a potent, fully brain-penetrant, RAS/MAPK pathway molecular glue inhibitor with efficacy in CNS tumor models
Ryan, Meagan B, Li, Chun, Han, Yongxin, Hoeflich, Klaus P, Hale, Michael R, Hagel, Margit
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Abstract A088: NST-628 is a potent, best-in-class MAPK pathway molecular glue that inhibits RAS- and RAF-driven cancers
Ryan, Meagan B, Schenk, Natasha, Zingg, Marshall, Koehler, Matthew, Swalm, Brooke, Quade, Bradley, Ye, Chaoyang, Dar, Arvin C, Han, Yongxin, Hoeflich, Klaus P, Hale, Michael R, Hagel, Margit
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
From fragments to leads: novel bacterial NAD+-dependent DNA ligase inhibitors
Hale, Michael R., Brassington, Claire, Carcanague, Dan, Embrey, Kevin, Eyermann, Charles J., Giacobbe, Robert A., Gingipalli, Lakshmaiah, Gowravaram, Madhusudhan, Harang, Jenna, Howard, Tina, Ioannidis, Georgine, Jahic, Haris, Kutschke, Amy, Laganas, Valerie A., Loch, James, Miller, Matthew D., Murphy-Benenato, Kerry E., Oguto, Herbert, Otterbein, Ludovic, Patel, Sahil Joe, Shapiro, Adam B., Boriack-Sjodin, P. Ann
Published in Tetrahedron letters (03.06.2015)
Published in Tetrahedron letters (03.06.2015)
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Journal Article
Activated Ketones as Inhibitors of Intracellular Ca2+-Dependent and Ca2+-Independent Phospholipase A2
Conde-Frieboes, Kilian, Reynolds, Laure J, Lio, Yi-Ching, Hale, Michael R, Wasserman, Harry H, Dennis, Edward A
Published in Journal of the American Chemical Society (19.06.1996)
Published in Journal of the American Chemical Society (19.06.1996)
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Journal Article
Self regulating modular battery
Stocker, Justin, Nemanick, Eric Joseph, Chervenak, Ann L, Brethorst, Andrew, Macdougall, Kevin, Fuerst, Joseph Z, Hale, Michael R
Year of Publication 10.10.2023
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Year of Publication 10.10.2023
Patent
SELF REGULATING MODULAR BATTERY
STOCKER, Justin, HALE, Michael R, MACDOUGALL, Kevin, FUERST, Joseph Z, CHERVENAK, Ann L, BRETHORST, Andrew, NEMANICK, Eric Joseph
Year of Publication 12.01.2023
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Year of Publication 12.01.2023
Patent
PYRROLE INHIBITORS OF ERK PROTEIN KINASE, SYNTHESIS THEREOF AND INTERMEDIATES THERETO
MARTINEZ-BOTELLA, Gabriel, MALTAIS, François, HALE, Michael, R, STRAUB, Judith, TANG, Qing
Year of Publication 26.01.2022
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Year of Publication 26.01.2022
Patent
Substituted macrocyclic compounds and related methods of treatment
Choi, Younggi, Mugge, Ingo Andreas, Aquila, Brian M, Hale, Michael R, Raymer, Brian Kenneth, Karra, Srinivasa, Hu, Yuan, Matharu, Daljit, Huynh, Hoan, Valiulin, Roman A, Woods, James R, Bentzien, Jörg Martin, Pennington, Lewis D, Lehmann, Jonathan Ward
Year of Publication 06.08.2024
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Year of Publication 06.08.2024
Patent