The genomic landscape of response to EGFR blockade in colorectal cancer
Bertotti, Andrea, Papp, Eniko, Jones, Siân, Adleff, Vilmos, Anagnostou, Valsamo, Lupo, Barbara, Sausen, Mark, Phallen, Jillian, Hruban, Carolyn A., Tokheim, Collin, Niknafs, Noushin, Nesselbush, Monica, Lytle, Karli, Sassi, Francesco, Cottino, Francesca, Migliardi, Giorgia, Zanella, Eugenia R., Ribero, Dario, Russolillo, Nadia, Mellano, Alfredo, Muratore, Andrea, Paraluppi, Gianluca, Salizzoni, Mauro, Marsoni, Silvia, Kragh, Michael, Lantto, Johan, Cassingena, Andrea, Li, Qing Kay, Karchin, Rachel, Scharpf, Robert, Sartore-Bianchi, Andrea, Siena, Salvatore, Diaz, Luis A., Trusolino, Livio, Velculescu, Victor E.
Published in Nature (London) (08.10.2015)
Published in Nature (London) (08.10.2015)
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The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer
Sánchez-Martín, Francisco J, Bellosillo, Beatriz, Gelabert-Baldrich, Mariona, Dalmases, Alba, Cañadas, Israel, Vidal, Joana, Martinez, Alejandro, Argilés, Guillem, Siravegna, Giulia, Arena, Sabrina, Koefoed, Klaus, Visa, Laura, Arpí, Oriol, Horak, Ivan David, Iglesias, Mar, Stroh, Christopher, Kragh, Michael, Rovira, Ana, Albanell, Joan, Tabernero, Josep, Bardelli, Alberto, Montagut, Clara
Published in Clinical cancer research (01.07.2016)
Published in Clinical cancer research (01.07.2016)
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Sym015: A Highly Efficacious Antibody Mixture against MET -Amplified Tumors
Poulsen, Thomas Tuxen, Grandal, Michael Monrad, Skartved, Niels Jørgen Østergaard, Hald, Rikke, Alifrangis, Lene, Koefoed, Klaus, Lindsted, Trine, Fröhlich, Camilla, Pollmann, Sofie Ellebæk, Eriksen, Karsten Wessel, Dahlman, Anna, Jacobsen, Helle Jane, Bouquin, Thomas, Pedersen, Mikkel Wandahl, Horak, Ivan David, Lantto, Johan, Kragh, Michael
Published in Clinical cancer research (01.10.2017)
Published in Clinical cancer research (01.10.2017)
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Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation
Jones, Sylwia, King, Peter J., Antonescu, Costin N., Sugiyama, Michael G., Bhamra, Amandeep, Surinova, Silvia, Angelopoulos, Nicos, Kragh, Michael, Pedersen, Mikkel W., Hartley, John A., Futter, Clare E., Hochhauser, Daniel
Published in Scientific reports (20.01.2020)
Published in Scientific reports (20.01.2020)
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Simultaneous targeting of HER family pro-survival signaling with Pan-HER antibody mixture is highly effective in TNBC: a preclinical trial with PDXs
Reddy, Tejaswini P, Choi, Dong S, Anselme, Ann C, Qian, Wei, Chen, Wen, Lantto, Johan, Horak, Ivan D, Kragh, Michael, Chang, Jenny C, Rosato, Roberto R
Published in Breast cancer research : BCR (15.05.2020)
Published in Breast cancer research : BCR (15.05.2020)
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Pan‐HER—An antibody mixture targeting EGFR, HER2 and HER3 abrogates preformed and ligand‐induced EGFR homo‐ and heterodimers
Ellebæk, Sofie, Brix, Susanne, Grandal, Michael, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Poulsen, Thomas Tuxen
Published in International journal of cancer (01.11.2016)
Published in International journal of cancer (01.11.2016)
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Sym004, a Novel EGFR Antibody Mixture, Can Overcome Acquired Resistance to Cetuximab
Iida, Mari, Brand, Toni M, Starr, Megan M, Li, Chunrong, Huppert, Evan J, Luthar, Neha, Pedersen, Mikkel W, Horak, Ivan D, Kragh, Michael, Wheeler, Deric L
Published in Neoplasia (New York, N.Y.) (01.10.2013)
Published in Neoplasia (New York, N.Y.) (01.10.2013)
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Interleukin 21: combination strategies for cancer therapy
Smyth, Mark J, Sivakumar, Pallavur V, Skak, Kresten, Kragh, Michael, Hausman, Diana
Published in Nature reviews. Drug discovery (01.03.2008)
Published in Nature reviews. Drug discovery (01.03.2008)
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Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor
Koefoed, Klaus, Steinaa, Lucilla, Søderberg, Josefine Nielsen, Kjær, Ida, Jacobsen, Helle Jane, Meijer, Per-Johan, Haurum, John Sørensen, Jensen, Allan, Kragh, Michael, Andersen, Peter Sejer, Pedersen, Mikkel Wandahl
Published in mAbs (01.11.2011)
Published in mAbs (01.11.2011)
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Preclinical Pharmacokinetics and Safety of Sym004: A Synergistic Antibody Mixture Directed against Epidermal Growth Factor Receptor
SKARTVED, Niels Jørgen Østergaard, JACOBSEN, Helle Jane, PEDERSEN, Mikkel Wandahl, JENSEN, Pernille Foged, SEN, Jette Wagtberg, JORGENSEN, Thomas Kjærsgaard, HEY, Adam, KRAGH, Michael
Published in Clinical cancer research (15.09.2011)
Published in Clinical cancer research (15.09.2011)
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Sym004, a novel anti-EGFR antibody mixture, augments radiation response in human lung and head and neck cancers
Huang, Shyhmin, Peet, Chimera R, Saker, Jarob, Li, Chunrong, Armstrong, Eric A, Kragh, Michael, Pedersen, Mikkel W, Harari, Paul M
Published in Molecular cancer therapeutics (01.12.2013)
Published in Molecular cancer therapeutics (01.12.2013)
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Sym004: A Novel Synergistic Anti-Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy
PEDERSEN, Mikkel Wandahl, JACOBSEN, Helle Jane, KOEFOED, Klaus, HEY, Adam, PYKE, Charles, HAURUM, John Sørensen, KRAGH, Michael
Published in Cancer research (Chicago, Ill.) (15.01.2010)
Published in Cancer research (Chicago, Ill.) (15.01.2010)
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HER-Family Ligands Promote Acquired Resistance to Trastuzumab in Gastric Cancer
Sampera, Aïda, Sánchez-Martín, Francisco Javier, Arpí, Oriol, Visa, Laura, Iglesias, Mar, Menéndez, Sílvia, Gaye, Élisabeth, Dalmases, Alba, Clavé, Sergi, Gelabert-Baldrich, Mariona, Poulsen, Thomas Tuxen, Kragh, Michael, Bellosillo, Beatriz, Albanell, Joan, Rovira, Ana, Montagut, Clara
Published in Molecular cancer therapeutics (01.11.2019)
Published in Molecular cancer therapeutics (01.11.2019)
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Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype
Lupo, Barbara, Sassi, Francesco, Pinnelli, Marika, Galimi, Francesco, Zanella, Eugenia R, Vurchio, Valentina, Migliardi, Giorgia, Gagliardi, Paolo Armando, Puliafito, Alberto, Manganaro, Daria, Luraghi, Paolo, Kragh, Michael, Pedersen, Mikkel W, Horak, Ivan D, Boccaccio, Carla, Medico, Enzo, Primo, Luca, Nichol, Daniel, Spiteri, Inmaculada, Heide, Timon, Vatsiou, Alexandra, Graham, Trevor A, Élez, Elena, Argiles, Guillem, Nuciforo, Paolo, Sottoriva, Andrea, Dienstmann, Rodrigo, Pasini, Diego, Grassi, Elena, Isella, Claudio, Bertotti, Andrea, Trusolino, Livio
Published in Science translational medicine (05.08.2020)
Published in Science translational medicine (05.08.2020)
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Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity
Jacobsen, Helle J, Poulsen, Thomas T, Dahlman, Anna, Kjær, Ida, Koefoed, Klaus, Sen, Jette W, Weilguny, Dietmar, Bjerregaard, Bolette, Andersen, Christina R, Horak, Ivan D, Pedersen, Mikkel W, Kragh, Michael, Lantto, Johan
Published in Clinical cancer research (15.09.2015)
Published in Clinical cancer research (15.09.2015)
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Abstract 357: Pan-HER, an antibody mixture simultaneously targeting EGFR, HER2, and HER3, is highly effective in triple negative breast cancer patient-derived xenografts
Rosato, Roberto R., Choi, Don S., Qian, Wei, Chen, Wen, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Chang, Jenny C.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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CD4 + and CD8a + PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models
Kristensen, Lotte K, Fröhlich, Camilla, Christensen, Camilla, Melander, Maria C, Poulsen, Thomas T, Galler, Gunther R, Lantto, Johan, Horak, Ivan D, Kragh, Michael, Nielsen, Carsten H, Kjaer, Andreas
Published in Theranostics (01.01.2019)
Published in Theranostics (01.01.2019)
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