Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy
Le, Kang, Soth, Michael J., Cross, Jason B., Liu, Gang, Ray, William J., Ma, Jiacheng, Goodwani, Sunil G., Acton, Paul J., Buggia-Prevot, Virginie, Akkermans, Onno, Barker, John, Conner, Michael L., Jiang, Yongying, Liu, Zhen, McEwan, Paul, Warner-Schmidt, Jennifer, Xu, Alan, Zebisch, Matthias, Heijnen, Cobi J., Abrahams, Brett, Jones, Philip
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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Journal Article
Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1
Fiskus, Warren, Mill, Christopher P., Birdwell, Christine, Davis, John A., Das, Kaberi, Boettcher, Steffen, Kadia, Tapan M., DiNardo, Courtney D., Takahashi, Koichi, Loghavi, Sanam, Soth, Michael J., Heffernan, Tim, McGeehan, Gerard M., Ruan, Xinjia, Su, Xiaoping, Vakoc, Christopher R., Daver, Naval, Bhalla, Kapil N.
Published in Blood cancer journal (New York) (13.04.2023)
Published in Blood cancer journal (New York) (13.04.2023)
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Journal Article
Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
Goodwani, Sunil, Fernandez, Celia, Acton, Paul J, Buggia-Prevot, Virginie, McReynolds, Morgan L, Ma, Jiacheng, Hu, Cheng Hui, Hamby, Mary E, Jiang, Yongying, Le, Kang, Soth, Michael J, Jones, Philip, Ray, William J
Published in International journal of molecular sciences (09.07.2020)
Published in International journal of molecular sciences (09.07.2020)
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Journal Article
Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties
Soth, Michael J, Le, Kang, Di Francesco, Maria Emilia, Hamilton, Matthew M, Liu, Gang, Burke, Jason P, Carroll, Chris L, Kovacs, Jeffrey J, Bardenhagen, Jennifer P, Bristow, Christopher A, Cardozo, Mario, Czako, Barbara, de Stanchina, Elisa, Feng, Ningping, Garvey, Jill R, Gay, Jason P, Do, Mary K. Geck, Greer, Jennifer, Han, Michelle, Harris, Angela, Herrera, Zachary, Huang, Sha, Giuliani, Virginia, Jiang, Yongying, Johnson, Sarah B, Johnson, Troy A, Kang, Zhijun, Leonard, Paul G, Liu, Zhen, McAfoos, Timothy, Miller, Meredith, Morlacchi, Pietro, Mullinax, Robert A, Palmer, Wylie S, Pang, Jihai, Rogers, Norma, Rudin, Charles M, Shepard, Hannah E, Spencer, Nakia D, Theroff, Jay, Wu, Qi, Xu, Alan, Yau, Ju Anne, Draetta, Giulio, Toniatti, Carlo, Heffernan, Timothy P, Jones, Philip
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Journal Article
Inhibition of dual leucine zipper kinase prevents chemotherapy-induced peripheral neuropathy and cognitive impairments
Ma, Jiacheng, Goodwani, Sunil, Acton, Paul J., Buggia-Prevot, Virginie, Kesler, Shelli R., Jamal, Imran, Mahant, Iteeben D., Liu, Zhen, Mseeh, Faika, Roth, Bruce L., Chakraborty, Chaitali, Peng, Bo, Wu, Qi, Jiang, Yongying, Le, Kang, Soth, Michael J., Jones, Philip, Kavelaars, Annemieke, Ray, William J., Heijnen, Cobi J.
Published in Pain (Amsterdam) (01.10.2021)
Published in Pain (Amsterdam) (01.10.2021)
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Journal Article
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme
Hamilton, Matthew M, Mseeh, Faika, McAfoos, Timothy J, Leonard, Paul G, Reyna, Naphtali J, Harris, Angela L, Xu, Alan, Han, Michelle, Soth, Michael J, Czako, Barbara, Theroff, Jay P, Mandal, Pijus K, Burke, Jason P, Virgin-Downey, Brett, Petrocchi, Alessia, Pfaffinger, Dana, Rogers, Norma E, Parker, Connor A, Yu, Simon S, Jiang, Yongying, Krapp, Stephan, Lammens, Alfred, Trevitt, Graham, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Cross, Jason B, Jones, Philip, Marszalek, Joseph R, Lewis, Richard T
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Journal Article
CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer
Yuan, Xueying, Hao, Xiaoxin, Chan, Hilda L, Zhao, Na, Pedroza, Diego A, Liu, Fengshuo, Le, Kang, Smith, Alex J, Calderon, Sebastian J, Lieu, Nadia, Soth, Michael J, Jones, Philip, Zhang, Xiang H-F, Rosen, Jeffrey M
Published in JCI insight (17.09.2024)
Published in JCI insight (17.09.2024)
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Journal Article
Designed molecules that fold to mimic protein secondary structures
Stigers, Kimberly D, Soth, Michael J, Nowick, James S
Published in Current Opinion in Chemical Biology (01.12.1999)
Published in Current Opinion in Chemical Biology (01.12.1999)
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Book Review
Journal Article
Convenient Method for the 3-Functionalization of Isoindazoles
Bunnell, Aaron, O'Yang, Counde, Petrica, Andra, Soth, Michael J.
Published in Synthetic communications (01.01.2006)
Published in Synthetic communications (01.01.2006)
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Journal Article
CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC
Yuan, Xueying, Hao, Xiaoxin, Chan, Hilda L, Zhao, Na, Pedroza, Diego A, Liu, Fengshuo, Le, Kang, Smith, Alex J, Calderon, Sebastian J, Lieu, Nadia, Soth, Michael J, Jones, Philip, Zhang, Xiang H-F, Rosen, Jeffrey M
Published in bioRxiv (27.04.2024)
Published in bioRxiv (27.04.2024)
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Journal Article
Abstract 2338: The GLS1 inhibitor IPN60090 enhances antitumor immune response through metabolic reprogramming of T cells and impacts on the tumor microenvironment
Suzuki, Erika, Molina, Jennifer, Spencer, Nakia D., Bristow, Christopher A., Harris, Angela L., Feng, Ningping, Mahendra, Mikhila, Gera, Sonal, Soth, Michael J., Le, Kang, Yap, Timothy A., Draetta, Giulio, Jones, Philip, Heffernan, Timothy P., Kovacs, Jeffrey J.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 87: Asparagine synthetase (ASNS) expression predicts response to the GLS1 inhibitor IPN60090 in ovarian cancer through selective modulation of redox homeostasis
Spencer, Nakia D., Bristow, Christopher A., Giulani, Virginia, Miller, Meredith A., Carugo, Alessandro, Harris, Angela L., Minelli, Rosalba, Feng, Ningpeng, Chang, Qing, Soth, Michael J., Le, Kang, Weinstein, John N., Lorenzi, Philip L., Liu, Jinsong, Wang, Wei-Lien, Yap, Timothy A., Draetta, Giulio, Jones, Philip, Heffernan, Timothy P., Kovacs, Jeffrey J.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Inhibition of dual leucine zipper kinase prevents chemotherapy-induced peripheral neuropathy and cognitive impairments
Ma, Jiacheng, Goodwani, Sunil, Acton, Paul J., Buggia-Prevot, Virginie, Kesler, Shelli R., Jamal, Imran, Mahant, Iteeben D., Liu, Zhen, Mseeh, Faika, Roth, Bruce L., Chakraborty, Chaitali, Peng, Bo, Wu, Qi, Jiang, Yongying, Le, Kang, Soth, Michael J., Jones, Philip, Kavelaars, Annemieke, Ray, William J., Heijnen, Cobi J.
Published in Pain (Amsterdam) (15.04.2021)
Published in Pain (Amsterdam) (15.04.2021)
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Journal Article
HETEROCYCLES AS MODULATORS OF NSD ACTIVITY
RAMASWAMY, Suyambu Kesava Vijayan, JONES, Philip, LE, Kang, SOTH, Michael J
Year of Publication 04.04.2024
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Year of Publication 04.04.2024
Patent