Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited
Bryan, Marian C., Dunn, Peter J., Entwistle, David, Gallou, Fabrice, Koenig, Stefan G., Hayler, John D., Hickey, Matthew R., Hughes, Shaun, Kopach, Michael E., Moine, Gerard, Richardson, Paul, Roschangar, Frank, Steven, Alan, Weiberth, Franz J.
Published in Green chemistry : an international journal and green chemistry resource : GC (2018)
Published in Green chemistry : an international journal and green chemistry resource : GC (2018)
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Journal Article
The History of Flow Chemistry at Eli Lilly and Company
Johnson, Martin D., Braden, Timothy, Calvin, Joel R., Campbell Brewer, Alison, Cole, Kevin P., Frank, Scott, Kerr, Mark, Kjell, Doug, Kopach, Michael E., Martinelli, Joseph R., May, Scott. A., Rincon, Juan, White, Timothy D., Yates, Matthew H.
Published in Chimia (31.05.2023)
Published in Chimia (31.05.2023)
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Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide
Wang, Jingyao, Berglund, Mark R., Braden, Timothy, Embry, Matthew C., Johnson, Martin D., Groskreutz, Stephen R., Sayyed, Fareed Bhasha, Tsukanov, Sergey Vladimirovich, White, Timothy D., Jalan, Ankur, Seibert, Kevin D., Kopach, Michael E.
Published in ACS omega (20.12.2022)
Published in ACS omega (20.12.2022)
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Journal Article
Improved Synthesis of 1-(Azidomethyl)-3,5-bis-(trifluoromethyl)benzene: Development of Batch and Microflow Azide Processes
Kopach, Michael E, Murray, Michael M, Braden, Timothy M, Kobierski, Michael E, Williams, Otis L
Published in Organic process research & development (20.03.2009)
Published in Organic process research & development (20.03.2009)
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Journal Article
Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Andrews, Benjamin I, Antia, Firoz D, Brueggemeier, Shawn B, Diorazio, Louis J, Koenig, Stefan G, Kopach, Michael E, Lee, Heewon, Olbrich, Martin, Watson, Anna L
Published in Journal of organic chemistry (01.01.2021)
Published in Journal of organic chemistry (01.01.2021)
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Journal Article
Sustainable Practices in Medicinal Chemistry: Current State and Future Directions
Bryan, Marian C, Dillon, Barry, Hamann, Lawrence G, Hughes, Gregory J, Kopach, Michael E, Peterson, Emily A, Pourashraf, Mehrnaz, Raheem, Izzat, Richardson, Paul, Richter, Daniel, Sneddon, Helen F
Published in Journal of medicinal chemistry (08.08.2013)
Published in Journal of medicinal chemistry (08.08.2013)
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Journal Article
Phosphine-Dependent Photoinitiation of Alkyl Thiols under Near-UV Light Facilitates User-Friendly Peptide Desulfurization
Venneti, Naresh M., Samala, Ganesh, Morsy, Rana M. I., Mendoza, Lawrence G., Isidro-Llobet, Albert, Tom, Janine K., Mukherjee, Subha, Kopach, Michael E., Stockdill, Jennifer L.
Published in Journal of the American Chemical Society (18.01.2023)
Published in Journal of the American Chemical Society (18.01.2023)
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Journal Article
A deeper shade of green: inspiring sustainable drug manufacturing
Roschangar, Frank, Colberg, Juan, Dunn, Peter J, Gallou, Fabrice, Hayler, John D, Koenig, Stefan G, Kopach, Michael E, Leahy, David K, Mergelsberg, Ingrid, Tucker, John L, Sheldon, Roger A, Senanayake, Chris H
Published in Green chemistry : an international journal and green chemistry resource : GC (2017)
Published in Green chemistry : an international journal and green chemistry resource : GC (2017)
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Journal Article
Quality by design of solid‐phase peptide/protein coupling reaction via mechanistic reaction kinetics modeling approach
Wang, Jingyao, Agrawal, Paridhi, Berglund, Mark R., Groh, Jennifer McClary, Kopach, Michael E., Seibert, Kevin D., Viswanath, Shekhar K.
Published in AIChE journal (01.08.2024)
Published in AIChE journal (01.08.2024)
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Journal Article
Improved iGAL 2.0 Metric Empowers Pharmaceutical Scientists to Make Meaningful Contributions to United Nations Sustainable Development Goal 12
Roschangar, Frank, Li, Jun, Zhou, Yanyan, Aelterman, Wim, Borovika, Alina, Colberg, Juan, Dickson, David P, Gallou, Fabrice, Hayler, John D, Koenig, Stefan G, Kopach, Michael E, Kosjek, Birgit, Leahy, David K, O’Brien, Erin, Smith, Austin G, Henry, Manuel, Cook, Jutta, Sheldon, Roger A
Published in ACS sustainable chemistry & engineering (25.04.2022)
Published in ACS sustainable chemistry & engineering (25.04.2022)
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Journal Article
Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production
Isidro-Llobet, Albert, Kenworthy, Martin N, Mukherjee, Subha, Kopach, Michael E, Wegner, Katarzyna, Gallou, Fabrice, Smith, Austin G, Roschangar, Frank
Published in Journal of organic chemistry (19.04.2019)
Published in Journal of organic chemistry (19.04.2019)
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Journal Article
Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis
Kekessie, Ivy, Wegner, Katarzyna, Martinez, Isamir, Kopach, Michael E., White, Timothy D., Tom, Janine K., Kenworthy, Martin N., Gallou, Fabrice, Lopez, John, Koenig, Stefan G., Payne, Philippa R., Eissler, Stefan, Arumugam, Balasubramanian, Li, Changfeng, Mukherjee, Subha, Isidro-Llobet, Albert, Ludemann-Hombourger, Olivier, Richardson, Paul, Kittelmann, Jörg, Sejer Pedersen, Daniel, van den Bos, Leendert J.
Published in Journal of organic chemistry (05.04.2024)
Published in Journal of organic chemistry (05.04.2024)
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Bringing Macrolactamization Full Circle: Self-Cleaving Head-to-Tail Macrocyclization of Unprotected Peptides via Mild N‑Acyl Urea Activation
Arbour, Christine A, Belavek, Kayla J, Tariq, Rooha, Mukherjee, Subha, Tom, Janine K, Isidro-Llobet, Albert, Kopach, Michael E, Stockdill, Jennifer L
Published in Journal of organic chemistry (18.01.2019)
Published in Journal of organic chemistry (18.01.2019)
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Journal Article
Inspiring process innovation via an improved green manufacturing metric: iGAL
Roschangar, Frank, Zhou, Yanyan, Constable, David J. C., Colberg, Juan, Dickson, David P., Dunn, Peter J., Eastgate, Martin D., Gallou, Fabrice, Hayler, John D., Koenig, Stefan G., Kopach, Michael E., Leahy, David K., Mergelsberg, Ingrid, Scholz, Ulrich, Smith, Austin G., Henry, Manuel, Mulder, Jason, Brandenburg, Jörg, Dehli, Juan R., Fandrick, Daniel R., Fandrick, Keith R., Gnad-Badouin, Frieder, Zerban, Georg, Groll, Klaus, Anastas, Paul T., Sheldon, Roger A., Senanayake, Chris H.
Published in Green chemistry : an international journal and green chemistry resource : GC (2018)
Published in Green chemistry : an international journal and green chemistry resource : GC (2018)
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Journal Article
One‐Pot Sequential Kumada–Tamao–Corriu Couplings of (Hetero)Aryl Polyhalides in the Presence of Grignard‐Sensitive Functional Groups Using Pd‐PEPPSI‐IPentCl
Sinha, Narayan, Champagne, Pier Alexandre, Rodriguez, Michael J., Lu, Yu, Kopach, Michael E., Mitchell, David, Organ, Michael G.
Published in Chemistry : a European journal (07.05.2019)
Published in Chemistry : a European journal (07.05.2019)
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Journal Article
One-Pot Sequential Kumada-Tamao-Corriu Couplings of (Hetero)Aryl Polyhalides in the Presence of Grignard-Sensitive Functional Groups Using Pd-PEPPSI-IPent Cl
Sinha, Narayan, Champagne, Pier Alexandre, Rodriguez, Michael J, Lu, Yu, Kopach, Michael E, Mitchell, David, Organ, Michael G
Published in Chemistry : a European journal (07.05.2019)
Published in Chemistry : a European journal (07.05.2019)
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Journal Article
Sodium Butylated Hydroxytoluene (NaBHT) as a New and Efficient Hydride Source for Pd‐Catalysed Reduction Reactions
Sharif, Sepideh, Rodriguez, Michael J., Lu, Yu, Kopach, Michael E., Mitchell, David, Hunter, Howard N., Organ, Michael G.
Published in Chemistry : a European journal (11.10.2019)
Published in Chemistry : a European journal (11.10.2019)
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Journal Article
A Green Chemistry Continuum for a Robust and Sustainable Active Pharmaceutical Ingredient Supply Chain
Koenig, Stefan G, Bee, Cisco, Borovika, Alina, Briddell, Christiana, Colberg, Juan, Humphrey, Guy R, Kopach, Michael E, Martinez, Isamir, Nambiar, Sudhir, Plummer, Scott V, Ribe, Seth D, Roschangar, Frank, Scott, Jeremy P, Sneddon, Helen F
Published in ACS sustainable chemistry & engineering (21.10.2019)
Published in ACS sustainable chemistry & engineering (21.10.2019)
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