Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRAS(G12C)
Shin, Youngsook, Jeong, Joon Won, Wurz, Ryan P., Achanta, Pragathi, Arvedson, Tara, Bartberger, Michael D., Campuzano, Iain D. G., Fucini, Ray, Hansen, Stig K., Ingersoll, John, Iwig, Jeffrey S., Lipford, J. Russell, Ma, Vu, Kopecky, David J., McCarter, John, San Miguel, Tisha, Mohr, Christopher, Sabet, Sudi, Saiki, Anne Y., Sawayama, Andrew, Sethofer, Steven, Tegley, Christopher M., Volak, Laurie P., Yang, Kevin, Lanman, Brian A., Erlanson, Daniel A., Cee, Victor J.
Published in ACS medicinal chemistry letters (12.09.2019)
Published in ACS medicinal chemistry letters (12.09.2019)
Get full text
Journal Article
A Kinetic Study of the Thermal Decarboxylation of α,α-Difluoro β-Lactones
Ocampo, Rogelio, Dolbier, William R, Bartberger, Michael D, Paredes, Rodrigo
Published in Journal of organic chemistry (10.01.1997)
Published in Journal of organic chemistry (10.01.1997)
Get full text
Journal Article
Abstract LB173: Discovery of ALTA-2618, the first allosteric, mutant-selective targeted therapy for AKT1 E17K driven cancers
Murphy, Eric A., Bartberger, Michael D., Ibanez, Maureen, Smith, Troy T., Alvarez, Nicole, Timple, Noel, Zhu, Xuefeng, Fan, Kevin, Yu, Kevin
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Get full text
Journal Article
Reactions of 1,3-Dibromo-1,1-difluoro Compounds with 1,8-Diazabicyclo[5.4.0]undec-7-ene
Elsheimer, Seth, Foti, Christopher J, Bartberger, Michael D
Published in Journal of organic chemistry (06.09.1996)
Published in Journal of organic chemistry (06.09.1996)
Get full text
Journal Article
Fragment-Linking Approach Using [superscript 19]F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of [beta]-Secretase
Jordan, John B., Whittington, Douglas A., Bartberger, Michael D., Sickmier, E. Allen, Chen, Kui, Cheng, Yuan, Judd, Ted
Published in Journal of medicinal chemistry (03.05.2016)
Published in Journal of medicinal chemistry (03.05.2016)
Get full text
Journal Article
Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase
Jordan, John B., Whittington, Douglas A., Bartberger, Michael D., Sickmier, E. Allen, Chen, Kui, Cheng, Yuan, Judd, Ted
Published in Journal of medicinal chemistry (28.04.2016)
Published in Journal of medicinal chemistry (28.04.2016)
Get full text
Journal Article
Correction to Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β‑Secretase
Jordan, John B, Whittington, Douglas A, Bartberger, Michael D, Sickmier, E. Allen, Chen, Kui, White, Ryan D, Cheng, Yuan, Judd, Ted
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
Get full text
Journal Article
Discovery of a Potent, Orally Active 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-(1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221
Veniant, Murielle M., Hale, Clarence, Hungate, Randall W., Gahm, Kyung, Emery, Maurice G., Jona, Janan, Joseph, Smriti, Adams, Jeffrey, Hague, Andrew, Moniz, George, Zhang, Jiandong, Bartberger, Michael D., Li, Vivian, Syed, Rashid, Jordan, Steven, Komorowski, Renee, Chen, Michelle M., Cupples, Rod, Kim, Ki Won, St Jean, David J., Johansson, Lars, Henriksson, Martin A., Williams, Meredith, Vallgarda, Jerk, Fotsch, Christopher, Wang, Minghan
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
Get full text
Journal Article
The reactive nature of α-ammonium distonic radical cations
Rios, Luz Amalia, Bartberger, Michael D, Dolbier, William R, Paredes, Rodrigo
Published in Tetrahedron letters (06.10.1997)
Published in Tetrahedron letters (06.10.1997)
Get full text
Journal Article
Synthesis and conformational analysis of α,α-difluoroalkyl heteroaryl ethers
Horne, Daniel B., Bartberger, Michael D., Kaller, Matthew R., Monenschein, Holger, Zhong, Wenge, Hitchcock, Stephen A.
Published in Tetrahedron letters (30.09.2009)
Published in Tetrahedron letters (30.09.2009)
Get full text
Journal Article
ChemInform Abstract: An Efficient, Regioselective Amination of 3,5-Disubstituted Pyridine N-Oxides Using Saccharin as an Ammonium Surrogate
Farrell, Robert P., Elipe, Maria Victoria Silva, Bartberger, Michael D., Tedrow, Jason S., Vounatsos, Filisaty
Published in ChemInform (21.05.2013)
Published in ChemInform (21.05.2013)
Get full text
Journal Article
Abstract 6258: The discovery and preclinical characterization of the potent covalent KRASG12C inhibitor UCT-001024
Rose, Tristin E., O'Boyle, Brendan M., Hilf, Justin A., Baker-Tripp, Emma L., Feng, Zhengao, Yang, Kevin, Bartberger, Michael D., Losón, Oliver C., O'Brien, Neil A., McDermott, Martina S., Kamranpour, Naeimeh, Jia, Weiping, Luo, Tong, Ayala, Raul, Glasby, John, Stoltz, Brian M., Slamon, Dennis J.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Get full text
Journal Article
Hydroxyethylamine-based inhibitors of BACE1: P-1-P-3 macrocyclization can improve potency, selectivity, and cell activity
Pennington, Lewis D., Whittington, Douglas A., Bartberger, Michael D., Jordan, Steven R., Monenschein, Holger, Nguyen, Thomas T., Yang, Bryant H., Xue, Qiufen M., Vounatsos, Filisaty, Wahl, Robert C., Chen, Kui, Wood, Stephen, Citron, Martin, Patel, Vinod F., Hitchcock, Stephen A., Zhong, Wenge
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Get full text
Journal Article
Insertion of Helium and Molecular Hydrogen Through the Orifice of an Open Fullerene This work was supported by grants from the National Science Foundation
Rubin, Yves, Jarrosson, Thibaut, Wang, Guan-Wu, Bartberger, Michael D., Houk, K. N., Schick, Georg, Saunders, Martin, Cross, R. James
Published in Angewandte Chemie International Edition (17.04.2001)
Get full text
Published in Angewandte Chemie International Edition (17.04.2001)
Journal Article
Enantioselective synthesis of highly oxygenated acyclic quaternary center-containing building blocks palladium-catalyzed decarboxylative allylic alkylation of cyclic siloxyketones
Ngamnithiporn, Aurapat, Iwayama, Toshihiko, Bartberger, Michael D, Stoltz, Brian M
Published in Chemical science (Cambridge) (21.10.2020)
Published in Chemical science (Cambridge) (21.10.2020)
Get full text
Journal Article
Iridium-catalyzed asymmetric -selective hydrogenation of 1,3-disubstituted isoquinolines
Kim, Alexia N, Ngamnithiporn, Aurapat, Bartberger, Michael D, Stoltz, Brian M
Published in Chemical science (Cambridge) (16.03.2022)
Published in Chemical science (Cambridge) (16.03.2022)
Get full text
Journal Article