Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING
Siu, Tony, Altman, Michael D, Baltus, Gretchen A, Childers, Matthew, Ellis, J. Michael, Gunaydin, Hakan, Hatch, Harold, Ho, Thu, Jewell, James, Lacey, Brian M, Lesburg, Charles A, Pan, Bo-Sheng, Sauvagnat, Berengere, Schroeder, Gottfried K, Xu, Serena
Published in ACS medicinal chemistry letters (10.01.2019)
Published in ACS medicinal chemistry letters (10.01.2019)
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Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance
NALAM, Madhavi N. L, ALI, Akbar, RANA, Tariq M, SCHIFFER, Celia A, ALTMAN, Michael D, KIRAN KUMAR REDDY, G. S, CHELLAPPAN, Sripriya, KAIRYS, Visvaldas, ZEN, Ayşegül Ö, HONG CAO, GILSON, Michael K, TIDOR, Bruce
Published in Journal of Virology (01.05.2010)
Published in Journal of Virology (01.05.2010)
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Journal Article
Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications
Lim, Jongwon, Altman, Michael D., Baker, James, Brubaker, Jason D., Chen, Hongmin, Chen, Yiping, Kleinschek, Melanie A., Li, Chaomin, Liu, Duan, Maclean, John K.F., Mulrooney, Erin F., Presland, Jeremy, Rakhilina, Larissa, Smith, Graham F., Yang, Ruojing
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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Journal Article
An orally available non-nucleotide STING agonist with antitumor activity
Pan, Bo-Sheng, Perera, Samanthi A, Piesvaux, Jennifer A, Presland, Jeremy P, Schroeder, Gottfried K, Cumming, Jared N, Trotter, B Wesley, Altman, Michael D, Buevich, Alexei V, Cash, Brandon, Cemerski, Saso, Chang, Wonsuk, Chen, Yiping, Dandliker, Peter J, Feng, Guo, Haidle, Andrew, Henderson, Timothy, Jewell, James, Kariv, Ilona, Knemeyer, Ian, Kopinja, Johnny, Lacey, Brian M, Laskey, Jason, Lesburg, Charles A, Liang, Rui, Long, Brian J, Lu, Min, Ma, Yanhong, Minnihan, Ellen C, O'Donnell, Greg, Otte, Ryan, Price, Laura, Rakhilina, Larissa, Sauvagnat, Berengere, Sharma, Sharad, Tyagarajan, Sriram, Woo, Hyun, Wyss, Daniel F, Xu, Serena, Bennett, David Jonathan, Addona, George H
Published in Science (American Association for the Advancement of Science) (21.08.2020)
Published in Science (American Association for the Advancement of Science) (21.08.2020)
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Journal Article
Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context
Severyn, Bryan, Nguyen, Thi, Altman, Michael D., Li, Lixia, Nagashima, Kumiko, Naumov, George N., Sathyanarayanan, Sriram, Cook, Erica, Morris, Erick, Ferrer, Marc, Arthur, Bill, Benita, Yair, Watters, Jim, Loboda, Andrey, Hermes, Jeff, Gilliland, D. Gary, Cleary, Michelle A., Carroll, Pamela M., Strack, Peter, Tudor, Matt, Andersen, Jannik N.
Published in Journal of biomolecular screening (01.10.2016)
Published in Journal of biomolecular screening (01.10.2016)
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Journal Article
The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: Hit to lead
Siu, Tony, Kozina, Ekaterina S., Jung, Joon, Rosenstein, Craig, Mathur, Anjili, Altman, Michael D., Chan, Grace, Xu, Lin, Bachman, Eric, Mo, Jan-Rung, Bouthillette, Melaney, Rush, Thomas, Dinsmore, Christopher J., Marshall, C. Gary, Young, Jonathan R.
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Journal Article
Strategy for Extending Half-life in Drug Design and Its Significance
Gunaydin, Hakan, Altman, Michael D, Ellis, J. Michael, Fuller, Peter, Johnson, Scott A, Lahue, Brian, Lapointe, Blair
Published in ACS medicinal chemistry letters (14.06.2018)
Published in ACS medicinal chemistry letters (14.06.2018)
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Journal Article
Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity
Kawamura, Shuhei, Palte, Rachel L., Kim, Hai-Young, Saurí, Josep, Sondey, Christopher, Mansueto, My S., Altman, Michael D., Machacek, Michelle R.
Published in Bioorganic & medicinal chemistry (15.07.2022)
Published in Bioorganic & medicinal chemistry (15.07.2022)
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Journal Article
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer
Chang, Wonsuk, Altman, Michael D, Lesburg, Charles A, Perera, Samanthi A, Piesvaux, Jennifer A, Schroeder, Gottfried K, Wyss, Daniel F, Cemerski, Saso, Chen, Yiping, DiNunzio, Edward, Haidle, Andrew M, Ho, Thu, Kariv, Ilona, Knemeyer, Ian, Kopinja, Johnny E, Lacey, Brian M, Laskey, Jason, Lim, Jongwon, Long, Brian J, Ma, Yanhong, Maddess, Matthew L, Pan, Bo-Sheng, Presland, Jeremy P, Spooner, Edward, Steinhuebel, Dietrich, Truong, Quang, Zhang, Zhibo, Fu, Jianmin, Addona, George H, Northrup, Alan B, Parmee, Emma, Tata, James R, Bennett, David Jonathan, Cumming, Jared N, Siu, Tony, Trotter, B. Wesley
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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Journal Article
Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction
Reutershan, Michael H, Machacek, Michelle R, Altman, Michael D, Bogen, Stephane, Cai, Mingmei, Cammarano, Carolyn, Chen, Dapeng, Christopher, Matthew, Cryan, John, Daublain, Pierre, Fradera, Xavier, Geda, Prasanthi, Goldenblatt, Peter, Hill, Armetta D, Kemper, Raymond A, Kutilek, Victoria, Li, Chaomin, Martinez, Michelle, McCoy, Mark, Nair, Latha, Pan, Weidong, Thompson, Christopher F, Scapin, Giovanna, Shizuka, Manami, Spatz, Marianne L, Steinhuebel, Dietrich, Sun, Binyuan, Voss, Matthew E, Wang, Xiao, Yang, Liping, Yeh, Tammie C, Dussault, Isabelle, Marshall, C. Gary, Trotter, B. Wesley
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
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Journal Article
Accurate solution of multi-region continuum biomolecule electrostatic problems using the linearized Poisson-Boltzmann equation with curved boundary elements
Altman, Michael D, Bardhan, Jaydeep P, White, Jacob K, Tidor, Bruce
Published in Journal of computational chemistry (15.01.2009)
Published in Journal of computational chemistry (15.01.2009)
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Journal Article
Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer
Simov, Vladimir, Altman, Michael D., Bianchi, Elisabetta, DelRizzo, Sonia, DiNunzio, Edward N., Feng, Guo, Goldenblatt, Peter, Ingenito, Raffaele, Johnson, Scott A., Mansueto, My Sam, Mayhood, Todd, Mortison, Jonathan D., Serebrov, Victor, Sondey, Christopher, Sriraman, Venkat, Tucker, Thomas J., Walji, Abbas, Wan, Hui, Yue, Yingzi, Stoeck, Alexander, DiMauro, Erin F.
Published in European journal of medicinal chemistry (15.11.2021)
Published in European journal of medicinal chemistry (15.11.2021)
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Journal Article
Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)
Palte, Rachel L, Schneider, Sebastian E, Altman, Michael D, Hayes, Robert P, Kawamura, Shuhei, Lacey, Brian M, Mansueto, My Sam, Reutershan, Michael, Siliphaivanh, Phieng, Sondey, Christopher, Xu, Haiyan, Xu, Zangwei, Ye, Yingchun, Machacek, Michelle R
Published in ACS medicinal chemistry letters (10.09.2020)
Published in ACS medicinal chemistry letters (10.09.2020)
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Journal Article
Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow
Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
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Journal Article
Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators
Methot, Joey L, Zhou, Hua, McGowan, Meredeth A, Anthony, Neville John, Christopher, Matthew, Garcia, Yudith, Achab, Abdelghani, Lipford, Kathryn, Trotter, Benjamin Wesley, Altman, Michael D, Fradera, Xavier, Lesburg, Charles A, Li, Chaomin, Alves, Stephen, Chappell, Craig P, Jain, Renu, Mangado, Ruban, Pinheiro, Elaine, Williams, Sybill M. G, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vincent, McLeod, Robbie L, Lee, Hyun-Hee, Yu, Hongshi, Shah, Sanjiv, Katz, Jason D
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
Discovery of a new series of PI3K-δ inhibitors from Virtual Screening
Fradera, Xavier, Deng, Qiaolin, Achab, Abdelganhi, Garcia, Yudith, Kattar, Solomon D., McGowan, Meredeth A., Methot, Joey L., Wilson, Kevin, Zhou, Hua, Shaffer, Lynsey, Goldenblatt, Peter, Tong, Vincent, Augustin, Martin A, Altman, Michael D., Lesburg, Charles A., Shah, Sanjiv, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
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Journal Article
Analyzing the Potential Root Causes of Variability of Pharmacokinetics in Preclinical Species
Daublain, Pierre, Feng, Kung-I, Altman, Michael D, Martin, Iain, Mukherjee, Suman, Nofsinger, Rebecca, Northrup, Alan B, Tschirret-Guth, Richard, Cartwright, Mark, McGregor, Caroline
Published in Molecular pharmaceutics (01.05.2017)
Published in Molecular pharmaceutics (01.05.2017)
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Journal Article
Corrigendum to “Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow” [Bioorg. Med. Chem. Lett. 29 (2019) 2575–2580]
Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
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Journal Article
Discovery of 1-Amino-5H-pyrido[4,3-b]indol-4-carboxamide Inhibitors of Janus Kinase 2 (JAK2) for the Treatment of Myeloproliferative Disorders
Lim, Jongwon, Taoka, Brandon, Otte, Ryan D, Spencer, Kerrie, Dinsmore, Christopher J, Altman, Michael D, Chan, Grace, Rosenstein, Craig, Sharma, Sujata, Su, Hua-Poo, Szewczak, Alexander A, Xu, Lin, Yin, Hong, Zugay-Murphy, Joan, Marshall, C. Gary, Young, Jonathan R
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Journal Article
Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections
Loughran, H. Marie, Schirripa, Kathy M., Roecker, Anthony J., Breslin, Michael J., Tong, Ling, Fillgrove, Kerry L., Kuo, Yuhsin, Bleasby, Kelly, Collier, Hannah, Altman, Michael D., Ford, Melissa C., Newman, Justin A., Drolet, Robert E., Cosden, Mali, Jinn, Sarah, Flick, Rosemarie B., Liu, Xiaomei, Minnick, Christina, Watt, Marla L., Lemaire, Wei, Burlein, Christine, Adam, Gregory C., Austin, Lauren A., Marcus, Jacob N., Smith, Sean M., Fraley, Mark E.
Published in ACS medicinal chemistry letters (11.01.2024)
Published in ACS medicinal chemistry letters (11.01.2024)
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