Collecting antibodies and large molecule biomarkers in mouse interstitial brain fluid: a comparison of microdialysis and cerebral open flow microperfusion
Le Prieult, Florie, Barini, Erica, Laplanche, Loic, Schlegel, Kerstin, Mezler, Mario
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Journal Article
Novel Developments to Enable Treatment of CNS Diseases with Targeted Drug Delivery
Meyer, Axel H, Feldsien, Thomas M, Mezler, Mario, Untucht, Christopher, Venugopalan, Ramakrishna, Lefebvre, Didier R
Published in Pharmaceutics (29.03.2023)
Published in Pharmaceutics (29.03.2023)
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Journal Article
Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media
Ye, Dong, López Mármol, Álvaro, Lenz, Verena, Muschong, Patricia, Wilhelm-Alkubaisi, Anita, Weinheimer, Manuel, Koziolek, Mirko, Sauer, Kerstin A, Laplanche, Loic, Mezler, Mario
Published in Pharmaceutics (24.03.2022)
Published in Pharmaceutics (24.03.2022)
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Journal Article
Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats
Nikiforuk, Agnieszka, Popik, Piotr, Drescher, Karla U, van Gaalen, Marcel, Relo, Ana-Lucia, Mezler, Mario, Marek, Gerard, Schoemaker, Hans, Gross, Gerhard, Bespalov, Anton
Published in The Journal of pharmacology and experimental therapeutics (01.12.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2010)
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Journal Article
Challenges in Permeability Assessment for Oral Drug Product Development
Koziolek, Mirko, Augustijns, Patrick, Berger, Constantin, Cristofoletti, Rodrigo, Dahlgren, David, Keemink, Janneke, Matsson, Pär, McCartney, Fiona, Metzger, Marco, Mezler, Mario, Niessen, Janis, Polli, James E, Vertzoni, Maria, Weitschies, Werner, Dressman, Jennifer
Published in Pharmaceutics (28.09.2023)
Published in Pharmaceutics (28.09.2023)
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Journal Article
Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model
Dallas, Shannon, Salphati, Laurent, Gomez-Zepeda, David, Wanek, Thomas, Chen, Liangfu, Chu, Xiaoyan, Kunta, Jeevan, Mezler, Mario, Menet, Marie-Claude, Chasseigneaux, Stephanie, Declèves, Xavier, Langer, Oliver, Pierre, Esaie, DiLoreto, Karen, Hoft, Carolin, Laplanche, Loic, Pang, Jodie, Pereira, Tony, Andonian, Clara, Simic, Damir, Rode, Anja, Yabut, Jocelyn, Zhang, Xiaolin, Scheer, Nico
Published in Molecular pharmacology (01.05.2016)
Published in Molecular pharmacology (01.05.2016)
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Journal Article
Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins
Salphati, Laurent, Chu, Xiaoyan, Chen, Liangfu, Prasad, Bhagwat, Dallas, Shannon, Evers, Raymond, Mamaril-Fishman, Donna, Geier, Ethan G, Kehler, Jonathan, Kunta, Jeevan, Mezler, Mario, Laplanche, Loic, Pang, Jodie, Rode, Anja, Soars, Matthew G, Unadkat, Jashvant D, van Waterschoot, Robert A B, Yabut, Jocelyn, Schinkel, Alfred H, Scheer, Nico
Published in Drug metabolism and disposition (01.08.2014)
Published in Drug metabolism and disposition (01.08.2014)
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Journal Article
Awake rat pharmacological magnetic resonance imaging as a translational pharmacodynamic biomarker: metabotropic glutamate 2/3 agonist modulation of ketamine-induced blood oxygenation level dependence signals
Chin, Chih-Liang, Upadhyay, Jaymin, Marek, Gerard J, Baker, Scott J, Zhang, Min, Mezler, Mario, Fox, Gerard B, Day, Mark
Published in The Journal of pharmacology and experimental therapeutics (01.03.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2011)
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Journal Article
Inhibitors of GlyT1 Affect Glycine Transport via Discrete Binding Sites
Mezler, Mario, Hornberger, Wilfried, Mueller, Reinhold, Schmidt, Martin, Amberg, Martin Schmidt Willi, Amberg, Willi, Braje, Wilfried, Ochse, Michael, Schoemaker, Hans, Behl, Berthold
Published in Molecular pharmacology (01.12.2008)
Published in Molecular pharmacology (01.12.2008)
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Journal Article
Cloning and functional expression of GABAB receptors from Drosophila
Mezler, Mario, Müller, Thomas, Raming, Klaus
Published in The European journal of neuroscience (01.02.2001)
Published in The European journal of neuroscience (01.02.2001)
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Journal Article
Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression
Bespalov, Anton Y., van Gaalen, Marcel M., Sukhotina, Irina A., Wicke, Karsten, Mezler, Mario, Schoemaker, Hans, Gross, Gerhard
Published in European journal of pharmacology (11.09.2008)
Published in European journal of pharmacology (11.09.2008)
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Journal Article
Establishment of a secondary screening assay for P/Q-type calcium channel blockers
Hermann, David, Mezler, Mario, Swensen, Andrew M, Bruehl, Claus, Obergrußerger, Ali, Wicke, Karsten, Schoemaker, Hans, Gross, Gerhard, Draguhn, Andreas, Nimmrich, Volker
Published in Combinatorial chemistry & high throughput screening (01.03.2013)
Published in Combinatorial chemistry & high throughput screening (01.03.2013)
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Journal Article
Development and validation of a fluorescence-based HTS assay for the identification of P/Q-type calcium channel blockers
Mezler, Mario, Hermann, David, Swensen, Andrew M, Draguhn, Andreas, Terstappen, Georg C, Gross, Gerhard, Schoemaker, Hans, Freiberg, Gail, Pratt, Steve, Gopalakrishnan, Sujatha M, Nimmrich, Volker
Published in Combinatorial chemistry & high throughput screening (01.06.2012)
Published in Combinatorial chemistry & high throughput screening (01.06.2012)
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Journal Article
Identification and characterization of mGlu3 ligands using a high throughput FLIPR assay for detection of agonists, antagonists, and allosteric modulators
Pratt, Steven D, Mezler, Mario, Geneste, Hervé, Bakker, Margot H M, Hajduk, Philip J, Gopalakrishnan, Sujatha M
Published in Combinatorial chemistry & high throughput screening (01.08.2011)
Published in Combinatorial chemistry & high throughput screening (01.08.2011)
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Journal Article
Correction: Improvement of Workfows and Assay Reproducibility by The Introduction of “Assay-Ready” Culturing of MDCK Cells for Transport Studie
Muschong, Patricia, Jin, Liang, Schejbal, Jan, Mezler, Mario, Weinheimer, Manuel
Published in Pharmaceutical research (01.06.2023)
Published in Pharmaceutical research (01.06.2023)
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Journal Article
Depletion of microglia with CSF1R inhibitor prevents tau aggregation in the mouse model Thy1P301S
Lombardo, Sylvia, Stanek, Agathe, Wuest, Carolin, Reich, Thomas, Secker, Philipp, Sefrin, Julian, Biber, Knut, Mezler, Mario, Klein, Corinna
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Journal Article