Parvalbumin Corrects Slowed Relaxation in Adult Cardiac Myocytes Expressing Hypertrophic Cardiomyopathy-Linked α-Tropomyosin Mutations
Coutu, Pierre, Bennett, Christina N, Favre, Elizabeth G, Day, Sharlene M, Metzger, Joseph M
Published in Circulation research (14.05.2004)
Published in Circulation research (14.05.2004)
Get full text
Journal Article
Discovery of Benzodiazepine Sulfonamide-Based Bombesin Receptor Subtype 3 Agonists and Their Unusual Chirality
Liu, Ping, Lanza, Thomas J, Chioda, Marc, Jones, Carrie, Chobanian, Harry R, Guo, Yan, Chang, Linda, Kelly, Theresa M, Kan, Yanqing, Palyha, Oksana, Guan, Xiao-Ming, Marsh, Donald J, Metzger, Joseph M, Ramsay, Katie, Wang, Sheng-Ping, Strack, Alison M, Miller, Randy, Pang, Jianmei, Lyons, Kathy, Dragovic, Jasminka, Ning, Jian G, Schafer, Wes A, Welch, Christopher J, Gong, Xiaoyi, Gao, Ying-Duo, Hornak, Viktor, Ball, Richard G, Tsou, Nancy, Reitman, Marc L, Wyvratt, Matthew J, Nargund, Ravi P, Lin, Linus S
Published in ACS medicinal chemistry letters (08.12.2011)
Published in ACS medicinal chemistry letters (08.12.2011)
Get full text
Journal Article
Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
Hadden, Mark, Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Henderson, Alan J., Pattamana, Kevin, Ruenz, Megan, Sargent, Bruce J., Swenson, Brian, Yet, Larry, Liu, Jian, He, Shuwen, Sebhat, Iyassu K., Lin, Linus S., Tamvakopoulos, Constantin, Peng, Qianping, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiao-Ming, Metzger, Joseph M., Reitman, Marc L., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Get full text
Journal Article
Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]-[2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists
CHENG GUO, GUZZO, Peter R, GAGEN, Karen, METZGER, Joseph M, DRAGOVIC, Jasminka, LYONS, Kathryn, LIN, Linus S, NARGUND, Ravi P, HADDEN, Mark, SARGENT, Bruce J, YET, Larry, YANQING KAN, PALYHA, Oksana, KELLY, Theresa M, XIAOMING GUAN, ROSKO, Kim
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Get full text
Journal Article
Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
Liu, Jian, He, Shuwen, Jian, Tianying, Dobbelaar, Peter H., Sebhat, Iyassu K., Lin, Linus S., Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Henderson, Alan J., Pattamana, Kevin, Ruenz, Megan, Sargent, Bruce J, Swenson, Brian, Yet, Larry, Tamvakopoulos, Constantin, Peng, Qianping, Pan, Jie, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiao-Ming, Howard, Andrew D., Marsh, Donald J., Metzger, Joseph M., Reitman, Marc L., Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Get full text
Journal Article
Gene transfer of human cardiomyopathy β-MyHC mutant R403Q directly alters intact cardiac myocyte calcium homeostasis and causes hyper-contractility
Herron, Todd J, Devaney, Eric, Guerrero-Serna, Guadalupe, Mundada, Lakshmi, Metzger, Joseph M
Published in bioRxiv (31.07.2024)
Published in bioRxiv (31.07.2024)
Get full text
Journal Article
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists
He, Shuwen, Dobbelaar, Peter H., Liu, Jian, Jian, Tianying, Sebhat, Iyassu K., Lin, Linus S., Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Henderson, Alan J., Ruenz, Megan, Sargent, Bruce J., Yet, Larry, Kelly, Theresa M., Palyha, Oksana, Kan, Yanqing, Pan, Jie, Chen, Howard, Marsh, Donald J., Shearman, Lauren P., Strack, Alison M., Metzger, Joseph M., Feighner, Scott D., Tan, Carina, Howard, Andrew D., Tamvakopoulos, Constantin, Peng, Qianping, Guan, Xiao-Ming, Reitman, Marc L., Patchett, Arthur A., Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Get full text
Journal Article
Skeletal Troponin C Reduces Contractile Sensitivity to Acidosis in Cardiac Myocytes from Transgenic Mice
METZGER, J. M, PARMACEK, M. S, BARR, E, PASYK, K, WAN-IN LIN, COCHRANE, K. L, FIELD, L. J, LEIDEN, J. M
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.1993)
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.1993)
Get full text
Journal Article
Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR
Finke, Paul E., Meurer, Laura C., Levorse, Dorothy A., Mills, Sander G., MacCoss, Malcolm, Sadowski, Sharon, Cascieri, Margaret A., Tsao, Kwei-Lan, Chicchi, Gary G., Metzger, Joseph M., MacIntyre, D. Euan
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Get full text
Journal Article
Cardiac Dysfunction in Hypertrophic Cardiomyopathy Mutant Tropomyosin Mice Is Transgene-Dependent, Hypertrophy-Independent, and Improved by β-Blockade
Michele, Daniel E, Gomez, Carlen A, Hong, Katie E, Westfall, Margaret V, Metzger, Joseph M
Published in Circulation research (09.08.2002)
Published in Circulation research (09.08.2002)
Get full text
Journal Article
Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
CHEN, A. S, METZGER, J. M, CAMACHO, R. E, STRACK, A. M, MELLIN, T. N, MACINTYRE, D. E, CHEN, H. Y, VAN DER PLOEG, L. H. T, TRUMBAUER, M. E, GUAN, X.-M, HONG YU, FRAZIER, E. G, MARSH, D. J, FORREST, M. J, GOPAL-TRUTER, S, FISHER, J
Published in Transgenic research (01.04.2000)
Published in Transgenic research (01.04.2000)
Get full text
Journal Article
Myofilament Calcium Sensitivity and Cardiac Disease: Insights From Troponin I Isoforms and Mutants
Westfall, Margaret V, Borton, Andrea R, Albayya, Faris P, Metzger, Joseph M
Published in Circulation research (20.09.2002)
Published in Circulation research (20.09.2002)
Get full text
Journal Article
The μ-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist
Zhang, Jiaping, Frassetto, Andrea, Huang, Ruey-Ruey C., Lao, Julie Z., Pasternak, Alexander, Wang, Sheng-ping, Metzger, Joseph M., Strack, Alison M., Fong, Tung M., Chen, Richard Z.
Published in European journal of pharmacology (18.09.2006)
Published in European journal of pharmacology (18.09.2006)
Get full text
Journal Article
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands
Hong, Qingmei, Bakshi, Raman K., Dellureficio, James, He, Shuwen, Ye, Zhixiong, Dobbelaar, Peter H., Sebhat, Iyassu K., Guo, Liangqin, Liu, Jian, Jian, Tianying, Tang, Rui, Kalyani, Rubana N., MacNeil, Tanya, Vongs, Aurawan, Rosenblum, Charles I., Weinberg, David H., Peng, Qingping, Tamvakopoulos, Constantin, Miller, Randy R., Stearns, Ralph A., Cashen, Doreen, Martin, Willian J., Chen, Airu S., Metzger, Joseph M., Chen, Howard Y., Strack, Allison M., Fong, Tung M., Maclntyre, Euan, Van der Ploeg, Lex H.T., Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Get full text
Journal Article
Parvalbumin gene delivery improves diastolic function in the aged myocardium in vivo
Michele, Daniel E, Szatkowski, Michael L, Albayya, Faris P, Metzger, Joseph M
Published in Molecular therapy (01.08.2004)
Published in Molecular therapy (01.08.2004)
Get full text
Journal Article