GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease
Oksenberg, Donna, Dufu, Kobina, Patel, Mira P., Chuang, Chihyuan, Li, Zhe, Xu, Qing, Silva‐Garcia, Abel, Zhou, Chengjing, Hutchaleelaha, Athiwat, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C., Sinha, Uma, Metcalf, Brian W., Archer, David R.
Published in British journal of haematology (01.10.2016)
Published in British journal of haematology (01.10.2016)
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INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology
Yue, Eddy W, Sparks, Richard, Polam, Padmaja, Modi, Dilip, Douty, Brent, Wayland, Brian, Glass, Brian, Takvorian, Amy, Glenn, Joseph, Zhu, Wenyu, Bower, Michael, Liu, Xiangdong, Leffet, Lynn, Wang, Qian, Bowman, Kevin J, Hansbury, Michael J, Wei, Min, Li, Yanlong, Wynn, Richard, Burn, Timothy C, Koblish, Holly K, Fridman, Jordan S, Emm, Tom, Scherle, Peggy A, Metcalf, Brian, Combs, Andrew P
Published in ACS medicinal chemistry letters (11.05.2017)
Published in ACS medicinal chemistry letters (11.05.2017)
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Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050
Fridman, Jordan S, Scherle, Peggy A, Collins, Robert, Burn, Timothy C, Li, Yanlong, Li, Jun, Covington, Maryanne B, Thomas, Beth, Collier, Paul, Favata, Margaret F, Wen, Xiaoming, Shi, Jack, McGee, Ryan, Haley, Patrick J, Shepard, Stacey, Rodgers, James D, Yeleswaram, Swamy, Hollis, Greg, Newton, Robert C, Metcalf, Brian, Friedman, Steven M, Vaddi, Kris
Published in The Journal of immunology (1950) (01.05.2010)
Published in The Journal of immunology (1950) (01.05.2010)
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Discovery of GBT440, an Orally Bioavailable R‑State Stabilizer of Sickle Cell Hemoglobin
Metcalf, Brian, Chuang, Chihyuan, Dufu, Kobina, Patel, Mira P, Silva-Garcia, Abel, Johnson, Carl, Lu, Qing, Partridge, James R, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C, Jacobson, Matthew P, Hua, Lan, Xu, Qing, Gwaltney, Stephen L, Yee, Calvin, Harris, Jason, Morgan, Bradley P, James, Joyce, Xu, Donghong, Hutchaleelaha, Athiwat, Paulvannan, Kumar, Oksenberg, Donna, Li, Zhe
Published in ACS medicinal chemistry letters (09.03.2017)
Published in ACS medicinal chemistry letters (09.03.2017)
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Enantioselective Synthesis of Janus Kinase Inhibitor INCB018424 via an Organocatalytic Aza-Michael Reaction
Lin, Qiyan, Meloni, David, Pan, Yongchun, Xia, Michael, Rodgers, James, Shepard, Stacey, Li, Mei, Galya, Laurine, Metcalf, Brian, Yue, Tai-Yuen, Liu, Pingli, Zhou, Jiacheng
Published in Organic letters (07.05.2009)
Published in Organic letters (07.05.2009)
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Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation
Fridman, Jordan S., Scherle, Peggy A., Collins, Robert, Burn, Timothy, Neilan, Claire L., Hertel, Denise, Contel, Nancy, Haley, Patrick, Thomas, Beth, Shi, Jack, Collier, Paul, Rodgers, James D., Shepard, Stacey, Metcalf, Brian, Hollis, Gregory, Newton, Robert C., Yeleswaram, Swamy, Friedman, Steven M., Vaddi, Kris
Published in Journal of investigative dermatology (01.09.2011)
Published in Journal of investigative dermatology (01.09.2011)
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Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells
Liu, Phillip C.C., Liu, Xiangdong, Li, Yanlong, Covington, Maryanne, Wynn, Richard, Huber, Reid, Hillman, Milton, Yang, Gengjie, Ellis, Dawn, Marando, Cindy, Katiyar, Kamna, Bradley, Jodi, Abremski, Kenneth, Stow, Mark, Rupar, Mark, Zhuo, Jincong, Li, Yun-Long, Lin, Qiyan, Burns, David, Xu, Meizhong, Zhang, Colin, Qian, Ding-Quan, He, Chunhong, Sharief, Vaqar, Weng, Lingkai, Agrios, Costas, Shi, Eric, Metcalf, Brian, Newton, Robert, Friedman, Steven, Yao, Wenqing, Scherle, Peggy A., Hollis, Gregory, Burn, Timothy C.
Published in Cancer biology & therapy (01.06.2006)
Published in Cancer biology & therapy (01.06.2006)
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Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist
Zheng, Changsheng, Cao, Ganfeng, Xia, Michael, Feng, Hao, Glenn, Joseph, Anand, Rajan, Zhang, Ke, Huang, Taisheng, Wang, Anlai, Kong, Ling, Li, Mei, Galya, Laurine, Hughes, Robert O., Devraj, Rajesh, Morton, Phillip A., Rogier, D. Joseph, Covington, Maryanne, Baribaud, Fred, Shin, Niu, Scherle, Peggy, Diamond, Sharon, Yeleswaram, Swamy, Vaddi, Kris, Newton, Robert, Hollis, Greg, Friedman, Steven, Metcalf, Brian, Xue, Chu-Biao
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist
Xue, Chu-Biao, Feng, Hao, Cao, Ganfeng, Huang, Taisheng, Glenn, Joseph, Anand, Rajan, Meloni, David, Zhang, Ke, Kong, Lingquan, Wang, Anlai, Zhang, Yingxin, Zheng, Changsheng, Xia, Michael, Chen, Lihua, Tanaka, Hiroyuki, Han, Qi, Robinson, D. J, Modi, Dilip, Storace, Lou, Shao, Lixin, Sharief, Vaqar, Li, Mei, Galya, Laurine G, Covington, Maryanne, Scherle, Peggy, Diamond, Sharon, Emm, Tom, Yeleswaram, Swamy, Contel, Nancy, Vaddi, Kris, Newton, Robert, Hollis, Greg, Friedman, Steven, Metcalf, Brian
Published in ACS medicinal chemistry letters (09.06.2011)
Published in ACS medicinal chemistry letters (09.06.2011)
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Discovery of a Potent, Selective, and Orally Active Human Epidermal Growth Factor Receptor-2 Sheddase Inhibitor for the Treatment of Cancer
Yao, Wenqing, Zhuo, Jincong, Burns, David M, Xu, Meizhong, Zhang, Colin, Li, Yun-Long, Qian, Ding-Quan, He, Chunhong, Weng, Lingkai, Shi, Eric, Lin, Qiyan, Agrios, Costas, Burn, Timothy C, Caulder, Eian, Covington, Maryanne B, Fridman, Jordan S, Friedman, Steven, Katiyar, Kamna, Hollis, Gregory, Li, Yanlong, Liu, Changnian, Liu, Xiangdong, Marando, Cindy A, Newton, Robert, Pan, Max, Scherle, Peggy, Taylor, Nancy, Vaddi, Kris, Wasserman, Zelda R, Wynn, Richard, Yeleswaram, Swamy, Jalluri, Ravi, Bower, Michael, Zhou, Bing-Bing, Metcalf, Brian
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (ID01) Inhibitor for Immunooncology
Yue, Eddy W., Sparks, Richard, Polam, Padmaja, Modi, Dilip, Douty, Brent, Wayland, Brian, Glass, Brian, Takvorian, Amy, Glenn, Joseph, Zhu, Wenyu, Bower, Michael, Liu, Xiangdong, Leffet, Lynn, Wang, Qian, Bowman, Kevin J., Hansbury, Michael J., Wei, Min, Li, Yanlong, Wynn, Richard, Burn, Timothy C., Koblish, Holly K., Fridman, Jordan S., Emm, Tom, Scherle, Peggy A., Metcalf, Brian, Combs, Andrew P.
Published in ACS medicinal chemistry letters (01.05.2017)
Published in ACS medicinal chemistry letters (01.05.2017)
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iGeneration And Their Acceptance of Technology
Linnes, Cathrine, Metcalf, Brian
Published in International journal of management & information systems (01.12.2017)
Published in International journal of management & information systems (01.12.2017)
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Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues
Meek, Thomas D, Lambert, Dennis M, Dreyer, Geoffrey B, Carr, Thomas J, Tomaszek, Thaddeus A, Moore, Michael L, Strickler, James E, Debouck, Christine, Hyland, Lawrence J, Matthews, Thomas J, Metcalf, Brian W, Petteway, Stephen R
Published in Nature (London) (04.01.1990)
Published in Nature (London) (04.01.1990)
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GBT440 Demonstrates High Specificity for Red Blood Cells in Nonclinical Species
Hutchaleelaha, Athiwat, Patel, Mira, Silva, Abel, Oksenberg, Donna, Metcalf, Brian
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Discovery of a novel 2-spiroproline steroid mimetic scaffold for the potent inhibition of 1113-HSD1
Burns, David M., He, Chunhong, Li, Yun-Long, Zhuo, Jincong, Qian, Ding-Quan, Chen, Lihua, Jalluri, Ravi, Diamond, Sharon, Covington, Maryanne B., Li, Yanlong, Wynn, Richard, Scherle, Peggy, Yeleswaram, Swamy, Hollis, Gregory, Friedman, Steve, Metcalf, Brian, Yao, Wenqing
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
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Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy
Shin, Niu, Stubbs, Matthew, Koblish, Holly, Yue, Eddy W., Soloviev, Maxim, Douty, Brent, Wang, Kathy He, Wang, Qian, Gao, Mingming, Feldman, Patricia, Yang, Gengjie, Hall, Leslie, Hansbury, Michael, O’Connor, Sybil, Leffet, Lynn, Collins, Robert, Katiyar, Kamna, He, Xin, Waeltz, Paul, Collier, Paul, Lu, Jin, Li, Yun-Long, Li, Yanlong, Liu, Phillip C.C., Burn, Timothy, Covington, Maryanne, Diamond, Sharon, Shuey, Dana, Roberts, Alan, Yeleswaram, Swamy, Hollis, Greg, Metcalf, Brian, Yao, Wenqing, Huber, Reid, Combs, Andrew, Newton, Robert, Scherle, Peggy
Published in The Journal of pharmacology and experimental therapeutics (01.07.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2020)
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Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition
Partridge, James R., Choy, Rebeca M., Silva-Garcia, Abel, Yu, Chul, Li, Zhe, Sham, Hing, Metcalf, Brian
Published in Journal of structural biology (01.05.2019)
Published in Journal of structural biology (01.05.2019)
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