Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease
Meredith, Jr, Jere E, Sankaranarayanan, Sethu, Guss, Valerie, Lanzetti, Anthony J, Berisha, Flora, Neely, Robert J, Slemmon, J Randall, Portelius, Erik, Zetterberg, Henrik, Blennow, Kaj, Soares, Holly, Ahlijanian, Michael, Albright, Charles F
Published in PloS one (07.10.2013)
Published in PloS one (07.10.2013)
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Journal Article
Pharmacodynamics of selective inhibition of γ-secretase by avagacestat
Albright, Charles F, Dockens, Randy C, Meredith, Jr, Jere E, Olson, Richard E, Slemmon, Randy, Lentz, Kimberley A, Wang, Jun-Sheng, Denton, R Rex, Pilcher, Gary, Rhyne, Paul W, Raybon, Joseph J, Barten, Donna M, Burton, Catherine, Toyn, Jeremy H, Sankaranarayanan, Sethu, Polson, Craig, Guss, Valerie, White, Randy, Simutis, Frank, Sanderson, Thomas, Gillman, Kevin W, Starrett, Jr, John E, Bronson, Joanne, Sverdlov, Oleksandr, Huang, Shu-Pang, Castaneda, Lorna, Feldman, Howard, Coric, Vlad, Zaczek, Robert, Macor, John E, Houston, John, Berman, Robert M, Tong, Gary
Published in The Journal of pharmacology and experimental therapeutics (01.03.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2013)
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Journal Article
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects
Toyn, Jeremy H, Boy, Kenneth M, Raybon, Joseph, Meredith, Jr, Jere E, Robertson, Alan S, Guss, Valerie, Hoque, Nina, Sweeney, Francis, Zhuo, Xiaoliang, Clarke, Wendy, Snow, Kimberly, Denton, R Rex, Zuev, Dmitry, Thompson, Lorin A, Morrison, John, Grace, James, Berisha, Flora, Furlong, Michael, Wang, Jun-Sheng, Lentz, Kimberly A, Padmanabha, Ramesh, Cook, Lynda, Wei, Cong, Drexler, Dieter M, Macor, John E, Albright, Charlie F, Gasior, Maciej, Olson, Richard E, Hong, Quan, Soares, Holly D, AbuTarif, Malaz, Ahlijanian, Michael K
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
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Journal Article
Synergistic inhibition of Aβ production by combinations of γ-secretase modulators
Robertson, Alan S., Iben, Lawrence G., Wei, Cong, Meredith, Jere E., Drexler, Dieter M., Banks, Martyn, Vite, Gregory D., Olson, Richard E., Thompson, Lorin A., Albright, Charles F., Ahlijanian, Michael K., Toyn, Jeremy H.
Published in European journal of pharmacology (05.10.2017)
Published in European journal of pharmacology (05.10.2017)
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Journal Article
Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis
Gerritz, Samuel W, Zhai, Weixu, Shi, Shuhao, Zhu, Shirong, Toyn, Jeremy H, Meredith, Jere E, Iben, Lawrence G, Burton, Catherine R, Albright, Charles F, Good, Andrew C, Tebben, Andrew J, Muckelbauer, Jodi K, Camac, Daniel M, Metzler, William, Cook, Lynda S, Padmanabha, Ramesh, Lentz, Kimberley A, Sofia, Michael J, Poss, Michael A, Macor, John E, Thompson, Lorin A
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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Journal Article
Stable isotope labeling by amino acids in cell culture-based liquid chromatography–mass spectrometry assay to measure microtubule dynamics in neuronal cell cultures
Polson, Craig, Cantone, Joseph L., Wei, Cong, Drexler, Dieter M., Meredith, Jere E.
Published in Analytical biochemistry (01.12.2014)
Published in Analytical biochemistry (01.12.2014)
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Journal Article
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor
Gillman, Kevin W, Starrett, John E, Parker, Michael F, Xie, Kai, Bronson, Joanne J, Marcin, Lawrence R, McElhone, Kate E, Bergstrom, Carl P, Mate, Robert A, Williams, Richard, Meredith, Jere E, Burton, Catherine R, Barten, Donna M, Toyn, Jeremy H, Roberts, Susan B, Lentz, Kimberley A, Houston, John G, Zaczek, Robert, Albright, Charles F, Decicco, Carl P, Macor, John E, Olson, Richard E
Published in ACS medicinal chemistry letters (10.06.2010)
Published in ACS medicinal chemistry letters (10.06.2010)
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Journal Article
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice
Meredith, Jr, Jere E, Thompson, Lorin A, Toyn, Jeremy H, Marcin, Lawrence, Barten, Donna M, Marcinkeviciene, Jovita, Kopcho, Lisa, Kim, Young, Lin, Alan, Guss, Valerie, Burton, Catherine, Iben, Lawrence, Polson, Craig, Cantone, Joe, Ford, Michael, Drexler, Dieter, Fiedler, Tracey, Lentz, Kimberley A, Grace, Jr, James E, Kolb, Janet, Corsa, Jason, Pierdomenico, Maria, Jones, Kelli, Olson, Richard E, Macor, John E, Albright, Charles F
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
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Journal Article
Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780
Toyn, Jeremy H., Thompson, Lorin A., Lentz, Kimberley A., Meredith, Jere E., Burton, Catherine R., Sankaranararyanan, Sethu, Guss, Valerie, Hall, Tracey, Iben, Lawrence G., Krause, Carol M., Krause, Rudy, Lin, Xu-Alan, Pierdomenico, Maria, Polson, Craig, Robertson, Alan S., Denton, R. Rex, Grace, James E., Morrison, John, Raybon, Joseph, Zhuo, Xiaoliang, Snow, Kimberly, Padmanabha, Ramesh, Agler, Michele, Esposito, Kim, Harden, David, Prack, Margaret, Varma, Sam, Wong, Victoria, Zhu, Yingjie, Zvyaga, Tatyana, Gerritz, Samuel, Marcin, Lawrence R., Higgins, Mendi A., Shi, Jianliang, Wei, Cong, Cantone, Joseph L., Drexler, Dieter M., Macor, John E., Olson, Richard E., Ahlijanian, Michael K., Albright, Charles F.
Published in International journal of alzheimer's disease (2014)
Published in International journal of alzheimer's disease (2014)
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Journal Article
Viable mouse gene ablations that robustly alter brain Aβ levels are rare
Toyn, Jeremy H, Lin, Xu-Alan, Thompson, Mark W, Guss, Valerie, Meredith, Jr, Jere E, Sankaranarayanan, Sethu, Barrezueta, Nestor, Corradi, John, Majumdar, Antara, Small, Daniel L, Hansard, Melissa, Lanthorn, Thomas, Westphal, Ryan S, Albright, Charles F
Published in BMC neuroscience (05.11.2010)
Published in BMC neuroscience (05.11.2010)
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Journal Article
P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid β Reduction by β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice
Jere E. Meredith, Jr, Lorin A. Thompson, Jeremy H. Toyn, Lawrence Marcin, Donna M. Barten, Jovita Marcinkeviciene, Lisa Kopcho, Young Kim, Alan Lin, Valerie Guss, Catherine Burton, Lawrence Iben, Craig Polson, Joe Cantone, Michael Ford, Dieter Drexler, Tracey Fiedler, Kimberley A. Lentz, James E. Grace, Jr, Janet Kolb, Jason Corsa, Maria Pierdomenico, Kelli Jones, Richard E. Olson, John E. Macor, Charles F. Albright
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
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Journal Article
γ-Secretase activity is not involved in presenilin-mediated regulation of β-catenin
Meredith, Jere E, Wang, Qian, Mitchell, Thomas J, Olson, Richard E, Zaczek, Robert, Stern, Andrew M, Seiffert, Dietmar
Published in Biochemical and biophysical research communications (20.12.2002)
Published in Biochemical and biophysical research communications (20.12.2002)
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Journal Article
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
Baldick, Carl J, McDonald, Ivar M, Devidze, Nino, Hagedorn, Peter, Cacace, Angela M, Jensen, Marianne Lerbech, Pendri, Annapurna, Meredith, Jr., Jere E, Olson, Richard E, Loy, James K
Year of Publication 20.09.2022
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Year of Publication 20.09.2022
Patent
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
Baldick, Carl J, McDonald, Ivar M, Devidze, Nino, Hagedorn, Peter, Cacace, Angela M, Jensen, Marianne Lerbech, Pendri, Annapurna, Meredith, Jr., Jere E, Olson, Richard E, Loy, James K
Year of Publication 14.06.2022
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Year of Publication 14.06.2022
Patent
Mutational Analysis of Cell Cycle Inhibition by Integrin β1C
Jere E. Meredith, Jr, William B. Kiosses, Yoshikazu Takada, Martin Alexander Schwartz
Published in The Journal of biological chemistry (19.03.1999)
Published in The Journal of biological chemistry (19.03.1999)
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Journal Article
ANTISENSE OLIGONUCLEOTIDES TARGETING ALPHA-SYNUCLEIN AND USES THEREOF
MEREDITH, Jr., Jere E, DEVIDZE, Nino, LOY, James K, CACACE, Angela M, MCDONALD, Ivar M, PENDRI, Annapurna, JENSEN, Marianne Lerbech, OLSON, Richard E, HAGEDORN, Peter, BALDICK, Carl J
Year of Publication 19.11.2020
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Year of Publication 19.11.2020
Patent
ANTISENSE OLIGONUCLEOTIDES TARGETING ALPHA-SYNUCLEIN AND USES THEREOF
MEREDITH, Jr., Jere E, DEVIDZE, Nino, LOY, James K, CACACE, Angela M, PENDRI, Annapurna, JENSEN, Marianne Lerbech, OLSON, Richard E, McDONALD, Ivar M, HAGEDORN, Peter, BALDICK, Carl J
Year of Publication 12.11.2020
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Year of Publication 12.11.2020
Patent
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
DEVIDZE, Nino, LOY, James K, CACACE, Angela M, MCDONALD, Ivar M, PENDRI, Annapurna, JENSEN, Marianne Lerbech, OLSON, Richard E, MEREDITH Jr., Jere E, HAGEDORN, Peter, BALDICK, Carl J
Year of Publication 23.07.2020
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Year of Publication 23.07.2020
Patent