SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis
Jacobs, Robert T, Nare, Bakela, Wring, Stephen A, Orr, Matthew D, Chen, Daitao, Sligar, Jessica M, Jenks, Matthew X, Noe, Robert A, Bowling, Tana S, Mercer, Luke T, Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J, Yarlett, Nigel, Plattner, Jacob J, Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y-K, Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Published in PLoS neglected tropical diseases (01.06.2011)
Published in PLoS neglected tropical diseases (01.06.2011)
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Journal Article
Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis
NARE, Bakela, WRING, Stephen, HUSSAIN, Ali, JARNAGIN, Kurt, JENKS, Matthew, KAISER, Marcel, MERCER, Luke, MEJIA, Elena, NOE, Andy, ORR, Matt, PARHAM, Robin, PLATTNER, Jacob, BACCHI, Cyrus, RANDOLPH, Ryan, RATTENDI, Donna, REWERTS, Cindy, SLIGAR, Jessica, YARLETT, Nigel, DON, Robert, JACOBS, Robert, BEAUDET, Beth, BOWLING, Tana, BRUN, Reto, DAITAO CHEN, DING, Charles, FREUND, Yvonne, GAUKEL, Eric
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
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Journal Article
Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis
WRING, STEPHEN, GAUKEL, ERIC, NARE, BAKELA, JACOBS, ROBERT, BEAUDET, BETH, BOWLING, TANA, MERCER, LUKE, BACCHI, CYRUS, YARLETT, NIGEL, RANDOLPH, RYAN, PARHAM, ROBIN, REWERTS, CINDY, PLATNER, JACOB, DON, ROBERT
Published in Parasitology (01.01.2014)
Published in Parasitology (01.01.2014)
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Journal Article
2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach
Mercer, Luke, Bowling, Tana, Perales, Joe, Freeman, Jennifer, Nguyen, Tien, Bacchi, Cyrus, Yarlett, Nigel, Don, Robert, Jacobs, Robert, Nare, Bakela
Published in PLoS neglected tropical diseases (08.02.2011)
Published in PLoS neglected tropical diseases (08.02.2011)
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Journal Article
Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)
Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater, Kirsten, Brun, Reto, Nare, Bakela, Mercer, Luke, Xu, Musheng, Wang, Jiangong, Liang, Hao
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
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Journal Article
Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human African trypanosomiasis
Bowling, Tana, Mercer, Luke, Don, Robert, Jacobs, Robert, Nare, Bakela
Published in International journal for parasitology -- drugs and drug resistance (01.12.2012)
Published in International journal for parasitology -- drugs and drug resistance (01.12.2012)
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Journal Article
Repurposing Pyramax®, quinacrine and tilorone as treatments for Ebola virus disease
Lane, Thomas R., Dyall, Julie, Mercer, Luke, Goodin, Caleb, Foil, Daniel H., Zhou, Huanying, Postnikova, Elena, Liang, Janie Y., Holbrook, Michael R., Madrid, Peter B., Ekins, Sean
Published in Antiviral research (01.10.2020)
Published in Antiviral research (01.10.2020)
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Journal Article
SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei
Perales, Joe B., Freeman, Jennifer, Bacchi, Cyrus J., Bowling, Tana, Don, Robert, Gaukel, Eric, Mercer, Luke, Moore III, Joseph A., Nare, Bakela, Nguyen, Tien M., Noe, Robert A., Randolph, Ryan, Rewerts, Cindy, Wring, Stephen A., Yarlett, Nigel, Jacobs, Robert T.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Journal Article
Modeling and Analyzing Wind Velocity at Entrance Doors to Avoid Accidents
Asaduzzaman, Abu, Mercer, Luke, Uddin, Md Raihan, Woldeyes, Yoel
Published in 2023 IEEE High Performance Extreme Computing Conference (HPEC) (25.09.2023)
Published in 2023 IEEE High Performance Extreme Computing Conference (HPEC) (25.09.2023)
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Conference Proceeding
SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis: e1151
Jacobs, Robert T, Nare, Bakela, Wring, Stephen A, Orr, Matthew D, Chen, Daitao, Sligar, Jessica M, Jenks, Matthew X, Noe, Robert A, Bowling, Tana S, Mercer, Luke T, Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J, Yarlett, Nigel, Plattner, Jacob J, Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y-K, Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Published in PLoS neglected tropical diseases (01.06.2011)
Published in PLoS neglected tropical diseases (01.06.2011)
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Journal Article
Repurposing Pyramax for the Treatment of Ebola Virus Disease: Additivity of the Lysosomotropic Pyronaridine and Non-Lysosomotropic Artesunate
Lane, Thomas R, Dyall, Julie, Mercer, Luke, Goodin, Caleb, Foil, Daniel H, Zhou, Huanying, Postnikova, Elena, Liang, Janie Y, Holbrook, Michael, Madrid, Peter, Ekins, Sean
Published in bioRxiv (27.04.2020)
Published in bioRxiv (27.04.2020)
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