Model‐Informed Dosing of Venetoclax in Healthy Subjects: An Exposure−Response Analysis
Dave, Nimita, Gopalakrishnan, Sathej, Mensing, Sven, Salem, Ahmed Hamed
Published in Clinical and translational science (01.11.2019)
Published in Clinical and translational science (01.11.2019)
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Integrating machine learning with pharmacokinetic models: Benefits of scientific machine learning in adding neural networks components to existing PK models
Valderrama, Diego, Ponce‐Bobadilla, Ana Victoria, Mensing, Sven, Fröhlich, Holger, Stodtmann, Sven
Published in CPT: pharmacometrics and systems pharmacology (01.01.2024)
Published in CPT: pharmacometrics and systems pharmacology (01.01.2024)
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Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV-infected Japanese Subjects in Phase 3 CERTAIN-1 and CERTAIN-2 Trials
Suleiman, Ahmed Abbas, Lin, Chih-Wei, Liu, Wei, Eckert, Doerthe, Mensing, Sven, Burroughs, Margaret, Kato, Koji, Chayama, Kazuaki, Kumada, Hiromitsu, Oberoi, Rajneet K
Published in Journal of clinical pharmacology (01.03.2020)
Published in Journal of clinical pharmacology (01.03.2020)
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Relationship Between Venetoclax Exposure and Undetectable Minimal Residual Disease Rates in Relapsed/Refractory Patients With Chronic Lymphocytic Leukemia: A Pooled Analysis of Six Clinical Studies
Gopalakrishnan, Sathej, Menon, Rajeev, Suleiman, Ahmed A., Kater, Arnon P., Stilgenbauer, Stephan, Seymour, John F., Chyla, Brenda, Lu, Tong, Young Kim, Su, Roberts, Andrew W., Woyach, Jennifer A., Mensing, Sven, Salem, Ahmed Hamed
Published in HemaSphere (01.12.2023)
Published in HemaSphere (01.12.2023)
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Journal Article
Model Informed Dosing Regimen and Phase I Results of the Anti‐PD‐1 Antibody Budigalimab (ABBV‐181)
Powderly, John, Spira, Alexander, Kondo, Shunsuke, Doi, Toshihiko, Luke, Jason J., Rasco, Drew, Gao, Bo, Tanner, Minna, Cassier, Philippe A., Gazzah, Anas, Italiano, Antoine, Tosi, Diego, Afar, Daniel E., Parikh, Apurvasena, Engelhardt, Benjamin, Englert, Stefan, Lambert, Stacie L., Kasichayanula, Sreeneeranj, Mensing, Sven, Menon, Rajeev, Vosganian, Gregory, Tolcher, Anthony
Published in Clinical and translational science (01.01.2021)
Published in Clinical and translational science (01.01.2021)
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Journal Article
Exposure–Response Relationship for Ombitasvir and Paritaprevir/Ritonavir in Hepatitis C Virus Subgenotype 1b-Infected Japanese Patients in the Phase 3 Randomized GIFT-I Study
Gopalakrishnan, Sathej, Khatri, Amit, Mensing, Sven, Redman, Rebecca, Menon, Rajeev, Zha, Jiuhong
Published in Advances in therapy (01.04.2016)
Published in Advances in therapy (01.04.2016)
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Journal Article
Population Pharmacokinetic and Exposure–Response Modeling to Inform Risankizumab Dose Selection in Patients With Ulcerative Colitis
Thakre, Neha, Goebel, Aline, Winzenborg, Insa, Suleiman, Ahmed A., D'Cunha, Ronilda, Mensing, Sven, Liu, Wei, Pang, Yinuo
Published in Clinical pharmacology and therapeutics (01.09.2024)
Published in Clinical pharmacology and therapeutics (01.09.2024)
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Journal Article
Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of navitoclax (ABT-263) induced thrombocytopenia
Kaefer, Aksana, Yang, Jianning, Noertersheuser, Peter, Mensing, Sven, Humerickhouse, Rod, Awni, Walid, Xiong, Hao
Published in Cancer chemotherapy and pharmacology (01.09.2014)
Published in Cancer chemotherapy and pharmacology (01.09.2014)
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Journal Article
Dose optimization and exposure-response analyses to support optimal dose of ABBV-400, a novel C-met–targeting antibody drug conjugate, in patients with metastatic colorectal cancer (mCRC)
Biesdorf de Almeida, Carla, Engelhardt, Benjamin, Babel, Heiko, Badillo, Jesus D, Sharma, Manish, Powderly, John D., Neagu Aristide, Martha Raluca, Freise, Kevin Jay, Mensing, Sven, Parikh, Apurvasena
Published in Journal of clinical oncology (01.06.2024)
Published in Journal of clinical oncology (01.06.2024)
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Journal Article
Exposure-Response Model With Time-Varying Predictors to Estimate the Effects of Veliparib in Combination With Carboplatin/Paclitaxel and as Monotherapy: Veliparib Phase 3 Study in BRCA-Mutated Advanced Breast Cancer (BROCADE3) Trial
Stodtmann, Sven, Eckert, Doerthe, Joshi, Rujuta, Nuthalapati, Silpa, Ratajczak, Christine K, Menon, Rajeev, Mensing, Sven, Xiong, Hao
Published in Journal of clinical pharmacology (01.10.2022)
Published in Journal of clinical pharmacology (01.10.2022)
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Journal Article
Opportunities and Challenges of Disease Progression Modeling in Drug Development – An IQ Perspective
Goteti, Kosalaram, Hanan, Nathan, Magee, Mindy, Wojciechowski, Jessica, Mensing, Sven, Lalovic, Bojan, Hang, Yaming, Solms, Alexander, Singh, Indrajeet, Singh, Rajendra, Rieger, Theodore Robert, Jin, Jin Y.
Published in Clinical pharmacology and therapeutics (01.08.2023)
Published in Clinical pharmacology and therapeutics (01.08.2023)
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Journal Article
A Population Pharmacokinetic Meta‐Analysis of Veliparib, a PARP Inhibitor, Across Phase 1/2/3 Trials in Cancer Patients
Stodtmann, Sven, Nuthalapati, Silpa, Eckert, Doerthe, Kasichayanula, Sreeneeranj, Joshi, Rujuta, Bach, Bruce A., Mensing, Sven, Menon, Rajeev, Xiong, Hao
Published in Journal of clinical pharmacology (01.09.2021)
Published in Journal of clinical pharmacology (01.09.2021)
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Journal Article
Integrated Mechanistic Model of Minimal Residual Disease Kinetics With Venetoclax Therapy in Chronic Lymphocytic Leukemia
Gopalakrishnan, Sathej, Wierda, William, Chyla, Brenda, Menon, Rajeev, Miles, Dale, Humerickhouse, Rod, Awni, Walid, Salem, Ahmed Hamed, Mensing, Sven, Freise, Kevin J
Published in Clinical pharmacology and therapeutics (01.02.2021)
Published in Clinical pharmacology and therapeutics (01.02.2021)
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Journal Article
Abstract 3024: Relationship between venetoclax concentrations and undetectable MRD in patients with chronic lymphocytic leukemia
Gopalakrishnan, Sathej, Menon, Rajeev, Chyla, Brenda, Samineni, Divya, Jacobson, Amanda, Kim, Su Young, Mensing, Sven, Salem, Ahmed Hamed
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Assessing the Impact of Immunogenicity and Improving Prediction of Trough Concentrations: Population Pharmacokinetic Modeling of Adalimumab in Patients with Crohn’s Disease and Ulcerative Colitis
Ponce-Bobadilla, Ana Victoria, Stodtmann, Sven, Chen, Mong-Jen, Winzenborg, Insa, Mensing, Sven, Blaes, Jonas, Haslberger, Tobias, Laplanche, Loic, Dreher, Ingeborg, Mostafa, Nael M.
Published in Clinical pharmacokinetics (01.04.2023)
Published in Clinical pharmacokinetics (01.04.2023)
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Journal Article
Impact of Venetoclax Exposure on Clinical Efficacy and Safety in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia
Freise, Kevin J., Jones, Aksana K., Eckert, Doerthe, Mensing, Sven, Wong, Shekman L., Humerickhouse, Rod A., Awni, Walid M., Salem, Ahmed Hamed
Published in Clinical pharmacokinetics (01.05.2017)
Published in Clinical pharmacokinetics (01.05.2017)
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Journal Article
Pooled Population Pharmacokinetic Analyses of Venetoclax in Patients Across Indications and Healthy Subjects from Phase 1, 2, and 3 Clinical Trials
Gong, Jingqi Q X, Suleiman, Ahmed A, Menon, Rajeev, Deng, Rong, Mensing, Sven, Salem, Ahmed Hamed
Published in Journal of clinical pharmacology (01.08.2023)
Published in Journal of clinical pharmacology (01.08.2023)
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Journal Article
Population Pharmacokinetics of Paritaprevir, Ombitasvir, Dasabuvir, Ritonavir, and Ribavirin in Hepatitis C Virus-Infected Cirrhotic and Non-cirrhotic Patients: Analyses Across Nine Phase III Studies
Gopalakrishnan, Sathej, Mensing, Sven, Menon, Rajeev M., Zha, Jiuhong
Published in Clinical pharmacokinetics (01.11.2018)
Published in Clinical pharmacokinetics (01.11.2018)
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Journal Article
Venetoclax Exposure-Efficacy and Exposure-Safety Relationships in Subjects with Treatment-Naïve Acute Myeloid Leukemia Who Are Ineligible for Intensive Chemotherapy
Eckert, Doerthe, Brackman, Deanna, Menon, Rajeev, Salem, Ahmed Hamed, Potluri, Jalaja, Smith, B. Douglas, Wei, Andrew H., Hayslip, John, Miles, Dale, Mensing, Sven, Gopalakrishnan, Sathej, Zha, Jiuhong
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Pharmacokinetics and exposure-efficacy relationship of adalimumab in pediatric patients with moderate to severe Crohn's disease: results from a randomized, multicenter, phase-3 study
Sharma, Shringi, Eckert, Doerthe, Hyams, Jeffrey S, Mensing, Sven, Thakkar, Roopal B, Robinson, Anne M, Rosh, Joel R, Ruemmele, Frank M, Awni, Walid M
Published in Inflammatory bowel diseases (01.04.2015)
Published in Inflammatory bowel diseases (01.04.2015)
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