Discovery of Selective Irreversible Inhibitors for Bruton's Tyrosine Kinase
Pan, Zhengying, Scheerens, Heleen, Li, Shyr-Jiann, Schultz, Brian E., Sprengeler, Paul A., Burrill, L. Chuck, Mendonca, Rohan V., Sweeney, Michael D., Scott, Keana C. K., Grothaus, Paul G., Jeffery, Douglas A., Spoerke, Jill M., Honigberg, Lee A., Young, Peter R., Dalrymple, Stacie A., Palmer, James T.
Published in ChemMedChem (15.01.2007)
Published in ChemMedChem (15.01.2007)
Get full text
Journal Article
Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors
Parr, Brendan T, Pastor, Richard, Sellers, Benjamin D, Pei, Zhonghua, Jaipuri, Firoz A, Castanedo, Georgette M, Gazzard, Lewis, Kumar, Sanjeev, Li, Xiaokai, Liu, Wen, Mendonca, Rohan, Pavana, Roheeth K, Potturi, Hima, Shao, Cheng, Velvadapu, Venkata, Waldo, Jesse P, Wu, Guosheng, Yuen, Po-wai, Zhang, Zuhui, Zhang, Yamin, Harris, Seth F, Oh, Angela J, DiPasquale, Antonio, Dement, Kevin, La, Hank, Goon, Leanne, Gustafson, Amy, VanderPorten, Erica C, Mautino, Mario R, Liu, Yichin
Published in ACS medicinal chemistry letters (09.04.2020)
Published in ACS medicinal chemistry letters (09.04.2020)
Get full text
Journal Article
Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors
Palmer, James T., Rydzewski, Robert M., Mendonca, Rohan V., Sperandio, David, Spencer, Jeffrey R., Hirschbein, Bernard L., Lohman, Julia, Beltman, Jeri, Nguyen, Margaret, Liu, Liang
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Get full text
Journal Article
Design and Synthesis of Tri-Ring P3 Benzamide-Containing Aminonitriles as Potent, Selective, Orally Effective Inhibitors of Cathepsin K
Palmer, James T, Bryant, Clifford, Wang, Dan-Xiong, Davis, Dana E, Setti, Eduardo L, Rydzewski, Robert M, Venkatraman, Shankar, Tian, Zong-Qiang, Burrill, Leland C, Mendonca, Rohan V, Springman, Eric, McCarter, John, Chung, Tobee, Cheung, Harry, Janc, James W, McGrath, Mary, Somoza, John R, Enriquez, Philip, Yu, Z. Walter, Strickley, Robert M, Liu, Liang, Venuti, Michael C, Percival, M. David, Falgueyret, Jean-Pierre, Prasit, Peppi, Oballa, Renata, Riendeau, Denis, Young, Robert N, Wesolowski, Gregg, Rodan, Sevgi B, Johnson, Colena, Kimmel, Donald B, Rodan, Gideon
Published in Journal of medicinal chemistry (01.12.2005)
Published in Journal of medicinal chemistry (01.12.2005)
Get full text
Journal Article
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling
Zak, Mark, Hanan, Emily J., Lupardus, Patrick, Brown, David G., Robinson, Colin, Siu, Michael, Lyssikatos, Joseph P., Romero, F. Anthony, Zhao, Guiling, Kellar, Terry, Mendonca, Rohan, Ray, Nicholas C., Goodacre, Simon C., Crackett, Peter H., McLean, Neville, Hurley, Christopher A., Yuen, Po-wai, Cheng, Yun-Xing, Liu, Xiongcai, Liimatta, Marya, Kohli, Pawan Bir, Nonomiya, Jim, Salmon, Gary, Buckley, Gerry, Lloyd, Julia, Gibbons, Paul, Ghilardi, Nico, Kenny, Jane R., Johnson, Adam
Published in Bioorganic & medicinal chemistry letters (15.06.2019)
Published in Bioorganic & medicinal chemistry letters (15.06.2019)
Get full text
Journal Article
Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2)
Pei, Zhonghua, Mendonca, Rohan, Gazzard, Lewis, Pastor, Richard, Goon, Leanne, Gustafson, Amy, VanderPorten, Erica, Hatzivassiliou, Georgia, Dement, Kevin, Cass, Robert, Yuen, Po-wai, Zhang, Yamin, Wu, Guosheng, Lin, Xingyu, Liu, Yichin, Sellers, Benjamin D
Published in ACS medicinal chemistry letters (10.05.2018)
Published in ACS medicinal chemistry letters (10.05.2018)
Get full text
Journal Article
Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1
Tellis, John C, Wei, BinQing, Siu, Michael, An, Le, Chan, Grace Kayan, Chen, Yong, Du, Xiangnan, Gazzard, Lewis, Hu, Baihua, Kiefer, James, Kakiuchi-Kiyota, Satoko, Lainchbury, Michael, Linehan, Jonathan L, Luo, Xifeng, Malhotra, Sushant, Mendonca, Rohan, Pang, Jodie, Ran, Yinqing, Sethuraman, Vijay, Seward, Eileen, Sneeringer, Chris, Su, Dian, Wang, Weiru, Wu, Ping, Moffat, John G, Heffron, Timothy P, Choo, Edna F, Chan, Bryan K
Published in ACS medicinal chemistry letters (12.09.2024)
Published in ACS medicinal chemistry letters (12.09.2024)
Get full text
Journal Article
Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors
Kulagowski, Janusz J, Blair, Wade, Bull, Richard J, Chang, Christine, Deshmukh, Gauri, Dyke, Hazel J, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Harrison, Trevor K, Hewitt, Peter R, Liimatta, Marya, Hurley, Christopher A, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Bir Kohli, Pawan, Maxey, Robert J, Mendonca, Rohan, Mortara, Kyle, Murray, Jeremy, Narukulla, Raman, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, Ultsch, Mark, van Abbema, Anne, Ward, Stuart I, Waszkowycz, Bohdan, Zak, Mark
Published in Journal of medicinal chemistry (28.06.2012)
Published in Journal of medicinal chemistry (28.06.2012)
Get full text
Journal Article
Identification of C‑2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2
Zak, Mark, Hurley, Christopher A, Ward, Stuart I, Bergeron, Philippe, Barrett, Kathy, Balazs, Mercedesz, Blair, Wade S, Bull, Richard, Chakravarty, Paroma, Chang, Christine, Crackett, Peter, Deshmukh, Gauri, DeVoss, Jason, Dragovich, Peter S, Eigenbrot, Charles, Ellwood, Charles, Gaines, Simon, Ghilardi, Nico, Gibbons, Paul, Gradl, Stefan, Gribling, Peter, Hamman, Chris, Harstad, Eric, Hewitt, Peter, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Koehler, Michael F. T, Bir Kohli, Pawan, Labadie, Sharada, Lee, Wyne P, Liao, Jiangpeng, Liimatta, Marya, Mendonca, Rohan, Narukulla, Raman, Pulk, Rebecca, Reeve, Austin, Savage, Scott, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, van Abbema, Anne, Aliagas, Ignacio, Avitabile-Woo, Barbara, Xiao, Yisong, Yang, Jing, Kulagowski, Janusz J
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
Get full text
Journal Article
Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2
Zak, Mark, Mendonca, Rohan, Balazs, Mercedesz, Barrett, Kathy, Bergeron, Philippe, Blair, Wade S, Chang, Christine, Deshmukh, Gauri, DeVoss, Jason, Dragovich, Peter S, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Gradl, Stefan, Hamman, Chris, Hanan, Emily J, Harstad, Eric, Hewitt, Peter R, Hurley, Christopher A, Jin, Tian, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Koehler, Michael F. T, Bir Kohli, Pawan, Kulagowski, Janusz J, Labadie, Sharada, Liao, Jiangpeng, Liimatta, Marya, Lin, Zhonghua, Lupardus, Patrick J, Maxey, Robert J, Murray, Jeremy M, Pulk, Rebecca, Rodriguez, Madeleine, Savage, Scott, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, Ultsch, Mark, van Abbema, Anne, Ward, Stuart I, Xiao, Ling, Xiao, Yisong
Published in Journal of medicinal chemistry (12.07.2012)
Published in Journal of medicinal chemistry (12.07.2012)
Get full text
Journal Article
Optimization of subsite binding to the beta 5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: Syntheses and cellular properties of potent, selective proteasome inhibitors
Rydzewski, Robert M., Burrill, Leland, Mendonca, Rohan, Palmer, James T., Rice, Mark, Tahilramani, Ram, Bass, Kathryn E., Leung, Ling, Gjerstad, Erik, Janc, James W., Pan, Lin
Published in Journal of medicinal chemistry (18.05.2006)
Published in Journal of medicinal chemistry (18.05.2006)
Get full text
Journal Article
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1
Hurley, Christopher A., Blair, Wade S., Bull, Richard J., Chang, Christine, Crackett, Peter H., Deshmukh, Gauri, Dyke, Hazel J., Fong, Rina, Ghilardi, Nico, Gibbons, Paul, Hewitt, Peter R., Johnson, Adam, Johnson, Tony, Kenny, Jane R., Kohli, Pawan Bir, Kulagowski, Janusz J., Liimatta, Marya, Lupardus, Patrick J., Maxey, Robert J., Mendonca, Rohan, Narukulla, Raman, Pulk, Rebecca, Ubhayakar, Savita, van Abbema, Anne, Ward, Stuart I., Waszkowycz, Bohdan, Zak, Mark
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Get full text
Journal Article
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
Labadie, Sharada, Dragovich, Peter S., Barrett, Kathy, Blair, Wade S., Bergeron, Philippe, Chang, Christine, Deshmukh, Gauri, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Hurley, Christopher A., Johnson, Adam, Kenny, Jane R., Kohli, Pawan Bir, Kulagowski, Janusz J., Liimatta, Marya, Lupardus, Patrick J., Mendonca, Rohan, Murray, Jeremy M., Pulk, Rebecca, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, Ultsch, Mark, van Abbema, Anne, Ward, Stuart, Zak, Mark
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Get full text
Journal Article
Design and synthesis of tri-ring P-3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K
Palmer, JT, Bryant, C, Wang, DX, Davis, DE, Setti, EL, Rydzewski, RM, Venkatraman, S, Tian, ZQ, Burrill, LC, Mendonca, RV, Springman, E, McCarter, J, Chung, T, Cheung, H, Janc, JW, McGrath, M, Somoza, Enriquez, P, Yu, ZW, Strickley, RM, Liu, L, Venuti, MC, Percival, MD, Falgueyret, JP, Prasit, P, Oballa, R, Riendeau, D, Young, RN, Wesolowski, G, Rodan, SB, Johnson, C, Kimmel, DB, Rodan, G
Published in Journal of medicinal chemistry (01.12.2005)
Published in Journal of medicinal chemistry (01.12.2005)
Get full text
Journal Article
Optimization of Subsite Binding to the β5 Subunit of the Human 20S Proteasome Using Vinyl Sulfones and 2-Keto-1,3,4-oxadiazoles: Syntheses and Cellular Properties of Potent, Selective Proteasome Inhibitors
Rydzewski, Robert M, Burrill, Leland, Mendonca, Rohan, Palmer, James T, Rice, Mark, Tahilramani, Ram, Bass, Kathryn E, Leung, Ling, Gjerstad, Erik, Janc, James W, Pan, Lin
Published in Journal of medicinal chemistry (18.05.2006)
Published in Journal of medicinal chemistry (18.05.2006)
Get full text
Journal Article
HPK1 억제제로서의 나프티리딘
CHAN BRYAN, WEI BINQING, LU AIJUN, WANG WEIRU, CARTWRIGHT MATTHEW W, LIANG JUN, HEFFRON TIMOTHY, FAVOR DAVID, DANIELS BLAKE, MADIN ANDREW, HU YONGHAN, MALHOTRA SUSHANT, ZHOU AIHE, GOOD ANDREW, TELLIS JOHN, DROBNICK JOY, SEWARD EILEEN, LAINCHBURY MICHAEL, HUESTIS MALCOLM, JONES GRAHAM, FONG KIN CHIU, SIU MICHAEL, RAJAPAKSA NAOMI, HU BAIHUA, GANCIA EMANUELA, MENDONCA ROHAN, STIVALA CRAIG, GAZZARD LEWIS
Year of Publication 09.12.2019
Get full text
Year of Publication 09.12.2019
Patent
HPK1의 억제제인 이소퀴놀린
GOOD ANDREW, TELLIS JOHN, CHAN BRYAN, DROBNICK JOY, WEI BINQING, WANG WEIRU, SEWARD EILEEN, LAINCHBURY MICHAEL, CARTWRIGHT MATTHEW W, LIANG JUN, FONG KIN CHIU, HEFFRON TIMOTHY, FAVOR DAVID, RAJAPAKSA NAOMI, GANCIA EMANUELA, MENDONCA ROHAN, MADIN ANDREW, HU YONGHAN, MALHOTRA SUSHANT, STIVALA CRAIG, ZHOU AIHE, GAZZARD LEWIS
Year of Publication 05.12.2019
Get full text
Year of Publication 05.12.2019
Patent
PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS
MAGNUSON STEVEN R, LYSSIKATOS JOSEPH P, MENDONCA ROHAN, GIBBONS PAUL, HANAN EMILY, ZHU BING YAN, PASTOR RICHARD, ZAK MARK E, RAWSON THOMAS E, SIU MICHAEL, ZHOU AIHE, LIU WENDY
Year of Publication 04.10.2018
Get full text
Year of Publication 04.10.2018
Patent
A Novel Class of Nonpeptidic Biaryl Inhibitors of Human Cathepsin K
Robichaud, Joël, Oballa, Renata, Prasit, Peppi, Falgueyret, Jean-Pierre, Percival, M. David, Wesolowski, Gregg, Rodan, Sevgi B, Kimmel, Donald, Johnson, Colena, Bryant, Cliff, Venkatraman, Shankar, Setti, Eduardo, Mendonca, Rohan, Palmer, James T
Published in Journal of medicinal chemistry (14.08.2003)
Published in Journal of medicinal chemistry (14.08.2003)
Get full text
Journal Article