The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex
Fastman, Nathan M., Liu, Yuxi, Ramanan, Vyas, Merritt, Hanne, Ambing, Eileen, DePaoli-Roach, Anna A., Roach, Peter J., Hurley, Thomas D., Mellem, Kevin T., Ullman, Julie C., Green, Eric, Morgans, David, Tzitzilonis, Christos
Published in Cell reports (Cambridge) (05.07.2022)
Published in Cell reports (Cambridge) (05.07.2022)
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Bioluminescent Assay for the Quantification of Cellular Glycogen Levels
Leippe, Donna, Choy, Rebeca, Vidugiris, Gediminas, Merritt, Hanne, Mellem, Kevin T., Beattie, David T., Ullman, Julie C., Vidugiriene, Jolanta
Published in ACS omega (30.07.2024)
Published in ACS omega (30.07.2024)
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Pseudoephenamine: A Practical Chiral Auxiliary for Asymmetric Synthesis
Morales, Marvin R., Mellem, Kevin T., Myers, Andrew G.
Published in Angewandte Chemie International Edition (07.05.2012)
Published in Angewandte Chemie International Edition (07.05.2012)
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Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors
Burnett, G. Leslie, Yang, Yu C., Aggen, James B., Pitzen, Jennifer, Gliedt, Micah K., Semko, Chris M., Marquez, Abby, Evans, James W., Wang, Gang, Won, Walter S., Tomlinson, Aidan C. A., Kiss, Gert, Tzitzilonis, Christos, Thottumkara, Arun P., Cregg, James, Mellem, Kevin T., Choi, Jong S., Lee, Julie C., Zhao, Yongyuan, Lee, Bianca J., Meyerowitz, Justin G., Knox, John E., Jiang, Jingjing, Wang, Zhican, Wildes, David, Wang, Zhengping, Singh, Mallika, Smith, Jacqueline A. M., Gill, Adrian L.
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders
Ullman, Julie C, Mellem, Kevin T, Xi, Yannan, Ramanan, Vyas, Merritt, Hanne, Choy, Rebeca, Gujral, Tarunmeet, Young, Lyndsay E A, Blake, Kerrigan, Tep, Samnang, Homburger, Julian R, O'Regan, Adam, Ganesh, Sandya, Wong, Perryn, Satterfield, Terrence F, Lin, Baiwei, Situ, Eva, Yu, Cecile, Espanol, Bryan, Sarwaikar, Richa, Fastman, Nathan, Tzitzilonis, Christos, Lee, Patrick, Reiton, Daniel, Morton, Vivian, Santiago, Pam, Won, Walter, Powers, Hannah, Cummings, Beryl B, Hoek, Maarten, Graham, Robert R, Chandriani, Sanjay J, Bainer, Russell, DePaoli-Roach, Anna A, Roach, Peter J, Hurley, Thomas D, Sun, Ramon C, Gentry, Matthew S, Sinz, Christopher, Dick, Ryan A, Noonberg, Sarah B, Beattie, David T, Morgans, Jr, David J, Green, Eric M
Published in Science translational medicine (17.01.2024)
Published in Science translational medicine (17.01.2024)
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Journal Article
Pseudoephenamine: A Practical Chiral Auxiliary for Asymmetric Synthesis
Morales, Marvin R., Mellem, Kevin T., Myers, Andrew G.
Published in Angewandte Chemie International Edition (07.05.2012)
Published in Angewandte Chemie International Edition (07.05.2012)
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mTOR 억제제로서의 C40-, C28- 및 C-32-연결된 라파마이신 유사체
THOTTUMKARA ARUN P, BURNETT G. LESLIE, WON WALTER, PITZEN JENNIFER, AGGEN JAMES BRADLEY, SEMKO CHRISTOPHER MICHAEL, GILL ADRIAN LIAM, MELLEM KEVIN T, KISS GERT, WANG GANG, CREGG JAMES JOSEPH, GLIEDT MICAH JAMES EVANS, LEE JULIE CHU LI
Year of Publication 17.02.2021
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Year of Publication 17.02.2021
Patent
알로스테릭 SHP2 억제제로서의 다환식 화합물
WON WALTER S, BUCKL ANDREAS, TZITZILONIS CHRISTOS, PITZEN JENNIFER, BLANK BRIAN R, GILL ADRIAN LIAM, MELLEM KEVIN T, WANG GANG, KOLTUN ELENA S, CREGG JAMES JOSEPH, LI JIE JACK, AAY NAING N, JOGALEKAR ASHUTOSH S
Year of Publication 24.08.2020
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Year of Publication 24.08.2020
Patent
Small molecule inhibition of glycogen synthase 1 restores autophagolysosomal and metabolic pathway dysfunction in a mouse model of Pompe disease
Ullman, Julie C., Xi, Yannan, Mellem, Kevin T., Merritt, Hanne, Choy, Rebeca, Gujral, Taru, Blake, Kerrigan, Tep, Samnang, O'Regan, Adam, Wong, Perryn, Wong, Casper, Pang, Lisa, Satterfield, Terrence F., Lin, Baiwei, Situ, Eva, Hoek, Maarten, Chandriani, Sanjay J., Bainer, Russell, Sinz, Christopher, Dick, Ryan, Noonberg, Sarah B., Beattie, David, Morgans, David J., Green, Eric M.
Published in Molecular genetics and metabolism (01.02.2023)
Published in Molecular genetics and metabolism (01.02.2023)
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Substrate reduction therapy for Pompe disease: Small molecule inhibition of glycogen synthase 1 in preclinical models
Ullman, Julie C., Mellem, Kevin T., Xi, Yannan, Satterfield, Terrence F., Gujral, Tarunmeet, Choy, Rebeca, Homburger, Julian R., Merritt, Hanne, Reiton, Daniel, Tep, Samnang, Lin, Baiwei, Yu, Cecile, Situ, Eva, Won, Walter, Powers, Hannah, Ramanan, Vyas, Hoek, Maarten, Graham, Robert, Chandriani, Sanjay J., Sinz, Christopher, Dick, Ryan A., Noonberg, Sarah B., Beattie, David T., Morgans, David J., Jr, Green, Eric M.
Published in Molecular genetics and metabolism (01.02.2022)
Published in Molecular genetics and metabolism (01.02.2022)
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Journal Article
Pharmacology of small molecule inhibitors of GYS1 in a mouse model of Pompe disease
Xi, Yannan, Satterfield, Terrence F., Choy, Rebeca, Gujral, Tarunmeet, Situ, Eva, Tep, Samnang, Morton, Vivian, Yu, Cecile, Reiton, Daniel, Lin, Baiwei, Merritt, Hanne, Santiago, Pam, Espanol, Bryan, Dick, Ryan A., Ullman, Julie C., Mellem, Kevin T., Noonberg, Sarah B., Green, Eric M., Morgans, David J., Chandriani, Sanjay J., Beattie, David T.
Published in Molecular genetics and metabolism (01.02.2022)
Published in Molecular genetics and metabolism (01.02.2022)
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Abstract 4878: RMC-4550, an allosteric inhibitor of SHP2: Synthesis, structure, and anti-tumor activity
Koltun, Elena S., Aay, Naing, Buckl, Andreas, Jogalekar, Ashutosh S., Kiss, Gert, Marquez, Abby, Mellem, Kevin T., Mordec, Kasia, Saldajeno-Concar, Mae, Semko, Chris M., Tibrewal, Nidhi, Tzitzilonis, Christos, Won, Walter, Smith, Jacqueline A., Wilson, Susan E., Nichols, Robert J., Wang, Zhengping, Wilds, David, Singh, Mallika, Gill, Adrian L.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 4877: Allosteric inhibition of SHP2 variants containing cancer-associated activating mutations
Wildes, David, Aay, Naing, Buckl, Andreas, Hsieh, Daphne, Jogalekar, Ashutosh S., Kiss, Gert, Koltun, Elena S., Marquez, Abby, Mellem, Kevin T., Romero, Jason, Saldajeno-Concar, Mae, Schulze, Christopher J., Semko, Chris M., Won, Walter, Nichols, Robert J., Stahlhut, Carlos, Tzitzilonis, Christos, Gill, Adrian L., Smith, Jacqueline A.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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DERIVATIVES OF AMPHOTERICIN B
KOLTUN, ELENA S, MELLEM, KEVIN T, BURKE, MARTIN D, SWEENEY, ZACHARY K, THOTTUMKARA, ARUN P
Year of Publication 24.10.2023
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Year of Publication 24.10.2023
Patent