Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity
Fell, Jay B, Fischer, John P, Baer, Brian R, Ballard, Joshua, Blake, James F, Bouhana, Karyn, Brandhuber, Barbara J, Briere, David M, Burgess, Laurence E, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Davidson, Kevin, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hee, Kenneth, Hicken, Erik J, Hinklin, Ronald J, Marx, Matthew A, Mejia, Macedonio J, Olson, Peter, Savechenkov, Pavel, Sudhakar, Niranjan, Tang, Tony P, Vigers, Guy P, Zecca, Henry, Christensen, James G
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
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Journal Article
Discovery of 5‑Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors
Elsayed, Mohamed S. A., Blake, James F., Boys, Mark L., Brown, Eric, Chapsal, Bruno D., Chicarelli, Mark J., Cook, Adam W., Fell, Jay B., Fischer, John P., Hanson, Lauren, Lemieux, Christine, Martinson, Matthew C., McCown, Joseph, McNulty, Oren T., Mejia, Macedonio J., Neitzel, Nickolas A., Otten, Jennifer N., Rodriguez, Martha E., Wilcox, Daniel, Wong, Christina E., Zhou, Yeyun, Hinklin, Ronald J.
Published in ACS medicinal chemistry letters (14.12.2023)
Published in ACS medicinal chemistry letters (14.12.2023)
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Journal Article
Identification of the Clinical Development Candidate MRTX849 , a Covalent KRAS G12C Inhibitor for the Treatment of Cancer
Fell, Jay B, Fischer, John P, Baer, Brian R, Blake, James F, Bouhana, Karyn, Briere, David M, Brown, Karin D, Burgess, Laurence E, Burns, Aaron C, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Cook, Adam W, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hartley, Dylan P, Hicken, Erik J, Hingorani, Gary P, Hinklin, Ronald J, Mejia, Macedonio J, Olson, Peter, Otten, Jennifer N, Rhodes, Susan P, Rodriguez, Martha E, Savechenkov, Pavel, Smith, Darin J, Sudhakar, Niranjan, Sullivan, Francis X, Tang, Tony P, Vigers, Guy P, Wollenberg, Lance, Christensen, James G, Marx, Matthew A
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer
Fell, Jay B, Fischer, John P, Baer, Brian R, Blake, James F, Bouhana, Karyn, Briere, David M, Brown, Karin D, Burgess, Laurence E, Burns, Aaron C, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Cook, Adam W, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hartley, Dylan P, Hicken, Erik J, Hingorani, Gary P, Hinklin, Ronald J, Mejia, Macedonio J, Olson, Peter, Otten, Jennifer N, Rhodes, Susan P, Rodriguez, Martha E, Savechenkov, Pavel, Smith, Darin J, Sudhakar, Niranjan, Sullivan, Francis X, Tang, Tony P, Vigers, Guy P, Wollenberg, Lance, Christensen, James G, Marx, Matthew A
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
단백질 티로신 포스파타제 억제제
HINKLIN RONALD JAY, JIANG YUTONG, MEJIA MACEDONIO J, FISCHER JOHN P, MCNULTY OREN T, FELL JAY BRADFORD, BOYS MARK LAURENCE, WONG CHRISTINA E, COOK ADAM W, BLAKE JAMES F, ELSAYED MOHAMED S. A, RODRIGUEZ MARTHA E, CHICARELLI MARK JOSEPH
Year of Publication 03.12.2021
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Year of Publication 03.12.2021
Patent
단백질 티로신 포스파타제 억제제
HINKLIN RONALD JAY, MEJIA MACEDONIO J, FISCHER JOHN P, MCNULTY OREN T, RODRIGUEZ MARTHA E, BOYS MARK LAURENCE, FELL JAY B, WONG CHRISTINA E, CHICARELLI MARK JOSEPH, BLAKE JAMES F, COOK ADAM, ELSAYED MOHAMED S. A
Year of Publication 23.06.2021
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Year of Publication 23.06.2021
Patent
Identification of the Clinical Development Candidate MRTX849, a Covalent KRAS(G12C) Inhibitor for the Treatment of Cancer
Fell, Jay B., Fischer, John P., Baer, Brian R., Blake, James F., Bouhana, Karyn, Briere, David M., Brown, Karin D., Burgess, Laurence E., Burns, Aaron C., Burkard, Michael R., Chiang, Harrah, Chicarelli, Mark J., Cook, Adam W., Gaudino, John J., Hallin, Jill, Hanson, Lauren, Hartley, Dylan P., Hicken, Erik J., Hingorani, Gary P., Hinklin, Ronald J., Mejia, Macedonio J., Olson, Peter, Otten, Jennifer N., Rhodes, Susan P., Rodriguez, Martha E., Savechenkov, Pavel, Smith, Darin J., Sudhakar, Niranjan, Sullivan, Francis X., Tang, Tony P., Vigers, Guy P., Wollenberg, Lance, Christensen, James G., Marx, Matthew A.
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
KRAS G12D 억제제
MEJIA MACEDONIO J, DAI DONGHUA, BLAKE JAMES FRANCIS, FELL JAY BRADFORD, WANG XIAOLUN, BURNS AARON CRAIG, TANG TONY P, CHRISTENSEN JAMES GAIL, ALLEN SHELLEY, VIGERS GUY P. A, NGUYEN PHONG, LAWSON JOHN DAVID, FISCHER JOHN PETER, CHICARELLI MARK JOSEPH, SMITH CHRISTOPHER RONALD, KAHN DEAN RUSSELL, DAHLKE JOSHUA RYAN, NEWHOUSE BRAD, ZHAO QIAN, GAUDINO JOHN, KETCHAM JOHN MICHAEL, MARX MATTHEW ARNOLD, RODRIGUEZ MARTHA E, HILTON MICHAEL CHRISTOPHER, PAJK SPENCER, SAVECHENKOV PAVEL, O'LEARY JACOB MATTHEW
Year of Publication 31.05.2022
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Year of Publication 31.05.2022
Patent
KRAS G12C 억제제
SMITH CHRISTOPHER RONALD, MEJIA MACEDONIO J, VIGERS GUY P.A, FISCHER JOHN P, FELL JAY BRADFORD, BLAKE JAMES F, CHRISTENSEN JAMES GAIL, MARX MATTHEW ARNOLD, RODRIGUEZ MARTHA E, CHICARELLI MARK JOSEPH, BURGESS LAURENCE E, SAVECHENKOV PAVEL, COOK ADAM
Year of Publication 26.08.2020
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Year of Publication 26.08.2020
Patent
KRAS G12C 억제제
HINKLIN RONALD JAY, MEJIA MACEDONIO J, VIGERS GUY P.A, FISCHER JOHN P, LEE MATTHEW RANDOLF, FELL JAY BRADFORD, GAUDINO JOHN J, ZECCA HENRY J, TANG TONY P, BLAKE JAMES F, CHRISTENSEN JAMES GAIL, HICKEN ERIK JAMES, MARX MATTHEW ARNOLD, CHICARELLI MARK JOSEPH, BURGESS LAURENCE E, SAVECHENKOV PAVEL
Year of Publication 12.04.2019
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Year of Publication 12.04.2019
Patent
KRAS G12C INHIBITORS
FELL, Jay, Bradford, MEJIA, Macedonio, J, MARX, Matthew, Arnold, BLAKE, James, F, FISCHER, John, P
Year of Publication 23.08.2023
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Year of Publication 23.08.2023
Patent
KRAS G12C INHIBITORS
FELL, Jay, Bradford, MEJIA, Macedonio, J, MARX, Matthew, Arnold, BLAKE, James, F, FISCHER, John, P
Year of Publication 13.04.2022
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Year of Publication 13.04.2022
Patent
PROTEIN TYROSINE PHOSPHATASE INHIBITORS
ELSAYED, Mohamed S. A, WONG, Christina Elizabeth, HINKLIN, Ronald Jay, MEJIA, Macedonio J, RODRIGUEZ, Martha E, BLAKE, James Francis, MCNULTY, Oren Teague, CHICARELLI, Mark Joseph, FISCHER, John P, FELL, Jay Bradford, COOK, Adam Wade, JIANG, Yutong, BOYS, Mark Laurence
Year of Publication 18.04.2024
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Year of Publication 18.04.2024
Patent
KRAS G12C INHIBITORS
Mejia, Macedonio J, Blake, James F, Fischer, John P, Marx, Matthew Arnold, Fell, Jay Bradford
Year of Publication 29.07.2021
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Year of Publication 29.07.2021
Patent
KRAS G12C INHIBITORS
SAVECHENKOV, Pavel, COOK, Adam, BLAKE, James F, MEJIA, Macedonio J, RODRIGUEZ, Martha E, CHRISTENSEN, James Gail, VIGERS, Guy P.A, CHICARELLI, Mark Joseph, FISCHER, John P, SMITH, Christopher Ronald, BURGESS, Laurence E, FELL, Jay Bradford, MARX, Matthew Arnold, TANG, Tony P
Year of Publication 28.03.2024
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Year of Publication 28.03.2024
Patent
KRAS G12C INHIBITORS
FELL, Jay, Bradford, MEJIA, Macedonio, J, MARX, Matthew, Arnold, BLAKE, James, F, FISCHER, John, P
Year of Publication 07.07.2021
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Year of Publication 07.07.2021
Patent
Protein tyrosine phosphatase inhibitors
Cook, Adam Wade, Wong, Christina Elizabeth, Hinklin, Ronald Jay, Fischer, John P, Mejia, Macedonio J, Rodriguez, Martha E, Blake, James Francis, Boys, Mark Laurence, Chicarelli, Mark Joseph, Jiang, Yutong, Elsayed, Mohamed S. A, Fell, Jay Bradford, McNulty, Oren Teague
Year of Publication 30.01.2024
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Year of Publication 30.01.2024
Patent
Protein tyrosine phosphatase inhibitors
HINKLIN, Ronald Jay, MEJIA, Macedonio J, RODRIGUEZ, Martha E, COOK, Adam, CHICARELLI, Mark Joseph, ELSAYED, Mohamed S. A, FISCHER, John P, BLAKE, James F, WONG, Christina E, BOYS, Mark Laurence, FELL, Jay B, MCNULTY, Oren T
Year of Publication 18.01.2024
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Year of Publication 18.01.2024
Patent
PROTEIN TYROSINE PHOSPHATASE INHIBITORS
HINKLIN, Ronald, Jay, MCNULTY, Oren, T, COOK, Adam, MEJIA, Macedonio, J, ELSAYED, Mohamed S. A, FELL, Jay, B, BLAKE, James, F, BOYS, Mark, Laurence, WONG, Christina, E, FISCHER, John, P, CHICARELLI, Mark, Joseph, RODRIGUEZ, Martha, E
Year of Publication 29.11.2023
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Year of Publication 29.11.2023
Patent
KRAS G12C INHIBITORS
SAVECHENKOV, Pavel, COOK, Adam, BLAKE, James F, MEJIA, Macedonio J, RODRIGUEZ, Martha E, CHRISTENSEN, James Gail, VIGERS, Guy P.A, CHICARELLI, Mark Joseph, FISCHER, John P, SMITH, Christopher Ronald, BURGESS, Laurence E, FELL, Jay Bradford, MARX, Matthew Arnold, TANG, Tony P
Year of Publication 23.11.2023
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Year of Publication 23.11.2023
Patent