Conservation of Amino Acids in Human Rhinovirus 3C Protease Correlates with Broad-Spectrum Antiviral Activity of Rupintrivir, a Novel Human Rhinovirus 3C Protease Inhibitor
BINFORD, S. L, MALDONADO, F, BROTHERS, M. A, WEADY, P. T, ZALMAN, L. S, MEADOR, J. W, MATTHEWS, D. A, PATICK, A. K
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Published in Antimicrobial Agents and Chemotherapy (01.02.2005)
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Structure-Assisted Design of Mechanism-Based Irreversible Inhibitors of Human Rhinovirus 3C Protease with Potent Antiviral Activity against Multiple Rhinovirus Serotypes
Matthews, D A, Dragovich, P S, Webber, S E, Fuhrman, S A, Patick, A K, Zalman, L S, Hendrickson, T F, Love, R A, Prins, T J, Marakovits, J T, Zhou, R, Tikhe, J, Ford, C E, Meador, J W, Ferre, R A, Brown, E L, Binford, S L, Brothers, M A, DeLisle, D M, Worland, S T
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.1999)
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In Vitro Antiviral Activity of AG7088, a Potent Inhibitor of Human Rhinovirus 3C Protease
PATICK, A. K, BINFORD, S. L, FUHRMAN, S. A, MEADOR, J. W, ZALMAN, L. S, MATTHEWS, D. A, WORLAND, S. T, BROTHERS, M. A, JACKSON, R. L, FORD, C. E, DIEM, M. D, MALDONADO, F, DRAGOVICH, P. S, ZHOU, R, PRINS, T. J
Published in Antimicrobial Agents and Chemotherapy (01.10.1999)
Published in Antimicrobial Agents and Chemotherapy (01.10.1999)
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 3. Structure−Activity Studies of Ketomethylene-Containing Peptidomimetics
Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Ford, Clifford E, Meador, James W, Ferre, Rose Ann, Worland, Stephen T
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease
Webber, Stephen E., Tikhe, Jayashree, Worland, Stephen T., Fuhrman, Shella A., Hendrickson, Thomas F., Matthews, David A., Love, Robert A., Patick, Amy K., Meador, James W., Ferre, Rose Ann, Brown, Edward L., DeLisle, Dorothy M., Ford, Clifford E., Binford, Susan L.
Published in Journal of medicinal chemistry (20.12.1996)
Published in Journal of medicinal chemistry (20.12.1996)
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Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease: Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P1 Glutamine Isosteric Replacements
Webber, Stephen E, Okano, Koji, Little, Thomas L, Reich, Siegfried H, Xin, Yue, Fuhrman, Shella A, Matthews, David A, Love, Robert A, Hendrickson, Thomas F, Patick, Amy K, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Ford, Clifford E, Binford, Susan L, Worland, Stephen T
Published in Journal of medicinal chemistry (16.07.1998)
Published in Journal of medicinal chemistry (16.07.1998)
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Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors
DRAGOVICH, P. S, RU ZHOU, MEADOR, J. W, PATICK, A. K, FORD, C. E, BROTHERS, M. A, BINFORD, S. L, MATTHEWS, D. A, FERRE, R. A, WORLAND, S. T, WEBBER, S. E, PRINS, T. J, KWOK, A. K, OKANO, K, FUHRMAN, S. A, ZALMAN, L. S, MALDONADO, F. C, BROWN, E. L
Published in Bioorganic & medicinal chemistry letters (03.01.2000)
Published in Bioorganic & medicinal chemistry letters (03.01.2000)
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 1. Michael Acceptor Structure−Activity Studies
Dragovich, Peter S, Webber, Stephen E, Babine, Robert E, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Lee, Caroline A, Reich, Siegfried H, Prins, Thomas J, Marakovits, Joseph T, Littlefield, Ethel S, Zhou, Ru, Tikhe, Jayashree, Ford, Clifford E, Wallace, Michael B, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Binford, Susan L, Harr, James E. V, DeLisle, Dorothy M, Worland, Stephen T
Published in Journal of medicinal chemistry (16.07.1998)
Published in Journal of medicinal chemistry (16.07.1998)
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Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids
Dragovich, Peter S, Webber, Stephen E, Prins, Thomas J, Zhou, Ru, Marakovits, Joseph T, Tikhe, Jayashree G, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Ford, Clifford E, Brown, Edward L, Binford, Susan L, Meador, James W, Ferre, Rose Ann, Worland, Stephen T
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 2. Peptide Structure−Activity Studies
Dragovich, Peter S, Webber, Stephen E, Babine, Robert E, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Reich, Siegfried H, Marakovits, Joseph T, Prins, Thomas J, Zhou, Ru, Tikhe, Jayashree, Littlefield, Ethel S, Bleckman, Ted M, Wallace, Michael B, Little, Thomas L, Ford, Clifford E, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Binford, Susan L, DeLisle, Dorothy M, Worland, Stephen T
Published in Journal of medicinal chemistry (16.07.1998)
Published in Journal of medicinal chemistry (16.07.1998)
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Solid-phase synthesis of irreversible human rhinovirus 3C protease inhibitors. Part 1: Optimization of tripeptides incorporating N-terminal amides
Dragovich, Peter S., Zhou, Ru, Skalitzky, Donald J., Fuhrman, Shella A., Patick, Amy K., Ford, Clifford E., Meador, James W., Worland, Stephen T.
Published in Bioorganic & medicinal chemistry (01.04.1999)
Published in Bioorganic & medicinal chemistry (01.04.1999)
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Polymorphism in the promoter region of HLA-DRB genes
Perfetto, Carmela, Zacheis, Michelle, McDaid, Dawn, Meador, James W., Schwartz, Benjamin D.
Published in Human immunology (1993)
Published in Human immunology (1993)
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Conference Proceeding
Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors
Webber, Stephen E., Marakovits, Joseph T., Dragovich, Peter S., Prins, Thomas J., Zhou, Ru, Fuhrman, Shella A., Patick, Amy K., Matthews, David A., Lee, Caroline A., Srinivasan, Babu, Moran, Terry, Ford, Clifford E., Brothers, Mary A., Harr, James E.V., Meador, James W., Ferre, Rose Ann, Worland, Stephen T.
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P1 Lactam Moieties as l-Glutamine Replacements
Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Webber, Stephen E, Marakovits, Joseph T, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Lee, Caroline A, Ford, Clifford E, Burke, Benjamin J, Rejto, Paul A, Hendrickson, Thomas F, Tuntland, Tove, Brown, Edward L, Meador, James W, Ferre, Rose Ann, Harr, James E. V, Kosa, Maha B, Worland, Stephen T
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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Peripheral vascular effects of glucagon, acetylocholine and dopamine with an implanted total artificial heart (TAH)
Kaku, K, Nagai, I, Hongo, T, Vakamudi, A K, Meador, J W, Akutsu, T
Published in Transactions - American Society for Artificial Internal Organs (1977)
Published in Transactions - American Society for Artificial Internal Organs (1977)
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 6. Structure−Activity Studies of Orally Bioavailable, 2-Pyridone-Containing Peptidomimetics
Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Brown, Edward L, Maldonado, Fausto C, Fuhrman, Shella A, Zalman, Leora S, Tuntland, Tove, Lee, Caroline A, Patick, Amy K, Matthews, David A, Hendrickson, Thomas F, Kosa, Maha B, Liu, Bo, Batugo, Minerva R, Gleeson, Jean-Paul R, Sakata, Sylvie K, Chen, Lijian, Guzman, Mark C, Meador, James W, Ferre, Rose Ann, Worland, Stephen T
Published in Journal of medicinal chemistry (11.04.2002)
Published in Journal of medicinal chemistry (11.04.2002)
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Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P-1 lactam moieties as L-glutamine replacements
Dragovich, PS, Prins, TJ, Zhou, R, Webber, SE, Marakovits, JT, Fuhrman, SA, Patick, AK, Matthews, DA, Lee, CA, Ford, CE, Burke, BJ, Rejto, PA, Hendrickson, TF, Tuntland, T, Brown, EL, Meador, JW, Ferre, RA, Harr, JEV, Kosa, MB, Worland, ST
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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