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Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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1-((3 S,4 S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes
Andrews, Kim M., Beebe, David A., Benbow, John W., Boyer, David A., Doran, Shawn D., Hui, Yu, Liu, Shenping, McPherson, R. Kirk, Neagu, Constantin, Parker, Janice C., Piotrowski, David W., Schneider, Steven R., Treadway, Judith L., VanVolkenberg, Maria A., Zembrowski, William J.
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cis-2,5-Dicyanopyrrolidine Inhibitors of Dipeptidyl Peptidase IV: Synthesis and in Vitro, in Vivo, and X-ray Crystallographic Characterization
Wright, Stephen W, Ammirati, Mark J, Andrews, Kim M, Brodeur, Anne M, Danley, Dennis E, Doran, Shawn D, Lillquist, Jay S, McClure, Lester D, McPherson, R. Kirk, Orena, Stephen J, Parker, Janice C, Polivkova, Jana, Qiu, Xiayang, Soeller, Walter C, Soglia, Carolyn B, Treadway, Judith L, VanVolkenburg, Maria A, Wang, Hong, Wilder, Donald C, Olson, Thanh V
Published in Journal of medicinal chemistry (01.06.2006)
Published in Journal of medicinal chemistry (01.06.2006)
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Establishment of Correlation between in Vitro Enzyme Binding Potency and in Vivo Pharmacological Activity: Application to Liver Glycogen Phosphorylase a Inhibitors
Yu, Li J, Chen, Yue, Treadway, Judith L, McPherson, R Kirk, McCoid, Scott C, Gibbs, E Michael, Hoover, Dennis J
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Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
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Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1
Dow, Robert L, Li, Jian-Cheng, Pence, Michael P, Gibbs, E. Michael, LaPerle, Jennifer L, Litchfield, John, Piotrowski, David W, Munchhof, Michael J, Manion, Tara B, Zavadoski, William J, Walker, Gregory S, McPherson, R. Kirk, Tapley, Susan, Sugarman, Eliot, Guzman-Perez, Angel, DaSilva-Jardine, Paul
Published in ACS medicinal chemistry letters (12.05.2011)
Published in ACS medicinal chemistry letters (12.05.2011)
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3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor
Ammirati, Mark J, Andrews, Kim M, Boyer, David D, Brodeur, Anne M, Danley, Dennis E, Doran, Shawn D, Hulin, Bernard, Liu, Shenping, McPherson, R Kirk, Orena, Stephen J, Parker, Janice C, Polivkova, Jana, Qiu, Xiayang, Soglia, Carolyn B, Treadway, Judith L, VanVolkenburg, Maria A, Wilder, Donald C, Piotrowski, David W
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
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Discovery of a Human Liver Glycogen Phosphorylase Inhibitor that Lowers Blood Glucose in vivo
Martin, William H., Hoover, Dennis J., Armento, Sandra J., Stock, Ingrid A., McPherson, R. Kirk, Danley, Dennis E., Stevenson, Ralph W., Barrett, Eugene J., Treadway, Judith L.
Published in Proceedings of the National Academy of Sciences - PNAS (17.02.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (17.02.1998)
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Anilinoquinazoline Inhibitors of Fructose 1,6-Bisphosphatase Bind at a Novel Allosteric Site: Synthesis, In Vitro Characterization, and X-ray Crystallography
Wright, Stephen W, Carlo, Anthony A, Carty, Maynard D, Danley, Dennis E, Hageman, David L, Karam, George A, Levy, Carolyn B, Mansour, Mahmoud N, Mathiowetz, Alan M, McClure, Lester D, Nestor, McPherson, R. Kirk, Pandit, Jayvardhan, Pustilnik, Leslie R, Schulte, Gayle K, Soeller, Walter C, Treadway, Judith L, Wang, Ing-Kae, Bauer, Paul H
Published in Journal of medicinal chemistry (29.08.2002)
Published in Journal of medicinal chemistry (29.08.2002)
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Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor
Tracey, W. Ross, Treadway, Judith L, Magee, William P, Sutt, Jill C, McPherson, R. Kirk, Levy, Carolyn B, Wilder, Donald E, Yu, Li J, Chen, Yue, Shanker, Ravi M, Mutchler, Alison K, Smith, Andrew H, Flynn, David M, Knight, Delvin R
Published in American journal of physiology. Heart and circulatory physiology (01.03.2004)
Published in American journal of physiology. Heart and circulatory physiology (01.03.2004)
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(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: Synthesis, in vitro, in vivo, and X-ray crystallographic characterization
Wright, Stephen W., Ammirati, Mark J., Andrews, Kim M., Brodeur, Anne M., Danley, Dennis E., Doran, Shawn D., Lillquist, Jay S., Liu, Shenping, McClure, Lester D., McPherson, R. Kirk, Olson, Thanh V., Orena, Stephen J., Parker, Janice C., Rocke, Benjamin N., Soeller, Walter C., Soglia, Carolyn B., Treadway, Judith L., VanVolkenburg, Maria A., Zhao, Zhengrong, Cox, Eric D.
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization
Wright, Stephen W., Rath, Virginia L., Genereux, Paul E., Hageman, David L., Levy, Carolyn B., McClure, Lester D., McCoid, Scott C., McPherson, R. Kirk, Schelhorn, Teresa M., Wilder, Donald E., Zavadoski, William J., Gibbs, E. Michael, Treadway, Judith L.
Published in Applied catalysis. B, Environmental (17.01.2005)
Published in Applied catalysis. B, Environmental (17.01.2005)
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Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes
PARKER, Janice C, MCPHERSON, R. Kirk, DEKKER, Koen A, TACHIKAWA, Kiyoshi, SUGIE, Yutaka, TREADWAY, Judith L, ANDREWS, Kim M, LEVY, Carolyn B, DUBINS, Jeffrey S, CHIN, Janice E, PERRY, Pia V, HULIN, Bernard, PERRY, David A, INAGAKI, Taisuke
Published in Diabetes (New York, N.Y.) (01.12.2000)
Published in Diabetes (New York, N.Y.) (01.12.2000)
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3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: A potent, selective, orally active dipeptidyl peptidase IV inhibitor
Ammirati, Mark J., Andrews, Kim M., Boyer, David D., Brodeur, Anne M., Danley, Dennis E., Doran, Shawn D., Hulin, Bernard, Liu, Shenping, McPherson, R. Kirk, Orena, Stephen J., Parker, Janice C., Polivkova, Jana, Qiu, Xiayang, Soglia, Carolyn B., Treadway, Judith L., VanVolkenburg, Maria A., Wilder, Donald C., Piotrowski, David W.
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
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Actions of novel antidiabetic agent englitazone in hyperglycemic hyperinsulinemic ob/ob mice
STEVENSON, R. W, HUTSON, N. J, GIBBS, E. M, KREUTTER, D. K, KRUPP, M. N, VOLKMANN, R. A, HOLLAND, G. F, EGGLER, J. F, CLARK, D. A, MCPHERSON, R. K, HALL, K. L, DANBURY, B. H
Published in Diabetes (New York, N.Y.) (01.10.1990)
Published in Diabetes (New York, N.Y.) (01.10.1990)
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The antihyperglycemic agent englitazone prevents the defect in glucose transport in rats fed a high-fat diet
STEVENSON, R. W, MCPHERSON, R. K, PERSSON, L. M, GENEREUX, P. E, SWICK, A. G, SPITZER, J, HERBST, J. J, ANDREWS, K. M, KREUTTER, D. K, GIBBS, E. M
Published in Diabetes (New York, N.Y.) (1996)
Published in Diabetes (New York, N.Y.) (1996)
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Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
Rath, Virginia L, Ammirati, Mark, Danley, Dennis E, Ekstrom, Jennifer L, Gibbs, E Michael, Hynes, Thomas R, Mathiowetz, Alan M, McPherson, R Kirk, Olson, Thanh V, Treadway, Judith L, Hoover, Dennis J
Published in Chemistry & biology (01.09.2000)
Published in Chemistry & biology (01.09.2000)
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(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone : A potent, selective, orally active dipeptidyl peptidase IV inhibitor
AMMIRATI, Mark J, ANDREWS, Kim M, PARKER, Janice C, POLIVKOVA, Jana, XIAYANG QIU, SOGLIA, Carolyn B, TREADWAY, Judith L, VANVOLKENBURG, Maria A, WILDER, Donald C, PIOTROWSKI, David W, BOYER, David D, BRODEUR, Anne M, DANLEY, Dennis E, DORAN, Shawn D, HULIN, Bernard, SHENPING LIU, KIRK MCPHERSON, R, ORENA, Stephen J
Published in Bioorganic & medicinal chemistry letters (2009)
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Published in Bioorganic & medicinal chemistry letters (2009)
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Indole-2-carboxamide Inhibitors of Human Liver Glycogen Phosphorylase
Hoover, Dennis J, Lefkowitz-Snow, Sheri, Burgess-Henry, Jana L, Martin, William H, Armento, Sandra J, Stock, Ingrid A, McPherson, R. Kirk, Genereux, Paul E, Gibbs, E. Michael, Treadway, Judith L
Published in Journal of medicinal chemistry (30.07.1998)
Published in Journal of medicinal chemistry (30.07.1998)
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Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene
Treadway, J L, Hargrove, D M, Nardone, N A, McPherson, R K, Russo, J F, Milici, A J, Stukenbrok, H A, Gibbs, E M, Stevenson, R W, Pessin, J E
Published in The Journal of biological chemistry (25.11.1994)
Published in The Journal of biological chemistry (25.11.1994)
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Journal Article
Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor
TRACEY, W. Ross, TREADWAY, Judith L, MUTCHLER, Alison K, SMITH, Andrew H, FLYNN, David M, KNIGHT, Delvin R, MAGEE, William P, SUTT, Jill C, MCPHERSON, R. Kirk, LEVY, Carolyn B, WILDER, Donald E, YU, Li J, YUE CHEN, SHANKER, Ravi M
Published in American journal of physiology. Heart and circulatory physiology (01.03.2004)
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Published in American journal of physiology. Heart and circulatory physiology (01.03.2004)
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