BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma
Bhadury, Joydeep, Nilsson, Lisa M, Muralidharan, Somsundar Veppil, Green, Lydia C, Li, Zhoulei, Gesner, Emily M, Hansen, Henrik C, Keller, Ulrich B, McLure, Kevin G, Nilsson, Jonas A
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.2014)
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Journal Article
RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist
McLure, Kevin G, Gesner, Emily M, Tsujikawa, Laura, Kharenko, Olesya A, Attwell, Sarah, Campeau, Eric, Wasiak, Sylwia, Stein, Adam, White, Andre, Fontano, Eric, Suto, Robert K, Wong, Norman C W, Wagner, Gregory S, Hansen, Henrik C, Young, Peter R
Published in PloS one (31.12.2013)
Published in PloS one (31.12.2013)
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Journal Article
Regulation of p53 Translation and Induction after DNA Damage by Ribosomal Protein L26 and Nucleolin
Takagi, Masatoshi, Absalon, Michael J., McLure, Kevin G., Kastan, Michael B.
Published in Cell (07.10.2005)
Published in Cell (07.10.2005)
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Journal Article
RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease
Jahagirdar, Ravi, Attwell, Sarah, Marusic, Suzana, Bendele, Alison, Shenoy, Narmada, McLure, Kevin G, Gilham, Dean, Norek, Karen, Hansen, Henrik C, Yu, Raymond, Tobin, Jennifer, Wagner, Gregory S, Young, Peter R, Wong, Norman C W, Kulikowski, Ewelina
Published in Molecular pharmacology (01.12.2017)
Published in Molecular pharmacology (01.12.2017)
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Journal Article
RVX-297- a novel BD2 selective inhibitor of BET bromodomains
Kharenko, Olesya A., Gesner, Emily M., Patel, Reena G., Norek, Karen, White, Andre, Fontano, Eric, Suto, Robert K., Young, Peter R., McLure, Kevin G., Hansen, Henrik C.
Published in Biochemical and biophysical research communications (12.08.2016)
Published in Biochemical and biophysical research communications (12.08.2016)
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Journal Article
Molecular Systems Architecture of Interactome in the Acute Myeloid Leukemia Microenvironment
Ayyadurai, V A Shiva, Deonikar, Prabhakar, McLure, Kevin G, Sakamoto, Kathleen M
Published in Cancers (01.02.2022)
Published in Cancers (01.02.2022)
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Journal Article
NAD+ Modulates p53 DNA Binding Specificity and Function
McLure, Kevin G., Takagi, Masatoshi, Kastan, Michael B.
Published in Molecular and Cellular Biology (01.11.2004)
Published in Molecular and Cellular Biology (01.11.2004)
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Journal Article
Data on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes
Wasiak, Sylwia, Gilham, Dean, Tsujikawa, Laura M., Halliday, Christopher, Norek, Karen, Patel, Reena G., McLure, Kevin G., Young, Peter R., Gordon, Allan, Kulikowski, Ewelina, Johansson, Jan, Sweeney, Michael, Wong, Norman C.
Published in Data in brief (01.09.2016)
Published in Data in brief (01.09.2016)
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Journal Article
A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice
Jahagirdar, Ravi, Zhang, Haiyan, Azhar, Salman, Tobin, Jennifer, Attwell, Sarah, Yu, Raymond, Wu, Jin, McLure, Kevin G, Hansen, Henrik C, Wagner, Gregory S, Young, Peter R, Srivastava, Rai Ajit K, Wong, Norman C.W, Johansson, Jan
Published in Atherosclerosis (01.09.2014)
Published in Atherosclerosis (01.09.2014)
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Journal Article
Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine
Kharenko, Olesya A, Patel, Reena G, Brown, S. David, Calosing, Cyrus, White, Andre, Lakshminarasimhan, Damodharan, Suto, Robert K, Duffy, Bryan C, Kitchen, Douglas B, McLure, Kevin G, Hansen, Henrik C, van der Horst, Edward H, Young, Peter R
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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Journal Article
Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design
Duffy, Bryan C., Liu, Shuang, Martin, Gregory S., Wang, Ruifang, Hsia, Ming Min, Zhao, He, Guo, Cheng, Ellis, Michael, Quinn, John F., Kharenko, Olesya A., Norek, Karen, Gesner, Emily M., Young, Peter R., McLure, Kevin G., Wagner, Gregory S., Lakshminarasimhan, Damodharan, White, Andre, Suto, Robert K., Hansen, Henrik C., Kitchen, Douglas B.
Published in Bioorganic & medicinal chemistry letters (15.07.2015)
Published in Bioorganic & medicinal chemistry letters (15.07.2015)
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Journal Article
Small molecule screen for inhibitors of expression from canonical CREB response element-containing promoters
Mitton, Bryan, Hsu, Katie, Dutta, Ritika, Tiu, Bruce C, Cox, Nick, McLure, Kevin G, Chae, Hee-Don, Smith, Mark, Eklund, Elizabeth A, Solow-Cordero, David E, Sakamoto, Kathleen M
Published in Oncotarget (23.02.2016)
Published in Oncotarget (23.02.2016)
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Journal Article
Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect
Nicholls, Chris D, McLure, Kevin G, Shields, Michael A, Lee, Patrick W K
Published in The Journal of biological chemistry (12.04.2002)
Published in The Journal of biological chemistry (12.04.2002)
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Journal Article
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
Lee, Patrick W. K, Woo, Richard A, McLure, Kevin G, Lees-Miller, Susan P, Rancourt, Derrick E
Published in Nature (London) (13.08.1998)
Published in Nature (London) (13.08.1998)
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Journal Article
Novel anti-inflammatory agents
KULIKOWSKI EWELINA B, ATTWELL SARAH C, HANSEN HENRIK C, WAGNER GREGORY S, MCLURE KEVIN G
Year of Publication 07.10.2020
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Year of Publication 07.10.2020
Patent
Novel anti-inflammatory agents
KULIKOWSKI EWELINA B, ATTWELL SARAH C, HANSEN HENRIK C, WAGNER GREGORY S, MCLURE KEVIN G
Year of Publication 06.08.2019
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Year of Publication 06.08.2019
Patent
Novel anti-inflammatory agents
KULIKOWSKI EWELINA B, ATTWELL SARAH C, HANSEN HENRIK C, WAGNER GREGORY S, MCLURE KEVIN G
Year of Publication 29.08.2018
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Year of Publication 29.08.2018
Patent
NOVEL ANTI-INFLAMMATORY AGENTS
KULIKOWSKI EWELINA B, ATTWELL SARAH C, HANSEN HENRIK C, WAGNER GREGORY S, MCLURE KEVIN G
Year of Publication 03.05.2012
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Year of Publication 03.05.2012
Patent