P-Glycoprotein Efflux at the Blood-Brain Barrier Mediates Differences in Brain Disposition and Pharmacodynamics between Two Structurally Related Neurokinin-1 Receptor Antagonists
Smith, B J, Doran, A C, McLean, S, Tingley, 3rd, F D, O'Neill, B T, Kajiji, S M
Published in The Journal of pharmacology and experimental therapeutics (01.09.2001)
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Published in The Journal of pharmacology and experimental therapeutics (01.09.2001)
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Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK$_1$) Receptor Antagonist
McLean, Stafford, Ganong, Alan H., Seeger, Thomas F., Bryce, Dianne K., Pratt, Kara G., Reynolds, Linda S., Siok, Chester J., Lowe, John A., Heym, James
Published in Science (American Association for the Advancement of Science) (25.01.1991)
Published in Science (American Association for the Advancement of Science) (25.01.1991)
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Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist
Rosen, Terry J., Coffman, Karen J., McLean, Stafford, Crawford, Rosemary T., Bryce, Dianne K., Gohda, Yoshiko, Tsuchiya, Megumi, Nagahisa, Atsushi, Nakane, Masami, Lowe, John A.
Published in Bioorganic & medicinal chemistry letters (03.02.1998)
Published in Bioorganic & medicinal chemistry letters (03.02.1998)
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Preclinical pharmacology of the alpha 4 beta 2 nAChR partial agonist varenicline related to effects on reward, mood and cognition
Rollema, Hans, Hajos, Mihaly, Seymour, Patricia A, Kozak, Rouba, Majchrzak, Mark J, Guanowsky, Victor, Horner, Weldon E, Chapin, Doug S, Hoffmann, William E, Johnson, David E, Mclean, Stafford, Freeman, Jody, Williams, Kathryn E
Published in Biochemical pharmacology (01.10.2009)
Published in Biochemical pharmacology (01.10.2009)
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Journal Article
Preclinical pharmacology of the α4β2 nAChR partial agonist varenicline related to effects on reward, mood and cognition
Rollema, Hans, Hajós, Mihály, Seymour, Patricia A., Kozak, Rouba, Majchrzak, Mark J., Guanowsky, Victor, Horner, Weldon E., Chapin, Doug S., Hoffmann, William E., Johnson, David E., Mclean, Stafford, Freeman, Jody, Williams, Kathryn E.
Published in Biochemical pharmacology (01.10.2009)
Published in Biochemical pharmacology (01.10.2009)
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Conference Proceeding
Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo
Kleiman, Robin J, Chapin, Douglas S, Christoffersen, Curt, Freeman, Jody, Fonseca, Kari R, Geoghegan, Kieran F, Grimwood, Sarah, Guanowsky, Victor, Hajós, Mihály, Harms, John F, Helal, Christopher J, Hoffmann, William E, Kocan, Geralyn P, Majchrzak, Mark J, McGinnis, Dina, McLean, Stafford, Menniti, Frank S, Nelson, Fredrick, Roof, Robin, Schmidt, Anne W, Seymour, Patricia A, Stephenson, Diane T, Tingley, Francis David, Vanase-Frawley, Michelle, Verhoest, Patrick R, Schmidt, Christopher J
Published in The Journal of pharmacology and experimental therapeutics (01.05.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2012)
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Cardiovascular Effects of Cholecystokinin-4 Are Mediated By the Cholecystokinin-B Receptor Subtype In the Conscious Guinea Pig and Dog
Fossa, A A, DePasquale, M J, Morrone, J, Zorn, S H, Bryce, D, Lowe, J A, McLean, S
Published in The Journal of pharmacology and experimental therapeutics (01.04.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.1997)
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Design and Discovery of a Selective Small Molecule κ Opioid Antagonist (2-Methyl-N-((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242)
Verhoest, Patrick R, Sawant Basak, Aarti, Parikh, Vinod, Hayward, Matthew, Kauffman, Gregory W, Paradis, Vanessa, McHardy, Stanton F, McLean, Stafford, Grimwood, Sarah, Schmidt, Anne W, Vanase-Frawley, Michelle, Freeman, Jodi, Van Deusen, Jeffrey, Cox, Loretta, Wong, Diane, Liras, Spiros
Published in Journal of medicinal chemistry (25.08.2011)
Published in Journal of medicinal chemistry (25.08.2011)
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An initial three-component pharmacophore for specific serotonin-3 receptor ligands
Rizzi, James P, Nagel, Arthur A, Rosen, Terry, McLean, Stafford, Seeger, Thomas
Published in Journal of medicinal chemistry (01.10.1990)
Published in Journal of medicinal chemistry (01.10.1990)
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Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand
Rosen, Terry, Seeger, Thomas F, McLean, Stafford, Desai, Manoj C, Guarino, Karen J, Bryce, Dianne, Pratt, Kara, Heym, James, Chalabi, Philip M
Published in Journal of medicinal chemistry (01.10.1993)
Published in Journal of medicinal chemistry (01.10.1993)
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Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel alpha 7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models
O'Donnell, Christopher J., Rogers, Bruce N., Bronk, Brian S., Bryce, Dianne K., Coe, Jotham W., Cook, Karen K., Duplantier, Allen J., Evrard, Edelweiss, Hajos, Mihaly, Hoffmann, William E., Hurst, Raymond S., Maklad, Noha, Mather, Robert J., McLean, Stafford, Nedza, Frank M., O'Neill, Brian T., Peng, Langu, Qian, Weimin, Rottas, Melinda M., Sands, Steven B., Schmidt, Anne W., Shrikhande, Alka V., Spracklin, Douglas K., Wong, Diane F., Zhang, Andy, Zhang, Lei
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Journal Article
Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models
O’Donnell, Christopher J, Rogers, Bruce N, Bronk, Brian S, Bryce, Dianne K, Coe, Jotham W, Cook, Karen K, Duplantier, Allen J, Evrard, Edelweiss, Hajós, Mihaly, Hoffmann, William E, Hurst, Raymond S, Maklad, Noha, Mather, Robert J, McLean, Stafford, Nedza, Frank M, O’Neill, Brian T, Peng, Langu, Qian, Weimin, Rottas, Melinda M, Sands, Steven B, Schmidt, Anne W, Shrikhande, Alka V, Spracklin, Douglas K, Wong, Diane F, Zhang, Andy, Zhang, Lei
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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5-Phenyl-3-ureidobenzazepin-2-ones as Cholecystokinin-B Receptor Antagonists
Lowe, John A, Hageman, David L, Drozda, Susan E, McLean, Stafford, Bryce, Dianne K, Crawford, Rosemary T, Zorn, Stevin, Morrone, Jean, Bordner, Jon
Published in Journal of medicinal chemistry (01.10.1994)
Published in Journal of medicinal chemistry (01.10.1994)
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Discovery of CP-866,087, a mu opioid receptor antagonist for the treatment of alcohol abuse and dependence
McHardy, Stanton F., Heck, Steven D., Guediche, Sara, Kalman, Monica, Allen, Martin P., Tu, Meihua, Bryce, Dianne K., Schmidt, Anne W., Vanase-Frawley, Michelle, Callegari, Ernesto, Doran, Shawn, Grahame, Nicholas J., McLean, Stafford, Liras, Spiros
Published in MedChemComm (01.10.2011)
Published in MedChemComm (01.10.2011)
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Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists
Nagel, Arthur A, Rosen, Terry, Rizzi, James, Daffeh, June, Guarino, Karen, Nowakowski, Jolanta, Vincent, Lawrence A, Heym, James, McLean, Stafford
Published in Journal of medicinal chemistry (01.01.1990)
Published in Journal of medicinal chemistry (01.01.1990)
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Biaryl piperidines as potent and selective delta opioid receptor ligands
Liras, Spiros, McHardy, Stanton F., Allen, Martin P., Segelstein, Barb E., Heck, Steven D., Bryce, Dianne K., Schmidt, Anne W., Vanase-Frawley, Michelle, Callegari, Ernesto, McLean, Stafford
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs
Piedimonte, Giovanni, Rodriguez, Maria M, King, Katherine A, McLean, Stafford, Jiang, Xiaobo
Published in American journal of physiology. Lung cellular and molecular physiology (01.10.1999)
Published in American journal of physiology. Lung cellular and molecular physiology (01.10.1999)
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