Search Results - "MCLAUGHLIN, Lesley A" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology

by Riddick, David S, Ding, Xinxin, Wolf, C Roland, Porter, Todd D, Pandey, Amit V, Zhang, Qing-Yu, Gu, Jun, Finn, Robert D, Ronseaux, Sebastien, McLaughlin, Lesley A, Henderson, Colin J, Zou, Ling, Flück, Christa E
Published in Drug metabolism and disposition (01.01.2013)

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Journal Article

Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy

Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy

by MacLeod, A Kenneth, Lin, De, Huang, Jeffrey T-J, McLaughlin, Lesley A, Henderson, Colin J, Wolf, C Roland
Published in Clinical cancer research (01.05.2018)

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Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models

Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models

by MacLeod, A Kenneth, McLaughlin, Lesley A, Henderson, Colin J, Wolf, C Roland
Published in Cancer research (Chicago, Ill.) (01.11.2015)

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Journal Article

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

by Scheer, Nico, Kapelyukh, Yury, Rode, Anja, Oswald, Stefan, Busch, Diana, McLaughlin, Lesley A, Lin, De, Henderson, Colin J, Wolf, C Roland
Published in Drug metabolism and disposition (01.11.2015)

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HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

by McMahon, Michael, Campbell, Kathryn H, MacLeod, A Kenneth, McLaughlin, Lesley A, Henderson, Colin J, Wolf, C Roland
Published in PloS one (26.11.2014)

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Defining the in Vivo Role for Cytochrome b5 in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b5

Defining the in Vivo Role for Cytochrome b5 in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b5

by Finn, Robert D., McLaughlin, Lesley A., Ronseaux, Sebastien, Rosewell, Ian, Houston, J. Brian, Henderson, Colin J., Wolf, C. Roland
Published in The Journal of biological chemistry (14.11.2008)

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Journal Article

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

by Henderson, Colin J, McLaughlin, Lesley A, Osuna-Cabello, Maria, Taylor, Malcolm, Gilbert, Ian, McLaren, Aileen W, Wolf, C Roland
Published in Biochemical journal (01.02.2015)

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Biochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traits

Biochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traits

by Lian, Lu-Yun, Widdowson, Philip, McLaughlin, Lesley A, Paine, Mark J I
Published in PloS one (31.05.2011)

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Journal Article

Functional Expression and Comparative Characterization of Nine Murine Cytochromes P450 by Fluorescent Inhibition Screening

Functional Expression and Comparative Characterization of Nine Murine Cytochromes P450 by Fluorescent Inhibition Screening

by MCLAUGHLIN, Lesley A, DICKMANN, Leslie J, WOLF, C. Roland, HENDERSON, Colin J
Published in Drug metabolism and disposition (01.07.2008)

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Journal Article

Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6

Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6

by Paine, Mark J.I., McLaughlin, Lesley A., Flanagan, Jack U., Kemp, Carol A., Sutcliffe, Michael J., Roberts, Gordon C.K., Wolf, C. Roland
Published in The Journal of biological chemistry (07.02.2003)

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Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system

Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system

by Henderson, Colin J, McLaughlin, Lesley A, Wolf, C Roland
Published in Molecular pharmacology (01.06.2013)

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Journal Article

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo

by Henderson, Colin J, McLaughlin, Lesley A, Scheer, Nico, Stanley, Lesley A, Wolf, C Roland
Published in Molecular pharmacology (01.04.2015)

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Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants

Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants

by MacLeod, A Kenneth, McLaughlin, Lesley A, Henderson, Colin J, Wolf, C Roland
Published in Drug metabolism and disposition (01.01.2017)

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Deletion of microsomal cytochrome b5 profoundly affects hepatic and extrahepatic drug metabolism

Deletion of microsomal cytochrome b5 profoundly affects hepatic and extrahepatic drug metabolism

by McLaughlin, Lesley A, Ronseaux, Sebastien, Finn, Robert D, Henderson, Colin J, Roland Wolf, C
Published in Molecular pharmacology (01.08.2010)

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Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

by Scheer, Nico, McLaughlin, Lesley A, Rode, Anja, Macleod, A Kenneth, Henderson, Colin J, Wolf, C Roland
Published in Drug metabolism and disposition (01.06.2014)

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A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice

A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice

by Henderson, Colin J, McLaughlin, Lesley A, Finn, Robert D, Ronseaux, Sebastien, Kapelyukh, Yury, Wolf, C Roland
Published in Drug metabolism and disposition (01.01.2014)

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The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function

The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function

by Scott, Emily E, Wolf, C Roland, Otyepka, Michal, Humphreys, Sara C, Reed, James R, Henderson, Colin J, McLaughlin, Lesley A, Paloncýová, Markéta, Navrátilová, Veronika, Berka, Karel, Anzenbacher, Pavel, Dahal, Upendra P, Barnaba, Carlo, Brozik, James A, Jones, Jeffrey P, Estrada, D Fernando, Laurence, Jennifer S, Park, Ji Won, Backes, Wayne L
Published in Drug metabolism and disposition (01.04.2016)

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Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

by Kostov, Rumen V., Knatko, Elena V., McLaughlin, Lesley A., Henderson, Colin J., Zheng, Suqing, Huang, Jeffrey T.-J., Honda, Tadashi, Dinkova-Kostova, Albena T.
Published in Biochemical and biophysical research communications (25.09.2015)

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Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite

by Flanagan, Jack U, Maréchal, Jean-Didier, Ward, Richard, Kemp, Carol A, McLaughlin, Lesley A, Sutcliffe, Michael J, Roberts, Gordon C K, Paine, Mark J I, Wolf, C Roland
Published in Biochemical journal (01.06.2004)

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Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding

by McLaughlin, Lesley A, Paine, Mark J I, Kemp, Carol A, Maréchal, Jean-Didier, Flanagan, Jack U, Ward, Clive J, Sutcliffe, Michael J, Roberts, Gordon C K, Wolf, C Roland
Published in The Journal of biological chemistry (18.11.2005)

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