MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease
LIVERTON, Nigel J, CARROLL, Steven S, OLSEN, David B, RUDD, Michael T, STAHLHUT, Mark, VACCA, Joseph P, DIMUZIO, Jillian, FANDOZZI, Christine, GRAHAM, Donald J, HAZUDA, Daria, KATHERINE HOLLOWAY, M, LUDMERER, Steven W, MCCAULEY, John A, MCINTYRE, Charles J
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Published in Antimicrobial Agents and Chemotherapy (01.01.2010)
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Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease
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Published in Journal of the American Chemical Society (09.04.2008)
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Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation
Trotter, B. Wesley, Nanda, Kausik K, Kett, Nathan R, Regan, Christopher P, Lynch, Joseph J, Stump, Gary L, Kiss, Laszlo, Wang, Jixin, Spencer, Robert H, Kane, Stefanie A, White, Rebecca B, Zhang, Rena, Anderson, Kenneth D, Liverton, Nigel J, McIntyre, Charles J, Beshore, Douglas C, Hartman, George D, Dinsmore, Christopher J
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
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Atrial Antifibrillatory Effects of Structurally Distinct IKur Blockers 3-[(Dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-Phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in Dogs with Underlying Heart Failure
Regan, Christopher P, Kiss, Laszlo, Stump, Gary L, McIntyre, Charles J, Beshore, Douglas C, Liverton, Nigel J, Dinsmore, Christopher J, Lynch, Jr, Joseph J
Published in The Journal of pharmacology and experimental therapeutics (01.01.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2008)
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Bismacrocyclic Inhibitors of Hepatitis C NS3/4a Protease
McCauley, John A, Rudd, Michael T, Nguyen, Kevin T, McIntyre, Charles J, Romano, Joseph J, Bush, Kimberly J, Varga, Sandor L, Ross, Charles W. III, Carroll, Steven S, DiMuzio, Jillian, Stahlhut, Mark W, Olsen, David B, Lyle, Terry A, Vacca, Joseph P, Liverton, Nigel J
Published in Angewandte Chemie (International ed.) (01.01.2008)
Published in Angewandte Chemie (International ed.) (01.01.2008)
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Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel
Beshore, Douglas C., Liverton, Nigel J., McIntyre, Charles J., Claiborne, Christopher F., Libby, Brian, Culberson, J. Christopher, Salata, Joseph J., Regan, Christopher P., Lynch, Joseph J., Kiss, Laszlo, Spencer, Robert H., Kane, Stephanie A., White, Rebecca B., Yeh, Suzie, Hartman, George D., Dinsmore, Christopher J.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
McCauley, John A, McIntyre, Charles J, Rudd, Michael T, Nguyen, Kevin T, Romano, Joseph J, Butcher, John W, Gilbert, Kevin F, Bush, Kimberly J, Holloway, M. Katharine, Swestock, John, Wan, Bang-Lin, Carroll, Steven S, DiMuzio, Jillian M, Graham, Donald J, Ludmerer, Steven W, Mao, Shi-Shan, Stahlhut, Mark W, Fandozzi, Christine M, Trainor, Nicole, Olsen, David B, Vacca, Joseph P, Liverton, Nigel J
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation Hepatitis C Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325
Rudd, Michael T., Butcher, John W., Nguyen, Kevin T., McIntyre, Charles J., Romano, Joseph J., Gilbert, Kevin F., Bush, Kimberly J., Liverton, Nigel J., Holloway, M. Katharine, Harper, Steven, Ferrara, Marco, DiFilippo, Marcello, Summa, Vincenzo, Swestock, John, Fritzen, Jeff, Carroll, Steven S., Burlein, Christine, DiMuzio, Jillian M., Gates, Adam, Graham, Donald J., Huang, Qian, McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark W., Black, Stuart, Chase, Robert, Soriano, Aileen, Fandozzi, Christine M., Taylor, Anne, Trainor, Nicole, Olsen, David B., Coleman, Paul J., Ludmerer, Steven W., McCauley, John A.
Published in ChemMedChem (01.04.2015)
Published in ChemMedChem (01.04.2015)
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Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers
Rudd, Michael T., McIntyre, Charles J., Romano, Joseph J., Butcher, John W., Holloway, M. Katharine, Bush, Kimberly, Nguyen, Kevin T., Gilbert, Kevin F., Lyle, Terry A., Liverton, Nigel J., Wan, Bang-Lin, Summa, Vincenzo, Harper, Steven, Rowley, Michael, Vacca, Joseph P., Carroll, Steven S., Burlein, Christine, DiMuzio, Jillian M., Gates, Adam, Graham, Donald J., Huang, Qian, Ludmerer, Steven W., McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark, Fandozzi, Christine, Taylor, Anne, Trainor, Nicole, Olsen, David B., McCauley, John A.
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
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Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease
Rudd, Michael T., McCauley, John A., Romano, Joseph J., Butcher, John W., Bush, Kimberly, McIntyre, Charles J., Nguyen, Kevin T., Gilbert, Kevin F., Lyle, Terry A., Holloway, M. Katharine, Wan, Bang-Lin, Vacca, Joseph P., Summa, Vincenzo, Harper, Steven, Rowley, Michael, Carroll, Steven S., Burlein, Christine, DiMuzio, Jillian M., Gates, Adam, Graham, Donald J., Huang, Qian, Ludmerer, Steven W., McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark, Fandozzi, Christine, Taylor, Anne, Trainor, Nicole, Olsen, David B., Liverton, Nigel J.
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
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Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure
Rudd, Michael T, McCauley, John A, Butcher, John W, Romano, Joseph J, McIntyre, Charles J, Nguyen, Kevin T, Gilbert, Kevin F, Bush, Kimberly J, Holloway, M. Katharine, Swestock, John, Wan, Bang-Lin, Carroll, Steven S, DiMuzio, Jillian M, Graham, Donald J, Ludmerer, Steven W, Stahlhut, Mark W, Fandozzi, Christine M, Trainor, Nicole, Olsen, David B, Vacca, Joseph P, Liverton, Nigel J
Published in ACS medicinal chemistry letters (10.03.2011)
Published in ACS medicinal chemistry letters (10.03.2011)
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P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation HepatitisC Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325
Rudd, Michael T, Butcher, John W, Nguyen, Kevin T, McIntyre, Charles J, Romano, Joseph J, Gilbert, Kevin F, Bush, Kimberly J, Liverton, Nigel J, Holloway, M Katharine, Harper, Steven, Ferrara, Marco, DiFilippo, Marcello, Summa, Vincenzo, Swestock, John, Fritzen, Jeff, Carroll, Steven S, Burlein, Christine, DiMuzio, Jillian M, Gates, Adam, Graham, Donald J, Huang, Qian, McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark W, Black, Stuart, Chase, Robert, Soriano, Aileen, Fandozzi, Christine M, Taylor, Anne, Trainor, Nicole, Olsen, David B, Coleman, Paul J, Ludmerer, Steven W, McCauley, John A
Published in ChemMedChem (01.04.2015)
Published in ChemMedChem (01.04.2015)
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Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists
McIntyre, Charles J., McCauley, John A., Bednar, Bohumil, Bednar, Rodney A., Butcher, John W., Claremon, David A., Cunningham, Michael E., Freidinger, Roger M., Gaul, Stanley L., Homnick, Carl F., Koblan, Ken S., Mosser, Scott D., Romano, Joseph J., Liverton, Nigel J.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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In vivo cardiac electrophysiologic and antiarrhythmic effects of an isoquinoline IKur blocker, ISQ-1, in rat, dog, and nonhuman primate
Regan, Christopher P, Stump, Gary L, Wallace, Audrey A, Anderson, Kenneth D, McIntyre, Charles J, Liverton, Nigel J, Lynch, Jr, Joseph J
Published in Journal of cardiovascular pharmacology (01.04.2007)
Published in Journal of cardiovascular pharmacology (01.04.2007)
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Journal Article
Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide
Selnick, Harold G, Liverton, Nigel J, Baldwin, John J, Butcher, John W, Claremon, David A, Elliott, Jason M, Freidinger, Roger M, King, Stella A, Libby, Brian E, McIntyre, Charles J, Pribush, David A, Remy, David C, Smith, Garry R, Tebben, Andrew J, Jurkiewicz, Nancy K, Lynch, Joseph J, Salata, Joseph J, Sanguinetti, Michael C, Siegl, Peter K. S, Slaughter, Donald E, Vyas, Kamlesh
Published in Journal of medicinal chemistry (21.11.1997)
Published in Journal of medicinal chemistry (21.11.1997)
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In vitro characterization of novel NR2B selective NMDA receptor antagonists
Kiss, Laszlo, Cheng, Gong, Bednar, Bohumil, Bednar, Rodney A., Bennett, Paul B., Kane, Stefanie A., McIntyre, Charles J., McCauley, John A., Koblan, Kenneth S.
Published in Neurochemistry international (01.05.2005)
Published in Neurochemistry international (01.05.2005)
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Pyridazine based inhibitors of p38 MAPK
McIntyre, Charles J, Ponticello, Gerald S, Liverton, Nigel J, O’Keefe, Stephen J, O’Neill, Edward A, Pang, Margaret, Schwartz, Cheryl D, Claremon, David A
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
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Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
Harper, Steven, McCauley, John A, Rudd, Michael T, Ferrara, Marco, DiFilippo, Marcello, Crescenzi, Benedetta, Koch, Uwe, Petrocchi, Alessia, Holloway, M. Katharine, Butcher, John W, Romano, Joseph J, Bush, Kimberly J, Gilbert, Kevin F, McIntyre, Charles J, Nguyen, Kevin T, Nizi, Emanuela, Carroll, Steven S, Ludmerer, Steven W, Burlein, Christine, DiMuzio, Jillian M, Graham, Donald J, McHale, Carolyn M, Stahlhut, Mark W, Olsen, David B, Monteagudo, Edith, Cianetti, Simona, Giuliano, Claudio, Pucci, Vincenzo, Trainor, Nicole, Fandozzi, Christine M, Rowley, Michael, Coleman, Paul J, Vacca, Joseph P, Summa, Vincenzo, Liverton, Nigel J
Published in ACS medicinal chemistry letters (12.04.2012)
Published in ACS medicinal chemistry letters (12.04.2012)
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Nonpeptide Glycoprotein IIb/IIIa Inhibitors. 15. Antithrombotic Efficacy of L-738,167, a Long-Acting GPIIb/IIIa Antagonist, Correlates with Inhibition of Adenosine Diphosphate-Induced Platelet Aggregation but not with Bleeding Time Prolongation
Cook, J J, Sitko, G R, Holahan, M A, Stranieri, M T, Glass, J D, Askew, B C, McIntyre, C J, Claremon, D A, Baldwin, J J, Hartman, G D, Gould, R J, Lynch, Jr, J J
Published in The Journal of pharmacology and experimental therapeutics (01.05.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.05.1997)
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HCV NS3 PROTEASE INHIBITORS
SUMMA VINCENZO, MACCAULEY JOHN A, BUTCHER JOHN W, DIFRANCESCO MARIA EMILIA, FERRARA MARCO, HOLLOWAY M. KATHARINE, MCINTYRE CHARLES J, GILBERT KEVIN F, HARPER STEVEN, PETROCCHI ALESSIA, RUDD MICHAEL T, LIVERTON NIGEL J, POMPEI MARCO, ROMANO JOSEPH J
Year of Publication 09.07.2009
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Year of Publication 09.07.2009
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