Targeting CD73 in the tumor microenvironment with MEDI9447
Hay, Carl M., Sult, Erin, Huang, Qihui, Mulgrew, Kathy, Fuhrmann, Stacy R., McGlinchey, Kelly A., Hammond, Scott A., Rothstein, Raymond, Rios-Doria, Jonathan, Poon, Edmund, Holoweckyj, Nick, Durham, Nicholas M., Leow, Ching Ching, Diedrich, Gundo, Damschroder, Melissa, Herbst, Ronald, Hollingsworth, Robert E., Sachsenmeier, Kris F.
Published in Oncoimmunology (02.08.2016)
Published in Oncoimmunology (02.08.2016)
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Journal Article
Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer
Zanvit, Peter, van Dyk, Dewald, Fazenbaker, Christine, McGlinchey, Kelly, Luo, Weichuan, Pezold, Jessica M, Meekin, John, Chang, Chien-Ying, Carrasco, Rosa A, Breen, Shannon, Cheung, Crystal Sao-Fong, Endlich-Frazier, Ariel, Clark, Benjamin, Chu, Nina J, Vantellini, Alessio, Martin, Philip L, Hoover, Clare E, Riley, Kenesha, Sweet, Steve M, Chain, David, Kim, Yeoun Jin, Tu, Eric, Harder, Nathalie, Phipps, Sandrina, Damschroder, Melissa, Gilbreth, Ryan N, Cobbold, Mark, Moody, Gordon, Bosco, Emily E
Published in The Journal of clinical investigation (15.11.2023)
Published in The Journal of clinical investigation (15.11.2023)
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Journal Article
Anti-PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC
Tu, Eric, McGlinchey, Kelly, Wang, Jixin, Martin, Philip, Ching, Steven Lk, Floc'h, Nicolas, Kurasawa, James, Starrett, Jacqueline H, Lazdun, Yelena, Wetzel, Leslie, Nuttall, Barrett, Ng, Felicia Sl, Coffman, Karen T, Smith, Paul D, Politi, Katerina, Cooper, Zachary A, Streicher, Katie
Published in JCI insight (08.02.2022)
Published in JCI insight (08.02.2022)
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Journal Article
325 Armored STEAP2 CAR-T (AZD0754) alone and in combination with enzalutamide demonstrates anti-tumor activity across a range of STEAP2 expressing prostate cancer PDX models
Zanvit, Peter, McGlinchey, Kelly, Fazenbaker, Christine, Luo, Weichuan, Pezold, Jessica, Hoover, Clare, Cobbold, Mark, Moody, Gordon, Bosco, Emily
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer
Schofield, Darren J, Percival-Alwyn, Jennifer, Rytelewski, Mateusz, Hood, John, Rothstein, Raymond, Wetzel, Leslie, McGlinchey, Kelly, Adjei, Grace, Watkins, Amanda, Machiesky, LeeAnn, Chen, Weimin, Andrews, John, Groves, Maria, Morrow, Michelle, Stewart, Ross A, Leinster, Andrew, Wilkinson, Robert W, Hammond, Scott A, Luheshi, Nadia, Dobson, Claire, Oberst, Michael
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Journal Article
GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory
Durham, Nick M, Holoweckyj, Nick, MacGill, Randall S, McGlinchey, Kelly, Leow, Ching Ching, Robbins, Scott H
Published in Journal for immunotherapy of cancer (20.06.2017)
Published in Journal for immunotherapy of cancer (20.06.2017)
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Journal Article
Dasatinib (BMS-354825) Pharmacokinetics and Pharmacodynamic Biomarkers in Animal Models Predict Optimal Clinical Exposure
LUO, Feng R, ZHENG YANG, WEN, Mei-Li, KRAMER, Robert, BLACKWOOD-CHIRCHIR, Anne, LEE, Francis Y, CAMUSO, Amy, SMYKLA, Richard, MCGLINCHEY, Kelly, FAGER, Krista, FLEFLEH, Christine, CASTANEDA, Stephen, INIGO, Ivan, KAN, David
Published in Clinical cancer research (01.12.2006)
Published in Clinical cancer research (01.12.2006)
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Journal Article
Cetuximab preclinical antitumor activity (monotherapy and combination based) is not predicted by relative total or activated epidermal growth factor receptor tumor expression levels
Wild, Robert, Fager, Krista, Flefleh, Christine, Kan, David, Inigo, Ivan, Castaneda, Stephen, Luo, Feng Roger, Camuso, Amy, McGlinchey, Kelly, Rose, William C
Published in Molecular cancer therapeutics (01.01.2006)
Published in Molecular cancer therapeutics (01.01.2006)
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Journal Article
Prediction of Active Drug Plasma Concentrations Achieved in Cancer Patients by Pharmacodynamic Biomarkers Identified from the Geo Human Colon Carcinoma Xenograft Model
LUO, Feng R, ZHENG YANG, WONG, Tai W, KRAMER, Robert A, WILD, Robert, LEE, Francis Y, HUIJIN DONG, CAMUSO, Amy, MCGLINCHEY, Kelly, FAGER, Krista, FLEFLEH, Christine, KAN, David, INIGO, Ivan, CASTANEDA, Stephen
Published in Clinical cancer research (01.08.2005)
Published in Clinical cancer research (01.08.2005)
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Journal Article
Abstract 2267: MEDI5083, a novel CD40L-Fc fusion protein, activates the CD40 pathway on antigen-presenting cells and promotes robust anti-tumor immune responses in both hot and cold murine tumor models
Malhotra, Deepali, Turman, Sean, McGlinchey, Kelly, Wang, Yaya, Wang, Yue
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Antibody-Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies
Rios-Doria, Jonathan, Harper, Jay, Rothstein, Raymond, Wetzel, Leslie, Chesebrough, Jon, Marrero, Allison, Chen, Cui, Strout, Patrick, Mulgrew, Kathy, McGlinchey, Kelly, Fleming, Ryan, Bezabeh, Binyam, Meekin, John, Stewart, David, Kennedy, Maureen, Martin, Philip, Buchanan, Andrew, Dimasi, Nazzareno, Michelotti, Emil, Hollingsworth, Robert
Published in Cancer research (Chicago, Ill.) (15.05.2017)
Published in Cancer research (Chicago, Ill.) (15.05.2017)
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Journal Article
Oncolytic VSV Primes Differential Responses to Immuno-oncology Therapy
Durham, Nicholas M., Mulgrew, Kathy, McGlinchey, Kelly, Monks, Noel R., Ji, Hong, Herbst, Ronald, Suzich, JoAnn, Hammond, Scott A., Kelly, Elizabeth J.
Published in Molecular therapy (02.08.2017)
Published in Molecular therapy (02.08.2017)
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Journal Article
Abstract 1534: MEDI5083, a novel CD40L-Fc fusion protein, activates the CD40 pathway on antigen presenting cells and promotes a robust anti-tumor immune response in a B16F10 murine tumor model
Turman, Sean, McGlinchey, Kelly, Wang, YaYa, Malhotra, Deepali, Herbst, Ronald, Wang, Yue
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 911: Anti-PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR mutant NSCLC
Tu, Eric, McGlinchey, Kelly, Lazdun, Yelena, Kurasawa, James, Wilson, Susan, Wetzel, Leslie, Coffman, Karen, Cooper, Zachary, Streicher, Katie
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Safety and Tolerability of MEDI0562, an OX40 Agonist mAb, in Combination with Durvalumab or Tremelimumab in Adult Patients with Advanced Solid Tumors
Goldman, Jonathan W., Piha-Paul, Sarina A., Curti, Brendan, Pedersen, Katrina S., Bauer, Todd M., Groenland, Stefanie L., Carvajal, Richard D., Chhaya, Vaishali, Kirby, Gray, McGlinchey, Kelly, Hammond, Scott A., Streicher, Katie, Townsley, Danielle M., Chae, Young Kwang, Voortman, Jens, Marabelle, Aurelien, Powderly, John
Published in Clinical cancer research (01.09.2022)
Published in Clinical cancer research (01.09.2022)
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Journal Article
Antitumor activity of AZD0754, a dnTGF[beta]RII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer
Zanvit, Peter, van Dyk, Dewald, Fazenbaker, Christine, McGlinchey, Kelly, Luo, Weichuan, Pezold, Jessica M, Meekin, John, Chang, Chien-ying, Carrasco, Rosa A, Breen, Shannon, Cheung, Crystal Sao-Fong, Endlich-Frazier, Ariel, Clark, Benjamin, Chu, Nina J, Vantellini, Alessio, Martin, Philip L, Hoover, Clare E, Riley, Kenesha, Sweet, Steve M, Chain, David, Kim, Yeoun Jin, Tu, Eric, Harder, Nathalie, Phipps, Sandrina, Damschroder, Melissa, Gilbreth, Ryan N, Cobbold, Mark, Moody, Gordon, Bosco, Emily E
Published in The Journal of clinical investigation (15.11.2023)
Published in The Journal of clinical investigation (15.11.2023)
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Journal Article
Recombinant Newcastle Disease Virus Immunotherapy Drives Oncolytic Effects and Durable Systemic Antitumor Immunity
Harper, James, Burke, Shannon, Travers, Jon, Rath, Nicola, Leinster, Andrew, Navarro, Christel, Franks, Ruth, Leyland, Rebecca, Mulgrew, Kathy, McGlinchey, Kelly, Brown, Lee, Dovedi, Simon J, Koopmann, Jens-Oliver, Durham, Nicholas M, Cheng, Xing, Jin, Hong, Eyles, Jim, Wilkinson, Robert W, Carroll, Danielle
Published in Molecular cancer therapeutics (01.09.2021)
Published in Molecular cancer therapeutics (01.09.2021)
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Journal Article
Abstract 5544: Newcastle Disease Virus in human derived tumors: Understanding immune recruitment and activation via virally delivered IL-12
Durham, Nicholas M., McGlinchey, Kelly, Burke, Shannon, Creasy, Todd, Rath, Nicola, Monks, Noel, Tammali, Ravinder, Schifferli, Kevin, Holoweckyj, Nick, Hayes, Susie, Jones, Emma, Kelly, Elizabeth J., Carroll, Danielle, Harper, James, Streicher, Katie
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
A Novel Murine GITR Ligand Fusion Protein Induces Antitumor Activity as a Monotherapy That Is Further Enhanced in Combination with an OX40 Agonist
Leyland, Rebecca, Watkins, Amanda, Mulgrew, Kathy A, Holoweckyj, Nicholas, Bamber, Lisa, Tigue, Natalie J, Offer, Emily, Andrews, John, Yan, Li, Mullins, Stefanie, Oberst, Michael D, Coates Ulrichsen, Jane, Leinster, David A, McGlinchey, Kelly, Young, Lesley, Morrow, Michelle, Hammond, Scott A, Mallinder, Philip, Herath, Athula, Leow, Ching Ching, Wilkinson, Robert W, Stewart, Ross
Published in Clinical cancer research (01.07.2017)
Published in Clinical cancer research (01.07.2017)
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Journal Article
Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein
Oberst, Michael D, Augé, Catherine, Morris, Chad, Kentner, Stacy, Mulgrew, Kathy, McGlinchey, Kelly, Hair, James, Hanabuchi, Shino, Du, Qun, Damschroder, Melissa, Feng, Hui, Eck, Steven, Buss, Nicholas, de Haan, Lolke, Pierce, Andrew J, Park, Haesun, Sylwester, Andrew, Axthelm, Michael K, Picker, Louis, Morris, Nicholas P, Weinberg, Andrew, Hammond, Scott A
Published in Molecular cancer therapeutics (01.05.2018)
Published in Molecular cancer therapeutics (01.05.2018)
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Journal Article