Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064
Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Jones, Stacey A., Kaldor, Istvan, Liu, Yaping, Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., III, Frank Navas, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Journal Article
FXR agonist activity of conformationally constrained analogs of GW 4064
Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Navas, Frank, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Bruce Wisely, G.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Journal Article
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Parks, Derek J., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
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Journal Article
Novel and potent cyclic cyanamide-based cathepsin K inhibitors
Deaton, David N., Hassell, Anne M., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Shewchuk, Lisa M., Tavares, Francis X., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (01.04.2005)
Published in Bioorganic & medicinal chemistry letters (01.04.2005)
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Journal Article
Acyclic cyanamide-based inhibitors of cathepsin K
Barrett, David G., Deaton, David N., Hassell, Anne M., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Payne, J. Alan, Shewchuk, Lisa M., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (15.06.2005)
Published in Bioorganic & medicinal chemistry letters (15.06.2005)
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Journal Article
Acyclic, orally bioavailable ketone-based cathepsin K inhibitors
Barrett, David G., Catalano, John G., Deaton, David N., Long, Stacey T., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Samano, Vicente, Tavares, Francis X., Wells-Knecht, Kevin J., Wright, Lois L., Zhou, Hui-Qiang Q.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Journal Article
Design of small molecule ketoamide-based inhibitors of cathepsin K
Catalano, John G., Deaton, David N., Long, Stacey T., McFadyen, Robert B., Miller, Larry R., Payne, J.Alan, Wells-Knecht, Kevin J., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
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Journal Article
A structural screening approach to ketoamide-based inhibitors of cathepsin K
Barrett, David G., Catalano, John G., Deaton, David N., Long, Stacey T., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Wells-Knecht, Kevin J., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
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Journal Article
Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?
Adkison, Kim K., Barrett, David G., Deaton, David N., Gampe, Robert T., Hassell, Anne M., Long, Stacey T., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Payne, J. Alan, Shewchuk, Lisa M., Wells-Knecht, Kevin J., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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Journal Article
P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K
BARRETT, David G, BONCEK, Virginia M, PAYNE, J. Alan, RAY, John A, SAMANO, Vicente, SHEWCHUK, Lisa M, TAVARES, Francis X, WELLS-KNECHT, Kevin J, WILLARD, Derril H, WRIGHT, Lois L, ZHOU, Hui-Qiang Q, CATALANO, John G, DEATON, David N, HASSELL, Anne M, JURGENSEN, Cynthia H, LONG, Stacey T, MCFADYEN, Robert B, MILLER, Aaron B, MILLER, Larry R
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
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Journal Article
Exploration of the P1 SAR of aldehyde cathepsin K inhibitors
CATALANO, John G, DEATON, David N, FURFINE, Eric S, HASSELL, Annie M, MCFADYEN, Robert B, MILLER, Aaron B, MILLER, Larry R, SHEWCHUK, Lisa M, WILLARD, Derril H, WRIGHT, Lois L
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
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Journal Article
P 2–P 3 conformationally constrained ketoamide-based inhibitors of cathepsin K
Barrett, David G., Boncek, Virginia M., Catalano, John G., Deaton, David N., Hassell, Anne M., Jurgensen, Cynthia H., Long, Stacey T., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Payne, J. Alan, Ray, John A., Samano, Vicente, Shewchuk, Lisa M., Tavares, Francis X., Wells-Knecht, Kevin J., Willard, Derril H., Wright, Lois L., Zhou, Hui-Qiang Q.
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
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Journal Article
Exploration of the P2–P3 SAR of aldehyde cathepsin K inhibitors
Boros, Eric E., Deaton, David N., Hassell, Anne M., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Paulick, Margot G., Shewchuk, Lisa M., Thompson, James B., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (01.07.2004)
Published in Bioorganic & medicinal chemistry letters (01.07.2004)
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Journal Article
Exploration of the P 2–P 3 SAR of aldehyde cathepsin K inhibitors
Boros, Eric E., Deaton, David N., Hassell, Anne M., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Paulick, Margot G., Shewchuk, Lisa M., Thompson, James B., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (2004)
Published in Bioorganic & medicinal chemistry letters (2004)
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Journal Article
Exploration of the P 1 SAR of aldehyde cathepsin K inhibitors
Catalano, John G., Deaton, David N., Furfine, Eric S., Hassell, Annie M., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Shewchuk, Lisa M., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (2004)
Published in Bioorganic & medicinal chemistry letters (2004)
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Journal Article
Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors
BORES, Eric E, DEATON, David N, WRIGHT, Lois L, HASSELL, Anne M, MCFADYEN, Robert B, MILLER, Aaron B, MILLER, Larry R, PAULICK, Margot G, SHEWCHUK, Lisa M, THOMPSON, James B, WILLARD, Derril H
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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Journal Article
Novel and Potent Cyclic Cyanamide-Based Cathepsin K Inhibitors
Deaton, David N., Hassell, Anne M., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Shewchuk, Lisa M., Tavares, Francis X., Willard, Derril H. Jr, Wright, Lois L.
Published in ChemInform (26.07.2005)
Published in ChemInform (26.07.2005)
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Journal Article
Alpha-ketoamide derivatives as cathepsin k inhibitors
MILLER AARON B, DEATON DAVID N, MCFADYEN ROBERT B, TAVARES FRANCIS X, RAY JOHN A, BARRETT DAVID GENE, ZHOU HUIQIANG
Year of Publication 19.05.2005
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Year of Publication 19.05.2005
Patent
Design of Small Molecule Ketoamide-Based Inhibitors of Cathepsin K
Catalano, John G., Deaton, David N., Long, Stacey T., McFadyen, Robert B., Miller, Larry R., Payne, J. Alan, Wells-Knecht, Kevin J., Wright, Lois L.
Published in ChemInform (08.06.2004)
Published in ChemInform (08.06.2004)
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Journal Article