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Published in Journal of medicinal chemistry (27.11.2019)
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Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice
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Published in Molecular neurodegeneration (18.05.2017)
Published in Molecular neurodegeneration (18.05.2017)
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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
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Published in Nature chemical biology (01.08.2008)
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MK-8719, a Novel and Selective O -GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy
Wang, Xiaohai, Li, Wenping, Marcus, Jacob, Pearson, Michelle, Song, Lixin, Smith, Karen, Terracina, Giuseppe, Lee, Julie, Hong, Kwok-Lam Karen, Lu, Sherry X., Hyde, Lynn, Chen, Shu-Cheng, Kinsley, David, Melchor, Jerry P., Rubins, Daniel J., Meng, Xiangjun, Hostetler, Eric, Sur, Cyrille, Zhang, Lili, Schachter, Joel B., Hess, J. Fred, Selnick, Harold G., Vocadlo, David J., McEachern, Ernest J., Uslaner, Jason M., Duffy, Joseph L., Smith, Sean M.
Published in The Journal of pharmacology and experimental therapeutics (01.08.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2020)
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Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms
Kolappan, Subramaniapillai, Shen, David L., Mosi, Renee, Sun, Jianyu, McEachern, Ernest J., Vocadlo, David J., Craig, Lisa
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2015)
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2015)
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Inorganic Carbonates as Nucleophiles for the Asymmetric Synthesis of Vinylglycidols
Trost, Barry M, McEachern, Ernest J
Published in Journal of the American Chemical Society (22.09.1999)
Published in Journal of the American Chemical Society (22.09.1999)
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Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice
Yuzwa, Scott A, Shan, Xiaoyang, Jones, Bryan A, Zhao, Gang, Woodward, Melissa L, Li, Xiaojing, Zhu, Yanping, McEachern, Ernest J, Silverman, Michael A, Watson, Neil V, Gong, Cheng-Xin, Vocadlo, David J
Published in Molecular neurodegeneration (26.10.2014)
Published in Molecular neurodegeneration (26.10.2014)
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Discovery of Novel Small Molecule Orally Bioavailable C−X−C Chemokine Receptor 4 Antagonists That Are Potent Inhibitors of T-Tropic (X4) HIV-1 Replication
Skerlj, Renato T, Bridger, Gary J, Kaller, Al, McEachern, Ernest J, Crawford, Jason B, Zhou, Yuanxi, Atsma, Bem, Langille, Jonathon, Nan, Susan, Veale, Duane, Wilson, Trevor, Harwig, Curtis, Hatse, Sigrid, Princen, Katrien, De Clercq, Erik, Schols, Dominique
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Copper Chloride-Catalyzed and Hydrochloric Acid-Mediated Chemoselective Protiodestannylations of Alkyl (Z)- or (E)-2,3-Bis(trimethylstannyl)-2-alkenoates. Stereoselective Preparation of Alkyl (E)- and (Z)-3-Trimethylstannyl-2-alkenoates
Piers, Edward, McEachern, Ernest J, Romero, Miguel A
Published in Journal of organic chemistry (22.08.1997)
Published in Journal of organic chemistry (22.08.1997)
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Concise Preparation of Amino-5,6,7,8-tetrahydroquinolines and Amino-5,6,7,8-tetrahydroisoquinolines via Catalytic Hydrogenation of Acetamidoquinolines and Acetamidoisoquinolines
Skupinska, Krystyna A, McEachern, Ernest J, Skerlj, Renato T, Bridger, Gary J
Published in Journal of organic chemistry (01.11.2002)
Published in Journal of organic chemistry (01.11.2002)
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GLYCOSIDASE INHIBITORS AND USES THEREOF
DANG QUN, KAUL RAMESH, MCEACHERN ERNEST J, ZHOU YUANXI, VOCADLO DAVID J, SELNICK HAROLD G
Year of Publication 08.07.2015
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Year of Publication 08.07.2015
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SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF
LI TONG SHUANG, MCEACHERN ERNEST J, ZHOU YUANXI, ZHU YONGBAO, VOCADLO DAVID J, SELNICK HAROLD G
Year of Publication 08.04.2014
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Year of Publication 08.04.2014
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