A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Green, Eric M., Wakimoto, Hiroko, Anderson, Robert L., Evanchik, Marc J., Gorham, Joshua M., Harrison, Brooke C., Henze, Marcus, Kawas, Raja, Oslob, Johan D., Rodriguez, Hector M., Song, Yonghong, Wan, William, Leinwand, Leslie A., Spudich, James A., McDowell, Robert S., Seidman, J. G., Seidman, Christine E.
Published in Science (American Association for the Advancement of Science) (05.02.2016)
Published in Science (American Association for the Advancement of Science) (05.02.2016)
Get full text
Journal Article
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II
Hawtin, Rachael E, Stockett, David E, Byl, Jo Ann W, McDowell, Robert S, Nguyen, Tan, Arkin, Michelle R, Conroy, Andrew, Yang, Wenjin, Osheroff, Neil, Fox, Judith A
Published in PloS one (15.04.2010)
Published in PloS one (15.04.2010)
Get full text
Journal Article
Allosteric inhibition of protein tyrosine phosphatase 1B
Hansen, Stig K, Wiesmann, Christian, Barr, Kenneth J, Kung, Jenny, Zhu, Jiang, Erlanson, Daniel A, Shen, Wang, Fahr, Bruce J, Zhong, Min, Taylor, Lisa, Randal, Mike, McDowell, Robert S
Published in Nature structural & molecular biology (01.08.2004)
Published in Nature structural & molecular biology (01.08.2004)
Get full text
Journal Article
Binding of Small Molecules to an Adaptive Protein-Protein Interface
Arkin, Michelle R., Randal, Mike, DeLano, Warren L., Hyde, Jennifer, Luong, Tinh N., Oslob, Johan D., Raphael, Darren R., Taylor, Lisa, Wang, Jun, McDowell, Robert S., Wells, James A., Braisted, Andrew C.
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2003)
Get full text
Journal Article
Discovery of a Potent Small Molecule IL-2 Inhibitor through Fragment Assembly
Braisted, Andrew C, Oslob, Johan D, Delano, Warren L, Hyde, Jennifer, McDowell, Robert S, Waal, Nathan, Yu, Chul, Arkin, Michelle R, Raimundo, Brian C
Published in Journal of the American Chemical Society (02.04.2003)
Published in Journal of the American Chemical Society (02.04.2003)
Get full text
Journal Article
Fragment-Based Discovery of Nonpeptidic BACE-1 Inhibitors Using Tethering
Yang, Wenjin, Fucini, Raymond V, Fahr, Bruce T, Randal, Mike, Lind, Kenneth E, Lam, Melissa B, Lu, Wanli, Lu, Yafan, Cary, Douglas R, Romanowski, Michael J, Colussi, Dennis, Pietrak, Beth, Allison, Timothy J, Munshi, Sanjeev K, Penny, David M, Pham, Phuongly, Sun, Jian, Thomas, Anila E, Wilkinson, Jennifer M, Jacobs, Jeffrey W, McDowell, Robert S, Ballinger, Marcus D
Published in Biochemistry (Easton) (02.06.2009)
Published in Biochemistry (Easton) (02.06.2009)
Get full text
Journal Article
Fragment-Based Drug Discovery
Erlanson, Daniel A, McDowell, Robert S, O'Brien, Tom
Published in Journal of medicinal chemistry (01.07.2004)
Published in Journal of medicinal chemistry (01.07.2004)
Get full text
Journal Article
Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery
Erlanson, Daniel A., Arndt, Joseph W., Cancilla, Mark T., Cao, Kathy, Elling, Robert A., English, Nicki, Friedman, Jessica, Hansen, Stig K., Hession, Cathy, Joseph, Ingrid, Kumaravel, Gnanasambandam, Lee, Wen-Cherng, Lind, Ken E., McDowell, Robert S., Miatkowski, Konrad, Nguyen, Christine, Nguyen, Thinh B., Park, Sophia, Pathan, Nuzhat, Penny, David M., Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Simmons, Robert L., Tangonan, Bradley T., Yang, Wenjin, Sun, Lihong
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Get full text
Journal Article
Discovery of a potent and selective Aurora kinase inhibitor
Oslob, Johan D., Romanowski, Michael J., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Elling, Robert A., Flanagan, William M., Fung, Amy D., Hanan, Emily J., Harris, Shannon, Heumann, Stacey A., Hoch, Ute, Jacobs, Jeffrey W., Lam, Joni, Lawrence, Chris E., McDowell, Robert S., Nannini, Michelle A., Shen, Wang, Silverman, Jeffrey A., Sopko, Michelle M., Tangonan, Bradley T., Teague, Juli, Yoburn, Josh C., Yu, Chul H., Zhong, Min, Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard
Published in Bioorganic & medicinal chemistry (01.09.2008)
Published in Bioorganic & medicinal chemistry (01.09.2008)
Get full text
Journal Article
Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation
Oslob, Johan D, Johnson, Russell J, Cai, Haiying, Feng, Shirley Q, Hu, Lily, Kosaka, Yuko, Lai, Julie, Sivaraja, Mohanram, Tep, Samnang, Yang, Hanbiao, Zaharia, Cristiana A, Evanchik, Marc J, McDowell, Robert S
Published in ACS medicinal chemistry letters (10.01.2013)
Published in ACS medicinal chemistry letters (10.01.2013)
Get full text
Journal Article
Structural studies of potent constrained RGD peptides
McDowell, Robert S, Gadek, Thomas R
Published in Journal of the American Chemical Society (01.11.1992)
Published in Journal of the American Chemical Society (01.11.1992)
Get full text
Journal Article
2-Aminobenzimidazoles as potent Aurora kinase inhibitors
Zhong, Min, Bui, Minna, Shen, Wang, Baskaran, Subramanian, Allen, Darin A., Elling, Robert A., Flanagan, W. Michael, Fung, Amy D., Hanan, Emily J., Harris, Shannon O., Heumann, Stacey A., Hoch, Ute, Ivy, Sheryl N., Jacobs, Jeffrey W., Lam, Stuart, Lee, Heman, McDowell, Robert S., Oslob, Johan D., Purkey, Hans E., Romanowski, Michael J., Silverman, Jeffrey A., Tangonan, Bradley T., Taverna, Pietro, Yang, Wenjin, Yoburn, Josh C., Yu, Chul H., Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Get full text
Journal Article
HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
WAGMAN ALLAN S, EVANCHIK MARC, BUCKLEY DOUGLAS I, DUKE GREGORY, MCDOWELL ROBERT S
Year of Publication 20.03.2024
Get full text
Year of Publication 20.03.2024
Patent
Mambin, a potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor structurally related to the short neurotoxins
McDowell, Robert S, Dennis, Mark S, Louie, Andrea, Shuster, Michael, Mulkerrin, Michael G, Lazarus, Robert A
Published in Biochemistry (Easton) (01.05.1992)
Published in Biochemistry (Easton) (01.05.1992)
Get full text
Journal Article
Aminoethylenes: A Tetrahedral Intermediate Isostere Yielding Potent Inhibitors of the Aspartyl Protease BACE-1
Yang, Wenjin, Lu, Wanli, Lu, Yafan, Zhong, Min, Sun, Jian, Thomas, Anila E, Wilkinson, Jennifer M, Fucini, Raymond V, Lam, Melissa, Randal, Mike, Shi, Xiao-Ping, Jacobs, Jeffrey W, McDowell, Robert S, Gordon, Eric M, Ballinger, Marcus D
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
Get full text
Journal Article
Integrating Fragment Assembly and Biophysical Methods in the Chemical Advancement of Small-Molecule Antagonists of IL-2: An Approach for Inhibiting Protein−Protein Interactions
Raimundo, Brian C, Oslob, Johan D, Braisted, Andrew C, Hyde, Jennifer, McDowell, Robert S, Randal, Mike, Waal, Nathan D, Wilkinson, Jennifer, Yu, Chul H, Arkin, Michelle R
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
Get full text
Journal Article
Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design
Choong, Ingrid C, Lew, Willard, Lee, Dennis, Pham, Phuongly, Burdett, Matthew T, Lam, Joni W, Wiesmann, Christian, Luong, Tinh N, Fahr, Bruce, DeLano, Warren L, McDowell, Robert S, Allen, Darin A, Erlanson, Daniel A, Gordon, Eric M, O'Brien, Tom
Published in Journal of medicinal chemistry (07.11.2002)
Published in Journal of medicinal chemistry (07.11.2002)
Get full text
Journal Article
A Minimal Peptide Scaffold for β-Turn Display: Optimizing a Strand Position in Disulfide-Cyclized β-Hairpins
Cochran, Andrea G, Tong, Ricky T, Starovasnik, Melissa A, Park, Eleanor J, McDowell, Robert S, Theaker, J. E, Skelton, Nicholas J
Published in Journal of the American Chemical Society (31.01.2001)
Published in Journal of the American Chemical Society (31.01.2001)
Get full text
Journal Article
Water-soluble prodrugs of an Aurora kinase inhibitor
Oslob, Johan D., Heumann, Stacey A., Yu, Chul H., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Delarosa, Erlie, Fung, Amy D., Hashash, Ahmad, Hau, Jonathan, Ivy, Sheryl, Jacobs, Jeffrey W., Lew, Willard, Maung, Jack, McDowell, Robert S., Ritchie, Sean, Romanowski, Michael J., Silverman, Jeffrey A., Yang, Wenjin, Zhong, Min, Fuchs-Knotts, Tarra
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Get full text
Journal Article