Targeting activated PI3K/mTOR signaling overcomes acquired resistance to CDK4/6-based therapies in preclinical models of hormone receptor-positive breast cancer
O'Brien, Neil A, McDermott, Martina S J, Conklin, Dylan, Luo, Tong, Ayala, Raul, Salgar, Suruchi, Chau, Kevin, DiTomaso, Emmanuelle, Babbar, Naveen, Su, Faye, Gaither, Alex, Hurvitz, Sara A, Linnartz, Ronald, Rose, Kristine, Hirawat, Samit, Slamon, Dennis J
Published in Breast cancer research : BCR (14.08.2020)
Published in Breast cancer research : BCR (14.08.2020)
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Concise total syntheses of (-)-jorunnamycin A and (-)-jorumycin enabled by asymmetric catalysis
Welin, Eric R, Ngamnithiporn, Aurapat, Klatte, Max, Lapointe, Guillaume, Pototschnig, Gerit M, McDermott, Martina S J, Conklin, Dylan, Gilmore, Christopher D, Tadross, Pamela M, Haley, Christopher K, Negoro, Kenji, Glibstrup, Emil, Grünanger, Christian U, Allan, Kevin M, Virgil, Scott C, Slamon, Dennis J, Stoltz, Brian M
Published in Science (American Association for the Advancement of Science) (18.01.2019)
Published in Science (American Association for the Advancement of Science) (18.01.2019)
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Alterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy
Gaynor, Nicola, Blanco, Alfonso, Madden, Stephen F., Moran, Barry, Fletcher, Jean M., Kaukonen, Damien, Ramírez, Javier Sánchez, Eustace, Alex J., McDermott, Martina S. J., Canonici, Alexandra, Toomey, Sinead, Teiserskiene, Ausra, Hennessy, Bryan T., O’Donovan, Norma, Crown, John, Collins, Denis M.
Published in British journal of cancer (05.10.2023)
Published in British journal of cancer (05.10.2023)
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Journal Article
Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer
Broude, Eugenia V, Győrffy, Balázs, Chumanevich, Alexander A, Chen, Mengqian, McDermott, Martina S J, Shtutman, Michael, Catroppo, James F, Roninson, Igor B
Published in Current cancer drug targets (01.10.2015)
Published in Current cancer drug targets (01.10.2015)
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Journal Article
CDK8/19 Mediator kinases potentiate induction of transcription by NFκB
Chen, Mengqian, Liang, Jiaxin, Ji, Hao, Yang, Zhengguan, Altilia, Serena, Hu, Bing, Schronce, Adam, McDermott, Martina S. J., Schools, Gary P., Lim, Chang-uk, Oliver, David, Shtutman, Michael S., Lu, Tao, Stark, George R., Porter, Donald C., Broude, Eugenia V., Roninson, Igor B.
Published in Proceedings of the National Academy of Sciences - PNAS (19.09.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (19.09.2017)
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Journal Article
Correction: PP2A inhibition overcomes acquired resistance to HER2 targeted therapy
McDermott, Martina S. J., Browne, Brigid C., Conlon, Neil T., O’Brien, Neil A., Slamon, Dennis J., Henry, Michael, Meleady, Paula, Clynes, Martin, Dowling, Paul, Crown, John, O’Donovan, Norma
Published in Molecular cancer (30.10.2023)
Published in Molecular cancer (30.10.2023)
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Journal Article
Tucatinib has Selective Activity in HER2-Positive Cancers and Significant Combined Activity with Approved and Novel Breast Cancer-Targeted Therapies
O'Brien, Neil A, Huang, Holly K T, McDermott, Martina S J, Madrid, Athena M, Luo, Tong, Ayala, Raul, Issakhanian, Shawnt, Gong, Ke Wei, Lu, Ming, Zhang, Jun, Slamon, Dennis J
Published in Molecular cancer therapeutics (04.05.2022)
Published in Molecular cancer therapeutics (04.05.2022)
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Journal Article
Preclinical Efficacy of the Antibody-Drug Conjugate CLDN6-23-ADC for the Treatment of CLDN6-Positive Solid Tumors
McDermott, Martina S J, O'Brien, Neil A, Hoffstrom, Benjamin, Gong, KeWei, Lu, Ming, Zhang, Jun, Luo, Tong, Liang, Min, Jia, Weiping, Hong, Jenny J, Chau, Kevin, Davenport, Simon, Xie, Bin, Press, Michael F, Panayiotou, Richard, Handly-Santana, Abram, Brugge, Joan S, Presta, Leonard, Glaspy, John, Slamon, Dennis J
Published in Clinical cancer research (01.06.2023)
Published in Clinical cancer research (01.06.2023)
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Journal Article
Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo
Ding, Xiaokai, Sharko, Amanda C, McDermott, Martina S J, Schools, Gary P, Chumanevich, Alexander, Ji, Hao, Li, Jing, Zhang, Li, Mack, Zachary T, Sikirzhytski, Vitali, Shtutman, Michael, Ivers, Laura, O'Donovan, Norma, Crown, John, Győrffy, Balázs, Chen, Mengqian, Roninson, Igor B, Broude, Eugenia V
Published in Proceedings of the National Academy of Sciences - PNAS (09.08.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (09.08.2022)
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Journal Article
Development of a Novel CLDN18.2-directed Monoclonal Antibody and Antibody-Drug Conjugate for Treatment of CLDN18.2-Positive Cancers
O'Brien, Neil A, McDermott, Martina S J, Zhang, Jun, Gong, Ke Wei, Lu, Ming, Hoffstrom, Benjamin, Luo, Tong, Ayala, Raul, Chau, Kevin, Liang, Min, Madrid, Athena M, Donahue, Timothy R, Glaspy, John A, Presta, Leonard, Slamon, Dennis J
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
PP2A inhibition overcomes acquired resistance to HER2 targeted therapy
McDermott, Martina Sj, Browne, Brigid C, Conlon, Neil T, O'Brien, Neil A, Slamon, Dennis J, Henry, Michael, Meleady, Paula, Clynes, Martin, Dowling, Paul, Crown, John, O'Donovan, Norma
Published in Molecular cancer (24.06.2014)
Published in Molecular cancer (24.06.2014)
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Journal Article
Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours
Browne, Brigid C., Eustace, Alex J., Kennedy, Susan, O’Brien, Neil A., Pedersen, Kasper, McDermott, Martina S. J., Larkin, Annemarie, Ballot, Jo, Mahgoub, Thamir, Sclafani, Francesco, Madden, Stephen, Kennedy, John, Duffy, Michael J., Crown, John, O’Donovan, Norma
Published in Breast cancer research and treatment (01.12.2012)
Published in Breast cancer research and treatment (01.12.2012)
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Journal Article
Dual inhibition of IGF1R and ER enhances response to trastuzumab in HER2 positive breast cancer cells
McDermott, Martina S J, Canonici, Alexandra, Ivers, Laura, Browne, Brigid C, Madden, Stephen F, O'Brien, Neil A, Crown, John, O'Donovan, Norma
Published in International journal of oncology (01.06.2017)
Published in International journal of oncology (01.06.2017)
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Journal Article
Analysis in epithelial ovarian cancer identifies KANSL1 as a biomarker and target gene for immune response and HDAC inhibition
Fejzo, Marlena S., Chen, Hsiao-Wang, Anderson, Lee, McDermott, Martina SJ, Karlan, Beth, Konecny, Gottfried E., Slamon, Dennis J.
Published in Gynecologic oncology (01.02.2021)
Published in Gynecologic oncology (01.02.2021)
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Journal Article
Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer
McDermott, Martina S J, Chumanevich, Alexander A, Lim, Chang-Uk, Liang, Jiaxin, Chen, Mengqian, Altilia, Serena, Oliver, David, Rae, James M, Shtutman, Michael, Kiaris, Hippokratis, Győrffy, Balázs, Roninson, Igor B, Broude, Eugenia V
Published in Oncotarget (21.02.2017)
Published in Oncotarget (21.02.2017)
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Journal Article
CDK7 Inhibition is Effective in all the Subtypes of Breast Cancer: Determinants of Response and Synergy with EGFR Inhibition
McDermott, Martina S J, Sharko, Amanda C, Munie, Jessica, Kassler, Susannah, Melendez, Theresa, Lim, Chang-Uk, Broude, Eugenia V
Published in Cells (Basel, Switzerland) (06.03.2020)
Published in Cells (Basel, Switzerland) (06.03.2020)
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Journal Article
HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells
McDermott, Martina S J, Conlon, Neil, Browne, Brigid C, Szabo, Adam, Synnott, Naoise C, O'Brien, Neil A, Duffy, Michael J, Crown, John, O'Donovan, Norma
Published in Cancers (08.02.2019)
Published in Cancers (08.02.2019)
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Journal Article
Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL
Eustace, Alex J, Conlon, Neil T, McDermott, Martina S J, Browne, Brigid C, O'Leary, Patrick, Holmes, Frankie A, Espina, Virginia, Liotta, Lance A, O'Shaughnessy, Joyce, Gallagher, Clair, O'Driscoll, Lorraine, Rani, Sweta, Madden, Stephen F, O'Brien, Neil A, Ginther, Charles, Slamon, Dennis, Walsh, Naomi, Gallagher, William M, Zagozdzon, Radoslaw, Watson, William R, O'Donovan, Norma, Crown, John
Published in BMC cancer (11.10.2018)
Published in BMC cancer (11.10.2018)
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Journal Article
The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs
Sharko, Amanda C, Lim, Chang-Uk, McDermott, Martina S J, Hennes, Chuck, Philavong, Kingsavanh P, Aiken, Tiffanie, Tatarskiy, Victor V, Roninson, Igor B, Broude, Eugenia V
Published in Cells (Basel, Switzerland) (12.01.2021)
Published in Cells (Basel, Switzerland) (12.01.2021)
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Journal Article
Neuromedin U: A Candidate Biomarker and Therapeutic Target to Predict and Overcome Resistance to HER-Tyrosine Kinase Inhibitors
RANI, Sweta, CORCORAN, Claire, GOGARTY, Martina, BYRNE, Annette T, O'DRISCOLL, Lorraine, SHIELS, Liam, GERMANO, Serena, BRESLIN, Susan, MADDEN, Stephen, MCDERMOTT, Martina S, BROWNE, Brigid C, O'DONOVAN, Norma, CROWN, John
Published in Cancer research (Chicago, Ill.) (15.07.2014)
Published in Cancer research (Chicago, Ill.) (15.07.2014)
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