Discovery and Optimization of a Novel Series of Thrombin Receptor (PAR-1) Antagonists: Potent, Selective Peptide Mimetics Based on Indole and Indazole Templates
Zhang, Han-Cheng, Derian, Claudia K, Andrade-Gordon, Patricia, Hoekstra, William J, McComsey, David F, White, Kimberly B, Poulter, Brenda L, Addo, Michael F, Cheung, Wai-Man, Damiano, Bruce P, Oksenberg, Donna, Reynolds, Elwood E, Pandey, Anjali, Scarborough, Robert M, Maryanoff, Bruce E
Published in Journal of medicinal chemistry (29.03.2001)
Published in Journal of medicinal chemistry (29.03.2001)
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Potential anxiolytic agents. 3. Novel A-ring modified pyrido[1,2- a]benzimidazoles
Maryanoff, Bruce E., Nortey, Samuel O., McNally, James J., Sanfilippo, Pauline J., McComsey, David F., Dubinsky, Barry, Shank, Richard P., Reitz, Allen B.
Published in Bioorganic & medicinal chemistry letters (07.06.1999)
Published in Bioorganic & medicinal chemistry letters (07.06.1999)
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Journal Article
Thrombin receptor-activating peptides (TRAPs): Investigation of bioactive conformations via structure–activity, spectroscopic, and computational studies
Ceruso, Marco A., McComsey, David F., Leo, Gregory C., Andrade-Gordon, Patricia, Addo, Michael F., Scarborough, Robert M., Oksenberg, Donna, Maryanoff, Bruce E.
Published in Bioorganic & medicinal chemistry (01.11.1999)
Published in Bioorganic & medicinal chemistry (01.11.1999)
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Journal Article
McN-5652: a highly potent inhibitor of serotonin uptake
SHANK, R. P, VAUGHT, J. L, PELLEY, K. A, SETLER, P. E, MCCOMSEY, D. F, MARYANOFF, B. E
Published in The Journal of pharmacology and experimental therapeutics (01.12.1988)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.1988)
Journal Article
Heterocycle-peptide hybrid compounds. Aminotriazole-containing agonists of the thrombin receptor (PAR-1)
McComsey, David F., Hawkins, Michael J., Andrade-Gordon, Patricia, Addo, Michael F., Oksenberg, Donna, Maryanoff, Bruce E.
Published in Bioorganic & medicinal chemistry letters (17.05.1999)
Published in Bioorganic & medicinal chemistry letters (17.05.1999)
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Journal Article
Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif
Hoekstra, William J., Hulshizer, Becky L., McComsey, David F., Andrade-Gordon, Patricia, Kauffman, Jack A., Addo, Michael F., Oksenberg, Donna, Scarborough, Robert M., Maryanoff, Bruce E.
Published in Bioorganic & medicinal chemistry letters (07.07.1998)
Published in Bioorganic & medicinal chemistry letters (07.07.1998)
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Journal Article
Novel Indolylindazolylmaleimides as Inhibitors of Protein Kinase C-β: Synthesis, Biological Activity, and Cardiovascular Safety
Zhang, Han-Cheng, Derian, Claudia K, McComsey, David F, White, Kimberly B, Ye, Hong, Hecker, Leonard R, Li, Jian, Addo, Michael F, Croll, Diane, Eckardt, Annette J, Smith, Charles E, Li, Quan, Cheung, Wai-Man, Conway, Bruce R, Emanuel, Stuart, Demarest, Keith T, Andrade-Gordon, Patricia, Damiano, Bruce P, Maryanoff, Bruce E
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Design, Synthesis, and Biological Characterization of a Peptide-Mimetic Antagonist for a Tethered-Ligand Receptor
Andrade-Gordon, Patricia, Maryanoff, Bruce E., Derian, Claudia K., Zhang, Han-Cheng, Addo, Michael F., Darrow, Andrew L., Eckardt, Annette J., Hoekstra, William J., McComsey, David F., Oksenberg, Donna, Reynolds, Elwood E., Santulli, Rosemary J., Scarborough, Robert M., Smith, Charles E., White, Kimberly B.
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.1999)
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Journal Article
Administration of a Potent Antagonist of Protease-Activated Receptor-1 (PAR-1) Attenuates Vascular Restenosis Following Balloon Angioplasty in Rats
Andrade-Gordon, P, Derian, C K, Maryanoff, B E, Zhang, H C, Addo, M F, Cheung Wm, Damiano, B P, D'Andrea, M R, Darrow, A L, de Garavilla, L, Eckardt, A J, Giardino, E C, Haertlein, B J, McComsey, D F
Published in The Journal of pharmacology and experimental therapeutics (01.07.2001)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.2001)
Journal Article
Preclinical evaluation of McN-5707 as a potential antidepressant
Shank, R P, Gardocki, J F, Schneider, C R, Vaught, J L, Setler, P E, Maryanoff, B E, McComsey, D F
Published in The Journal of pharmacology and experimental therapeutics (01.07.1987)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.1987)
Journal Article
Protease-Activated Receptor-2 (PAR-2): Structure-Function Study of Receptor Activation by Diverse Peptides Related to Tethered-Ligand Epitopes
Maryanoff, Bruce E., Santulli, Rosemary J., McComsey, David F., Hoekstra, William J., Hoey, Kenway, Smith, Charles E., Addo, Michael, Darrow, Andrew L., Andrade-Gordon, Patricia
Published in Archives of biochemistry and biophysics (15.02.2001)
Published in Archives of biochemistry and biophysics (15.02.2001)
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Journal Article
Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure−Activity Studies Leading to the Discovery of RWJ-53308
Hoekstra, William J, Maryanoff, Bruce E, Damiano, Bruce P, Andrade-Gordon, Patricia, Cohen, Judith H, Costanzo, Michael J, Haertlein, Barbara J, Hecker, Leonard R, Hulshizer, Becky L, Kauffman, Jack A, Keane, Patricia, McComsey, David F, Mitchell, John A, Scott, Lorraine, Shah, Rekha D, Yabut, Stephen C
Published in Journal of medicinal chemistry (16.12.1999)
Published in Journal of medicinal chemistry (16.12.1999)
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Journal Article
Thrombin receptor (PAR-1) antagonists. Solid-Phase synthesis of indole-Based peptide mimetics by anchoring to a secondary amide
Zhang, Han-Cheng, McComsey, David F, White, Kimberly B, Addo, Michael F, Andrade-Gordon, Patricia, Derian, Claudia K, Oksenberg, Donna, Maryanoff, Bruce E
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
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Journal Article
Pyrroloisoquinoline antidepressants. 3. A focus on serotonin
Maryanoff, Bruce E, Vaught, Jeffry L, Shank, Richard P, McComsey, David F, Costanzo, Michael J, Nortey, Samuel O
Published in Journal of medicinal chemistry (01.10.1990)
Published in Journal of medicinal chemistry (01.10.1990)
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Journal Article
Reaction of amines with methylene chloride. Evidence for rapid aminal formation from N-methylenepyrrolidinium chloride and pyrrolidine
Mills, John E, Maryanoff, Cynthia A, McComsey, David F, Stanzione, Robin C, Scott, Lorraine
Published in Journal of organic chemistry (01.05.1987)
Published in Journal of organic chemistry (01.05.1987)
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