Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
Lintner, Nathanael G, McClure, Kim F, Petersen, Donna, Londregan, Allyn T, Piotrowski, David W, Wei, Liuqing, Xiao, Jun, Bolt, Michael, Loria, Paula M, Maguire, Bruce, Geoghegan, Kieran F, Huang, Austin, Rolph, Tim, Liras, Spiros, Doudna, Jennifer A, Dullea, Robert G, Cate, Jamie H D
Published in PLoS biology (21.03.2017)
Published in PLoS biology (21.03.2017)
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Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing
Rouet, Romain, Thuma, Benjamin A, Roy, Marc D, Lintner, Nathanael G, Rubitski, David M, Finley, James E, Wisniewska, Hanna M, Mendonsa, Rima, Hirsh, Ariana, de Oñate, Lorena, Compte Barrón, Joan, McLellan, Thomas J, Bellenger, Justin, Feng, Xidong, Varghese, Alison, Chrunyk, Boris A, Borzilleri, Kris, Hesp, Kevin D, Zhou, Kaihong, Ma, Nannan, Tu, Meihua, Dullea, Robert, McClure, Kim F, Wilson, Ross C, Liras, Spiros, Mascitti, Vincent, Doudna, Jennifer A
Published in Journal of the American Chemical Society (30.05.2018)
Published in Journal of the American Chemical Society (30.05.2018)
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Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule
Li, Wenfei, Ward, Fred R, McClure, Kim F, Chang, Stacey Tsai-Lan, Montabana, Elizabeth, Liras, Spiros, Dullea, Robert G, Cate, Jamie H D
Published in Nature structural & molecular biology (01.06.2019)
Published in Nature structural & molecular biology (01.06.2019)
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Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
Lintner, Nathanael G, McClure, Kim F, Petersen, Donna, Londregan, Allyn T, Piotrowski, David W, Wei, Liuqing, Xiao, Jun, Bolt, Michael, Loria, Paula M, Maguire, Bruce, Geoghegan, Kieran F, Huang, Austin, Rolph, Tim, Liras, Spiros, Doudna, Jennifer A, Dullea, Robert G, Cate, Jamie H D
Published in PLoS biology (01.04.2018)
Published in PLoS biology (01.04.2018)
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Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response
McClure, Kim F, Darout, Etzer, Guimarães, Cristiano R. W, DeNinno, Michael P, Mascitti, Vincent, Munchhof, Michael J, Robinson, Ralph P, Kohrt, Jeffrey, Harris, Anthony R, Moore, Dianna E, Li, Bryan, Samp, Lacey, Lefker, Bruce A, Futatsugi, Kentaro, Kung, Daniel, Bonin, Paul D, Cornelius, Peter, Wang, Ruduan, Salter, Eben, Hornby, Sam, Kalgutkar, Amit S, Chen, Yue
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
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Design and Synthesis of Diazatricyclodecane Agonists of the G‑Protein-Coupled Receptor 119
Darout, Etzer, Robinson, Ralph P, McClure, Kim F, Corbett, Matthew, Li, Bryan, Shavnya, Andrei, Andrews, Melissa P, Jones, Christopher S, Li, Qifang, Minich, Martha L, Mascitti, Vincent, Guimarães, Cristiano R. W, Munchhof, Michael J, Bahnck, Kevin B, Cai, Cuiman, Price, David A, Liras, Spiros, Bonin, Paul D, Cornelius, Peter, Wang, Ruduan, Bagdasarian, Victoria, Sobota, Colleen P, Hornby, Sam, Masterson, Victoria M, Joseph, Reena M, Kalgutkar, Amit S, Chen, Yue
Published in Journal of medicinal chemistry (10.01.2013)
Published in Journal of medicinal chemistry (10.01.2013)
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Oxidative Metabolism of a Quinoxaline Derivative by Xanthine Oxidase in Rodent Plasma
Sharma, Raman, Eng, Heather, Walker, Gregory S, Barreiro, Gabriela, Stepan, Antonia F, McClure, Kim F, Wolford, Angela, Bonin, Paul D, Cornelius, Peter, Kalgutkar, Amit S
Published in Chemical research in toxicology (19.12.2011)
Published in Chemical research in toxicology (19.12.2011)
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Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice
Rohde, L E, Ducharme, A, Arroyo, L H, Aikawa, M, Sukhova, G H, Lopez-Anaya, A, McClure, K F, Mitchell, P G, Libby, P, Lee, R T
Published in Circulation (New York, N.Y.) (15.06.1999)
Published in Circulation (New York, N.Y.) (15.06.1999)
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Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
KALGUTKAR, Amit S, DALVIE, Deepak K, MAURER, Tristan S, COELHO, Richard V, SOLIMAN, Victor F, SCHILDKNEGT, Klaas, AUBRECHT, Jiri, SMITH, Evan B, COFFING, Stephanie L, CHEUNG, Jennifer R, VAGE, Chandra, LAME, Mary E, CHIANG, Phoebe, MCCLURE, Kim F
Published in Drug metabolism and disposition (01.06.2007)
Published in Drug metabolism and disposition (01.06.2007)
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Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor
Mascitti, Vincent, Stevens, Benjamin D., Choi, Chulho, McClure, Kim F., Guimarães, Cristiano R.W., Farley, Kathleen A., Munchhof, Michael J., Robinson, Ralph P., Futatsugi, Kentaro, Lavergne, Sophie Y., Lefker, Bruce A., Cornelius, Peter, Bonin, Paul D., Kalgutkar, Amit S., Sharma, Raman, Chen, Yue
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Mechanism of Stabilization of Helical Conformations of Polypeptides by Water Containing Trifluoroethanol
Cammers-Goodwin, Arthur, Allen, Thomas J, Oslick, Sherri L, McClure, Kim F, Lee, Janette H, Kemp, D. S
Published in Journal of the American Chemical Society (03.04.1996)
Published in Journal of the American Chemical Society (03.04.1996)
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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease
Gopalsamy, Ariamala, Aulabaugh, Ann E., Barakat, Amey, Beaumont, Kevin C., Cabral, Shawn, Canterbury, Daniel P., Casimiro-Garcia, Agustin, Chang, Jeanne S., Chen, Ming Z., Choi, Chulho, Dow, Robert L., Fadeyi, Olugbeminiyi O., Feng, Xidong, France, Scott P., Howard, Roger M., Janz, Jay M., Jasti, Jayasankar, Jasuja, Reema, Jones, Lyn H., King-Ahmad, Amanda, Knee, Kelly M., Kohrt, Jeffrey T., Limberakis, Chris, Liras, Spiros, Martinez, Carlos A., McClure, Kim F., Narayanan, Arjun, Narula, Jatin, Novak, Jonathan J., O'Connell, Thomas N., Parikh, Mihir D., Piotrowski, David W., Plotnikova, Olga, Robinson, Ralph P., Sahasrabudhe, Parag, Sharma, Raman, Thuma, Benjamin A., Vasa, Dipy, Wei, Liuqing, Wenzel, A. Zane, Withka, Jane M., Xiao, Jun, Yayla, Hatice G.
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups
Aspnes, Gary E., Coffey, Steven B., Darout, Etzer, Dechert-Schmitt, Anne-Marie, Dullea, Robert G., Kamlet, Adam S., Limberakis, Chris, Londregan, Allyn T., McClure, Kim F., Menhaji-Klotz, Elnaz, Piotrowski, David W., Polivkova, Jana, Raymer, Brian, Ruggeri, Roger B., Salatto, Christopher T., Tu, Meihua, Wei, Liuqing, Xiao, Jun
Published in Bioorganic & medicinal chemistry letters (15.08.2023)
Published in Bioorganic & medicinal chemistry letters (15.08.2023)
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Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents
Londregan, Allyn T, Wei, Liuqing, Xiao, Jun, Lintner, Nathanael G, Petersen, Donna, Dullea, Robert G, McClure, Kim F, Bolt, Michael W, Warmus, Joseph S, Coffey, Steven B, Limberakis, Chris, Genovino, Julien, Thuma, Benjamin A, Hesp, Kevin D, Aspnes, Gary E, Reidich, Benjamin, Salatto, Christopher T, Chabot, Jeffrey R, Cate, Jamie H. D, Liras, Spiros, Piotrowski, David W
Published in Journal of medicinal chemistry (12.07.2018)
Published in Journal of medicinal chemistry (12.07.2018)
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Liver‐Targeted Small‐Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis
McClure, Kim F., Piotrowski, David W., Petersen, Donna, Wei, Liuqing, Xiao, Jun, Londregan, Allyn T., Kamlet, Adam S., Dechert‐Schmitt, Anne‐Marie, Raymer, Brian, Ruggeri, Roger B., Canterbury, Daniel, Limberakis, Chris, Liras, Spiros, DaSilva‐Jardine, Paul, Dullea, Robert G., Loria, Paula M., Reidich, Benjamin, Salatto, Christopher T., Eng, Heather, Kimoto, Emi, Atkinson, Karen, King‐Ahmad, Amanda, Scott, Dennis, Beaumont, Kevin, Chabot, Jeffrey R., Bolt, Michael W., Maresca, Kevin, Dahl, Kenneth, Arakawa, Ryosuke, Takano, Akihiro, Halldin, Christer
Published in Angewandte Chemie International Edition (18.12.2017)
Published in Angewandte Chemie International Edition (18.12.2017)
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Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9
Londregan, Allyn T., Aspnes, Gary, Limberakis, Chris, Loria, Paula M., McClure, Kim F., Petersen, Donna N., Raymer, Brian, Ruggeri, Roger B., Wei, Liuqing, Xiao, Jun, Piotrowski, David W.
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
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